Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: GUANOSINE-5'-MONOPHOSPHATE
PDB ligand accession: 5GP
DrugBank: DB01972
PubChem: 6804;5280325;135398631;
ChEMBL: CHEMBL283807
InChI Key: RQFCJASXJCIDSX-UUOKFMHZSA-N
SMILES: c1nc2c(n1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(NC2=O)N

ClassyFire chemical classification:

List of proteins that are targets for 5GP

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q9Y233_5GP Q9Y233 cAMP and cAMP-inhibited n/a
2 Q07010_5GP Q07010 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) n/a
3 G3X9S2_5GP G3X9S2 Ectonucleotide pyrophosphatase/phosphodiesterase 1 n/a
4 P51900_5GP P51900 Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGPRT) n/a
5 O57947_5GP O57947 Ribose 1,5-bisphosphate isomerase n/a
6 P12268_5GP P12268 Inosine-5'-monophosphate dehydrogenase 2 n/a
7 P31335_5GP P31335 Bifunctional purine biosynthesis n/a
8 B6YWC1_5GP B6YWC1 CRISPR system Cms n/a
9 C4LYI2_5GP C4LYI2 Histidine triad nucleotide-binding n/a
10 G8UY25_5GP G8UY25 deleted n/a
11 P00496_5GP P00496 Amidophosphoribosyltransferase (ATase) (EC n/a
12 P49773_5GP P49773 Adenosine 5'-monophosphoramidase HINT1 n/a
13 Q38DE2_5GP Q38DE2 CCHC-type domain-containing protein n/a
14 O74859_5GP O74859 Aprataxin-like protein (EC n/a
15 Q9NRG1_5GP Q9NRG1 Phosphoribosyltransferase domain-containing protein n/a
16 B7SY86_5GP B7SY86 Glucosyl-3-phosphoglycerate synthase (EC n/a
17 Q756Z6_5GP Q756Z6 Inosine-5'-monophosphate dehydrogenase (IMP n/a
18 P49902_5GP P49902 Cytosolic purine 5'-nucleotidase n/a
19 Q64520_5GP Q64520 Guanylate kinase (EC n/a
20 P36959_5GP P36959 GMP reductase 1 n/a
21 Q8J307_5GP Q8J307 Selenocysteine-specific elongation factor n/a
22 O04379_5GP O04379 Protein argonaute 1 n/a
23 P23540_5GP P23540 Ribonuclease MC (RNase n/a
24 Q859P9_5GP Q859P9 Virion DNA-directed RNA n/a
25 Q8ZC05_5GP Q8ZC05 Xanthine-guanine phosphoribosyltransferase (XGPRT) n/a
26 Q9V118_5GP Q9V118 Exosome complex component n/a
27 P78356_5GP P78356 Phosphatidylinositol 5-phosphate 4-kinase n/a
28 P16094_5GP P16094 Ribosome-inactivating protein momordin n/a
29 Q81JJ9_5GP Q81JJ9 GMP reductase (EC n/a
30 P15454_5GP P15454 Guanylate kinase (EC n/a
31 Q9HTM2_5GP Q9HTM2 Guanylate kinase (EC n/a
32 F1RY70_5GP F1RY70 Large ribosomal subunit n/a
33 P20035_5GP P20035 Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGPRT) inhibitor
34 O76083_5GP O76083 High affinity cGMP-specific n/a
35 Q9NJI5_5GP Q9NJI5 Hypoxanthine phosphoribosyltransferase (EC n/a
36 Q9KNC3_5GP Q9KNC3 Cyclic di-GMP binding n/a
37 Q9I4L6_5GP Q9I4L6 Outer-membrane lipoprotein YfiB n/a
38 Q9WZJ0_5GP Q9WZJ0 Epoxyqueuosine reductase QueH n/a
39 O57978_5GP O57978 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC n/a
40 P60546_5GP P60546 Guanylate kinase (EC n/a
41 Q2YQ74_5GP Q2YQ74 Beta-lactamase-like n/a
42 Q980A5_5GP Q980A5 Translation initiation factor n/a
43 Q04178_5GP Q04178 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) n/a
44 P40107_5GP P40107 GDP-mannose transporter 1 n/a
45 P0DTC9_5GP P0DTC9 Nucleoprotein (N) (Nucleocapsid n/a
46 Q9SSV1_5GP Q9SSV1 RNase NGR3 (Ribonuclease n/a
47 Q9V119_5GP Q9V119 Exosome complex component n/a
48 P0C794_5GP P0C794 Matrix protein (gp18) n/a
49 A5K709_5GP A5K709 guanylate kinase (EC n/a
50 P22434_5GP P22434 3',5'-cyclic-nucleotide phosphodiesterase 1 n/a
51 P00492_5GP P00492 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) n/a
52 Q9WLZ8_5GP Q9WLZ8 Genome polyprotein n/a
53 P80912_5GP P80912 Adenosine 5'-monophosphoramidase HINT1 n/a
54 Q9X1T1_5GP Q9X1T1 Uncharacterized protein n/a
55 P50098_5GP P50098 Inosine-5'-monophosphate dehydrogenase (IMP n/a
56 O07347_5GP O07347 Signal recognition particle n/a
57 Q83EL7_5GP Q83EL7 Guanylate kinase (EC n/a
