Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: 2-OXOGLUTARIC ACID
PDB ligand accession: AKG
DrugBank: DB08845
PubChem: 51;156274072;
ChEMBL: CHEMBL1686
InChI Key: KPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES: C(CC(=O)O)C(=O)C(=O)O

ClassyFire chemical classification:

List of proteins that are targets for AKG

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 D0VX22_AKG D0VX22 CytC3 n/a
2 A0A0E3URV8_AKG A0A0E3URV8 Leucine hydroxylase n/a
3 Q96Q83_AKG Q96Q83 Alpha-ketoglutarate-dependent dioxygenase alkB n/a
4 G9MBV2_AKG G9MBV2 Hydroxylase (EC 1.14.11.41) n/a
5 Q05581_AKG Q05581 Clavaminate synthase 1 n/a
6 P0C870_AKG P0C870 Bifunctional peptidase and n/a
7 J3BZS6_AKG J3BZS6 L-lysine 4-hydroxylase (EC n/a
8 P70731_AKG P70731 Nitrogen regulatory protein n/a
9 P0A3F4_AKG P0A3F4 Nitrogen regulatory protein n/a
10 O28524_AKG O28524 Nitrogen regulatory protein n/a
11 F6YRW4_AKG F6YRW4 Lysine (K)-specific demethylase n/a
12 P00509_AKG P00509 Aspartate aminotransferase (AspAT) n/a
13 P31026_AKG P31026 NADP-specific glutamate dehydrogenase n/a
14 Q9UT12_AKG Q9UT12 Uncharacterized protein P8A3.02c n/a
15 A0A067YX61_AKG A0A067YX61 WelO5 n/a
16 Q1XGK3_AKG Q1XGK3 4-oxalocrotonate decarboxylase NahK n/a
17 Q8ZNF3_AKG Q8ZNF3 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase (EC n/a
18 P40032_AKG P40032 Prolyl 3,4-dihydroxylase TPA1 n/a
19 Q88RA3_AKG Q88RA3 Alpha-ketoglutarate-dependent taurine dioxygenase n/a
20 Q3KRA9_AKG Q3KRA9 Alpha-ketoglutarate-dependent dioxygenase alkB n/a
21 Q5AR53_AKG Q5AR53 Iron/alpha-ketoglutarate-dependent dioxygenase asqJ n/a
22 O60568_AKG O60568 Multifunctional procollagen lysine n/a
23 A8JI83_AKG A8JI83 deleted n/a
24 Q6NS38_AKG Q6NS38 DNA oxidative demethylase n/a
25 O14832_AKG O14832 Phytanoyl-CoA dioxygenase, peroxisomal n/a
26 A0A1D8PMH8_AKG A0A1D8PMH8 Glutamate dehydrogenase n/a
27 A0A3G5LE49_AKG A0A3G5LE49 deleted n/a
28 Q13PB7_AKG Q13PB7 Mandelate racemase/muconate lactonizing n/a
29 Q8N371_AKG Q8N371 Bifunctional peptidase and n/a
30 Q4J989_AKG Q4J989 Homocitrate synthase (HCS) n/a
31 A0A097ZPD5_AKG A0A097ZPD5 Dioxygenase andA (EC n/a
32 P47016_AKG P47016 Deaminated glutathione amidase n/a
33 P30615_AKG P30615 Pyruvate kinase 1 n/a
34 Q9A9H3_AKG Q9A9H3 GDP-perosamine synthase (EC n/a
35 Q969Q7_AKG Q969Q7 Hypoxia-inducible factor 1-alpha n/a
36 P21954_AKG P21954 Isocitrate dehydrogenase [NADP], n/a
37 G8GV69_AKG G8GV69 Dioxygenase easH (EC n/a
