Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: ADENOSINE
PDB ligand accession: ADN
DrugBank: DB00640
PubChem: 60961
ChEMBL: CHEMBL477
InChI Key: OIRDTQYFTABQOQ-KQYNXXCUSA-N
SMILES: c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CO)O)O)N

ClassyFire chemical classification:

List of proteins that are targets for DB00640

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P0DTD1_ADN P0DTD1 Replicase polyprotein 1ab n/a
2 A0A0H2UPF3_ADN A0A0H2UPF3 Lipoprotein n/a
3 P0DMV8_ADN P0DMV8 Heat shock 70 n/a IC50(nM) = 560000.0
4 Q5EEL8_ADN Q5EEL8 Purine nucleoside phosphorylase n/a
5 P07949_ADN P07949 Proto-oncogene tyrosine-protein kinase n/a
6 O67191_ADN O67191 RNA ligase n/a
7 P55263_ADN P55263 Adenosine kinase (AK) n/a
8 T2MHS6_ADN T2MHS6 Glycosaminoglycan xylosylkinase n/a
9 G4V7G8_ADN G4V7G8 deleted n/a
10 P07814_ADN P07814 Bifunctional glutamate/proline--tRNA ligase n/a
11 P42527_ADN P42527 Myosin heavy chain n/a
12 P49773_ADN P49773 Adenosine 5'-monophosphoramidase HINT1 n/a
13 P60176_ADN P60176 Adenosylhomocysteinase (EC 3.13.2.1) n/a
14 O34656_ADN O34656 Spore coat protein n/a
15 P30613_ADN P30613 Pyruvate kinase PKLR n/a
16 Q2KDX6_ADN Q2KDX6 Probable sugar kinase n/a
17 P53396_ADN P53396 ATP-citrate synthase (EC n/a
18 P00959_ADN P00959 Methionine--tRNA ligase (EC n/a
19 Q5CR27_ADN Q5CR27 Lysine--tRNA ligase (EC n/a
20 P29274_ADN P29274 Adenosine receptor A2a agonist Ki(nM) = 20.0
Kd(nM) = 17.0
EC50(nM) = 25.0
21 B7V419_ADN B7V419 Adenosylhomocysteinase (EC 3.13.2.1) n/a
22 Q5JIZ8_ADN Q5JIZ8 4-phosphopantoate--beta-alanine ligase (EC n/a
23 Q58293_ADN Q58293 tRNA (guanine(37)-N(1))-methyltransferase Trm5b n/a
24 Q9V2G1_ADN Q9V2G1 tRNA (guanine(37)-N(1))/4-demethylwyosine(37)-methyltransferase Taw22 n/a
25 Q5SLL8_ADN Q5SLL8 RNA 2'-O ribose n/a
26 O83774_ADN O83774 FAD:protein FMN transferase n/a
27 P55264_ADN P55264 Adenosine kinase (AK) n/a
28 Q9BX68_ADN Q9BX68 Adenosine 5'-monophosphoramidase HINT2 n/a
29 O34925_ADN O34925 Purine nucleoside phosphorylase n/a
30 O59198_ADN O59198 RNA 3'-terminal phosphate n/a
31 B1ASP2_ADN B1ASP2 Tyrosine-protein kinase (EC n/a
32 O43318_ADN O43318 Mitogen-activated protein kinase n/a Kd(nM) = 4400.0
33 Q584S0_ADN Q584S0 Adenosine kinase (AK) n/a
34 P74008_ADN P74008 Adenosylhomocysteinase (EC 3.13.2.1) n/a
35 Q5VTE6_ADN Q5VTE6 Protein angel homolog n/a
36 Q9Y8P1_ADN Q9Y8P1 Membrane lipoprotein family n/a
37 O33839_ADN O33839 Vitamin B12-dependent ribonucleotide n/a
38 P50247_ADN P50247 Adenosylhomocysteinase (AdoHcyase) (EC n/a
39 Q383X0_ADN Q383X0 Adenosylhomocysteinase (EC 3.13.2.1) n/a
