Ligand name: Regorafenib
PDB ligand accession: n/a
DrugBank: DB08896
InChI Key:
SMILES: CNC(=O)C1=CC(OC2=CC(F)=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C=C2)=CC=N1

List of proteins that are targets for DB08896

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P15056_DB08896	P15056	Serine/threonine-protein kinase B-raf	inhibitor	IC50(nM) = 1.5
2	P10721_DB08896	P10721	Mast/stem cell growth	inhibitor	IC50(nM) = 6.1
3	Q15759_DB08896	Q15759	Mitogen-activated protein kinase	inhibitor
4	Q16832_DB08896	Q16832	Discoidin domain-containing receptor	inhibitor
5	P00519_DB08896	P00519	Tyrosine-protein kinase ABL1	inhibitor	IC50(nM) = 500.0
6	P21802_DB08896	P21802	Fibroblast growth factor	inhibitor	IC50(nM) = 7.5
7	P04049_DB08896	P04049	RAF proto-oncogene serine/threonine-protein	inhibitor	IC50(nM) = 1.5
8	P16234_DB08896	P16234	Platelet-derived growth factor	inhibitor	IC50(nM) = 16.0
9	P35968_DB08896	P35968	Vascular endothelial growth	inhibitor	Ki(nM) = 4.2 IC50(nM) = 4.0
10	P11362_DB08896	P11362	Fibroblast growth factor	inhibitor	IC50(nM) = 1.5
11	Q02763_DB08896	Q02763	Angiopoietin-1 receptor (EC	inhibitor	IC50(nM) = 1.5
12	P42685_DB08896	P42685	Tyrosine-protein kinase FRK	inhibitor
13	P29317_DB08896	P29317	Ephrin type-A receptor	inhibitor	Kd(nM) = 869.0
14	P09619_DB08896	P09619	Platelet-derived growth factor	inhibitor	IC50(nM) = 1.5
15	P35916_DB08896	P35916	Vascular endothelial growth	inhibitor	IC50(nM) = 10.0
16	P07949_DB08896	P07949	Proto-oncogene tyrosine-protein kinase	inhibitor	IC50(nM) = 1.5
17	P17948_DB08896	P17948	Vascular endothelial growth	inhibitor	IC50(nM) = 1.5
18	P04629_DB08896	P04629	High affinity nerve	inhibitor