Ligand name: Clozapine
PDB ligand accession: n/a
DrugBank: DB00363
InChI Key: QZUDBNBUXVUHMW-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)C2=Nc3cc(ccc3Nc4c2cccc4)Cl

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Benzodiazepines
      • Subclass: Dibenzodiazepines

List of proteins that are targets for DB00363

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P21917_DB00363	P21917	D(4) dopamine receptor	antagonist	Ki(nM) = 7.27 IC50(nM) = 17.0
2	P35368_DB00363	P35368	Alpha-1B adrenergic receptor	antagonist
3	P20309_DB00363	P20309	Muscarinic acetylcholine receptor	antagonist	Ki(nM) = 34.0 EC50(nM) = 10000.0
4	P35367_DB00363	P35367	Histamine H1 receptor	antagonist	Ki(nM) = 1.0 Kd(nM) = 3.1
5	P46098_DB00363	P46098	5-hydroxytryptamine receptor 3A	antagonist	Ki(nM) = 186.0
6	P14416_DB00363	P14416	D(2) dopamine receptor	antagonist	Ki(nM) = 6.87 IC50(nM) = 9.0
7	P18825_DB00363	P18825	Alpha-2C adrenergic receptor	antagonist	Ki(nM) = 2.9
8	Q9H3N8_DB00363	Q9H3N8	Histamine H4 receptor	agonist	Ki(nM) = 200.0 Kd(nM) = 11.9
9	P18089_DB00363	P18089	Alpha-2B adrenergic receptor	antagonist
10	P28221_DB00363	P28221	5-hydroxytryptamine receptor 1D	antagonist
11	P08173_DB00363	P08173	Muscarinic acetylcholine receptor	partial agonist	Ki(nM) = 13.0 EC50(nM) = 10000.0
12	P28222_DB00363	P28222	5-hydroxytryptamine receptor 1B	antagonist
13	P35462_DB00363	P35462	D(3) dopamine receptor	antagonist	Ki(nM) = 6.62 IC50(nM) = 450.0
14	P35348_DB00363	P35348	Alpha-1A adrenergic receptor	antagonist	Ki(nM) = 19.0
15	P11229_DB00363	P11229	Muscarinic acetylcholine receptor	partial agonist	Ki(nM) = 0.98 IC50(nM) = 9.4 EC50(nM) = 10000.0
16	P08172_DB00363	P08172	Muscarinic acetylcholine receptor	partial agonist	EC50(nM) = 10000.0
17	P28335_DB00363	P28335	5-hydroxytryptamine receptor 2C	antagonist	Ki(nM) = 2.9 IC50(nM) = 10.0
18	P08913_DB00363	P08913	Alpha-2A adrenergic receptor	antagonist	Ki(nM) = 24.0
19	P50406_DB00363	P50406	5-hydroxytryptamine receptor 6	antagonist	Ki(nM) = 4.0 IC50(nM) = 17.0
20	P08912_DB00363	P08912	Muscarinic acetylcholine receptor	antagonist
21	P08908_DB00363	P08908	5-hydroxytryptamine receptor 1A	antagonist	Ki(nM) = 6.4 IC50(nM) = 150.0
22	P21728_DB00363	P21728	D(1A) dopamine receptor	antagonist	Ki(nM) = 7.5
23	P34969_DB00363	P34969	5-hydroxytryptamine receptor 7	antagonist	Ki(nM) = 9.0
24	P09211_DB00363	P09211	Glutathione S-transferase P	n/a
25	P28566_DB00363	P28566	5-hydroxytryptamine receptor 1E	antagonist
26	P28223_DB00363	P28223	5-hydroxytryptamine receptor 2A	antagonist	Ki(nM) = 1.4 IC50(nM) = 12.0