Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: CHOLESTEROL
PDB ligand accession: CLR
DrugBank: DB04540
PubChem: 5997
ChEMBL: CHEMBL112570
InChI Key: HVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C

ClassyFire chemical classification:

List of proteins that are targets for DB04540

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q70Q12_CLR Q70Q12 FXYD domain-containing ion n/a
2 P29275_CLR P29275 Adenosine receptor A2b n/a
3 P02730_CLR P02730 Band 3 anion n/a
4 Q86Y34_CLR Q86Y34 Adhesion G protein-coupled n/a
5 Q9BXC1_CLR Q9BXC1 Probable G-protein coupled n/a
6 P21728_CLR P21728 D(1A) dopamine receptor n/a
7 Q8IWT6_CLR Q8IWT6 Volume-regulated anion channel n/a
8 Q13936-20_CLR Q13936-20 n/a
9 G3V8S4_CLR G3V8S4 Sodium/potassium-transporting ATPase subunit n/a
10 I7HD36_CLR I7HD36 Sodium/potassium-transporting ATPase subunit n/a
11 P69332_CLR P69332 G-protein coupled receptor n/a
12 P25106_CLR P25106 Atypical chemokine receptor n/a
13 Q96RJ0_CLR Q96RJ0 Trace amine-associated receptor n/a
14 Q02643_CLR Q02643 Growth hormone-releasing hormone n/a
15 P32241_CLR P32241 Vasoactive intestinal polypeptide n/a
16 P61916_CLR P61916 NPC intracellular cholesterol n/a
17 Q96BI3_CLR Q96BI3 Gamma-secretase subunit APH-1A n/a
18 A0A0B4KEX2_CLR A0A0B4KEX2 Transporter n/a
19 P47900_CLR P47900 P2Y purinoceptor 1 n/a
20 P02710_CLR P02710 Acetylcholine receptor subunit n/a
21 P41143_CLR P41143 Delta-type opioid receptor n/a
22 P13866_CLR P13866 Sodium/glucose cotransporter 1 n/a
23 P23978_CLR P23978 Sodium- and chloride-dependent n/a
24 Q9H244_CLR Q9H244 P2Y purinoceptor 12 n/a
25 Q7K4Y6_CLR Q7K4Y6 Sodium-dependent dopamine transporter n/a
26 P21462_CLR P21462 fMet-Leu-Phe receptor (fMLP n/a
27 P27449_CLR P27449 V-type proton ATPase n/a
28 P35372_CLR P35372 Mu-type opioid receptor n/a
29 Q80KM9_CLR Q80KM9 Envelope protein US28 n/a
30 P07550_CLR P07550 Beta-2 adrenergic receptor n/a
31 P23945_CLR P23945 Follicle-stimulating hormone receptor n/a
32 P29274_CLR P29274 Adenosine receptor A2a n/a
33 Q14833_CLR Q14833 Metabotropic glutamate receptor n/a
34 P48039_CLR P48039 Melatonin receptor type n/a
35 P31645_CLR P31645 Sodium-dependent serotonin transporter n/a
36 P30550_CLR P30550 Gastrin-releasing peptide receptor n/a
37 Q15465_CLR Q15465 Sonic hedgehog protein n/a
38 P11473_CLR P11473 Vitamin D3 receptor n/a
39 P60033_CLR P60033 CD81 antigen (26 n/a
40 Q13324_CLR Q13324 Corticotropin-releasing factor receptor n/a
41 P36544_CLR P36544 Neuronal acetylcholine receptor n/a
42 P19491_CLR P19491 Glutamate receptor 2 n/a
43 Q14994_CLR Q14994 Nuclear receptor subfamily n/a
44 Q9WTR1_CLR Q9WTR1 Transient receptor potential n/a
45 Q5L1G5_CLR Q5L1G5 Amino acid transporter n/a
46 Q08DA1_CLR Q08DA1 Sodium/potassium-transporting ATPase subunit n/a
47 P30556_CLR P30556 Type-1 angiotensin II n/a
48 Q12791_CLR Q12791 Calcium-activated potassium channel n/a
49 O64989_CLR O64989 Steroid (22S)-hydroxylase (EC n/a
50 Q9Y5Y9_CLR Q9Y5Y9 Sodium channel protein n/a
51 P15570_CLR P15570 Beta-elicitin cryptogein (CRY) n/a
52 P02712_CLR P02712 Acetylcholine receptor subunit n/a
53 P25090_CLR P25090 N-formyl peptide receptor n/a
54 P13569_CLR P13569 Cystic fibrosis transmembrane n/a
55 P21439_CLR P21439 Phosphatidylcholine translocator ABCB4 n/a
56 Q14108_CLR Q14108 Lysosome membrane protein n/a
57 P78423_CLR P78423 Fractalkine (C-X3-C motif n/a