38 Q81LZ8_AKG Q81LZ8 Prolyl 4-hydroxylase, alpha n/a
39 A0A0M3KL01_AKG A0A0M3KL01 EvdO2 (Phytanoyl-CoA dioxygenase n/a
40 A8I3W3_AKG A8I3W3 deleted n/a
41 P29375_AKG P29375 Lysine-specific demethylase 5A n/a
42 A0A9Y2YA87_AKG A0A9Y2YA87 Dioxygenase n/a
43 P32021_AKG P32021 2-oxoglutarate-dependent ethylene/succinate-forming enzyme n/a
44 Q9C0B1_AKG Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO n/a
45 Q9GZT9_AKG Q9GZT9 Egl nine homolog n/a
46 Q10BI6_AKG Q10BI6 Oxidoreductase, 2OG-Fe oxygenase n/a
47 Q7RYZ9_AKG Q7RYZ9 Thymine dioxygenase n/a
48 Q989T9_AKG Q989T9 L-proline cis-4-hydroxylase (P4H) n/a
49 Q8IUF8_AKG Q8IUF8 Ribosomal oxygenase 2 n/a
50 Q0B2N4_AKG Q0B2N4 Prolyl 4-hydroxylase alpha n/a
51 O57946_AKG O57946 Aminotransferase class I/classII n/a
52 A0A1L1QK38_AKG A0A1L1QK38 Alpha-ketoglutarate-dependent non-heme iron n/a
53 A2RUC4_AKG A2RUC4 tRNA wybutosine-synthesizing protein n/a
54 P29283_AKG P29283 Global nitrogen regulator n/a
55 O75164_AKG O75164 Lysine-specific demethylase 4A n/a
56 P73862_AKG P73862 Rubisco operon transcriptional n/a
57 A0A1E1FFL0_AKG A0A1E1FFL0 Multifunctional dioxygenase prhA n/a
58 Q9NWT6_AKG Q9NWT6 Hypoxia-inducible factor 1-alpha n/a
59 P18548_AKG P18548 Deacetoxycephalosporin C synthase n/a
60 A6YEH4_AKG A6YEH4 CmnC n/a
61 A0A140NAE3_AKG A0A140NAE3 Glyoxylate/hydroxypyruvate reductase A n/a
62 Q6B0I6_AKG Q6B0I6 Lysine-specific demethylase 4D n/a
63 Q6ZMT4_AKG Q6ZMT4 Lysine-specific demethylase 7A n/a
64 Q9Y823_AKG Q9Y823 Homocitrate synthase, mitochondrial n/a
65 Q08BA6_AKG Q08BA6 RNA demethylase ALKBH5 n/a
66 Q6L732_AKG Q6L732 Kanamycin B dioxygenase n/a
67 Q9HUX5_AKG Q9HUX5 Pseudopaline synthase (EC n/a
68 Q9XJ43_AKG Q9XJ43 Hyoscyamine 6-beta-hydroxylase (EC n/a
69 Q01IX6_AKG Q01IX6 2-oxoglutarate-dependent dioxygenase DAO n/a
70 Q4WAW9_AKG Q4WAW9 Verruculogen synthase (EC n/a
71 P08328_AKG P08328 D-3-phosphoglycerate dehydrogenase (PGDH) n/a
72 Q82IZ1_AKG Q82IZ1 1-deoxypentalenic acid 11-beta-hydroxylase n/a
73 Q5SRE7_AKG Q5SRE7 Phytanoyl-CoA dioxygenase domain-containing n/a
74 Q9F118_AKG Q9F118 Pyridoxamine 5-phosphate-dependent dehydrase n/a
75 Q6DNF2_AKG Q6DNF2 CurA n/a
76 Q84406_AKG Q84406 Prolyl 4-hydroxylase n/a
77 Q8N5Z0_AKG Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial n/a
78 Q2MFS1_AKG Q2MFS1 Putative oxidase/hydroxylase n/a
79 Q9VU77_AKG Q9VU77 Bifunctional peptidase and n/a
80 O87198_AKG O87198 Homocitrate synthase (HCS) n/a
