Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: 2,3-DIHYDROXY-1,4-DITHIOBUTANE
PDB ligand accession: DTT
DrugBank: DB04447
PubChem: 439196
ChEMBL: CHEMBL406270
InChI Key: VHJLVAABSRFDPM-IMJSIDKUSA-N
SMILES: C(C(C(CS)O)O)S

ClassyFire chemical classification:

List of proteins that are targets for DTT

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q9HAU4_DTT Q9HAU4 E3 ubiquitin-protein ligase n/a
2 A0A4V8GZY0_DTT A0A4V8GZY0 3-hydroxy-3-methylglutaryl coenzyme A n/a
3 Q99497_DTT Q99497 Parkinson disease protein n/a
4 P51114_DTT P51114 RNA-binding protein FXR1 n/a
5 Q7L266_DTT Q7L266 Isoaspartyl peptidase/L-asparaginase (EC n/a
6 Q9Y5L0_DTT Q9Y5L0 Transportin-3 (Importin-12) (Imp12) n/a
7 Q64331_DTT Q64331 Unconventional myosin-VI (Protein n/a
8 Q5XUX0_DTT Q5XUX0 F-box only protein n/a
9 P22734_DTT P22734 Catechol O-methyltransferase (EC n/a
10 Q9Y7D1_DTT Q9Y7D1 Monacolin J acid n/a
11 Q88N37_DTT Q88N37 3-carboxy-cis,cis-muconate cycloisomerase (EC n/a
12 Q9KPS1_DTT Q9KPS1 Na(+)-translocating NADH-quinone reductase n/a
13 Q9U1E1_DTT Q9U1E1 Nucleoside diphosphate kinase n/a
14 P63897_DTT P63897 Diaminopimelate epimerase (DAP n/a
15 Q13137_DTT Q13137 Calcium-binding and coiled-coil n/a
16 P06626_DTT P06626 Protein TraJ n/a
17 A0A0T9EA39_DTT A0A0T9EA39 deleted n/a
18 O58462_DTT O58462 Orotidine 5'-phosphate decarboxylase n/a
19 Q9HTJ1_DTT Q9HTJ1 NAD/NADP-dependent betaine aldehyde n/a
20 P36655_DTT P36655 Thiol:disulfide interchange protein n/a
21 Q80U58_DTT Q80U58 Pumilio homolog 2 n/a
22 P00374_DTT P00374 Dihydrofolate reductase (EC n/a
23 Q9UQM7_DTT Q9UQM7 Calcium/calmodulin-dependent protein kinase n/a
24 A0A0M4HL56_DTT A0A0M4HL56 D-xylose reductase [NAD(P)H] n/a
25 P96618_DTT P96618 Holo-[acyl-carrier-protein] synthase (Holo-ACP n/a
26 Q9Y253_DTT Q9Y253 DNA polymerase eta n/a
27 Q16186_DTT Q16186 Proteasomal ubiquitin receptor n/a
28 P10275_DTT P10275 Androgen receptor (Dihydrotestosterone n/a
29 Q9UNL4_DTT Q9UNL4 Inhibitor of growth n/a
30 Q03689_DTT Q03689 Heterokaryon incompatibility protein n/a
31 P29597_DTT P29597 Non-receptor tyrosine-protein kinase n/a
32 P14779_DTT P14779 Bifunctional cytochrome P450/NADPH--P450 n/a
33 P26662_DTT P26662 Genome polyprotein [Cleaved n/a
34 Q13557_DTT Q13557 Calcium/calmodulin-dependent protein kinase n/a
35 P24941_DTT P24941 Cyclin-dependent kinase 2 n/a
36 O24770_DTT O24770 4'-phospho-dehydrooxetanocin synthase (EC n/a
37 Q6GIL6_DTT Q6GIL6 Triosephosphate isomerase (TIM) n/a
38 Q581W1_DTT Q581W1 Pteridine reductase, putative n/a
39 C3RVP5_DTT C3RVP5 SxtDIOX n/a
40 Q8X5G6_DTT Q8X5G6 deleted n/a
41 P29366_DTT P29366 Bud emergence protein n/a
42 Q9F3C7_DTT Q9F3C7 Formylglycine-generating enzyme (FGE) n/a
43 P69834_DTT P69834 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, n/a
44 O75460_DTT O75460 Serine/threonine-protein kinase/endoribonuclease IRE1 n/a
