Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
PDB ligand accession: BTB
DrugBank: n/a
PubChem: 81462
ChEMBL: n/a
InChI Key: OWMVSZAMULFTJU-UHFFFAOYSA-N
SMILES: C(CO)N(CCO)C(CO)(CO)CO

ClassyFire chemical classification:

List of proteins that are targets for BTB

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 B4RL16_BTB B4RL16 Ribose-5-phosphate isomerase A n/a
2 Q9UPX8_BTB Q9UPX8 SH3 and multiple n/a
3 A0A1H7TQR5_BTB A0A1H7TQR5 Glucosamine kinase (GlcN n/a
4 P0DTD1_BTB P0DTD1 Replicase polyprotein 1ab n/a
5 A0A376JR14_BTB A0A376JR14 DNA-binding dual transcriptional n/a
6 A0A237MVZ9_BTB A0A237MVZ9 Putative NAD(P)H nitroreductase n/a
7 P04958_BTB P04958 Tetanus toxin (EC n/a
8 P22259_BTB P22259 Phosphoenolpyruvate carboxykinase (ATP) n/a
9 P38428_BTB P38428 Coupling of ubiquitin n/a
10 Q92A04_BTB Q92A04 Lin2118 protein n/a
11 D9TT09_BTB D9TT09 Sucrose 6(F)-phosphate phosphorylase n/a
12 B8NHE1_BTB B8NHE1 Terpene cyclase-like protein n/a
13 G9NTY1_BTB G9NTY1 Glucanase (EC 3.2.1.-) n/a
14 Q03304_BTB Q03304 Toluene-4-monooxygenase system, ferredoxin--NAD(+) n/a
15 B8LFD6_BTB B8LFD6 Beta-galactosidase (Beta-gal) (EC n/a
16 P24855_BTB P24855 Deoxyribonuclease-1 (EC 3.1.21.1) n/a
17 Q48800_BTB Q48800 IcmW (Intracellular multiplication n/a
18 Q08255_BTB Q08255 Glucose/galactose-binding lipoprotein n/a
19 H9L477_BTB H9L477 Mono(ADP-ribosyl)transferase SpvB (EC n/a
20 O07177_BTB O07177 Maltokinase (MaK) (EC n/a
21 Q06187_BTB Q06187 Tyrosine-protein kinase BTK n/a
22 Q9Y6K1_BTB Q9Y6K1 DNA (cytosine-5)-methyltransferase 3A n/a
23 O69262_BTB O69262 non-reducing end alpha-L-arabinofuranosidase n/a
24 P13134_BTB P13134 Kexin (EC 3.4.21.61) n/a
25 Q31KX8_BTB Q31KX8 Periplasmic divalent cation n/a
26 Q8NFQ8_BTB Q8NFQ8 Torsin-1A-interacting protein 2 n/a
27 Q8ZQW9_BTB Q8ZQW9 Phosphoglucomutase (EC 5.4.2.2) n/a
28 A0A0R7P4S4_BTB A0A0R7P4S4 4-alpha-glucanotransferase (EC 2.4.1.25) n/a
29 Q1A2D0_BTB Q1A2D0 Cel44C n/a
30 Q8IXJ6_BTB Q8IXJ6 NAD-dependent protein deacetylase n/a
31 Q6G8A9_BTB Q6G8A9 Leucotoxin LukDv (Variant n/a
32 A0A0U4WRC5_BTB A0A0U4WRC5 deleted n/a
33 D4G3D4_BTB D4G3D4 RidA family protein n/a
34 P15559_BTB P15559 NAD(P)H dehydrogenase [quinone] n/a
35 P04824_BTB P04824 Alpha-galactosidase 1 (EC n/a
36 O34453_BTB O34453 Nitric oxide synthase n/a
37 Q5SRI9_BTB Q5SRI9 Glycoprotein endo-alpha-1,2-mannosidase (Endo-alpha n/a
38 P60668_BTB P60668 Putative N-acetylmannosamine-6-phosphate 2-epimerase n/a
39 P0A434_BTB P0A434 Parathion hydrolase (EC n/a
40 Q8TMX3_BTB Q8TMX3 Beta/gama crystallin family n/a
41 C4YJ02_BTB C4YJ02 Aromatic amino acid n/a
42 P0AEC6_BTB P0AEC6 Signal transduction histidine-protein n/a
43 P23686_BTB P23686 S-adenosylmethionine synthase 1 n/a
44 O49908_BTB O49908 Cell wall / n/a
45 C6XID6_BTB C6XID6 beta-lactamase (EC 3.5.2.6) n/a
46 Q00457_BTB Q00457 Toluene-4-monooxygenase system, hydroxylase n/a
47 P22914_BTB P22914 Gamma-crystallin S (Beta-crystallin n/a
