Ligand name: 10-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPYL]-2-TRIFLUOROMETHYL-10H-PHENOTHIAZINE
PDB ligand accession: TFP
DrugBank: DB00831
PubChem: 5566
ChEMBL: CHEMBL422
InChI Key: ZEWQUBUPAILYHI-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)CCCN2c3ccccc3Sc4c2cc(cc4)C(F)(F)F

ClassyFire chemical classification:

List of proteins that are targets for DB00831

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P62161_TFP P62161 Calmodulin-2 n/a
2 P0DP23_TFP P0DP23 Calmodulin-1 inhibitor IC50(nM) = 1060.0
Kd(nM) = 1000.0
3 P14416_TFP P14416 D(2) dopamine receptor antagonist Ki(nM) = 0.96
4 P62158_TFP P62158 Calmodulin-2 n/a
5 P63316_TFP P63316 Troponin C, slow n/a
6 P35348_TFP P35348 Alpha-1A adrenergic receptor antagonist Ki(nM) = 23.8
7 P26447_TFP P26447 Protein S100-A4 (Calvasculin) inhibitor
8 P62157_TFP P62157 Calmodulin (CaM) n/a Kd(nM) = 3400.0