Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
PDB ligand accession: ACP
DrugBank: DB03909
PubChem: 91532
ChEMBL: CHEMBL133463
InChI Key: UFZTZBNSLXELAL-IOSLPCCCSA-N
SMILES: c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(CP(=O)(O)O)O)O)O)N

ClassyFire chemical classification:

List of proteins that are targets for ACP

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q5SHX3_ACP Q5SHX3 Thymidylate kinase (EC n/a
2 O14983_ACP O14983 Sarcoplasmic/endoplasmic reticulum calcium n/a
3 Q3K5N8_ACP Q3K5N8 Transcriptional initiation protein n/a
4 G8UQH9_ACP G8UQH9 ATPase n/a
5 Q5ZSZ6_ACP Q5ZSZ6 HipA-like C-terminal domain-containing n/a
6 P11021_ACP P11021 Endoplasmic reticulum chaperone n/a
7 P33221_ACP P33221 Formate-dependent phosphoribosylglycinamide formyltransferase n/a
8 P9WJA9_ACP P9WJA9 Glycogen accumulation regulator n/a
9 Q8NG68_ACP Q8NG68 Tubulin--tyrosine ligase (TTL) n/a
10 Q9TVW2_ACP Q9TVW2 Adenosine kinase (AK) n/a
11 P00459_ACP P00459 Nitrogenase iron protein n/a
12 Q05823_ACP Q05823 2-5A-dependent ribonuclease (2-5A-dependent n/a
13 Q9X0X3_ACP Q9X0X3 Phosphoribosylformylglycinamidine synthase subunit n/a
14 Q9I5Q5_ACP Q9I5Q5 Anhydro-N-acetylmuramic acid kinase n/a
15 Q12756_ACP Q12756 Kinesin-like protein KIF1A n/a
16 P15056_ACP P15056 Serine/threonine-protein kinase B-raf n/a
17 P28482_ACP P28482 Mitogen-activated protein kinase n/a
18 P11362_ACP P11362 Fibroblast growth factor n/a
19 P32660_ACP P32660 Phospholipid-transporting ATPase DNF1 n/a
20 A0A140K0M0_ACP A0A140K0M0 RimK domain-containing protein n/a
21 Q9X278_ACP Q9X278 Probable butyrate kinase n/a
22 O43353_ACP O43353 Receptor-interacting serine/threonine-protein kinase n/a
23 Q57600_ACP Q57600 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase n/a
24 A0A1S4NYE5_ACP A0A1S4NYE5 PpkA N terminal n/a
25 P41743_ACP P41743 Protein kinase C n/a
26 P45066_ACP P45066 UDP-N-acetylmuramate--L-alanine ligase (EC n/a
27 O28025_ACP O28025 tRNA(Ile2) 2-agmatinylcytidine synthetase n/a
28 O34757_ACP O34757 Sensor histidine kinase n/a
29 Q15418_ACP Q15418 Ribosomal protein S6 n/a
30 P15925_ACP P15925 Folylpolyglutamate synthase (FPGS) n/a
31 Q9NRK6_ACP Q9NRK6 ATP-binding cassette sub-family n/a
32 P14825_ACP P14825 Lysine--tRNA ligase, heat n/a
33 O43520_ACP O43520 Phospholipid-transporting ATPase IC n/a
34 Q8YC53_ACP Q8YC53 Blue-light-activated histidine kinase n/a
35 Q5SKR5_ACP Q5SKR5 Uridine kinase (EC n/a
36 Q01813_ACP Q01813 ATP-dependent 6-phosphofructokinase, platelet n/a
37 Q6FV03_ACP Q6FV03 Candida glabrata strain n/a
38 G3V8S4_ACP G3V8S4 Sodium/potassium-transporting ATPase subunit n/a
39 P29317_ACP P29317 Ephrin type-A receptor n/a
40 P0A6F3_ACP P0A6F3 Glycerol kinase (EC n/a
41 O59791_ACP O59791 Serine racemase (EC n/a