48 Q186X0_BTB Q186X0 Phenazine biosynthesis PhzC/PhzF n/a
49 A0A482M8M0_BTB A0A482M8M0 SilF n/a
50 P21549_BTB P21549 Alanine--glyoxylate aminotransferase (AGT) n/a
51 O07001_BTB O07001 Uncharacterized HTH-type transcriptional n/a
52 P61823_BTB P61823 Ribonuclease pancreatic (EC n/a
53 Q8PSW8_BTB Q8PSW8 histidine kinase (EC n/a
54 S8EY38_BTB S8EY38 Ornithine aminotransferase (EC n/a
55 Q57X73_BTB Q57X73 Nucleoside hydrolase, putative n/a
56 B2HH81_BTB B2HH81 Cytochrome P450 51B1 n/a
57 P9WPZ9_BTB P9WPZ9 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) n/a
58 P22033_BTB P22033 Methylmalonyl-CoA mutase, mitochondrial n/a
59 Q77J90_BTB Q77J90 thymidylate synthase (EC n/a
60 Q9PNY2_BTB Q9PNY2 Bifunctional purine biosynthesis n/a
61 Q02159_BTB Q02159 Ubiquitin-conjugating enzyme E2 n/a
62 Q5SLP1_BTB Q5SLP1 Ribonuclease TTHA0252 (EC n/a
63 P04062_BTB P04062 Lysosomal acid glucosylceramidase n/a
64 F9VPE5_BTB F9VPE5 Sulerythrin n/a
65 P63104_BTB P63104 14-3-3 protein zeta/delta n/a
66 B2HE62_BTB B2HE62 Beta-1,3-glucanase n/a
67 Q81TB4_BTB Q81TB4 Ribonucleoside-diphosphate reductase subunit n/a
68 Q8DQ62_BTB Q8DQ62 Teichoic acid phosphorylcholine n/a
69 G0SFD1_BTB G0SFD1 Mannosyl-oligosaccharide glucosidase (EC n/a
70 Q8I4X0_BTB Q8I4X0 Actin-1 (PfAct1) (EC n/a
71 P0ABD3_BTB P0ABD3 Bacterioferritin (BFR) (EC n/a
72 P09455_BTB P09455 Retinol-binding protein 1 n/a
73 A0A0H2US78_BTB A0A0H2US78 F5/8 type C n/a
74 A0A0T9TPS2_BTB A0A0T9TPS2 Tagatose-1,6-bisphosphate aldolase kbaY n/a
75 Q81X75_BTB Q81X75 Phosphoglycerate kinase (EC n/a
76 F5SYD3_BTB F5SYD3 Flavin-containing monooxygenase, Fmo n/a
77 Q8GGD4_BTB Q8GGD4 N(alpha)-acyl-glutamine aminoacylase (N-AGA) n/a
78 Q16555_BTB Q16555 Dihydropyrimidinase-related protein 2 n/a
79 A9D857_BTB A9D857 Hoefavidin n/a
80 Q9HTR2_BTB Q9HTR2 Phosphorylcholine phosphatase (PChP) n/a
81 A0A1E7P7U4_BTB A0A1E7P7U4 deleted n/a
82 Q665C6_BTB Q665C6 Putative carbohydrate kinase n/a
83 Q59H79_BTB Q59H79 DNA cytosine-5 methyltransferase n/a
84 O75208_BTB O75208 Ubiquinone biosynthesis protein n/a
85 O81192_BTB O81192 (+)-bornyl diphosphate synthase, n/a
86 A1SPF2_BTB A1SPF2 Glyoxalase/bleomycin resistance protein/dioxygenase n/a
87 P29283_BTB P29283 Global nitrogen regulator n/a
88 P63562_BTB P63562 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) n/a
89 Q9A0E2_BTB Q9A0E2 Glutathione reductase (GR) n/a
90 Q18014_BTB Q18014 GDP-fucose protein O-fucosyltransferase n/a
91 Q2TAY7_BTB Q2TAY7 WD40 repeat-containing protein n/a
92 K5B7Z4_BTB K5B7Z4 Glucosyl-3-phosphoglycerate synthase (EC n/a
93 Q96CA5_BTB Q96CA5 Baculoviral IAP repeat-containing n/a
94 P76318_BTB P76318 Abasic site processing n/a
95 A7LXT7_BTB A7LXT7 Xyloglucan-specific endo-beta-1,4-glucanase BoGH5A n/a
96 P00722_BTB P00722 Beta-galactosidase (Beta-gal) (EC n/a
97 P26831_BTB P26831 Hyaluronoglucosaminidase (Hyaluronidase) (EC n/a
98 Q1M7F4_BTB Q1M7F4 Biuret amidohydrolase (EC n/a
99 P0ABU0_BTB P0ABU0 1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA n/a