58 P25025_CLR P25025 C-X-C chemokine receptor n/a
59 P45844_CLR P45844 ATP-binding cassette sub-family n/a
60 A0A5G2QYH2_CLR A0A5G2QYH2 deleted n/a
61 P58743_CLR P58743 Prestin (Solute carrier n/a
62 P41145_CLR P41145 Kappa-type opioid receptor n/a
63 Q9UBS5_CLR Q9UBS5 Gamma-aminobutyric acid type n/a
64 O95342_CLR O95342 Bile salt export n/a
65 Q8N6U8_CLR Q8N6U8 G-protein coupled receptor n/a
66 P35398_CLR P35398 Nuclear receptor ROR-alpha n/a
67 Q14832_CLR Q14832 Metabotropic glutamate receptor n/a
68 P20963_CLR P20963 T-cell surface glycoprotein n/a
69 P49238_CLR P49238 CX3C chemokine receptor n/a
70 Q14416_CLR Q14416 Metabotropic glutamate receptor n/a
71 A7T1N0_CLR A7T1N0 Transient receptor potential n/a
72 A0A0C4DFX6_CLR A0A0C4DFX6 NPC1 like intracellular n/a
73 Q58K79_CLR Q58K79 FXYD domain-containing ion n/a
74 P54708_CLR P54708 Potassium-transporting ATPase alpha n/a
75 A0A1Z2R994_CLR A0A1Z2R994 Structural polyprotein (p130) n/a
76 Q8TDU6_CLR Q8TDU6 G-protein coupled bile n/a
77 P28335_CLR P28335 5-hydroxytryptamine receptor 2C n/a
78 P34972_CLR P34972 Cannabinoid receptor 2 n/a
79 Q9NS75_CLR Q9NS75 Cysteinyl leukotriene receptor n/a
80 O43603_CLR O43603 Galanin receptor type n/a
81 P54826_CLR P54826 Growth arrest-specific protein n/a
82 Q8HXQ5_CLR Q8HXQ5 Multidrug resistance-associated protein n/a
83 P0ABE7_CLR P0ABE7 Soluble cytochrome b562 n/a
84 Q9NRK6_CLR Q9NRK6 ATP-binding cassette sub-family n/a
85 P25103_CLR P25103 Substance-P receptor (SPR) n/a
86 Q96RD7_CLR Q96RD7 Pannexin-1 (PANX1) [Cleaved n/a
87 Q96KN9_CLR Q96KN9 Gap junction delta-4 n/a
88 Q6CUK7_CLR Q6CUK7 KLLA0C04147p n/a
89 P07340_CLR P07340 Sodium/potassium-transporting ATPase subunit n/a
90 Q9GZN0_CLR Q9GZN0 G protein-coupled receptor n/a
91 Q9NB97_CLR Q9NB97 Sodium-dependent dopamine transporter n/a
92 P34998_CLR P34998 Corticotropin-releasing factor receptor n/a
93 Q9BXW6_CLR Q9BXW6 Oxysterol-binding protein-related protein n/a
94 Q5T848_CLR Q5T848 Metabotropic glycine receptor n/a
95 P22059_CLR P22059 Oxysterol-binding protein 1 n/a
96 Q01118_CLR Q01118 Sodium channel protein n/a
97 O43613_CLR O43613 Orexin/Hypocretin receptor type n/a
98 P05108_CLR P05108 Cholesterol side-chain cleavage n/a
99 Q03431_CLR Q03431 Parathyroid hormone/parathyroid hormone-related n/a
100 Q98SW5_CLR Q98SW5 Protein smoothened n/a
101 Q8TDS4_CLR Q8TDS4 Hydroxycarboxylic acid receptor n/a
102 P48546_CLR P48546 Gastric inhibitory polypeptide n/a
103 P19156_CLR P19156 Potassium-transporting ATPase alpha n/a
104 P48547_CLR P48547 Voltage-gated potassium channel n/a
105 Q9UHC9_CLR Q9UHC9 NPC1-like intracellular cholesterol n/a
106 P43004_CLR P43004 Excitatory amino acid n/a
107 P42866_CLR P42866 Mu-type opioid receptor n/a
108 Q9H3N8_CLR Q9H3N8 Histamine H4 receptor n/a
109 C4IX13_CLR C4IX13 Sodium/potassium-transporting ATPase subunit n/a
110 Q3MHW7_CLR Q3MHW7 Sigma intracellular receptor n/a
111 D2WKD6_CLR D2WKD6 Sodium/potassium-transporting ATPase subunit n/a
112 Q4H132_CLR Q4H132 Sodium/potassium-transporting ATPase subunit n/a
113 P02718_CLR P02718 Acetylcholine receptor subunit n/a
114 O15118_CLR O15118 NPC intracellular cholesterol n/a
115 Q99788_CLR Q99788 Chemerin-like receptor 1 n/a
116 P02724_CLR P02724 Glycophorin-A (MN sialoglycoprotein) n/a
117 Q04645_CLR Q04645 Sodium/potassium-transporting ATPase subunit n/a
