Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: GLUTATHIONE
PDB ligand accession: GSH
DrugBank: DB00143
PubChem: 124886;25246407;171390563;
ChEMBL: CHEMBL1543
InChI Key: RWSXRVCMGQZWBV-WDSKDSINSA-N
SMILES: C(CC(=O)NC(CS)C(=O)NCC(=O)O)C(C(=O)O)N

ClassyFire chemical classification:

List of proteins that are targets for DB00143

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P30711_GSH P30711 Glutathione S-transferase theta-1 n/a
2 A0A1S4FIB3_GSH A0A1S4FIB3 glutathione transferase (EC n/a
3 P0CG29_GSH P0CG29 Glutathione S-transferase theta-2 n/a
4 Q962Y6_GSH Q962Y6 thioredoxin-disulfide reductase (EC n/a
5 P81065_GSH P81065 Glutathione S-transferase (EC n/a
6 P28338_GSH P28338 Glutathione S-transferase 1 n/a
7 P08684_GSH P08684 Cytochrome P450 3A4 n/a
8 O35543_GSH O35543 Hematopoietic prostaglandin D n/a
9 Q12390_GSH Q12390 Glutathione S-transferase 2 n/a
10 P35754_GSH P35754 Glutaredoxin-1 (Thioltransferase-1) (TTase-1) n/a
11 P25373_GSH P25373 Glutaredoxin-1 (EC 1.11.1.9) n/a
12 M4MQ92_GSH M4MQ92 deleted n/a
13 Q9H4Y5_GSH Q9H4Y5 Glutathione S-transferase omega-2 n/a
14 P41043_GSH P41043 Glutathione S-transferase S1 n/a
15 Q7YT09_GSH Q7YT09 Lipocalin AI-4 n/a
16 B8ZLL4_GSH B8ZLL4 deleted n/a
17 Q9FRL8_GSH Q9FRL8 Glutathione S-transferase DHAR2 n/a
18 Q4WB03_GSH Q4WB03 Glutathione S-transferase psoE n/a
19 Q7JZM3_GSH Q7JZM3 RE21095p n/a
20 O60760_GSH O60760 Hematopoietic prostaglandin D n/a
21 P10768_GSH P10768 S-formylglutathione hydrolase (FGH) n/a
22 Q7PVS6_GSH Q7PVS6 glutathione transferase (EC n/a
23 O65032_GSH O65032 Probable glutathione S-transferase n/a
24 P23202_GSH P23202 Transcriptional regulator URE2 n/a
25 Q28640_GSH Q28640 Histidine-rich glycoprotein (Histidine-proline-rich n/a
26 P30347_GSH P30347 Protein LigF n/a
27 V9GZ94_GSH V9GZ94 Glutaredoxin n/a
28 A0A0R4I981_GSH A0A0R4I981 PcUre2p6 n/a
29 G9B5E4_GSH G9B5E4 Glutathione S-transferase (EC n/a
30 E3Y3H4_GSH E3Y3H4 deleted n/a
31 P15214_GSH P15214 Glutathione S-transferase GST-6.0 n/a
32 Q7JYX0_GSH Q7JYX0 Glutathione S-transferase E14 n/a
33 Q09596_GSH Q09596 Probable glutathione S-transferase n/a
34 O43813_GSH O43813 Glutathione S-transferase LANCL1 n/a
35 Q16873_GSH Q16873 Leukotriene C4 synthase n/a
36 A7ILT8_GSH A7ILT8 Glutathione S-transferase domain n/a
37 Q9N0A4_GSH Q9N0A4 Prostaglandin E synthase n/a
38 P68688_GSH P68688 Glutaredoxin 1 (Grx1) n/a
39 O14684_GSH O14684 Prostaglandin E synthase n/a
40 A0A1W6I4R7_GSH A0A1W6I4R7 Glutaredoxin n/a
41 Q25595_GSH Q25595 glutathione transferase (EC n/a
42 Q2G542_GSH Q2G542 Glutathione S-transferase-like protein n/a