40 P50389_ADN P50389 Purine nucleoside phosphorylase n/a
41 P11653_ADN P11653 Methylmalonyl-CoA mutase large n/a
42 Q7VTJ9_ADN Q7VTJ9 Argininosuccinate synthase (EC n/a
43 O58212_ADN O58212 (R)-S-adenosyl-L-methionine hydrolase (EC n/a
44 P83734_ADN P83734 Adenosine kinase (ADK) n/a
45 P11309_ADN P11309 Serine/threonine-protein kinase pim-1 n/a
46 Q9K5E4_ADN Q9K5E4 S-adenosylmethionine synthase (AdoMet n/a
47 O14744_ADN O14744 Protein arginine N-methyltransferase n/a
48 G7K2D1_ADN G7K2D1 thermospermine synthase (EC n/a
49 P11142_ADN P11142 Heat shock cognate n/a Kd(nM) = 110000.0
50 Q93AT8_ADN Q93AT8 AcsD n/a
51 A0A197BYF0_ADN A0A197BYF0 deleted n/a
52 E4S1L1_ADN E4S1L1 Basic membrane protein n/a
53 A0A077EDS4_ADN A0A077EDS4 Adenosylhomocysteinase (EC 3.13.2.1) n/a
54 Q9TVW2_ADN Q9TVW2 Adenosine kinase (AK) n/a Ki(nM) = 8900.0
55 Q03656_ADN Q03656 Serine/threonine-protein kinase SKY1 n/a
56 O15530_ADN O15530 3-phosphoinositide-dependent protein kinase n/a
57 O75758_ADN O75758 Pyruvate kinase PKLR n/a
58 Q8TZR3_ADN Q8TZR3 Protein-L-isoaspartate O-methyltransferase (EC n/a
59 P50750_ADN P50750 Cyclin-dependent kinase 9 n/a
60 Q4Q124_ADN Q4Q124 Adenosylhomocysteinase (EC 3.13.2.1) n/a
61 B0BAN6_ADN B0BAN6 Lysine--tRNA ligase (EC n/a
62 P23526_ADN P23526 Adenosylhomocysteinase (AdoHcyase) (EC n/a
63 P0DMS8_ADN P0DMS8 Adenosine receptor A3 agonist Ki(nM) = 290.0
IC50(nM) = 1.1
Kd(nM) = 740.0
EC50(nM) = 13.0
64 C4LXG4_ADN C4LXG4 Purine nucleoside phosphorylase, n/a
65 A4X3Q0_ADN A4X3Q0 Adenosyl-chloride synthase (EC n/a
66 P24627_ADN P24627 Lactotransferrin (Lactoferrin) (EC n/a
67 Q7SIA1_ADN Q7SIA1 Oxidoreductase n/a
68 Q9SP37_ADN Q9SP37 Adenosylhomocysteinase (AdoHcyase) (EC n/a
69 Q6WB93_ADN Q6WB93 RNA-directed RNA polymerase n/a
70 P45983_ADN P45983 Mitogen-activated protein kinase n/a
71 Q8ZVF7_ADN Q8ZVF7 Adenosine monophosphate-protein transferase n/a
72 P21589_ADN P21589 5'-nucleotidase (5'-NT) (EC n/a
73 P08173_ADN P08173 Muscarinic acetylcholine receptor n/a
74 P31153_ADN P31153 S-adenosylmethionine synthase isoform n/a
75 O51933_ADN O51933 Adenosylhomocysteinase (EC 3.13.2.1) n/a
76 L8H6B5_ADN L8H6B5 Adenosylhomocysteinase (EC 3.13.2.1) n/a
77 Q8KHZ8_ADN Q8KHZ8 Tryptophan 7-halogenase RebH n/a
78 Q9I685_ADN Q9I685 Adenosylhomocysteinase (EC 3.13.2.1) n/a
79 Q5SID9_ADN Q5SID9 Uridine phosphorylase (EC n/a
80 P16094_ADN P16094 Ribosome-inactivating protein momordin n/a
81 A0A1Z0YU84_ADN A0A1Z0YU84 Adenosylhomocysteinase (EC 3.13.2.1) n/a
82 Q2YQX8_ADN Q2YQX8 Adenosylhomocysteinase (EC 3.13.2.1) n/a
