Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: LEUCINE
PDB ligand accession: LEU
DrugBank: DB00149
PubChem: 6106;7045798;
ChEMBL: CHEMBL291962
InChI Key: ROHFNLRQFUQHCH-YFKPBYRVSA-N
SMILES: CC(C)CC(C(=O)O)N

ClassyFire chemical classification:

List of proteins that are targets for DB00149

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P00727_LEU P00727 Cytosol aminopeptidase (EC n/a
2 P96420_LEU P96420 2-isopropylmalate synthase (EC n/a
3 P96896_LEU P96896 Leucine-responsive regulatory protein n/a
4 Q7CX36_LEU Q7CX36 ABC transporter, substrate n/a
5 B4RNT1_LEU B4RNT1 Leucine--tRNA ligase (EC n/a
6 Q695T7_LEU Q695T7 Sodium-dependent neutral amino n/a
7 Q72LL6_LEU Q72LL6 2-aminoadipate transaminase (EC n/a
8 Q13936_LEU Q13936 Voltage-dependent L-type calcium n/a
9 P04816_LEU P04816 Leucine-specific-binding protein (L-BP) n/a
10 A0A4Y7X244_LEU A0A4Y7X244 Na+-dependent transporter (Sodium-dependent n/a
11 Q834W6_LEU Q834W6 Hydrophobic dipeptide epimerase n/a
12 Q9PPK3_LEU Q9PPK3 Glycine--tRNA ligase alpha n/a
13 Q9K0L9_LEU Q9K0L9 Transcriptional regulator, AsnC n/a
14 A0A494C0S0_LEU A0A494C0S0 Sorting nexin 25 n/a
15 P0A988_LEU P0A988 Beta sliding clamp n/a
16 O75112_LEU O75112 LIM domain-binding protein n/a
17 O67854_LEU O67854 Na(+):neurotransmitter symporter (Snf n/a
18 Q9P2J5_LEU Q9P2J5 Leucine--tRNA ligase, cytoplasmic n/a
19 R4NRX5_LEU R4NRX5 deleted n/a
20 Q3MFZ5_LEU Q3MFZ5 Amino acid/amide ABC n/a
21 P02917_LEU P02917 Leu/Ile/Val-binding protein (LIV-BP) n/a
22 P12955_LEU P12955 Xaa-Pro dipeptidase (X-Pro n/a
23 P15145_LEU P15145 Aminopeptidase N (AP-N) n/a
24 Q9Y566_LEU Q9Y566 SH3 and multiple n/a
25 A0A0J9X221_LEU A0A0J9X221 40S ribosomal protein n/a
26 P00777_LEU P00777 Streptogrisin-B (EC 3.4.21.81) n/a
27 P01900_LEU P01900 H-2 class I n/a
28 F6IQS1_LEU F6IQS1 MHC class I n/a
29 Q7SIE4_LEU Q7SIE4 Leucine--tRNA ligase (EC n/a
30 P9WPC2_LEU P9WPC2 ATP-dependent Clp protease n/a
31 A0A0E3URV8_LEU A0A0E3URV8 Leucine hydroxylase n/a
32 Q28943_LEU Q28943 Dihydropyrimidine dehydrogenase [NADP(+)] n/a
33 P0DTC2_LEU P0DTC2 Spike glycoprotein (S n/a
34 Q2U1F3_LEU Q2U1F3 Leucine aminopeptidase A n/a
35 Q9WXM1_LEU Q9WXM1 L-Ala-D/L-Glu epimerase (AE n/a
36 P01901_LEU P01901 H-2 class I n/a
37 P96084_LEU P96084 Proline iminopeptidase (PIP) n/a
38 P9WPC4_LEU P9WPC4 ATP-dependent Clp protease n/a
39 B8FZ96_LEU B8FZ96 Extracellular ligand-binding receptor n/a
40 P00800_LEU P00800 Thermolysin (EC 3.4.24.27) n/a
41 Q3K7T6_LEU Q3K7T6 Putative methyl-accepting chemotaxis n/a
42 A7Y7W1_LEU A7Y7W1 Periplasmic dipeptide-binding protein n/a
43 W9BH30_LEU W9BH30 Bestrophin family ion n/a
44 Q5M4H8_LEU Q5M4H8 Di-or tripeptide:H+ symporter n/a
45 Q9NTG7_LEU Q9NTG7 NAD-dependent protein deacetylase n/a
46 Q13936-20_LEU Q13936-20 n/a
47 A0A3X8N4T9_LEU A0A3X8N4T9 deleted n/a
48 P04825_LEU P04825 Aminopeptidase N (EC n/a
49 P69905_LEU P69905 Hemoglobin subunit alpha n/a
50 P26321_LEU P26321 Large ribosomal subunit n/a
51 Q72IC0_LEU Q72IC0 Glutamate dehydrogenase n/a
52 Q72GM3_LEU Q72GM3 Leucine--tRNA ligase (EC n/a
53 P07813_LEU P07813 Leucine--tRNA ligase (EC n/a
54 Q01693_LEU Q01693 Bacterial leucyl aminopeptidase n/a
55 P15034_LEU P15034 Xaa-Pro aminopeptidase (EC n/a
56 Q147X3_LEU Q147X3 N-alpha-acetyltransferase 30 (EC n/a
57 Q8YEE8_LEU Q8YEE8 Leu/Ile/Val-binding protein homolog n/a
58 P58004_LEU P58004 Sestrin-2 (EC 1.11.1.-) n/a
59 O84049_LEU O84049 Probable cytosol aminopeptidase n/a
60 P41805_LEU P41805 Large ribosomal subunit n/a
61 Q8XUX2_LEU Q8XUX2 Probable substrate-binding periplasmic n/a
62 A0A140T871_LEU A0A140T871 Glutamate dehydrogenase 1, n/a
63 Q9UHI5_LEU Q9UHI5 Large neutral amino n/a
64 Q9RVZ5_LEU Q9RVZ5 Aminopeptidase N (EC n/a
65 P0A8P1_LEU P0A8P1 Leucyl/phenylalanyl-tRNA--protein transferase (EC n/a
66 Q08787_LEU Q08787 Surfactin synthase subunit n/a
67 Q9WXZ2_LEU Q9WXZ2 tRNA N6-adenosine threonylcarbamoyltransferase n/a
68 V5YM14_LEU V5YM14 Dipeptidyl aminopeptidase BII n/a
69 P23847_LEU P23847 Dipeptide-binding protein (DBP) n/a
70 Q16769_LEU Q16769 Glutaminyl-peptide cyclotransferase (EC n/a
71 P48247_LEU P48247 Glutamate-1-semialdehyde 2,1-aminomutase (GSA) n/a
72 Q9SKE2_LEU Q9SKE2 Jasmonoyl--L-amino acid synthetase n/a
73 Q9HXN1_LEU Q9HXN1 Membrane-bound lytic murein n/a
74 A0A1B4XP18_LEU A0A1B4XP18 Global transcriptional regulator n/a
75 P22262_LEU P22262 Listeriolysin regulatory protein n/a
76 P80561_LEU P80561 Aminopeptidase S (EC n/a
77 Q72IC1_LEU Q72IC1 Glutamate dehydrogenase n/a