Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: ADENOSINE-5-DIPHOSPHORIBOSE
PDB ligand accession: APR
DrugBank: n/a
PubChem: 445794
ChEMBL: CHEMBL1231026
InChI Key: SRNWOUGRCWSEMX-KEOHHSTQSA-N
SMILES: c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)O)O)O)O)O)N

ClassyFire chemical classification:

List of proteins that are targets for APR

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 T2BBC3_APR T2BBC3 ORF1a n/a
2 A0A193AUK9_APR A0A193AUK9 Mitochondrial association factor n/a
3 Q96DE0_APR Q96DE0 U8 snoRNA-decapping enzyme n/a
4 P0DTC1_APR P0DTC1 Replicase polyprotein 1a n/a
5 P0A9S2_APR P0A9S2 Lactaldehyde reductase (EC n/a
6 Q52437_APR Q52437 Ferredoxin reductase n/a
7 P0A8D6_APR P0A8D6 O-acetyl-ADP-ribose deacetylase (EC n/a
8 O75367-2_APR O75367-2 n/a
9 P06700_APR P06700 NAD-dependent histone deacetylase n/a
10 B7A854_APR B7A854 deleted n/a
11 P26397_APR P26397 CDP-glucose 4,6-dehydratase (EC n/a
12 P32324_APR P32324 Elongation factor 2 n/a
13 Q460N5_APR Q460N5 Protein mono-ADP-ribosyltransferase PARP14 n/a
14 A0A4D6GPC4_APR A0A4D6GPC4 Polyprotein P1234 (Non-structural n/a
15 Q98VG9_APR Q98VG9 Replicase polyprotein 1ab n/a
16 P36328_APR P36328 Polyprotein P1234 (P1234) n/a
17 Q9UKK9_APR Q9UKK9 ADP-sugar pyrophosphatase (EC n/a
18 T2B9G2_APR T2B9G2 ORF1a n/a
19 Q4F883_APR Q4F883 Senescence-associated carboxylesterase 101 n/a
20 Q60164_APR Q60164 NAD(P) transhydrogenase subunit n/a
21 P45799_APR P45799 ADP compounds hydrolase n/a
22 P0CG48_APR P0CG48 Polyubiquitin-C [Cleaved into: n/a
23 P11439_APR P11439 Exotoxin A (ETA) n/a
24 I6L8L8_APR I6L8L8 poly(ADP-ribose) glycohydrolase (EC n/a
25 Q9SU72_APR Q9SU72 Protein EDS1 (Enhanced n/a
26 A0A140H546_APR A0A140H546 Mitochondrial association factor n/a
27 Q1JGN6_APR Q1JGN6 deleted n/a
28 P0C6U2_APR P0C6U2 Replicase polyprotein 1a n/a
29 Q93K97_APR Q93K97 ADP-ribose pyrophosphatase (EC n/a
30 P94368_APR P94368 ADP-dependent (S)-NAD(P)H-hydrate dehydratase n/a
31 P59641_APR P59641 Replicase polyprotein 1a n/a
32 Q8N6T7_APR Q8N6T7 NAD-dependent protein deacylase n/a
33 Q9Y530_APR Q9Y530 ADP-ribose glycohydrolase OARD1 n/a
34 O28597_APR O28597 NAD-dependent protein deacylase n/a
35 A0A0M1QQ83_APR A0A0M1QQ83 deleted n/a
36 Q9X024_APR Q9X024 Bifunctional NAD(P)H-hydrate repair n/a
37 P0DTD1_APR P0DTD1 Replicase polyprotein 1ab n/a
38 P28907_APR P28907 ADP-ribosyl cyclase/cyclic ADP-ribose n/a
39 Q59765_APR Q59765 NAD(P) transhydrogenase subunit n/a
40 Q86UW9_APR Q86UW9 Probable E3 ubiquitin-protein n/a
41 Q9WYW0_APR Q9WYW0 NAD-dependent protein deacetylase n/a
42 P38218_APR P38218 ADP-ribose 1''-phosphate phosphatase n/a
43 Q5CYZ3_APR Q5CYZ3 L-lactate dehydrogenase n/a
44 Q5SHB0_APR Q5SHB0 CinA-like protein n/a
45 A0A654FCP3_APR A0A654FCP3 ADP-ribosyl cyclase/cyclic ADP-ribose n/a
46 O33199_APR O33199 MutT/nudix family protein n/a
47 P53686_APR P53686 NAD-dependent protein deacetylase n/a
48 P0C6W3_APR P0C6W3 Replicase polyprotein 1ab n/a
49 Q6MIH8_APR Q6MIH8 ADP-ribose pyrophosphatase (EC n/a
50 Q04299_APR Q04299 Probable ADP-ribose 1''-phosphate n/a
51 A0A143SL92_APR A0A143SL92 Polyprotein P1234 (Non-structural n/a
52 O30124_APR O30124 NAD-dependent protein deacylase n/a
53 A0A143T1U9_APR A0A143T1U9 Malate dehydrogenase (EC n/a
54 P56649_APR P56649 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) n/a
55 C3TEL7_APR C3TEL7 O-acetyl-ADP-ribose deacetylase (EC n/a
56 P00327_APR P00327 Alcohol dehydrogenase E n/a
57 A9W386_APR A9W386 Malate dehydrogenase (EC n/a
58 Q8EFJ3_APR Q8EFJ3 Transcriptional repressor of n/a
59 O75367_APR O75367 Core histone macro-H2A.1 n/a
60 P0A9S1_APR P0A9S1 Lactaldehyde reductase (EC n/a
61 Q96EB6_APR Q96EB6 NAD-dependent protein deacetylase n/a
62 A0A654FE24_APR A0A654FE24 ADP-ribosyl cyclase/cyclic ADP-ribose n/a
63 P0C6V5_APR P0C6V5 Replicase polyprotein 1a n/a
64 A0A0D2UG83_APR A0A0D2UG83 Histone macroH2A1.1 n/a
65 P00438_APR P00438 p-hydroxybenzoate hydroxylase (PHBH) n/a
66 Q9NTG7_APR Q9NTG7 NAD-dependent protein deacetylase n/a
67 P11766_APR P11766 Alcohol dehydrogenase class-3 n/a
68 Q55928_APR Q55928 Bifunctional NMN adenylyltransferase/Nudix n/a
69 Q9NXA8_APR Q9NXA8 NAD-dependent protein deacylase n/a
70 P68135_APR P68135 Actin, alpha skeletal n/a
71 Q84CU3_APR Q84CU3 ADP-ribose pyrophosphatase n/a
72 Q7Z6Z7_APR Q7Z6Z7 E3 ubiquitin-protein ligase n/a
73 P42574_APR P42574 Caspase-3 (CASP-3) (EC n/a
74 Q8JUX6_APR Q8JUX6 Polyprotein P1234 (P1234) n/a