83 Q4QNY4_ADN Q4QNY4 NAD nucleotidase n/a
84 P00669_ADN P00669 Seminal ribonuclease (S-RNase) n/a
85 Q57849_ADN Q57849 Nucleoside kinase (NK) n/a
86 P66881_ADN P66881 5'/3'-nucleotidase SurE (EC n/a
87 P10760_ADN P10760 Adenosylhomocysteinase (AdoHcyase) (EC n/a
88 P30542_ADN P30542 Adenosine receptor A1 agonist Ki(nM) = 813.0
IC50(nM) = 2.3
Kd(nM) = 295.0
EC50(nM) = 39.0
89 O14965_ADN O14965 Aurora kinase A n/a
90 P32697_ADN P32697 Class B acid n/a
91 Q8IW19_ADN Q8IW19 Aprataxin and PNK-like n/a
92 C4PZB4_ADN C4PZB4 deleted n/a
93 A5KE01_ADN A5KE01 Adenosine deaminase (EC n/a
94 P94255_ADN P94255 AlcC n/a
95 Q9K0P8_ADN Q9K0P8 Magnesium and cobalt n/a
96 Q58435_ADN Q58435 Probable ribosomal RNA n/a
97 A3DF72_ADN A3DF72 Histidine triad (HIT) n/a
98 Q94BU8_ADN Q94BU8 Guanosine deaminase (EC n/a
99 Q9KPM0_ADN Q9KPM0 Purine nucleoside phosphorylase n/a
100 A0R3E2_ADN A0R3E2 Methionine--tRNA ligase (EC n/a
101 O57883_ADN O57883 235aa long hypothetical n/a
102 P48730_ADN P48730 Casein kinase I n/a
103 P29724_ADN P29724 Membrane lipoprotein TmpC n/a
104 Q569R2_ADN Q569R2 U8 snoRNA-decapping enzyme n/a
105 Q5SM60_ADN Q5SM60 Ribosomal RNA small n/a
106 B2RH75_ADN B2RH75 Ribosomal RNA small n/a
107 P80912_ADN P80912 Adenosine 5'-monophosphoramidase HINT1 n/a
108 Q5CPH1_ADN Q5CPH1 Adenosylhomocysteinase (EC 3.13.2.1) n/a
109 Q9KPL5_ADN Q9KPL5 Nucleoside permease n/a
110 P0ABP9_ADN P0ABP9 Purine nucleoside phosphorylase n/a
111 P49902_ADN P49902 Cytosolic purine 5'-nucleotidase n/a
112 P29275_ADN P29275 Adenosine receptor A2b agonist EC50(nM) = 52.0
113 Q92T17_ADN Q92T17 Sugar kinase (EC n/a
114 Q8N5Y8_ADN Q8N5Y8 Protein mono-ADP-ribosyltransferase PARP16 n/a
115 Q8TEK3_ADN Q8TEK3 Histone-lysine N-methyltransferase, H3 n/a IC50(nM) = 100000.0
116 Q9WZC8_ADN Q9WZC8 Adenosyl-chloride synthase n/a
117 Q11XG9_ADN Q11XG9 deleted n/a
118 P43912_ADN P43912 tRNA (guanine-N(1)-)-methyltransferase (EC n/a
119 Q8Y5E4_ADN Q8Y5E4 Diadenylate cyclase (DAC) n/a
120 A0A087WNH6_ADN A0A087WNH6 Adenosylhomocysteinase (EC 3.13.2.1) n/a
121 P07024_ADN P07024 Protein UshA [Includes: n/a
122 P05132_ADN P05132 cAMP-dependent protein kinase n/a
123 Q4JAZ7_ADN Q4JAZ7 Adenosylhomocysteinase (EC 3.13.2.1) n/a
124 W0W999_ADN W0W999 Fluorinase (EC 2.5.1.63) n/a
125 P50250_ADN P50250 Adenosylhomocysteinase (AdoHcyase) (EC n/a
126 Q86U44_ADN Q86U44 N(6)-adenosine-methyltransferase catalytic subunit n/a IC50(nM) = 495000.0
127 O68183_ADN O68183 APH(2'')-Id n/a
128 Q9BMI9_ADN Q9BMI9 Purine nucleoside phosphorylase n/a
129 P09989_ADN P09989 Ribosome-inactivating protein alpha-trichosanthin n/a