Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: PYRUVIC ACID
PDB ligand accession: PYR
DrugBank: DB00119
PubChem: 1060
ChEMBL: CHEMBL1162144
InChI Key: LCTONWCANYUPML-UHFFFAOYSA-N
SMILES: CC(=O)C(=O)O

ClassyFire chemical classification:

List of proteins that are targets for DB00119

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q84LQ5_PYR Q84LQ5 Malic enzyme n/a
2 Q5SKN7_PYR Q5SKN7 Aspartate 1-decarboxylase (EC n/a
3 P30615_PYR P30615 Pyruvate kinase 1 n/a
4 O15375_PYR O15375 Monocarboxylate transporter 6 n/a
5 I6SYK8_PYR I6SYK8 L-lactate oxidase n/a
6 P61889_PYR P61889 Malate dehydrogenase (EC n/a
7 Q87T87_PYR Q87T87 Methyl-accepting chemotaxis protein n/a
8 Q9WXS1_PYR Q9WXS1 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase n/a
9 P00341_PYR P00341 L-lactate dehydrogenase A n/a
10 Q57764_PYR Q57764 Pyruvoyl-dependent arginine decarboxylase n/a
11 P06169_PYR P06169 Pyruvate decarboxylase isozyme n/a
12 O25064_PYR O25064 Chorismate mutase domain-containing n/a
13 P16528_PYR P16528 Transcriptional repressor IclR n/a
14 P21874_PYR P21874 Pyruvate dehydrogenase E1 n/a
15 Q2K340_PYR Q2K340 Pyruvate carboxylase (EC n/a
16 Q3J1R2_PYR Q3J1R2 Alpha-keto acid-binding periplasmic n/a
17 P0A6L2_PYR P0A6L2 4-hydroxy-tetrahydrodipicolinate synthase (HTPA n/a
18 Q5HG25_PYR Q5HG25 4-hydroxy-tetrahydrodipicolinate synthase (HTPA n/a
19 Q9BHM6_PYR Q9BHM6 Octopine dehydrogenase (OcDH) n/a
20 P22259_PYR P22259 Phosphoenolpyruvate carboxykinase (ATP) n/a
21 Q8R7R4_PYR Q8R7R4 Phosphoenolpyruvate-protein phosphotransferase (EC n/a
22 P27696_PYR P27696 Acetolactate synthase, catabolic n/a
23 P11177_PYR P11177 Pyruvate dehydrogenase E1 n/a
24 Q9X9I8_PYR Q9X9I8 Salicylate synthetase, Irp9 n/a
25 D0CFC3_PYR D0CFC3 4-hydroxy-tetrahydrodipicolinate synthase (HTPA n/a
26 O60669_PYR O60669 Monocarboxylate transporter 2 n/a
27 P0A6L4_PYR P0A6L4 N-acetylneuraminate lyase (AcNeu n/a
28 O54983_PYR O54983 Ketimine reductase mu-crystallin n/a
29 Q9RW27_PYR Q9RW27 NimA-related protein n/a
30 P17707_PYR P17707 S-adenosylmethionine decarboxylase proenzyme n/a
31 Q96XT4_PYR Q96XT4 2-oxoacid:ferredoxin oxidoreductase 2, n/a
32 A0A2A9IR05_PYR A0A2A9IR05 deleted n/a
33 P11498_PYR P11498 Pyruvate carboxylase, mitochondrial n/a
34 P9WPE1_PYR P9WPE1 Citrate lyase subunit n/a
35 Q3MFZ5_PYR Q3MFZ5 Amino acid/amide ABC n/a
36 P00897_PYR P00897 Anthranilate synthase component n/a
37 Q97BK3_PYR Q97BK3 NDP-sugar epimerase n/a
38 Q94JQ4_PYR Q94JQ4 Reactive Intermediate Deaminase n/a
39 Q8UB77_PYR Q8UB77 Probable 5-dehydro-4-deoxyglucarate dehydratase n/a
40 Q7TNG8_PYR Q7TNG8 Probable D-lactate dehydrogenase, n/a