118 Q15878_CLR Q15878 Voltage-dependent R-type calcium n/a
119 P30518_CLR P30518 Vasopressin V2 receptor n/a
120 P41180-1_CLR P41180-1 n/a
121 Q9NUT2_CLR Q9NUT2 Mitochondrial potassium channel n/a
122 Q14973_CLR Q14973 Hepatic sodium/bile acid n/a
123 Q8NFT2_CLR Q8NFT2 Metalloreductase STEAP2 (EC n/a
124 Q9UPC5_CLR Q9UPC5 Probable G-protein coupled n/a
125 Q92847_CLR Q92847 Growth hormone secretagogue n/a
126 P05027_CLR P05027 Sodium/potassium-transporting ATPase subunit n/a
127 P21554_CLR P21554 Cannabinoid receptor 1 n/a
128 Q9H222_CLR Q9H222 ATP-binding cassette sub-family n/a
129 P47211_CLR P47211 Galanin receptor type n/a
130 Q03720_CLR Q03720 Calcium-activated potassium channel n/a
131 D9IEF7_CLR D9IEF7 Endolysin (EC 3.2.1.17) n/a
132 Q9HC97_CLR Q9HC97 G-protein coupled receptor n/a
133 P30411_CLR P30411 B2 bradykinin receptor n/a
134 A4IGB6_CLR A4IGB6 Receptor for retinol n/a
135 Q01650_CLR Q01650 Large neutral amino n/a
136 F1RM59_CLR F1RM59 Sodium/potassium-transporting ATPase subunit n/a
137 P28223_CLR P28223 5-hydroxytryptamine receptor 2A n/a
138 Q96LB1_CLR Q96LB1 Mas-related G-protein coupled n/a
139 P56726_CLR P56726 Protein smoothened n/a
140 Q9H221_CLR Q9H221 ATP-binding cassette sub-family n/a
141 P18434_CLR P18434 Potassium-transporting ATPase subunit n/a
142 O75899_CLR O75899 Gamma-aminobutyric acid type n/a
143 P05106_CLR P05106 Integrin beta-3 (Platelet n/a
144 Q99835_CLR Q99835 Protein smoothened (Protein n/a
145 Q9ULY5_CLR Q9ULY5 C-type lectin domain ligand
146 Q13563_CLR Q13563 Polycystin-2 (PC2) (Autosomal n/a
147 Q6IYF9_CLR Q6IYF9 Succinate receptor 1 n/a
148 P29972_CLR P29972 Aquaporin-1 (AQP-1) (Aquaporin-CHIP) n/a
149 I0YUS5_CLR I0YUS5 Family A G n/a
150 Q12675_CLR Q12675 Phospholipid-transporting ATPase DNF2 n/a
151 Q16581_CLR Q16581 C3a anaphylatoxin chemotactic n/a
152 Q02094_CLR Q02094 Ammonium transporter Rh n/a
153 P30559_CLR P30559 Oxytocin receptor (OT-R) n/a
154 P30874_CLR P30874 Somatostatin receptor type n/a
155 P08034_CLR P08034 Gap junction beta-1 n/a
156 Q9Y5N1_CLR Q9Y5N1 Histamine H3 receptor n/a
157 P51686_CLR P51686 C-C chemokine receptor n/a
158 P33897_CLR P33897 ATP-binding cassette sub-family n/a
159 Q9V2J8_CLR Q9V2J8 Glycogen synthase n/a
160 A0A6P3EL78_CLR A0A6P3EL78 Uncharacterized protein n/a
161 P35844_CLR P35844 Oxysterol-binding protein homolog n/a
162 M1MR49_CLR M1MR49 Japanin (18 kDa n/a
163 Q8N697_CLR Q8N697 Solute carrier family n/a
164 P32246_CLR P32246 C-C chemokine receptor n/a
165 G1K3Q0_CLR G1K3Q0 Rhodopsin-2 n/a
166 Q9UNQ0_CLR Q9UNQ0 Broad substrate specificity n/a
167 P29973_CLR P29973 Cyclic nucleotide-gated channel n/a
168 P05024_CLR P05024 Sodium/potassium-transporting ATPase subunit n/a
169 P16452_CLR P16452 Protein 4.2 (P4.2) n/a
170 P02714_CLR P02714 Acetylcholine receptor subunit n/a
171 P43220_CLR P43220 Glucagon-like peptide 1 n/a
172 P49190_CLR P49190 Parathyroid hormone 2 n/a
173 P51449_CLR P51449 Nuclear receptor ROR-gamma n/a
174 Q5T601_CLR Q5T601 Adhesion G-protein coupled n/a
175 P08183_CLR P08183 ATP-dependent translocase ABCB1 n/a
176 P41180_CLR P41180 Extracellular calcium-sensing receptor n/a
177 P16473_CLR P16473 Thyrotropin receptor (Thyroid-stimulating n/a
178 P24530_CLR P24530 Endothelin receptor type n/a
179 P41595_CLR P41595 5-hydroxytryptamine receptor 2B n/a
180 Q13936_CLR Q13936 Voltage-dependent L-type calcium n/a