Ligand name: Dabrafenib
PDB ligand accession: P06
DrugBank: DB08912
PubChem: 44462760
ChEMBL: CHEMBL2028663
InChI Key: BFSMGDJOXZAERB-UHFFFAOYSA-N
SMILES: CC(C)(C)c1nc(c(s1)c2ccnc(n2)N)c3cccc(c3F)NS(=O)(=O)c4c(cccc4F)F

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Benzenoids
    • Class: Benzene and substituted derivatives
      • Subclass: Sulfanilides

List of proteins that are targets for DB08912

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	Q8NG66_P06	Q8NG66	Serine/threonine-protein kinase Nek11	inhibitor
2	P15056_P06	P15056	Serine/threonine-protein kinase B-raf	inhibitor	IC50(nM) = 0.4 EC50(nM) = 0.7
3	P57059_P06	P57059	Serine/threonine-protein kinase SIK1	inhibitor
4	P04049_P06	P04049	RAF proto-oncogene serine/threonine-protein	inhibitor	IC50(nM) = 5.0
5	O75469_P06	O75469	Nuclear receptor subfamily	n/a	EC50(nM) = 87.0
6	P53667_P06	P53667	LIM domain kinase	inhibitor