41 D4GTL2_PYR D4GTL2 Malate synthase (MSH) n/a
42 B7M0T7_PYR B7M0T7 N-acetylneuraminate lyase (NAL) n/a
43 Q7D785_PYR Q7D785 Salicylate synthase (Chorismate n/a
44 P30613_PYR P30613 Pyruvate kinase PKLR n/a
45 A0A075B5G8_PYR A0A075B5G8 L-lactate dehydrogenase n/a
46 O75164_PYR O75164 Lysine-specific demethylase 4A n/a
47 Q9I5E2_PYR Q9I5E2 2-methylisocitrate lyase (2-MIC) n/a
48 P37330_PYR P37330 Malate synthase G n/a
49 D1A3K8_PYR D1A3K8 4-hydroxy-2-oxovalerate aldolase (HOA) n/a
50 Q5H4T8_PYR Q5H4T8 Cystathionine gamma-lyase-like protein n/a
51 C6VNC6_PYR C6VNC6 deleted n/a
52 Q81QR8_PYR Q81QR8 Methylisocitrate lyase (EC n/a
53 C6KTA4_PYR C6KTA4 Pyruvate kinase (EC n/a
54 P80404_PYR P80404 4-aminobutyrate aminotransferase, mitochondrial inhibitor
55 Q56062_PYR Q56062 2-methylisocitrate lyase (2-MIC) n/a
56 Q8F3Q1_PYR Q8F3Q1 (R)-citramalate synthase CimA n/a
57 H8EVV4_PYR H8EVV4 Isocitrate lyase 1 n/a
58 Q48AL6_PYR Q48AL6 Extracellular solute-binding protein, n/a
59 P23368_PYR P23368 NAD-dependent malic enzyme, n/a
60 A0A080VH08_PYR A0A080VH08 deleted n/a
61 P06672_PYR P06672 Pyruvate decarboxylase (PDC) n/a
62 O15403_PYR O15403 Monocarboxylate transporter 7 n/a
63 O52792_PYR O52792 4-hydroxymandelate oxidase (EC n/a
64 Q5CYZ2_PYR Q5CYZ2 L-lactate dehydrogenase n/a
65 Q9UVD4_PYR Q9UVD4 Macrophomate synthase n/a
66 Q8NMD2_PYR Q8NMD2 Dihydrodipicolinate synthase/N-acetylneuraminate lyase n/a
67 P53985_PYR P53985 Monocarboxylate transporter 1 n/a
68 P07379_PYR P07379 Phosphoenolpyruvate carboxykinase, cytosolic n/a
69 P36021_PYR P36021 Monocarboxylate transporter 8 n/a
70 P11974_PYR P11974 Pyruvate kinase PKM n/a
71 A0A1R4GQY2_PYR A0A1R4GQY2 deleted n/a
72 Q9BYV1_PYR Q9BYV1 Alanine--glyoxylate aminotransferase 2, n/a
73 P37063_PYR P37063 Pyruvate oxidase (EC n/a
74 Q8A5J2_PYR Q8A5J2 Ryanodine receptor n/a
75 Q1NEI7_PYR Q1NEI7 2,4-didehydro-3-deoxy-L-rhamnonate hydrolase (EC n/a
76 Q5HJD7_PYR Q5HJD7 L-lactate dehydrogenase 1 n/a
77 P37355_PYR P37355 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (SHCHC n/a
78 Q643B8_PYR Q643B8 Enduracididine biosynthesis enzyme n/a
79 O15427_PYR O15427 Monocarboxylate transporter 4 n/a
80 P30234_PYR P30234 Alanine dehydrogenase (EC n/a
81 Q5KUA3_PYR Q5KUA3 Alanine dehydrogenase (EC n/a
82 O54288_PYR O54288 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC n/a
83 Q6W6X5_PYR Q6W6X5 Phosphoenolpyruvate carboxykinase (ATP) n/a
84 D7C0E5_PYR D7C0E5 Acetoacetate decarboxylase n/a
85 P14618_PYR P14618 Pyruvate kinase PKM n/a
86 Q4JC35_PYR Q4JC35 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase (EC n/a
87 O31671_PYR O31671 Sporulation kinase D n/a
