Ligand name: (6S)-5,6,7,8-TETRAHYDROFOLATE
PDB ligand accession: THG
DrugBank: DB02031
PubChem: 5289465;5460413;135398650;
ChEMBL: n/a
InChI Key: MSTNYGQPCMXVAQ-RYUDHWBXSA-N
SMILES: c1cc(ccc1C(=O)NC(CCC(=O)O)C(=O)O)NCC2CNC3=C(N2)C(=O)NC(=N3)N

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Pteridines and derivatives
      • Subclass: Pterins and derivatives

List of proteins that are targets for DB02031

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	Q3ACR9_THG	Q3ACR9	5-methyltetrahydrofolate corrinoid/iron sulfur	n/a
2	P0A884_THG	P0A884	Thymidylate synthase (TS)	n/a
3	Q4FP21_THG	Q4FP21	Dimethylsulfoniopropionate demethylase DmdA	n/a
4	B8FW00_THG	B8FW00	Dihydropteroate synthase DHPS	n/a
5	Q5SID2_THG	Q5SID2	Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC	n/a
6	P08773_THG	P08773	Deoxycytidylate 5-hydroxymethyltransferase (Deoxycytidylate	n/a
7	O34453_THG	O34453	Nitric oxide synthase	n/a
8	O50008_THG	O50008	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	n/a
9	Q99707_THG	Q99707	Methionine synthase (MS)	n/a
10	E3NZ06_THG	E3NZ06	10-formyltetrahydrofolate dehydrogenase (EC	n/a
11	Q9WY54_THG	Q9WY54	Aminomethyltransferase (EC 2.1.2.10)	n/a
12	P0ABQ5_THG	P0ABQ5	Dihydrofolate reductase (EC	n/a
13	G2IQS7_THG	G2IQS7	Vanillate/3-O-methylgallate O-demethylase (Vanillate/3MGA	n/a
14	Q49135_THG	Q49135	Methenyltetrahydrofolate cyclohydrolase (EC	n/a
15	P0ABQ4_THG	P0ABQ4	Dihydrofolate reductase (EC	n/a
16	Q5RKL4_THG	Q5RKL4	Dimethylglycine dehydrogenase	n/a
17	O67224_THG	O67224	Hydrogenase regulation HoxX	n/a
18	Q9AGP8_THG	Q9AGP8	Dimethylglycine oxidase (DMGO)	n/a
19	Q4DLS1_THG	Q4DLS1	Bifunctional dihydrofolate reductase-thymidylate	n/a
20	O60341_THG	O60341	Lysine-specific histone demethylase	n/a