Ligand name: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE
PDB ligand accession: IZA
DrugBank: DB04716
PubChem: 5494425
ChEMBL: CHEMBL21156
InChI Key: VNDWQCSOSCCWIP-UHFFFAOYSA-N
SMILES: CC(C)(C)c1[nH]c2c3c(c4cc(ccc4c2n1)F)C(=O)NC=C3

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Isoquinolines and derivatives
      • Subclass: Isoquinolones and derivatives

List of proteins that are targets for DB04716

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P52333_IZA	P52333	Tyrosine-protein kinase JAK3	inhibitor	IC50(nM) = 5.0
2	O60674_IZA	O60674	Tyrosine-protein kinase JAK2	inhibitor	IC50(nM) = 1.0
3	Q59GQ2_IZA	Q59GQ2	Tyrosine-protein kinase JAK1	n/a
4	G5E852_IZA	G5E852	Tyrosine-protein kinase JAK2	n/a
5	P23458_IZA	P23458	Tyrosine-protein kinase JAK1	n/a	IC50(nM) = 4.0
6	O43293_IZA	O43293	Death-associated protein kinase	n/a
7	P29597_IZA	P29597	Non-receptor tyrosine-protein kinase	inhibitor	IC50(nM) = 1.0
8	P32361_IZA	P32361	Serine/threonine-protein kinase/endoribonuclease IRE1	n/a