100 A0A493R6T1_BTB A0A493R6T1 Paenibacillus xanthan lyase n/a
101 A0A0W8LFT3_BTB A0A0W8LFT3 deleted n/a
102 E3NZ06_BTB E3NZ06 10-formyltetrahydrofolate dehydrogenase (EC n/a
103 D1LZK0_BTB D1LZK0 Beta-D-galactosidase n/a
104 P32277_BTB P32277 RNA ligase 2 n/a
105 Q9VAA9_BTB Q9VAA9 JIL-1 anchoring and n/a
106 A7YT55_BTB A7YT55 Hdac6 protein n/a
107 P60763_BTB P60763 Ras-related C3 botulinum n/a
108 Q812G0_BTB Q812G0 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A n/a
109 Q9FD71_BTB Q9FD71 Hydroxymethylglutaryl-CoA synthase (HMG-CoA n/a
110 Q8VDU0_BTB Q8VDU0 G-protein-signaling modulator 2 n/a
111 U5T8W0_BTB U5T8W0 Phycoerythrin beta subunit n/a
112 A9CKK7_BTB A9CKK7 ABC transporter, substrate n/a
113 Q8ZPF0_BTB Q8ZPF0 Malto-oligosyltrehalose trehalohydrolase (MTHase) n/a
114 P41365_BTB P41365 Lipase B (EC n/a
115 P83467_BTB P83467 Ostreolysin A6 n/a
116 P17301_BTB P17301 Integrin alpha-2 (CD49 n/a
117 A0A173VPY3_BTB A0A173VPY3 RagB/SusD domain protein n/a
118 F2Q7T0_BTB F2Q7T0 Bifunctional cytochrome P450/NADPH--P450 n/a
119 Q8KYA6_BTB Q8KYA6 Glyoxalase-like domain protein n/a
120 P29808_BTB P29808 Aminoglycoside N(3)-acetyltransferase III n/a
121 B0SWV2_BTB B0SWV2 Mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC n/a
122 Q5KXG9_BTB Q5KXG9 NADPH dehydrogenase (EC n/a
123 P29474_BTB P29474 Nitric oxide synthase n/a
124 O69061_BTB O69061 Probable phosphite transport n/a
125 Q13GE3_BTB Q13GE3 Short-chain dehydrogenase/reductase n/a
126 Q21PD3_BTB Q21PD3 Cellulose-binding protein n/a
127 A0A247D6Y4_BTB A0A247D6Y4 N2152 n/a
128 A2QAN3_BTB A2QAN3 Beta-galactosidase A (An-beta-gal) n/a
129 Q8T0W7_BTB Q8T0W7 Beta-glucosidase (EC 3.2.1.21) n/a
130 P22734_BTB P22734 Catechol O-methyltransferase (EC n/a
131 A0A0U3HD14_BTB A0A0U3HD14 Cytochrome n/a
132 A5U1W4_BTB A5U1W4 non-specific serine/threonine protein n/a
133 Q5SLE7_BTB Q5SLE7 Peptidyl-prolyl cis-trans isomerase n/a
134 Q6M8A6_BTB Q6M8A6 deleted n/a
135 A0R724_BTB A0R724 MaoC like domain n/a
136 P61769_BTB P61769 Beta-2-microglobulin [Cleaved into: n/a
137 P61964_BTB P61964 WD repeat-containing protein n/a
138 A0A0C1MLE8_BTB A0A0C1MLE8 Aminotransferase class I/classII n/a
139 Q9JLU4_BTB Q9JLU4 SH3 and multiple n/a
140 Q6R308_BTB Q6R308 RING-type E3 ubiquitin n/a
141 Q86UY6_BTB Q86UY6 N-alpha-acetyltransferase 40 (EC n/a
142 A0A411J078_BTB A0A411J078 MHC class I n/a
143 A5EEL3_BTB A5EEL3 deleted n/a
144 A0A197BYF0_BTB A0A197BYF0 deleted n/a
145 A0P0F0_BTB A0P0F0 Putative cyclase n/a
146 Q40322_BTB Q40322 4S-limonene synthase n/a
147 Q6WVP7_BTB Q6WVP7 NADP-dependent (R)-specific alcohol n/a
148 Q81Y15_BTB Q81Y15 Transketolase (EC 2.2.1.1) n/a
149 P31572_BTB P31572 L-carnitine CoA-transferase (EC n/a
150 P0A632_BTB P0A632 Indole-3-glycerol phosphate synthase n/a
151 V9M398_BTB V9M398 Disease resistance protein n/a
152 Q08499_BTB Q08499 3',5'-cyclic-AMP phosphodiesterase 4D n/a
153 P52293_BTB P52293 Importin subunit alpha-1 n/a