43 Q84895_GSH Q84895 Genome polyprotein n/a
44 A0A1M2V359_GSH A0A1M2V359 Glutathione S-transferase omega-1 n/a
45 Q3J568_GSH Q3J568 2-hydroxychromene-2-carboxylate isomerase (EC n/a
46 A6TBY7_GSH A6TBY7 Glutathione S-transferase n/a
47 I6ZUH3_GSH I6ZUH3 Glutathione transferase n/a
48 B6TPH0_GSH B6TPH0 Lactoylglutathione lyase (EC n/a
49 Q4TVQ0_GSH Q4TVQ0 PrfA (Positive regulatory n/a
50 P19157_GSH P19157 Glutathione S-transferase P n/a
51 R7S6N2_GSH R7S6N2 GST N-terminal domain-containing n/a
52 P77526_GSH P77526 Disulfide-bond oxidoreductase YfcG n/a
53 J9Q529_GSH J9Q529 glutathione transferase (EC n/a
54 A0A3F2YM27_GSH A0A3F2YM27 Glutathione transferase Xi n/a
55 Q5CCJ4_GSH Q5CCJ4 glutathione transferase (EC n/a
56 U5GTL0_GSH U5GTL0 glutathione transferase (EC n/a
57 O76003_GSH O76003 Glutaredoxin-3 (PKC-interacting cousin n/a
58 Q9Y5Y6_GSH Q9Y5Y6 Suppressor of tumorigenicity n/a
59 A0A4Y5R087_GSH A0A4Y5R087 Glutathione S-transferase (EC n/a
60 B9HM14_GSH B9HM14 GST N-terminal domain-containing n/a
61 B4KM86_GSH B4KM86 Glutathione transferase n/a
62 A6L2G9_GSH A6L2G9 Putative thiol-disulfide oxidoreductase n/a
63 Q8F2Y8_GSH Q8F2Y8 Glutathione transferase n/a
64 Q5NHD0_GSH Q5NHD0 Glutaredoxin 1 n/a
65 P09792_GSH P09792 Glutathione S-transferase class-mu n/a
66 Q16772_GSH Q16772 Glutathione S-transferase A3 n/a
67 Q8D0L3_GSH Q8D0L3 Glutathione S-transferase (Glutathionine n/a
68 P0AC69_GSH P0AC69 Glutaredoxin 4 (Grx4) n/a
69 P0AC59_GSH P0AC59 Glutaredoxin 2 (Grx2) n/a
70 Q9WVL0_GSH Q9WVL0 Maleylacetoacetate isomerase (MAAI) n/a
71 O30347_GSH O30347 Glutathione S-transferase n/a
72 Q0B681_GSH Q0B681 Glutathione S-transferase, N-terminal n/a
73 A0A384E158_GSH A0A384E158 Glutathione transferase (EC n/a
74 P78417_GSH P78417 Glutathione S-transferase omega-1 n/a
75 Q99828_GSH Q99828 Calcium and integrin-binding n/a
76 Q57UN0_GSH Q57UN0 Glutathione synthetase (GSH-S) n/a
77 A8MJH2_GSH A8MJH2 Glutaredoxin n/a
78 O14746_GSH O14746 Telomerase reverse transcriptase n/a
79 Q9Y2Q3_GSH Q9Y2Q3 Glutathione S-transferase kappa n/a IC50(nM) = 20.0
80 P24472_GSH P24472 Glutathione S-transferase A4 n/a
81 Q2YLQ3_GSH Q2YLQ3 Glyoxalase/Bleomycin resistance protein/dioxygenase n/a
82 Q4K8I0_GSH Q4K8I0 Glutathione S-transferase (EC n/a
83 Q1GZF4_GSH Q1GZF4 Glutathione S-transferase-like protein n/a
84 A5VWI3_GSH A5VWI3 Beta-lactamase domain protein n/a
85 Q8DRG2_GSH Q8DRG2 ABC transporter substrate-binding n/a
86 D2X9R3_GSH D2X9R3 glutathione transferase (EC n/a
87 Q5SID2_GSH Q5SID2 Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC n/a
88 B2TEQ2_GSH B2TEQ2 Beta-lactamase domain protein n/a
