Ligand name: Paroxetine
PDB ligand accession: 8PR
DrugBank: DB00715
PubChem: 43815
ChEMBL: CHEMBL490
InChI Key: AHOUBRCZNHFOSL-YOEHRIQHSA-N
SMILES: c1cc(ccc1C2CCNCC2COc3ccc4c(c3)OCO4)F

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Piperidines
      • Subclass: Phenylpiperidines

List of proteins that are targets for 8PR

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P00178_8PR	P00178	Cytochrome P450 2B4	n/a
2	P05164_8PR	P05164	Myeloperoxidase (MPO) (EC	n/a	IC50(nM) = 20.0
3	O67854_8PR	O67854	Na(+):neurotransmitter symporter (Snf	n/a
4	P35367_8PR	P35367	Histamine H1 receptor	inhibitor	Ki(nM) = 10000.0
5	P14416_8PR	P14416	D(2) dopamine receptor	other/unknown	Ki(nM) = 10000.0
6	P23975_8PR	P23975	Sodium-dependent noradrenaline transporter	inhibitor	Ki(nM) = 40.0 IC50(nM) = 100.0 Kd(nM) = 40.0
7	P25098_8PR	P25098	Beta-adrenergic receptor kinase	n/a	IC50(nM) = 1100.0 Kd(nM) = 2980.0
8	P41595_8PR	P41595	5-hydroxytryptamine receptor 2B	agonist	n/a	Ki(nM) = 10000.0
9	A0A0U3BWW0_8PR	A0A0U3BWW0	Envelope glycoprotein (GP1,2)	n/a
10	P28327_8PR	P28327	Rhodopsin kinase GRK1	n/a	IC50(nM) = 100000.0
11	A0A0E3NBB1_8PR	A0A0E3NBB1	Envelope glycoprotein (GP1,2)	n/a
12	P31645_8PR	P31645	Sodium-dependent serotonin transporter	inhibitor	Ki(nM) = 0.04 IC50(nM) = 0.2 Kd(nM) = 0.13
13	P28223_8PR	P28223	5-hydroxytryptamine receptor 2A	n/a	agonist	Ki(nM) = 10000.0