Ligand name: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
PDB ligand accession: Z80
DrugBank: DB00477
PubChem: 2726
ChEMBL: CHEMBL71
InChI Key: ZPEIMTDSQAKGNT-UHFFFAOYSA-N
SMILES: CN(C)CCCN1c2ccccc2Sc3c1cc(cc3)Cl

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Benzothiazines
      • Subclass: Phenothiazines

List of proteins that are targets for DB00477

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P35368_Z80	P35368	Alpha-1B adrenergic receptor	inhibitor
2	P21918_Z80	P21918	D(1B) dopamine receptor	inhibitor	Ki(nM) = 133.0
3	P02638_Z80	P02638	Protein S100-B (S-100	n/a
4	P11229_Z80	P11229	Muscarinic acetylcholine receptor	antagonist	Ki(nM) = 25.0
5	P50406_Z80	P50406	5-hydroxytryptamine receptor 6	binder	Ki(nM) = 4.0
6	Q9H3N8_Z80	Q9H3N8	Histamine H4 receptor	binder	Ki(nM) = 50.2
7	P22535_Z80	P22535	Major capsid protein	n/a
8	P19652_Z80	P19652	Alpha-1-acid glycoprotein 2	binder
9	P21728_Z80	P21728	D(1A) dopamine receptor	inhibitor	Ki(nM) = 44.0
10	P0DP23_Z80	P0DP23	Calmodulin-1	inhibitor	Ki(nM) = 19280.0 IC50(nM) = 7260.0
11	P28223_Z80	P28223	5-hydroxytryptamine receptor 2A	antagonist	Ki(nM) = 1.8
12	P35348_Z80	P35348	Alpha-1A adrenergic receptor	antagonist	Ki(nM) = 0.28
13	Q9VWX8_Z80	Q9VWX8	Frequenin-2	n/a
14	P14416_Z80	P14416	D(2) dopamine receptor	antagonist	Ki(nM) = 0.66 IC50(nM) = 1.0
15	P35367_Z80	P35367	Histamine H1 receptor	antagonist	Ki(nM) = 3.0 IC50(nM) = 12.0
16	P34969_Z80	P34969	5-hydroxytryptamine receptor 7	binder	Ki(nM) = 11.0
17	P08908_Z80	P08908	5-hydroxytryptamine receptor 1A	antagonist	Ki(nM) = 116.4
18	P35462_Z80	P35462	D(3) dopamine receptor	inhibitor	Ki(nM) = 0.84
19	P17405_Z80	P17405	Sphingomyelin phosphodiesterase (EC	inhibitor	IC50(nM) = 11000.0
20	P04925_Z80	P04925	Major prion protein	n/a	EC50(nM) = 2000.0
21	P02754_Z80	P02754	Beta-lactoglobulin (Beta-LG) (allergen	n/a
22	P21917_Z80	P21917	D(4) dopamine receptor	binder	Ki(nM) = 1.15
23	P28335_Z80	P28335	5-hydroxytryptamine receptor 2C	binder	Ki(nM) = 1.4
24	E0SJQ4_Z80	E0SJQ4	Gamma-aminobutyric-acid receptor subunit	n/a
25	P20309_Z80	P20309	Muscarinic acetylcholine receptor	antagonist	Ki(nM) = 47.0
26	Q12809_Z80	Q12809	Voltage-gated inwardly rectifying	inhibitor	IC50(nM) = 1470.0