89 Q99735_GSH Q99735 Microsomal glutathione S-transferase n/a
90 B9VX79_GSH B9VX79 Rho-class glutathione S-transferase n/a
91 P46434_GSH P46434 Glutathione S-transferase 1 n/a
92 C5A7Z5_GSH C5A7Z5 deleted n/a
93 G0XSZ1_GSH G0XSZ1 glutathione transferase (EC n/a
94 E2PZ87_GSH E2PZ87 Thioredoxin reductase n/a
95 M2R618_GSH M2R618 CsMn06 n/a
96 Q9I774_GSH Q9I774 DSBA-like thioredoxin domain-containing n/a
97 Q5PSJ1_GSH Q5PSJ1 Glutaredoxin n/a
98 Q8XVV6_GSH Q8XVV6 Probable glutathione s-transferase n/a
99 B4E6Q3_GSH B4E6Q3 Stringent starvation protein n/a
100 P08515_GSH P08515 Glutathione S-transferase class-mu n/a
101 P19440_GSH P19440 Glutathione hydrolase 1 n/a
102 Q46845_GSH Q46845 Disulfide-bond oxidoreductase YghU n/a
103 O18598_GSH O18598 Glutathione S-transferase (EC n/a
104 Q7CQR3_GSH Q7CQR3 Glutaredoxin 2 n/a
105 P10620_GSH P10620 Microsomal glutathione S-transferase n/a
106 Q86LL8_GSH Q86LL8 Glutathione S-transferase (EC n/a
107 A8R5V3_GSH A8R5V3 Omega-class glutathione S-transferase n/a
108 P46439_GSH P46439 Glutathione S-transferase Mu n/a
109 P01899_GSH P01899 H-2 class I n/a
110 Q9GPL8_GSH Q9GPL8 glutathione transferase (EC n/a
111 A4I8P2_GSH A4I8P2 Thiol-dependent reductase 1 n/a
112 O14880_GSH O14880 Glutathione S-transferase 3, n/a
113 Q9FWR4_GSH Q9FWR4 Glutathione S-transferase DHAR1, n/a
114 Q2LKZ0_GSH Q2LKZ0 Genome polyprotein [Cleaved n/a
115 Q9NS18_GSH Q9NS18 Glutaredoxin-2, mitochondrial n/a
116 A0A8F1AEX2_GSH A0A8F1AEX2 deleted n/a
117 Q9Y4U1_GSH Q9Y4U1 Cyanocobalamin reductase / n/a
118 B9ICN7_GSH B9ICN7 deleted n/a
119 M9ZT87_GSH M9ZT87 Glutathione S-transferase (EC n/a
120 Q16775_GSH Q16775 Hydroxyacylglutathione hydrolase, mitochondrial n/a
121 Q8L7C9_GSH Q8L7C9 Glutathione S-transferase U20 n/a
122 P03950_GSH P03950 Angiogenin (EC 3.1.27.-) n/a
123 P0AES0_GSH P0AES0 Bifunctional glutathionylspermidine synthetase/amidase n/a
124 P13745_GSH P13745 Glutathione S-transferase A1 n/a
125 P03819_GSH P03819 Glutathione-regulated potassium-efflux system n/a
126 Q02KA8_GSH Q02KA8 deleted n/a
127 P20432_GSH P20432 Glutathione S-transferase D1 n/a
128 P09211_GSH P09211 Glutathione S-transferase P n/a
129 Q9WXJ9_GSH Q9WXJ9 Glutathione S-transferase homolog n/a
130 P30113_GSH P30113 Glutathione S-transferase class-mu n/a
131 Q96SL4_GSH Q96SL4 Glutathione peroxidase 7 n/a cofactor
132 P17695_GSH P17695 Glutaredoxin-2 (EC 1.11.1.9) n/a
133 B9I0G5_GSH B9I0G5 Glutathione S-transferase (EC n/a
134 Q4KDJ6_GSH Q4KDJ6 Glutathione S-transferase domain n/a
135 O75715_GSH O75715 Epididymal secretory glutathione n/a cofactor
136 Q8WVC1_GSH Q8WVC1 ST14 protein n/a
