Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: 2-HYDROXYBENZOIC ACID
PDB ligand accession: SAL
DrugBank: DB00936
PubChem: 338;118212070;
ChEMBL: CHEMBL424
InChI Key: YGSDEFSMJLZEOE-UHFFFAOYSA-N
SMILES: c1ccc(c(c1)C(=O)O)O

ClassyFire chemical classification:

List of proteins that are targets for DB00936

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q67FT0_SAL Q67FT0 Gentisate 1,2-dioxygenase n/a
2 P23219_SAL P23219 Prostaglandin G/H synthase inhibitor Ki(nM) = 10000.0
IC50(nM) = 40000.0
3 P35354_SAL P35354 Prostaglandin G/H synthase inhibitor Ki(nM) = 10000.0
IC50(nM) = 40000.0
4 P22830_SAL P22830 Ferrochelatase, mitochondrial (EC n/a
5 P02768_SAL P02768 Albumin n/a Ki(nM) = 5880.0
6 B0LPL6_SAL B0LPL6 Matrix protein VP40 n/a
7 Q59713_SAL Q59713 Salicylate 1-monooxygenase (EC n/a
8 Q9LYU4_SAL Q9LYU4 4-substituted benzoates-glutamate ligase n/a
9 P42336_SAL P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase n/a
10 P27986_SAL P27986 Phosphatidylinositol 3-kinase regulatory n/a
11 P00918_SAL P00918 Carbonic anhydrase 2 inhibitor Ki(nM) = 7100.0
IC50(nM) = 680000.0
12 B0JEU3_SAL B0JEU3 Vicilin n/a
13 P27245_SAL P27245 Multiple antibiotic resistance n/a
14 P54507_SAL P54507 Major biofilm matrix n/a
15 Q04828_SAL Q04828 Aldo-keto reductase family inhibitor
16 A0A140DJY3_SAL A0A140DJY3 Salicylate-AMP ligase n/a
17 P05979_SAL P05979 Prostaglandin G/H synthase n/a
18 D7PC76_SAL D7PC76 Prestin (Solute carrier n/a
19 O26413_SAL O26413 Transcriptional regulator n/a
20 Q9X9I8_SAL Q9X9I8 Salicylate synthetase, Irp9 n/a
21 A0A022MRT4_SAL A0A022MRT4 AMP-dependent synthetase and n/a
22 P22985_SAL P22985 Xanthine dehydrogenase/oxidase [Includes: n/a
23 Q9L2B5_SAL Q9L2B5 Transcriptional regulator n/a
24 A0A452CSM5_SAL A0A452CSM5 Vicilin-like antimicrobial peptides n/a
25 C5CSP2_SAL C5CSP2 Transcriptional regulator, MarR n/a
26 Q6GEG9_SAL Q6GEG9 Uncharacterized HTH-type transcriptional n/a
27 Q5HLN6_SAL Q5HLN6 Transcriptional regulator TcaR n/a
28 P58743_SAL P58743 Prestin (Solute carrier n/a
29 Q1LCS4_SAL Q1LCS4 3-hydroxyanthranilate 3,4-dioxygenase (EC n/a
30 P80457_SAL P80457 Xanthine dehydrogenase/oxidase [Includes: n/a Ki(nM) = 1.0E8
31 Q9BPX1_SAL Q9BPX1 L-fucose dehydrogenase (EC n/a
32 Q96ZY1_SAL Q96ZY1 MarR family transcriptional n/a
33 P9WFX1_SAL P9WFX1 Salicylate synthase (Chorismate n/a
34 P66992_SAL P66992 Anthranilate phosphoribosyltransferase (EC n/a
35 A0A133QQ41_SAL A0A133QQ41 deleted n/a
36 Q51507_SAL Q51507 Isochorismate pyruvate lyase n/a
37 P40676_SAL P40676 Transcriptional regulator SlyA n/a
38 Q8WWQ0_SAL Q8WWQ0 PH-interacting protein (PHIP) n/a
39 Q6RYA0_SAL Q6RYA0 Salicylic acid-binding protein n/a
40 Q86U86_SAL Q86U86 Protein polybromo-1 (hPB1) n/a
41 Q9SPV4_SAL Q9SPV4 Salicylate carboxymethyltransferase (EC n/a
42 Q7WT50_SAL Q7WT50 LysR-type regulatory protein n/a
43 P47989_SAL P47989 Xanthine dehydrogenase/oxidase [Includes: n/a
44 O22822_SAL O22822 UDP-glycosyltransferase 74F2 (EC n/a
45 Q88JK6_SAL Q88JK6 Methyl-accepting chemotaxis protein n/a
46 P9WME9_SAL P9WME9 HTH-type transcriptional repressor n/a
47 P0CT50_SAL P0CT50 Salicylate decarboxylase (EC n/a
48 P63104_SAL P63104 14-3-3 protein zeta/delta n/a