Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
PDB ligand accession: AGS
DrugBank: DB02930
PubChem: 440317;444377;
ChEMBL: CHEMBL131890
InChI Key: NLTUCYMLOPLUHL-KQYNXXCUSA-N
SMILES: c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=S)(O)O)O)O)N

ClassyFire chemical classification:

List of proteins that are targets for AGS

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 A0A098D3M4_AGS A0A098D3M4 Myosin-1 (Class I n/a
2 Q8IIJ8_AGS Q8IIJ8 Heat shock protein n/a
3 A0A6A5PUY8_AGS A0A6A5PUY8 deleted n/a
4 G0SGH3_AGS G0SGH3 Structural maintenance of n/a
5 Q96C45_AGS Q96C45 Serine/threonine-protein kinase ULK4 n/a
6 A0A0D6IHD2_AGS A0A0D6IHD2 protein-secreting ATPase (EC n/a
7 P09119_AGS P09119 Cell division control n/a
8 G3XCV0_AGS G3XCV0 Transcriptional regulator FleQ n/a
9 Q183M9_AGS Q183M9 Protein translocase subunit n/a
10 P42345_AGS P42345 Serine/threonine-protein kinase mTOR n/a
11 P54651_AGS P54651 Heat shock cognate n/a
12 Q02750_AGS Q02750 Dual specificity mitogen-activated n/a
13 P06710_AGS P06710 DNA polymerase III n/a
14 P17600_AGS P17600 Synapsin-1 (Brain protein n/a
15 A0A2U2MES7_AGS A0A2U2MES7 deleted n/a
16 Q79PF4_AGS Q79PF4 Circadian clock oscillator n/a
17 P29597_AGS P29597 Non-receptor tyrosine-protein kinase n/a
18 E8XBD7_AGS E8XBD7 tRNA N6-adenosine threonylcarbamoyltransferase n/a
19 Q03243_AGS Q03243 Non-structural protein 2 n/a
20 P0A7G6_AGS P0A7G6 Protein RecA (Recombinase n/a
21 Q8VRL1_AGS Q8VRL1 ATP binding motif-containing n/a
22 P80428_AGS P80428 Actin-related protein 4 n/a
23 G0SFC6_AGS G0SFC6 Protein kinase domain-containing n/a
24 A0A085S0Z4_AGS A0A085S0Z4 AAA family ATPase n/a
25 P24733_AGS P24733 Myosin heavy chain, n/a
26 P47811_AGS P47811 Mitogen-activated protein kinase n/a
27 Q87KD2_AGS Q87KD2 Trk system potassium n/a
28 P51955_AGS P51955 Serine/threonine-protein kinase Nek2 n/a
29 A5TY84_AGS A5TY84 Serine/threonine-protein kinase PknB n/a
30 Q7SDP4_AGS Q7SDP4 PAN2-PAN3 deadenylation complex n/a
31 Q15257_AGS Q15257 Serine/threonine-protein phosphatase 2A n/a
32 P25114_AGS P25114 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase n/a
33 P03587_AGS P03587 Replicase large subunit n/a
34 A0A087X2I1_AGS A0A087X2I1 Proteasome 26S subunit, n/a
35 P23371_AGS P23371 Poly(A) polymerase catalytic n/a
36 P59653_AGS P59653 Transport/processing ATP-binding protein n/a
37 P24279_AGS P24279 DNA replication licensing n/a
38 P38630_AGS P38630 Replication factor C n/a
39 G0SE15_AGS G0SE15 Actin n/a
40 P9WPD0_AGS P9WPD0 Chaperone protein ClpB n/a
41 F1NBW0_AGS F1NBW0 Mitochondrial poly(A) polymerase n/a
42 P22869_AGS P22869 Methane monooxygenase component n/a
43 E5DV50_AGS E5DV50 Large subunit terminase n/a