137 P61626_GSH P61626 Lysozyme C (EC n/a
138 A9PHH6_GSH A9PHH6 glutathione transferase (EC n/a
139 Q51669_GSH Q51669 Glutathione-dependent formaldehyde-activating enzyme n/a
140 B9MWW0_GSH B9MWW0 glutathione transferase (EC n/a
141 B1FXZ2_GSH B1FXZ2 Disulfide-bond oxidoreductase YghU n/a
142 P46419_GSH P46419 Glutathione S-transferase (EC n/a
143 Q8Z859_GSH Q8Z859 Glutathione S-transferase n/a
144 O49235_GSH O49235 Glutathione S-transferase (EC n/a
145 P09488_GSH P09488 Glutathione S-transferase Mu n/a
146 C8CGT7_GSH C8CGT7 glutathione transferase (EC n/a
147 A0A9E8RZN7_GSH A0A9E8RZN7 glutathione transferase (EC n/a
148 P46427_GSH P46427 Glutathione S-transferase 2 n/a
149 Q04760_GSH Q04760 Lactoylglutathione lyase (EC n/a Ki(nM) = 955000.0
150 A1ZB71_GSH A1ZB71 Glutathione S transferase n/a
151 A5VPS6_GSH A5VPS6 deleted n/a
152 P36156_GSH P36156 Glutathione S-transferase omega-like n/a
153 B0Y813_GSH B0Y813 glutathione transferase (EC n/a
154 C3TEC2_GSH C3TEC2 Glutaredoxin (Glutaredoxin glutaredoxin) n/a
155 P42620_GSH P42620 Glutathionyl-hydroquinone reductase YqjG n/a
156 Q49SB0_GSH Q49SB0 glutathione transferase (EC n/a
157 P31670_GSH P31670 Glutathione S-transferase class-mu n/a
158 D3U1A6_GSH D3U1A6 glutathione transferase (EC n/a
159 Q9GNE9_GSH Q9GNE9 glutathione transferase (EC n/a
160 Q9NP58_GSH Q9NP58 ATP-binding cassette sub-family n/a
161 P08011_GSH P08011 Microsomal glutathione S-transferase n/a
162 P00390_GSH P00390 Glutathione reductase, mitochondrial n/a
163 O80852_GSH O80852 Glutathione S-transferase F9 n/a
164 P14780_GSH P14780 Matrix metalloproteinase-9 (MMP-9) n/a
165 A3STM0_GSH A3STM0 deleted n/a
166 O00299_GSH O00299 Chloride intracellular channel n/a
167 Q51948_GSH Q51948 2-hydroxychromene-2-carboxylate isomerase (HCCA n/a
168 Q86SX6_GSH Q86SX6 Glutaredoxin-related protein 5, n/a
169 Q9M9F1_GSH Q9M9F1 Glutathione S-transferase U23 n/a
170 P22217_GSH P22217 Thioredoxin-1 (Thioredoxin I) n/a
171 D0LNW1_GSH D0LNW1 Glutathione S-transferase domain n/a
172 A0A4Y5R032_GSH A0A4Y5R032 Glutathione S-transferase (EC n/a
173 D2WL63_GSH D2WL63 glutathione transferase (EC n/a
174 M2QJS8_GSH M2QJS8 GST N-terminal domain-containing n/a
175 B1FZ96_GSH B1FZ96 Glutathione S-transferase GstB n/a
176 Q39034_GSH Q39034 Peroxidase 59 (Atperox n/a
177 R7S7J5_GSH R7S7J5 GST N-terminal domain-containing n/a
178 O86043_GSH O86043 Maleylpyruvate isomerase (MPI) n/a
179 Q99PF4_GSH Q99PF4 Cadherin-23 (Otocadherin) n/a
180 P08263_GSH P08263 Glutathione S-transferase A1 n/a
181 P40416_GSH P40416 Iron-sulfur clusters transporter n/a