58 Q57ZS7_5GP Q57ZS7 Inosine-5'-monophosphate dehydrogenase (EC n/a
59 O59245_5GP O59245 tRNA-splicing ligase RtcB n/a
60 Q64PD9_5GP Q64PD9 Putative exopolyphosphatase-related protein n/a
61 P32455_5GP P32455 Guanylate-binding protein 1 n/a
62 A0A8I3B064_5GP A0A8I3B064 5,10-methenyltetrahydromethanopterin hydrogenase (EC n/a
63 A0QYE8_5GP A0QYE8 GMP reductase (EC n/a
64 P61823_5GP P61823 Ribonuclease pancreatic (EC n/a
65 Q88EQ6_5GP Q88EQ6 Flagellar brake protein n/a
66 P31016_5GP P31016 Disks large homolog n/a
67 P00497_5GP P00497 Amidophosphoribosyltransferase (ATase) (EC n/a
68 P78587_5GP P78587 mRNA-capping enzyme subunit n/a
69 Q99QC1_5GP Q99QC1 Beta-lactamase CMY-10 (EC n/a
70 Q7XZV5_5GP Q7XZV5 Ribonuclease NW n/a
71 Q763K9_5GP Q763K9 16S rRNA (guanine(1405)-N(7))-methyltransferase n/a
72 Q9Y3I0_5GP Q9Y3I0 RNA-splicing ligase RtcB n/a
73 B6YWB8_5GP B6YWB8 CRISPR system single-strand-specific n/a
74 Q9I4L4_5GP Q9I4L4 Negative regulator YfiR n/a
75 Q38087_5GP Q38087 DNA-directed DNA polymerase n/a
76 P32471_5GP P32471 Elongation factor 1-beta n/a
77 O35820_5GP O35820 5-hydroxymethyl-dUMP N-hydrolase (EC n/a
78 Q9R1E6_5GP Q9R1E6 Autotaxin (EC 3.1.4.39) n/a
79 O76074_5GP O76074 cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor
80 P14583_5GP P14583 Putative mRNA-capping enzyme n/a
81 C0QQ26_5GP C0QQ26 Metal dependent phosphohydrolase n/a
82 B6YWC0_5GP B6YWC0 CRISPR system Cms n/a
83 P42085_5GP P42085 Xanthine phosphoribosyltransferase (XPRTase) n/a
84 X5MEI1_5GP X5MEI1 3'-5' exonuclease n/a
85 B1WBP0_5GP B1WBP0 Metallophosphoesterase MPPED2 (EC n/a
86 Q05599_5GP Q05599 Bifunctional adenosylcobalamin biosynthesis n/a
87 Q71LY2_5GP Q71LY2 Genome polyprotein [Cleaved n/a
88 P0DTD1_5GP P0DTD1 Replicase polyprotein 1ab n/a
89 Q8C6L5_5GP Q8C6L5 Cyclic GMP-AMP synthase n/a
90 Q9UKV8_5GP Q9UKV8 Protein argonaute-2 (Argonaute2) n/a
91 O35014_5GP O35014 Uncharacterized EAL-domain containing n/a
92 P07741_5GP P07741 Adenine phosphoribosyltransferase (APRT) n/a
93 Q26997_5GP Q26997 Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGPRT) n/a
94 P0A9M2_5GP P0A9M2 Hypoxanthine phosphoribosyltransferase (HPRT) n/a
95 Q182D4_5GP Q182D4 Histidine triad (HIT) n/a
96 D9J2T9_5GP D9J2T9 rRNA N-glycosylase (EC n/a
97 B2FT06_5GP B2FT06 Guanylate kinase (EC n/a
98 P41007_5GP P41007 Bifunctional protein PyrR n/a
99 Q9P2T1_5GP Q9P2T1 GMP reductase 2 n/a
100 Q5SLS3_5GP Q5SLS3 Hypoxanthine phosphoribosyltransferase (EC n/a
101 Q5ZZB6_5GP Q5ZZB6 Cytosolic IMP-GMP specific n/a
102 C4TPE0_5GP C4TPE0 Genome polyprotein n/a
103 Q97W22_5GP Q97W22 Purine phosphoribosyltransferase (GpT-2) n/a
104 J9VQ84_5GP J9VQ84 guanylate kinase (EC n/a
105 P0ACE7_5GP P0ACE7 Purine nucleoside phosphoramidase n/a
106 Q89VT8_5GP Q89VT8 Amino acid--[acyl-carrier-protein] ligase n/a
107 O28126_5GP O28126 CCA-adding enzyme (EC n/a
108 C4M1P9_5GP C4M1P9 Lariat debranching enzyme n/a
109 Q38CA1_5GP Q38CA1 Hypoxanthine-guanine phosphoribosyltransferase, putative n/a
110 P83749_5GP P83749 Signal recognition particle n/a
111 P0A5I4_5GP P0A5I4 Guanylate kinase (EC n/a
112 P02994_5GP P02994 Elongation factor 1-alpha n/a
113 P0A9M5_5GP P0A9M5 Xanthine-guanine phosphoribosyltransferase (XGPRT) n/a
114 A7ZS61_5GP A7ZS61 Polyribonucleotide nucleotidyltransferase (EC n/a
115 Q5HGM3_5GP Q5HGM3 Guanylate kinase (EC n/a
116 D0CB74_5GP D0CB74 Riboflavin biosynthesis protein n/a
117 C3P9L0_5GP C3P9L0 deleted n/a
118 Q2GLF7_5GP Q2GLF7 Guanylate kinase (EC n/a
119 Q6SA23_5GP Q6SA23 Nucleocapsid protein n/a
120 Q8LPL7_5GP Q8LPL7 N6-mAMP deaminase (AtMAPDA) n/a
121 P57665_5GP P57665 Oligoribonuclease (EC 3.1.15.-) n/a
122 I6YCM5_5GP I6YCM5 deleted n/a
123 O06961_5GP O06961 Propionate kinase (EC n/a