44 D5IEZ9_AGS D5IEZ9 Uncharacterized protein n/a
45 A3DCU1_AGS A3DCU1 ABC-type bacteriocin transporter n/a
46 Q96P20_AGS Q96P20 NACHT, LRR and n/a
47 P07271_AGS P07271 ATP-dependent DNA helicase n/a
48 P29496_AGS P29496 Minichromosome maintenance protein n/a
49 P35557_AGS P35557 Hexokinase-4 (HK4) (EC n/a
50 Q87WW0_AGS Q87WW0 Sulfate adenylyltransferase subunit n/a
51 P53667_AGS P53667 LIM domain kinase n/a
52 Q12386_AGS Q12386 Actin-like protein ARP8 n/a
53 G0SBW4_AGS G0SBW4 Actin-like protein n/a
54 P63284_AGS P63284 Chaperone protein ClpB n/a
55 A0A0H2ZMB9_AGS A0A0H2ZMB9 ATP-dependent Clp protease, n/a
56 Q9Y616_AGS Q9Y616 Interleukin-1 receptor-associated kinase n/a
57 P9WKX5_AGS P9WKX5 Putative ATPase Rv3679 n/a
58 P17599_AGS P17599 Synapsin-1 (Synapsin I) n/a
59 P0A452_AGS P0A452 Protein RecA (Recombinase n/a
60 Q57280_AGS Q57280 ParA protein (S.pyogenes n/a
61 Q15645_AGS Q15645 Pachytene checkpoint protein n/a
62 Q58718_AGS Q58718 DNA double-strand break n/a
63 Q1PLI0_AGS Q1PLI0 FtsK/SpoIIIE domain-containing protein n/a
64 Q1R3B6_AGS Q1R3B6 Chaperonin GroEL (EC n/a
65 P08799_AGS P08799 Myosin-2 heavy chain n/a
66 P83734_AGS P83734 Adenosine kinase (ADK) n/a
67 P43686_AGS P43686 26S proteasome regulatory n/a
68 P16118_AGS P16118 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase n/a
69 P62333_AGS P62333 26S proteasome regulatory n/a
70 D0VWX4_AGS D0VWX4 Amino acid ABC n/a
71 O15992_AGS O15992 Arginine kinase (AK) n/a
72 A0A8J0PCL3_AGS A0A8J0PCL3 TnsC n/a
73 A0A1U7R319_AGS A0A1U7R319 ATP-binding cassette sub-family n/a
74 O75643_AGS O75643 U5 small nuclear n/a
75 P60010_AGS P60010 Actin (EC 3.6.4.-) n/a
76 Q9H078_AGS Q9H078 Mitochondrial disaggregase (EC n/a
77 P51834_AGS P51834 Chromosome partition protein n/a
78 P47037_AGS P47037 Structural maintenance of n/a
79 O14757_AGS O14757 Serine/threonine-protein kinase Chk1 n/a
80 G0SHW7_AGS G0SHW7 DNA repair protein n/a
81 Q51460_AGS Q51460 AAA domain-containing protein n/a
82 Q2K340_AGS Q2K340 Pyruvate carboxylase (EC n/a
83 Q9I0M3_AGS Q9I0M3 DNA translocase FtsK n/a
84 P0A5S4_AGS P0A5S4 Serine/threonine-protein kinase PknB n/a
85 P17980_AGS P17980 26S proteasome regulatory n/a
86 P00523_AGS P00523 Proto-oncogene tyrosine-protein kinase n/a
87 A0A836NDF2_AGS A0A836NDF2 ATP-dependent Clp protease n/a
88 P54791_AGS P54791 Origin recognition complex n/a
89 G0S6Y2_AGS G0S6Y2 Putative cell division n/a
90 A0A485JBB4_AGS A0A485JBB4 Protein RecA (Recombinase n/a
91 P32657_AGS P32657 Chromo domain-containing protein n/a
92 O14874_AGS O14874 Branched-chain alpha-ketoacid dehydrogenase n/a
93 P40348_AGS P40348 Replication factor C n/a
94 Q113V7_AGS Q113V7 Cyanophycin synthetase (EC n/a