182 O15247_GSH O15247 Chloride intracellular channel n/a
183 P46436_GSH P46436 Glutathione S-transferase 1 n/a
184 Q8PG02_GSH Q8PG02 deleted n/a
185 D3U1A5_GSH D3U1A5 glutathione transferase (EC n/a
186 P03952_GSH P03952 Plasma kallikrein (EC n/a
187 Q9SHH7_GSH Q9SHH7 Glutathione S-transferase U25 n/a
188 Q8YY76_GSH Q8YY76 glutathione gamma-glutamylcysteinyltransferase (EC n/a
189 Q60CN1_GSH Q60CN1 Glutathione S-transferase (EC n/a
190 B8J605_GSH B8J605 Maleylacetoacetate isomerase n/a
191 B9HM36_GSH B9HM36 Uncharacterized protein n/a
192 H2D5F4_GSH H2D5F4 Toll-like receptor 2 n/a
193 B3VQJ7_GSH B3VQJ7 Glutathione-S-transferase n/a
194 O50725_GSH O50725 Surface protein n/a
195 P30712_GSH P30712 Glutathione S-transferase theta-2B n/a
196 C5ATQ9_GSH C5ATQ9 Maleylacetoacetate isomerase (Glutathione n/a
197 O15217_GSH O15217 Glutathione S-transferase A4 n/a
198 O33374_GSH O33374 RegF (Stringent starvation n/a
199 Q9U795_GSH Q9U795 Glutathione s-transferase 6B n/a
200 U5G7B9_GSH U5G7B9 deleted n/a
201 P0AC62_GSH P0AC62 Glutaredoxin 3 (Grx3) n/a
202 A0A1C7D1H4_GSH A0A1C7D1H4 S-crystallin OctvuS4 n/a
203 D3VKV1_GSH D3VKV1 Glutathione S-transferase enzyme n/a
204 P30114_GSH P30114 Glutathione S-transferase class-mu n/a
205 P0ACA1_GSH P0ACA1 Uncharacterized GST-like protein n/a
206 Q9GN60_GSH Q9GN60 glutathione transferase (EC n/a
207 Q8MU52_GSH Q8MU52 Glutathione S-transferase (PfGST) n/a
208 P78352_GSH P78352 Disks large homolog n/a
209 O33705_GSH O33705 Glutathione S-transferase n/a
210 Q8GWS0_GSH Q8GWS0 Glutaredoxin-C5, chloroplastic (AtGrxC5) n/a
211 Q81F54_GSH Q81F54 Glyoxalase family protein n/a
212 P15121_GSH P15121 Aldo-keto reductase family n/a
213 P21333_GSH P21333 Filamin-A (FLN-A) (Actin-binding n/a
214 A0A1P8NWC2_GSH A0A1P8NWC2 glutathione transferase (EC n/a
215 Q7RTV2_GSH Q7RTV2 Glutathione S-transferase A5 n/a
216 P25858_GSH P25858 Glyceraldehyde-3-phosphate dehydrogenase GAPC1, n/a
217 P04905_GSH P04905 Glutathione S-transferase Mu n/a
218 Q8N0B3_GSH Q8N0B3 Glutathione S-transferase (Seminal n/a
219 Q65XA0_GSH Q65XA0 Probable glutathione S-transferase n/a
220 O88273_GSH O88273 Gremlin-2 (Cysteine knot n/a
221 P41921_GSH P41921 Glutathione reductase (GR) n/a
222 I0BZV0_GSH I0BZV0 Thioredoxin-like protein 2.1 n/a
223 Q9PE18_GSH Q9PE18 Glutathione S-transferase n/a
224 P16152_GSH P16152 Carbonyl reductase [NADPH] n/a
225 O43708_GSH O43708 Maleylacetoacetate isomerase (MAAI) n/a
226 Q9VGA1_GSH Q9VGA1 Glutathione S transferase n/a
227 Q03013_GSH Q03013 Glutathione S-transferase Mu n/a
228 P03951_GSH P03951 Coagulation factor XI n/a
229 Q60860_GSH Q60860 Leukotriene C4 synthase n/a