88 Q8ZNT7_PYR Q8ZNT7 D-cysteine desulfhydrase (EC n/a
89 V5MX36_PYR V5MX36 deleted n/a
90 Q15TH9_PYR Q15TH9 deleted n/a
91 Q70AC7_PYR Q70AC7 Methylmalonyl-CoA carboxyltransferase 5S n/a
92 P0A955_PYR P0A955 KHG/KDPG aldolase ((4S)-4-hydroxy-2-oxoglutarate n/a
93 A0A0D6I7M8_PYR A0A0D6I7M8 deleted n/a
94 P25325_PYR P25325 3-mercaptopyruvate sulfurtransferase (MST) n/a
95 P76469_PYR P76469 2-keto-3-deoxy-L-rhamnonate aldolase (KDR n/a
96 A2DXT4_PYR A2DXT4 L-dopachrome isomerase (EC n/a
97 P63945_PYR P63945 4-hydroxy-tetrahydrodipicolinate synthase (HTPA n/a
98 Q44467_PYR Q44467 L-lactate oxidase (LOD) n/a
99 P21873_PYR P21873 Pyruvate dehydrogenase E1 n/a
100 Q704D1_PYR Q704D1 2-dehydro-3-deoxy-D-gluconate/2-dehydro-3-deoxy-phosphogluconate aldolase (KD(P)G n/a
101 P94692_PYR P94692 Pyruvate:ferredoxin oxidoreductase (PFOR) n/a
102 B1IS70_PYR B1IS70 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase (EC n/a
103 P0A5H3_PYR P0A5H3 Isocitrate lyase (ICL) n/a
104 Q9X0Z6_PYR Q9X0Z6 [FeFe] hydrogenase maturase n/a
105 A0A5R9HKL3_PYR A0A5R9HKL3 deleted n/a
106 S6C1Z0_PYR S6C1Z0 deleted n/a
107 G2IPX5_PYR G2IPX5 Fumarylacetoacetase-like C-terminal domain-containing n/a
108 Q396C7_PYR Q396C7 anthranilate synthase (EC n/a
109 P07342_PYR P07342 Acetolactate synthase catalytic n/a
110 P09373_PYR P09373 Formate acetyltransferase 1 n/a
111 A0A0H3FJT8_PYR A0A0H3FJT8 N-acetylneuraminate lyase (NAL) n/a
112 P00175_PYR P00175 L-lactate dehydrogenase (cytochrome) n/a
113 P39669_PYR P39669 Glucose-1-phosphate adenylyltransferase (EC n/a
114 P23522_PYR P23522 5-keto-4-deoxy-D-glucarate aldolase (KDGluc n/a
115 B4SII9_PYR B4SII9 Cystathionine gamma-lyase (EC n/a
116 D0ZHW1_PYR D0ZHW1 deleted n/a
117 P22221_PYR P22221 Pyruvate, phosphate dikinase, n/a
118 Q99UY8_PYR Q99UY8 deleted n/a
119 P75682_PYR P75682 Putative 2-dehydro-3-deoxy-D-gluconate aldolase n/a
120 A5W059_PYR A5W059 4-hydroxy-4-methyl-2-oxoglutarate aldolase/4-carboxy-4-hydroxy-2-oxoadipate aldolase n/a
121 P0A9G6_PYR P0A9G6 Isocitrate lyase (ICL) n/a
122 Q1H157_PYR Q1H157 Oxaloacetate decarboxylase alpha n/a
123 Q51507_PYR Q51507 Isochorismate pyruvate lyase n/a
124 Q96XT2_PYR Q96XT2 2-oxoacid:ferredoxin oxidoreductase 2, n/a
125 O15374_PYR O15374 Monocarboxylate transporter 5 n/a
126 P77541_PYR P77541 2-methylisocitrate lyase (2-MIC) n/a
127 A0A075B5H0_PYR A0A075B5H0 L-lactate dehydrogenase n/a
128 D2YW47_PYR D2YW47 2-dehydro-3-deoxy-phosphogluconate aldolase (EC n/a
129 O52942_PYR O52942 Alanine dehydrogenase (EC n/a
130 Q7YW97_PYR Q7YW97 L-threonine 3-dehydrogenase (EC n/a
131 A0A045JB88_PYR A0A045JB88 citrate synthase (unknown n/a