Ligand name: Loxapine
PDB ligand accession: n/a
DrugBank: DB00408
InChI Key:
SMILES: CN1CCN(CC1)C1=NC2=CC=CC=C2OC2=C1C=C(Cl)C=C2

List of proteins that are targets for DB00408

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P23975_DB00408	P23975	Sodium-dependent noradrenaline transporter	binder
2	P35348_DB00408	P35348	Alpha-1A adrenergic receptor	binder	Ki(nM) = 27.77
3	P34969_DB00408	P34969	5-hydroxytryptamine receptor 7	binder	Ki(nM) = 87.2
4	Q9H3N8_DB00408	Q9H3N8	Histamine H4 receptor	binder	Ki(nM) = 3981.0
5	P28222_DB00408	P28222	5-hydroxytryptamine receptor 1B	binder
6	P28221_DB00408	P28221	5-hydroxytryptamine receptor 1D	binder
7	P08173_DB00408	P08173	Muscarinic acetylcholine receptor	binder	Ki(nM) = 300.0
8	P35368_DB00408	P35368	Alpha-1B adrenergic receptor	binder
9	P11229_DB00408	P11229	Muscarinic acetylcholine receptor	binder	Ki(nM) = 63.9 IC50(nM) = 5500.0
10	P18089_DB00408	P18089	Alpha-2B adrenergic receptor	binder	Ki(nM) = 107.6
11	P35462_DB00408	P35462	D(3) dopamine receptor	binder	Ki(nM) = 18.0 IC50(nM) = 22.0
12	P28566_DB00408	P28566	5-hydroxytryptamine receptor 1E	binder
13	P21728_DB00408	P21728	D(1A) dopamine receptor	binder
14	P08912_DB00408	P08912	Muscarinic acetylcholine receptor	binder	Ki(nM) = 241.0
15	P35367_DB00408	P35367	Histamine H1 receptor	binder	Ki(nM) = 4.9
16	P50406_DB00408	P50406	5-hydroxytryptamine receptor 6	binder	Ki(nM) = 15.0
17	P08913_DB00408	P08913	Alpha-2A adrenergic receptor	binder	Ki(nM) = 150.8
18	P14416_DB00408	P14416	D(2) dopamine receptor	antagonist	Ki(nM) = 5.2 IC50(nM) = 54.0
19	P25021_DB00408	P25021	Histamine H2 receptor	binder
20	P47898_DB00408	P47898	5-hydroxytryptamine receptor 5A	binder
21	P31645_DB00408	P31645	Sodium-dependent serotonin transporter	binder
22	P08588_DB00408	P08588	Beta-1 adrenergic receptor	binder
23	P21917_DB00408	P21917	D(4) dopamine receptor	binder	Ki(nM) = 4.3 IC50(nM) = 14.0
24	Q01959_DB00408	Q01959	Sodium-dependent dopamine transporter	binder
25	P28335_DB00408	P28335	5-hydroxytryptamine receptor 2C	antagonist	Ki(nM) = 1.69
26	P20309_DB00408	P20309	Muscarinic acetylcholine receptor	binder	Ki(nM) = 122.0
27	P46098_DB00408	P46098	5-hydroxytryptamine receptor 3A	binder
28	P08908_DB00408	P08908	5-hydroxytryptamine receptor 1A	binder	Ki(nM) = 2456.0
29	P28223_DB00408	P28223	5-hydroxytryptamine receptor 2A	antagonist	Ki(nM) = 2.0
30	P18825_DB00408	P18825	Alpha-2C adrenergic receptor	binder	Ki(nM) = 79.9
31	P21918_DB00408	P21918	D(1B) dopamine receptor	binder
32	P08172_DB00408	P08172	Muscarinic acetylcholine receptor	binder	Ki(nM) = 300.0