81 P83310_AKG P83310 (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase (RdpA) (EC n/a
82 Q05755_AKG Q05755 Glutamate synthase [NADPH] n/a
83 Q60381_AKG Q60381 Nitrogen regulatory protein n/a
84 O75874_AKG O75874 Isocitrate dehydrogenase [NADP] n/a
85 Q12797_AKG Q12797 Aspartyl/asparaginyl beta-hydroxylase (EC n/a
86 B3DUR4_AKG B3DUR4 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) n/a
87 P0A4U6_AKG P0A4U6 Global nitrogen regulator n/a
88 P38885_AKG P38885 Altered inheritance of n/a
89 P37610_AKG P37610 Alpha-ketoglutarate-dependent taurine dioxygenase n/a
90 A3EYF7_AKG A3EYF7 Beta-transaminase n/a
91 Q9FFF6_AKG Q9FFF6 Jasmonate-induced oxygenase 2 n/a
92 P0C872_AKG P0C872 Bifunctional peptidase and n/a
93 Q96323_AKG Q96323 Leucoanthocyanidin dioxygenase (LDOX) n/a
94 Q9BT30_AKG Q9BT30 Alpha-ketoglutarate-dependent dioxygenase alkB n/a
95 Q43314_AKG Q43314 Glutamate dehydrogenase 1 n/a
96 P27431_AKG P27431 Ribosomal protein uL16 n/a
97 D4N500_AKG D4N500 Thebaine 6-O-demethylase (EC n/a
98 Q5AR34_AKG Q5AR34 Multifunctional dioxygenase ausE n/a
99 Q9XI75_AKG Q9XI75 2-oxoglutarate (2OG) and n/a
100 A0A6J4CX17_AKG A0A6J4CX17 2-oxoglutarate/Fe(II)-dependent dioxygenase SptF n/a
101 A0L8G4_AKG A0L8G4 Pyruvate flavodoxin/ferredoxin oxidoreductase n/a
102 Q5JPR9_AKG Q5JPR9 Histone lysine demethylase n/a
103 P00366_AKG P00366 Glutamate dehydrogenase 1, n/a
104 P48735_AKG P48735 Isocitrate dehydrogenase [NADP], n/a
105 P17109_AKG P17109 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC n/a
106 A0A8M0FGT0_AKG A0A8M0FGT0 Lysine hydroxylase n/a
107 Q9GYI0_AKG Q9GYI0 Lysine-specific demethylase 7 n/a
108 Q8NYS7_AKG Q8NYS7 deleted n/a
109 Q8S0S6_AKG Q8S0S6 Gibberellin 2-beta-dioxygenase 3 n/a
110 Q7WEE8_AKG Q7WEE8 deleted n/a
111 C4NCJ7_AKG C4NCJ7 Beta-hydroxylase n/a
112 Q96BT7_AKG Q96BT7 tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ALKBH8 n/a
113 G8XHD5_AKG G8XHD5 L-lysine 4-chlorinase (EC n/a
114 A0A0A7GJ30_AKG A0A0A7GJ30 Branched-chain-amino-acid aminotransferase (BCAT) n/a
115 O14607_AKG O14607 Histone demethylase UTY n/a
116 Q13686_AKG Q13686 Nucleic acid dioxygenase n/a
117 P08200_AKG P08200 Isocitrate dehydrogenase [NADP] n/a
118 A0L8G5_AKG A0L8G5 Pyruvate ferredoxin/flavodoxin oxidoreductase, n/a
119 Q6EZB3_AKG Q6EZB3 Hyoscyamine 6 beta-hydroxylase n/a
120 O15054_AKG O15054 Lysine-specific demethylase 6B n/a
121 Q6P6C2_AKG Q6P6C2 RNA demethylase ALKBH5 n/a
122 Q53WJ1_AKG Q53WJ1 Lysine-specific demethylase JMJ703 n/a