42 O67518_ACP O67518 DNA mismatch repair n/a
43 O73946_ACP O73946 ATP-dependent DNA helicase n/a
44 P46859_ACP P46859 Thermoresistant gluconokinase (EC n/a
45 O67883_ACP O67883 Thiamine-monophosphate kinase (TMP n/a
46 P82197_ACP P82197 Pyridoxal kinase (EC n/a
47 A1TH50_ACP A1TH50 Maltokinase (MaK) (EC n/a
48 Q8U3I1_ACP Q8U3I1 Cell division inhibitor n/a
49 A0A024L5I2_ACP A0A024L5I2 Potassium-transporting ATPase ATP-binding n/a
50 Q59EX4_ACP Q59EX4 Phospholipid-transporting ATPase (EC n/a
51 Q38C91_ACP Q38C91 methionine--tRNA ligase (EC n/a
52 P05132_ACP P05132 cAMP-dependent protein kinase n/a
53 Q16875_ACP Q16875 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase n/a
54 Q8TZ25_ACP Q8TZ25 Uncharacterized conserved protein n/a
55 P53355_ACP P53355 Death-associated protein kinase n/a
56 P54708_ACP P54708 Potassium-transporting ATPase alpha n/a
57 Q5SJV7_ACP Q5SJV7 Universal stress protein n/a
58 P07900_ACP P07900 Heat shock protein n/a
59 Q8ZKR2_ACP Q8ZKR2 Aminoimidazole riboside kinase n/a
60 P04191_ACP P04191 Sarcoplasmic/endoplasmic reticulum calcium n/a
61 Q2YKK7_ACP Q2YKK7 Blue-light-activated histidine kinase n/a
62 P53779_ACP P53779 Mitogen-activated protein kinase n/a
63 P0A4Z2_ACP P0A4Z2 Shikimate kinase (SK) n/a
64 O31663_ACP O31663 Methylthioribose kinase (MTR n/a
65 P48730_ACP P48730 Casein kinase I n/a
66 A3WE14_ACP A3WE14 acetate--CoA ligase (EC n/a
67 P13000_ACP P13000 ATP-dependent dethiobiotin synthetase n/a
68 P42527_ACP P42527 Myosin heavy chain n/a
69 Q9VUL1_ACP Q9VUL1 CTP synthase (EC n/a
70 P23874_ACP P23874 Serine/threonine-protein kinase toxin n/a
71 P83734_ACP P83734 Adenosine kinase (ADK) n/a
72 P16615_ACP P16615 Sarcoplasmic/endoplasmic reticulum calcium n/a
73 Q8TZW1_ACP Q8TZW1 S-adenosylmethionine synthase (AdoMet n/a
74 P40527_ACP P40527 Phospholipid-transporting ATPase NEO1 n/a
75 Q6XHB2_ACP Q6XHB2 Probable serine/threonine-protein kinase n/a
76 A0LU48_ACP A0LU48 Depupylase (EC 3.4.-.-) n/a
77 P68400_ACP P68400 Casein kinase II n/a
78 D5IEZ9_ACP D5IEZ9 Uncharacterized protein n/a
79 Q9XYQ1_ACP Q9XYQ1 Inositol-tetrakisphosphate 1-kinase (EC n/a
80 P03960_ACP P03960 Potassium-transporting ATPase ATP-binding n/a
81 P05054_ACP P05054 Ribokinase (RK) (EC n/a
82 P06213_ACP P06213 Insulin receptor (IR) inhibitor
83 E9BIX7_ACP E9BIX7 Ribokinase (RK) (EC n/a
84 P63810_ACP P63810 Pantothenate kinase (EC n/a
85 P0A6Y8_ACP P0A6Y8 Chaperone protein DnaK n/a
86 P54651_ACP P54651 Heat shock cognate n/a
87 Q56310_ACP Q56310 Chemotaxis protein CheA n/a
88 P81947_ACP P81947 Tubulin alpha-1B chain n/a
89 Q9RA63_ACP Q9RA63 Chaperone protein ClpB n/a
90 A0A068N621_ACP A0A068N621 Cyanophycin synthetase (EC n/a
91 O29777_ACP O29777 Probable copper-exporting P-type n/a