95 P32641_AGS P32641 Checkpoint protein RAD24 n/a
96 Q56404_AGS Q56404 V-type ATP synthase n/a
97 P38132_AGS P38132 DNA replication licensing n/a
98 P53091_AGS P53091 DNA replication licensing n/a
99 Q59560_AGS Q59560 Protein RecA (Recombinase n/a
100 Q56403_AGS Q56403 V-type ATP synthase n/a
101 P63820_AGS P63820 Phosphopantetheine adenylyltransferase (EC n/a
102 P07900_AGS P07900 Heat shock protein n/a
103 C3TLS7_AGS C3TLS7 ATP-dependent Clp protease n/a
104 Q10588_AGS Q10588 ADP-ribosyl cyclase/cyclic ADP-ribose n/a
105 E0J719_AGS E0J719 Chaperone protein ClpB n/a
106 P38251_AGS P38251 Replication factor C n/a
107 P35249_AGS P35249 Replication factor C n/a
108 P0A5U4_AGS P0A5U4 Protein RecA (Recombinase n/a
109 A0A059VAZ3_AGS A0A059VAZ3 Lon protease (EC n/a
110 P23528_AGS P23528 Cofilin-1 (18 kDa n/a
111 P54278_AGS P54278 Mismatch repair endonuclease n/a
112 Q7BK04_AGS Q7BK04 Cag alpha (Cag n/a
113 P17157_AGS P17157 Cyclin-dependent protein kinase n/a
114 A7M6E7_AGS A7M6E7 ToMV resistance protein n/a
115 Q5TCX8_AGS Q5TCX8 Mitogen-activated protein kinase n/a
116 P33991_AGS P33991 DNA replication licensing n/a
117 Q877G8_AGS Q877G8 Chaperonin n/a
118 P15108_AGS P15108 ATP-dependent molecular chaperone n/a
119 P32908_AGS P32908 Structural maintenance of n/a
120 P29317_AGS P29317 Ephrin type-A receptor n/a
121 P0A1C1_AGS P0A1C1 Type 3 secretion n/a
122 Q9EQP2_AGS Q9EQP2 EH domain-containing protein n/a
123 V2RJ62_AGS V2RJ62 deleted n/a
124 Q86UE8_AGS Q86UE8 Serine/threonine-protein kinase tousled-like n/a
125 Q7VL96_AGS Q7VL96 Chromosome partition protein n/a
126 P05023_AGS P05023 Sodium/potassium-transporting ATPase subunit n/a
127 Q72KB4_AGS Q72KB4 Transcription-repair-coupling factor (TRCF) n/a
128 Q9FD73_AGS Q9FD73 diphosphomevalonate decarboxylase (EC n/a
129 A0A1Q9L861_AGS A0A1Q9L861 deleted n/a
130 Q9WYC3_AGS Q9WYC3 ABC transporter, ATP-binding n/a
131 Q8RDL3_AGS Q8RDL3 DNA replication and n/a
132 G0S0B9_AGS G0S0B9 Pre-mRNA splicing helicase-like n/a
133 P15043_AGS P15043 ATP-dependent DNA helicase n/a
134 O75449_AGS O75449 Katanin p60 ATPase-containing n/a
135 Q16513_AGS Q16513 Serine/threonine-protein kinase N2 n/a
136 P04530_AGS P04530 DnaB-like replicative helicase n/a
137 P33221_AGS P33221 Formate-dependent phosphoribosylglycinamide formyltransferase n/a
138 P0A6H1_AGS P0A6H1 ATP-dependent Clp protease n/a
139 Q9WZU0_AGS Q9WZU0 Cell division protein n/a
140 P36776_AGS P36776 Lon protease homolog, n/a
141 P52917_AGS P52917 Vacuolar protein sorting-associated n/a
142 A0A089QYG8_AGS A0A089QYG8 deleted n/a
143 P33919_AGS P33919 Putative DNA repair n/a
144 P42443_AGS P42443 Protein RecA (Recombinase n/a
145 Q2Z0T5_AGS Q2Z0T5 Putative GroEL-like chaperonine n/a
