Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: PROGESTERONE
PDB ligand accession: STR
DrugBank: DB00396
PubChem: 5994
ChEMBL: CHEMBL103
InChI Key: RJKFOVLPORLFTN-LEKSSAKUSA-N
SMILES: CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

ClassyFire chemical classification:

List of proteins that are targets for DB00396

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P05090_STR P05090 Apolipoprotein D (Apo-D) n/a
2 A9FDB7_STR A9FDB7 C-19 steroid 1alpha-hydroxylase n/a
3 A7U483_STR A7U483 Cytochrome P450 17A2 n/a
4 P02701_STR P02701 Avidin n/a
5 P06401_STR P06401 Progesterone receptor (PR) agonist Ki(nM) = 3.4
IC50(nM) = 0.2
EC50(nM) = 0.1
6 P71278_STR P71278 Pentaerythritol tetranitrate reductase n/a
7 P51857_STR P51857 Aldo-keto reductase family n/a
8 P08235_STR P08235 Mineralocorticoid receptor (MR) antagonist IC50(nM) = 14.0
Kd(nM) = 0.39
9 P01011_STR P01011 Alpha-1-antichymotrypsin (ACT) (Cell n/a
10 P10275_STR P10275 Androgen receptor (Dihydrotestosterone agonist Ki(nM) = 8.5
IC50(nM) = 14.0
11 Q04828_STR Q04828 Aldo-keto reductase family n/a
12 P52895_STR P52895 Aldo-keto reductase family n/a
13 P08185_STR P08185 Corticosteroid-binding globulin (CBG) n/a Ki(nM) = 42.0
14 P41145_STR P41145 Kappa-type opioid receptor activator
15 P04278_STR P04278 Sex hormone-binding globulin binder Kd(nM) = 115.0
16 P04150_STR P04150 Glucocorticoid receptor (GR) partial agonist Ki(nM) = 30.5
IC50(nM) = 1000.0
17 D6N9X1_STR D6N9X1 Progesterone 5-beta-reductase (EC n/a
18 Q16874_STR Q16874 Steroid 21-hydroxylase (EC n/a
19 P02763_STR P02763 Alpha-1-acid glycoprotein 1 binder
20 P01868_STR P01868 Ig gamma-1 chain n/a
21 Q5YNS8_STR Q5YNS8 Cytochrome P450 monooxygenase n/a
22 P03372_STR P03372 Estrogen receptor (ER) agonist IC50(nM) = 1000.0
23 P08684_STR P08684 Cytochrome P450 3A4 n/a
24 Q92731_STR Q92731 Estrogen receptor beta agonist
25 P05093_STR P05093 Steroid 17-alpha-hydroxylase/17,20 lyase substrate