230 P28161_GSH P28161 Glutathione S-transferase Mu n/a
231 Q3IZT6_GSH Q3IZT6 Glutathione S-transferase (EC n/a
232 A0A1P8PEY0_GSH A0A1P8PEY0 Putative glutathione S-transferase n/a
233 O61996_GSH O61996 Glutathione S-transferase n/a
234 D3U1A7_GSH D3U1A7 glutathione transferase (EC n/a
235 A5E437_GSH A5E437 Glutathione S-transferase n/a
236 P04425_GSH P04425 Glutathione synthetase (EC n/a
237 Q6DH06_GSH Q6DH06 Glutaredoxin-2, mitochondrial n/a
238 Q59721_GSH Q59721 Glutathione S-transferase (EC n/a
239 A7JQU5_GSH A7JQU5 deleted n/a
240 P26697_GSH P26697 Glutathione S-transferase 3 n/a
241 Q7M8V9_GSH Q7M8V9 PUTATIVE PERIPLASMIC PROTEIN n/a
242 P48637_GSH P48637 Glutathione synthetase (GSH n/a
243 Q7P0B4_GSH Q7P0B4 Penicillin-binding protein activator n/a
244 P24473_GSH P24473 Glutathione S-transferase kappa n/a
245 A0A7M7GUY7_GSH A0A7M7GUY7 Glutathione S-transferase D1 n/a
246 Q12438_GSH Q12438 Monothiol glutaredoxin-6 n/a
247 Q06A71_GSH Q06A71 glutathione transferase (EC n/a
248 P14141_GSH P14141 Carbonic anhydrase 3 n/a
249 Q88RE7_GSH Q88RE7 Glutathione S-transferase (EC n/a
250 Q9Y316_GSH Q9Y316 Protein MEMO1 (C21orf19-like n/a
251 A5EI34_GSH A5EI34 deleted n/a
252 D0FXZ0_GSH D0FXZ0 Photosystem I P700 n/a
253 P23907_GSH P23907 Major prion protein n/a
254 P09210_GSH P09210 Glutathione S-transferase A2 n/a
255 D2YW48_GSH D2YW48 Probable glutathione S-transferase n/a
256 Q10740_GSH Q10740 Leucine aminopeptidase 2 n/a
257 Q9NP99_GSH Q9NP99 Triggering receptor expressed n/a
258 R4S8C5_GSH R4S8C5 Glutathione S-transferase D1 n/a
259 Q9RAF0_GSH Q9RAF0 Glutathione S-transferase (EC n/a
260 Q2G506_GSH Q2G506 ATM1-type heavy metal n/a
261 G0SBE6_GSH G0SBE6 Iron-sulfur clusters transporter n/a
262 P56598_GSH P56598 Glutathione S-transferase class-mu n/a
263 P04818_GSH P04818 Thymidylate synthase (TS) n/a
264 G2IN93_GSH G2IN93 Beta-etherase n/a
265 Q5PY77_GSH Q5PY77 glutathione transferase (EC n/a
266 Q4KED9_GSH Q4KED9 Glutathione S-transferase (EC n/a
267 M5BPX4_GSH M5BPX4 glutathione transferase (EC n/a
268 A0A6I8WFT8_GSH A0A6I8WFT8 Photosystem I reaction n/a
269 P37231_GSH P37231 Peroxisome proliferator-activated receptor n/a
270 P21266_GSH P21266 Glutathione S-transferase Mu n/a
271 Q4K4R5_GSH Q4K4R5 Glutathione S-transferase-like protein n/a
272 A0A384E145_GSH A0A384E145 Glutathione transferase (EC n/a
273 P15530_GSH P15530 B-cell antigen receptor n/a
274 P39040_GSH P39040 Trypanothione reductase (TR) n/a
275 Q16875_GSH Q16875 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase n/a
276 P32477_GSH P32477 Glutamate--cysteine ligase (EC n/a