154 P09095_BTB P09095 Tyrocidine synthase 1 n/a
155 A0A856TAI5_BTB A0A856TAI5 Beta-fructofuranosidase (EC 3.2.1.26) n/a
156 Q6Q8Q7_BTB Q6Q8Q7 Toluene-4-monooxygenase system, hydroxylase n/a
157 F2Z7L1_BTB F2Z7L1 Endoglucanase (EC 3.2.1.4) n/a
158 Q6WY08_BTB Q6WY08 Anti-tumor lectin (EC n/a
159 A0A1Z0YU86_BTB A0A1Z0YU86 Deoxyuridine 5'-triphosphate nucleotidohydrolase n/a
160 P28623_BTB P28623 Endoglucanase D (EC n/a
161 A0A485PVH1_BTB A0A485PVH1 Alginate lyase (PL7) n/a
162 P32527_BTB P32527 Zuotin (DnaJ-related protein n/a
163 Q93VR3_BTB Q93VR3 GDP-mannose 3,5-epimerase (GDP-Man n/a
164 Q5SM82_BTB Q5SM82 DUF3208 domain-containing protein n/a
165 Q76BV4_BTB Q76BV4 non-reducing end alpha-L-arabinofuranosidase n/a
166 E4VCC5_BTB E4VCC5 deleted n/a
167 P0A4V4_BTB P0A4V4 Diacylglycerol acyltransferase/mycolyltransferase Ag85C n/a
168 Q0KFV0_BTB Q0KFV0 Aspergillus nuclease S1 n/a
169 Q868M7_BTB Q868M7 Galactose/N-acetylgalactosamine-binding lectin CEL-III n/a
170 Q00459_BTB Q00459 Toluene-4-monooxygenase system, effector n/a
171 Q96E17_BTB Q96E17 Ras-related protein Rab-3C n/a
172 A0A1C5AE13_BTB A0A1C5AE13 Methyltransferase domain-containing protein n/a
173 P08987_BTB P08987 Glucosyltransferase-I (GTF-I) (EC n/a
174 A0A3A1BNP8_BTB A0A3A1BNP8 deleted n/a
175 P09622_BTB P09622 Dihydrolipoyl dehydrogenase, mitochondrial n/a
176 A7V1Q0_BTB A7V1Q0 deleted n/a
177 Q9ER97_BTB Q9ER97 Neuroglobin (Nitrite reductase) n/a
178 Q8YAE6_BTB Q8YAE6 oligo-1,6-glucosidase (EC 3.2.1.10) n/a
179 G5DDB8_BTB G5DDB8 Glycoside hydrolase type n/a
180 P28482_BTB P28482 Mitogen-activated protein kinase n/a
181 O14656_BTB O14656 Torsin-1A (Dystonia 1 n/a
182 A0A1L4BKS3_BTB A0A1L4BKS3 Terminase, large subunit n/a
183 P24021_BTB P24021 Nuclease S1 (EC n/a
184 Q8DV70_BTB Q8DV70 Glucosamine-6-phosphate deaminase (EC n/a
185 Q6XHB2_BTB Q6XHB2 Probable serine/threonine-protein kinase n/a
186 P03950_BTB P03950 Angiogenin (EC 3.1.27.-) n/a
187 P0DTC1_BTB P0DTC1 Replicase polyprotein 1a n/a
188 B9MKU7_BTB B9MKU7 Endoglucanase (EC 3.2.1.4) n/a
189 Q87XG5_BTB Q87XG5 tRNA U34 carboxymethyltransferase n/a
190 Q40577_BTB Q40577 5-epi-aristolochene synthase (TEAS) n/a
191 A0S0A6_BTB A0S0A6 Nitric oxide synthase n/a
192 Q99XG5_BTB Q99XG5 DNA gyrase subunit n/a
193 Q11174_BTB Q11174 Probable endochitinase (EC n/a
194 Q92835_BTB Q92835 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase n/a
195 G0SEG4_BTB G0SEG4 RNA helicase (EC n/a
196 P61949_BTB P61949 Flavodoxin 1 (Flavodoxin n/a
197 P05091_BTB P05091 Aldehyde dehydrogenase, mitochondrial n/a
198 P07711_BTB P07711 Procathepsin L (EC n/a
199 A0A2K9UWM4_BTB A0A2K9UWM4 Outer capsid protein n/a
200 P00558_BTB P00558 Phosphoglycerate kinase 1 n/a
201 Q3LRX8_BTB Q3LRX8 Neurotoxin type A n/a
202 O06629_BTB O06629 cAMP/cGMP dual specificity n/a
203 Q889N2_BTB Q889N2 DNA-binding protein n/a
204 P13591_BTB P13591 Neural cell adhesion n/a
205 A0A372DCN7_BTB A0A372DCN7 LynF/TruF/PatF family peptide n/a