Ligand name: 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID
PDB ligand accession: C2F
DrugBank: DB11256
PubChem: 444412;5287865;135398561;
ChEMBL: CHEMBL1231574
InChI Key: ZNOVTXRBGFNYRX-STQMWFEESA-N
SMILES: CN1C(CNC2=C1C(=O)NC(=N2)N)CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Pteridines and derivatives
      • Subclass: Pterins and derivatives

List of proteins that are targets for C2F

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P0AEZ1_C2F	P0AEZ1	5,10-methylenetetrahydrofolate reductase (MTHFR)	n/a
2	P67044_C2F	P67044	Thymidylate synthase (TS)	n/a
3	Q46389_C2F	Q46389	5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase	n/a
4	Q9WYA5_C2F	Q9WYA5	Methionine synthase (EC	n/a
5	Q9X112_C2F	Q9X112	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC	n/a
6	B8FW00_C2F	B8FW00	Dihydropteroate synthase DHPS	n/a
7	Q3ACR9_C2F	Q3ACR9	5-methyltetrahydrofolate corrinoid/iron sulfur	n/a
8	P82610_C2F	P82610	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC	n/a
9	P13255_C2F	P13255	Glycine N-methyltransferase (EC	n/a
10	P27248_C2F	P27248	Aminomethyltransferase (EC 2.1.2.10)	n/a
11	P42326_C2F	P42326	Thymidylate synthase 1	n/a
12	Q544L2_C2F	Q544L2	Thymidylate synthase (EC	n/a
13	O50008_C2F	O50008	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	n/a
14	P00470_C2F	P00470	Thymidylate synthase (TS)	n/a
15	Q5SKM5_C2F	Q5SKM5	Methionine synthase (EC	n/a
16	P00394_C2F	P00394	5,10-methylenetetrahydrofolate reductase (MTHFR)	n/a
17	A3DHS7_C2F	A3DHS7	Methylenetetrahydrofolate reductase	n/a