92 O00764_ACP O00764 Pyridoxal kinase (EC n/a
93 B6CAM1_ACP B6CAM1 Calcium-transporting ATPase (EC n/a
94 P9WI81_ACP P9WI81 Serine/threonine-protein kinase PknB n/a
95 E1BQ43_ACP E1BQ43 deleted n/a
96 G3FFN6_ACP G3FFN6 N6-succino-2-amino-2'-deoxyadenylate synthase (EC n/a
97 P21802_ACP P21802 Fibroblast growth factor n/a
98 O67099_ACP O67099 Thymidylate kinase (EC n/a
99 O53174_ACP O53174 tetrahydrofolate synthase (EC n/a
100 O67572_ACP O67572 Tetraacyldisaccharide 4'-kinase (EC n/a
101 Q12675_ACP Q12675 Phospholipid-transporting ATPase DNF2 n/a
102 P33173_ACP P33173 Kinesin-like protein KIF1A n/a
103 P13637_ACP P13637 Sodium/potassium-transporting ATPase subunit n/a
104 Q97ZE2_ACP Q97ZE2 Uridylate kinase (UK) n/a
105 P9WHK7_ACP P9WHK7 CTP synthase (EC n/a
106 Q9FD68_ACP Q9FD68 diphosphomevalonate decarboxylase (EC n/a
107 Q0J0U8_ACP Q0J0U8 Heat shock protein n/a
108 Q02750_ACP Q02750 Dual specificity mitogen-activated n/a
109 I6WX66_ACP I6WX66 deleted n/a
110 Q99W31_ACP Q99W31 deleted n/a
111 G0S196_ACP G0S196 Phospholipid-transporting ATPase DNF1 n/a
112 P0A5S4_ACP P0A5S4 Serine/threonine-protein kinase PknB n/a
113 B0ZE06_ACP B0ZE06 Chromosome partitioning protein n/a
114 P00558_ACP P00558 Phosphoglycerate kinase 1 n/a
115 P0ABN1_ACP P0ABN1 Diacylglycerol kinase (DAGK) n/a
116 P11607_ACP P11607 Sarcoplasmic/endoplasmic reticulum calcium n/a
117 C8MK44_ACP C8MK44 deleted n/a
118 O68106_ACP O68106 Cobalt import ATP-binding n/a
119 Q5BJD7_ACP Q5BJD7 Obg-like ATPase 1 n/a
120 Q07912_ACP Q07912 Activated CDC42 kinase n/a
121 Q9HVZ7_ACP Q9HVZ7 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC n/a
122 A0A8V0Z8P0_ACP A0A8V0Z8P0 Tubulin--tyrosine ligase (EC n/a
123 R9WYL1_ACP R9WYL1 deleted n/a
124 O14965_ACP O14965 Aurora kinase A n/a
125 P19456_ACP P19456 ATPase 2, plasma n/a
126 Q8NB49_ACP Q8NB49 Phospholipid-transporting ATPase IG n/a
127 B1L3C9_ACP B1L3C9 Acyl-CoA synthetase (NDP n/a
128 O66659_ACP O66659 Chromosomal replication initiator n/a
129 Q9H477_ACP Q9H477 Ribokinase (RK) (EC n/a
130 A0A369R1N0_ACP A0A369R1N0 Type III glutamate--ammonia n/a
131 B1L7P8_ACP B1L7P8 ATP-grasp domain-containing protein n/a
132 P24559_ACP P24559 Type IV pilus n/a
133 P08069_ACP P08069 Insulin-like growth factor n/a
134 P98194_ACP P98194 Calcium-transporting ATPase type n/a
135 P22607_ACP P22607 Fibroblast growth factor n/a
136 P00957_ACP P00957 Alanine--tRNA ligase (EC n/a
137 Q5JIH4_ACP Q5JIH4 Iron-sulfur cluster carrier n/a
138 Q7SIB7_ACP Q7SIB7 Phosphoglycerate kinase 1 n/a
139 Q5JDA3_ACP Q5JDA3 Carbohydrate/pyrimidine kinase, PfkB n/a
140 Q0VCY0_ACP Q0VCY0 Sarcoplasmic/endoplasmic reticulum calcium n/a
141 P43873_ACP P43873 Biotin carboxylase (EC n/a
142 Q2XVP4_ACP Q2XVP4 Tubulin alpha-1B chain n/a