Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER
PDB ligand accession: APC
DrugBank: DB02596
PubChem: 91557
ChEMBL: CHEMBL132722
InChI Key: CAWZRIXWFRFUQB-IOSLPCCCSA-N
SMILES: c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(CP(=O)(O)OP(=O)(O)O)O)O)O)N

ClassyFire chemical classification:

List of proteins that are targets for DB02596

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 B1MDL6_APC B1MDL6 Phosphopantetheine adenylyltransferase (EC n/a
2 Q97ZS7_APC Q97ZS7 Primase X domain-containing n/a
3 P04050_APC P04050 DNA-directed RNA polymerase n/a
4 Q70LM7_APC Q70LM7 Linear gramicidin synthase n/a
5 Q9WVY4_APC Q9WVY4 Lincosamide nucleotidyltransferase n/a
6 A0A164SIT4_APC A0A164SIT4 deleted n/a
7 R4NRX5_APC R4NRX5 deleted n/a
8 Q96T66_APC Q96T66 Nicotinamide/nicotinic acid mononucleotide n/a
9 P26281_APC P26281 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC n/a
10 Q6FNA9_APC Q6FNA9 FAD synthase (EC n/a
11 Q97Z83_APC Q97Z83 DNA primase small n/a
12 Q29599_APC Q29599 2'-5'-oligoadenylate synthase 1 n/a
13 Q97CA5_APC Q97CA5 Ribose-phosphate pyrophosphokinase (RPPK) n/a
14 C8MLE4_APC C8MLE4 deleted n/a
15 O31611_APC O31611 GTP pyrophosphokinase YjbM n/a
16 Q08AH3_APC Q08AH3 Acyl-coenzyme A synthetase n/a
17 P0A530_APC P0A530 Phosphopantetheine adenylyltransferase (EC n/a
18 Q9R8E3_APC Q9R8E3 Carboxyethyl-arginine beta-lactam-synthase (EC n/a
19 P0A5L6_APC P0A5L6 Glutamine-dependent NAD(+) synthetase n/a
20 Q8C6L5_APC Q8C6L5 Cyclic GMP-AMP synthase n/a
21 Q9LYU4_APC Q9LYU4 4-substituted benzoates-glutamate ligase n/a
22 A0A0H1ZSM1_APC A0A0H1ZSM1 deleted n/a
23 W8U368_APC W8U368 GTP pyrophosphokinase (GTP n/a
24 Q9WXZ2_APC Q9WXZ2 tRNA N6-adenosine threonylcarbamoyltransferase n/a
25 O67139_APC O67139 Selenide, water dikinase n/a
26 Q81RP3_APC Q81RP3 NH(3)-dependent NAD(+) synthetase n/a
27 Q8RDB0_APC Q8RDB0 Carbamoyltransferase (EC 6.2.-.-) n/a
28 O32393_APC O32393 histidine kinase (EC n/a
29 P00971_APC P00971 RNA ligase 1 n/a
30 A0A4V8GZR7_APC A0A4V8GZR7 cGAS/DncV-like nucleotidyltransferase in n/a
31 P0A776_APC P0A776 RNA pyrophosphohydrolase (EC n/a
32 Q8RQE9_APC Q8RQE9 DNA-directed RNA polymerase n/a
33 Q6X3H6_APC Q6X3H6 AadB n/a
34 Q6GDK5_APC Q6GDK5 Pantothenate synthetase (PS) n/a
35 Q94M05_APC Q94M05 NTPase P4 n/a
36 P0DSP4_APC P0DSP4 Cyclic AMP-AMP-GMP synthase n/a
37 P05057_APC P05057 Kanamycin nucleotidyltransferase (Neo(R)) n/a
38 C4QZQ7_APC C4QZQ7 DNA-directed RNA polymerase n/a
39 Q8IE38_APC Q8IE38 Nicotinamide/nicotinic acid mononucleotide n/a
40 Q70IY1_APC Q70IY1 nebramycin 5' synthase n/a
41 P40136_APC P40136 Calmodulin-sensitive adenylate cyclase n/a
42 G2SLH8_APC G2SLH8 Cyclic UMP-AMP synthase n/a
43 O07732_APC O07732 Bifunctional lipase/adenylate cyclase n/a
44 A0QLU8_APC A0QLU8 Acetate kinase (EC n/a
45 Q7CKD7_APC Q7CKD7 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC n/a
46 P17562_APC P17562 S-adenosylmethionine synthase 2 n/a
47 Q57514_APC Q57514 Kanamycin nucleotidyltransferase n/a
48 A0A101DCH0_APC A0A101DCH0 CCA-adding enzyme (EC n/a
49 O66728_APC O66728 A-adding tRNA nucleotidyltransferase n/a
50 Q2A2W3_APC Q2A2W3 deleted n/a
51 P08337_APC P08337 8-oxo-dGTP diphosphatase (8-oxo-dGTPase) n/a
52 Q96PN6_APC Q96PN6 Adenylate cyclase type n/a
53 Q25704_APC Q25704 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase n/a
54 Q47506_APC Q47506 MccB protein n/a
55 Q9WY43_APC Q9WY43 DNA integrity scanning n/a
56 Q15046_APC Q15046 Lysine--tRNA ligase (EC n/a
57 O28126_APC O28126 CCA-adding enzyme (EC n/a
58 Q9XB61_APC Q9XB61 Carbapenam-3-carboxylate synthase (EC n/a
59 G0S6G2_APC G0S6G2 tRNA ligase (EC n/a
60 Q9BVA6_APC Q9BVA6 Protein adenylyltransferase FICD n/a
61 A0A2P7CAT2_APC A0A2P7CAT2 deleted n/a
62 P09838_APC P09838 DNA nucleotidylexotransferase (EC n/a
63 C4R4Y0_APC C4R4Y0 DNA-directed RNA polymerase n/a
64 O67575_APC O67575 6-carboxyhexanoate--CoA ligase (EC n/a
65 P41250_APC P41250 Glycine--tRNA ligase (EC n/a
66 P75838_APC P75838 Ribosomal protein S12 n/a
67 P05058_APC P05058 Kanamycin nucleotidyltransferase (EC n/a
68 O14638_APC O14638 Ectonucleotide pyrophosphatase/phosphodiesterase family n/a
69 P00573_APC P00573 T7 RNA polymerase n/a
70 O28025_APC O28025 tRNA(Ile2) 2-agmatinylcytidine synthetase n/a
71 A0A1K9YMY7_APC A0A1K9YMY7 deleted n/a
72 Q7CH76_APC Q7CH76 Adenylate cyclase 2 n/a
73 P08518_APC P08518 DNA-directed RNA polymerase n/a
74 P07900_APC P07900 Heat shock protein n/a
75 P08164_APC P08164 NH(3)-dependent NAD(+) synthetase n/a
76 P0A5R0_APC P0A5R0 Pantothenate synthetase (PS) n/a
77 D1GLU5_APC D1GLU5 Non-ribosomal peptide synthetase n/a
78 Q8RQE8_APC Q8RQE8 DNA-directed RNA polymerase n/a