123 Q9RBY6_AKG Q9RBY6 L-threonyl-[L-threonyl-carrier protein] 4-chlorinase n/a
124 P9WK11_AKG P9WK11 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC n/a
125 A0A075X7C6_AKG A0A075X7C6 Oxidoreductase n/a
126 P39956_AKG P39956 DNA damage-responsive transcriptional n/a
127 A0A3B6UEU3_AKG A0A3B6UEU3 (3R)-3-[(carboxymethyl)amino]fatty acid oxygenase/decarboxylase n/a
128 A0A0F4XRB2_AKG A0A0F4XRB2 ArpA protein n/a
129 Q79FW0_AKG Q79FW0 Bifunctional aminodeoxychorismate lyase n/a
130 Q2G1L5_AKG Q2G1L5 Bifunctional metallophosphatase/5'-nucleotidase n/a
131 Q8N465_AKG Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial n/a
132 P55038_AKG P55038 Ferredoxin-dependent glutamate synthase n/a
133 Q72KX8_AKG Q72KX8 Lipopolysaccaride biosynthesis protein n/a
134 Q387G0_AKG Q387G0 Isocitrate dehydrogenase [NADP] n/a
135 P96847_AKG P96847 Valine--pyruvate aminotransferase (EC n/a
136 C7QJ42_AKG C7QJ42 L-lysine 3-hydroxylase (EC n/a
137 Q6NYC1_AKG Q6NYC1 Bifunctional arginine demethylase n/a
138 Q6WZB0_AKG Q6WZB0 Alpha-ketoglutarate-dependent L-arginine hydroxylase n/a
139 A0A0N9HQ36_AKG A0A0N9HQ36 Deoxypodophyllotoxin synthase (EC n/a
140 Q8KSC8_AKG Q8KSC8 (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase (RdpA) (EC n/a
141 Q9WWU5_AKG Q9WWU5 Alpha-ketoglutarate-dependent sulfate ester n/a
142 D1BN29_AKG D1BN29 deleted n/a
143 P05050_AKG P05050 Alpha-ketoglutarate-dependent dioxygenase AlkB n/a
144 A0A075X7F9_AKG A0A075X7F9 Oxidoreductase n/a
145 A0A0J9X1V2_AKG A0A0J9X1V2 deleted n/a
146 Q9RN60_AKG Q9RN60 SnoK n/a
147 D2W6T1_AKG D2W6T1 Tet-like dioxygenase 1 n/a
148 P63509_AKG P63509 L-lysine-epsilon aminotransferase (L-lysine n/a
149 Q1GNW5_AKG Q1GNW5 Ectoine dioxygenase (EC n/a
150 Q9SIE1_AKG Q9SIE1 Bifunctional aspartate aminotransferase n/a
151 Q9XB59_AKG Q9XB59 (5R)-carbapenem-3-carboxylate synthase (EC n/a
152 Q9Y2K7_AKG Q9Y2K7 Lysine-specific demethylase 2A n/a
153 A0A0F7R8C5_AKG A0A0F7R8C5 deleted n/a
154 Q9FU53_AKG Q9FU53 Gibberellin 3-beta-dioxygenase 2 n/a
155 Q2SZ78_AKG Q2SZ78 Glutamate dehydrogenase n/a
156 S5TUM1_AKG S5TUM1 Phytanoyl-CoA dioxygenase n/a
157 A0A9Y2YA89_AKG A0A9Y2YA89 Dioxygenase n/a
158 B6V7E4_AKG B6V7E4 Glutamate dehydrogenase n/a
159 A0A4V8H042_AKG A0A4V8H042 [2-(trimethylamino)ethyl]phosphonate dioxygenase (EC n/a
160 Q9RN67_AKG Q9RN67 SnoN n/a
161 Q9I0L4_AKG Q9I0L4 Isocitrate dehydrogenase [NADP] n/a
162 Q1RD16_AKG Q1RD16 Isocitrate dehydrogenase [NADP] n/a