146 Q99558_AGS Q99558 Mitogen-activated protein kinase n/a
147 P30665_AGS P30665 DNA replication licensing n/a
148 Q56148_AGS Q56148 Chloramphenicol 3-O phosphotransferase n/a
149 P33897_AGS P33897 ATP-binding cassette sub-family n/a
150 P50613_AGS P50613 Cyclin-dependent kinase 7 n/a
151 P35998_AGS P35998 26S proteasome regulatory n/a
152 P0A6F5_AGS P0A6F5 Chaperonin GroEL (EC n/a
153 B2FT06_AGS B2FT06 Guanylate kinase (EC n/a
154 Q8K183_AGS Q8K183 Pyridoxal kinase (EC n/a
155 P62191_AGS P62191 26S proteasome regulatory n/a
156 P29469_AGS P29469 DNA replication licensing n/a
157 P15056_AGS P15056 Serine/threonine-protein kinase B-raf n/a
158 P21164_AGS P21164 Formate--tetrahydrofolate ligase (EC n/a
159 Q716H3_AGS Q716H3 Gene 2 protein n/a
160 Q9WYC4_AGS Q9WYC4 Uncharacterized ABC transporter n/a
161 B9VUU3_AGS B9VUU3 Genome polyprotein [Cleaved n/a
162 P40938_AGS P40938 Replication factor C n/a
163 P00519_AGS P00519 Tyrosine-protein kinase ABL1 n/a
164 P58555_AGS P58555 Ribulose bisphosphate carboxylase/oxygenase n/a
165 P06243_AGS P06243 Cell division control n/a
166 P67775_AGS P67775 Serine/threonine-protein phosphatase 2A n/a
167 P32794_AGS P32794 ATPase family gene n/a
168 A0A376NU07_AGS A0A376NU07 Protein RecA (Recombinase n/a
169 P54784_AGS P54784 Origin recognition complex n/a
170 P30750_AGS P30750 Methionine import ATP-binding n/a
171 A0A4S4P650_AGS A0A4S4P650 deleted n/a
172 A0A4Y9BNB2_AGS A0A4Y9BNB2 deleted n/a
173 P38629_AGS P38629 Replication factor C n/a
174 P40339_AGS P40339 Replication factor C n/a
175 O86150_AGS O86150 ABC-type lipopolysaccharide transporter n/a
176 Q58504_AGS Q58504 Homoserine kinase (HK) n/a
177 A0A0K2H586_AGS A0A0K2H586 deleted n/a
178 Q00972_AGS Q00972 Branched-chain alpha-ketoacid dehydrogenase n/a
179 B8GY04_AGS B8GY04 deleted n/a
180 X5EJW5_AGS X5EJW5 ABC transporter ATP-binding n/a
181 P31539_AGS P31539 Heat shock protein n/a
182 Q14289_AGS Q14289 Protein-tyrosine kinase 2-beta n/a
183 Q97UL5_AGS Q97UL5 Diphosphomevalonate decarboxylase (DMD) n/a
184 P33993_AGS P33993 DNA replication licensing n/a
185 G3XD64_AGS G3XD64 Antiactivator FleN n/a
186 P9WI73_AGS P9WI73 Serine/threonine-protein kinase PknG n/a
187 P40937_AGS P40937 Replication factor C n/a
188 Q5SL87_AGS Q5SL87 Holliday junction branch n/a
189 P35250_AGS P35250 Replication factor C n/a
190 A0A8G4Z850_AGS A0A8G4Z850 deleted n/a
191 P55072_AGS P55072 Transitional endoplasmic reticulum n/a
192 Q61743_AGS Q61743 ATP-sensitive inward rectifier n/a
193 A0A7S9SV99_AGS A0A7S9SV99 DnaB-like replicative helicase n/a
194 A0A045JSR5_AGS A0A045JSR5 Chaperone protein ClpB n/a
195 P50874_AGS P50874 Origin recognition complex n/a