45 P00970_DTT P00970 DNA ligase (EC n/a
46 Q66526_DTT Q66526 Nucleoprotein (Nucleocapsid protein) n/a
47 Q06187_DTT Q06187 Tyrosine-protein kinase BTK n/a
48 Q94G59_DTT Q94G59 Sinapyl alcohol dehydrogenase n/a
49 Q16555_DTT Q16555 Dihydropyrimidinase-related protein 2 n/a
50 Q6FI27_DTT Q6FI27 Glycogen synthase kinase-3 n/a
51 P56217_DTT P56217 Galectin-1 (Gal-1) n/a
52 P35790_DTT P35790 Choline kinase alpha n/a
53 D6RT90_DTT D6RT90 6-dimethylallyltryptophan synthase (Tryptophan n/a
54 P08160_DTT P08160 Early 35 kDa n/a
55 Q9UIK4_DTT Q9UIK4 Death-associated protein kinase n/a
56 A0A0H0XV02_DTT A0A0H0XV02 Fibronectin type III-like n/a
57 Q99279_DTT Q99279 Receptor-type adenylate cyclase n/a
58 C0JV69_DTT C0JV69 Arsenite methyltransferase (EC n/a
59 P9WFF7_DTT P9WFF7 Decaprenyl diphosphate synthase n/a
60 Q72498_DTT Q72498 POL polyprotein n/a
61 P01112_DTT P01112 GTPase HRas (EC n/a
62 C5YLL4_DTT C5YLL4 NAD-dependent epimerase/dehydratase domain-containing n/a
63 A3ESP1_DTT A3ESP1 deleted n/a
64 Q8DLC2_DTT Q8DLC2 Lipoyl synthase 2 n/a
65 Q6DQW3_DTT Q6DQW3 Non-reducing polyketide synthase n/a
66 P10807_DTT P10807 Alcohol dehydrogenase (EC n/a
67 P22059_DTT P22059 Oxysterol-binding protein 1 n/a
68 P33590_DTT P33590 Nickel-binding periplasmic protein n/a
69 P78417_DTT P78417 Glutathione S-transferase omega-1 n/a
70 A6STU3_DTT A6STU3 deleted n/a
71 Q9C005_DTT Q9C005 Protein dpy-30 homolog n/a
72 P49841_DTT P49841 Glycogen synthase kinase-3 n/a
73 P07385_DTT P07385 Serine proteinase inhibitor n/a
74 P54149_DTT P54149 Mitochondrial peptide methionine n/a
75 P61586_DTT P61586 Transforming protein RhoA n/a
76 Q9NP87_DTT Q9NP87 DNA-directed DNA/RNA polymerase n/a
77 Q9ZEU2_DTT Q9ZEU2 Amylosucrase (EC 2.4.1.4) n/a
78 O15530_DTT O15530 3-phosphoinositide-dependent protein kinase n/a
79 P20509_DTT P20509 DNA polymerase (EC n/a
80 Q0PA35_DTT Q0PA35 Bifunctional protein FolD n/a
81 A0A202B6V5_DTT A0A202B6V5 Organic hydroperoxide resistance n/a
82 G0S8G9_DTT G0S8G9 Eukaryotic translation initiation n/a
83 P09382_DTT P09382 Galectin-1 (Gal-1) (14 n/a
84 O43708_DTT O43708 Maleylacetoacetate isomerase (MAAI) n/a
85 P00489_DTT P00489 Glycogen phosphorylase, muscle n/a
86 Q93LE9_DTT Q93LE9 Peptide deformylase (PDF) n/a
87 O43293_DTT O43293 Death-associated protein kinase n/a
88 P03300_DTT P03300 Genome polyprotein [Cleaved n/a
89 Q51945_DTT Q51945 Tartrate dehydrogenase/decarboxylase (TDH) n/a
90 W0KCK5_DTT W0KCK5 deleted n/a
91 P49959_DTT P49959 Double-strand break repair n/a
92 P63945_DTT P63945 4-hydroxy-tetrahydrodipicolinate synthase (HTPA n/a
93 P03355_DTT P03355 Gag-Pol polyprotein (Pr180gag-pol) n/a
94 P06988_DTT P06988 Histidinol dehydrogenase (HDH) n/a
95 Q8SSJ3_DTT Q8SSJ3 NUCLEAR MOVEMENT PROTEIN n/a
96 P20248_DTT P20248 Cyclin-A2 (Cyclin-A) (Cyclin n/a
97 P23284_DTT P23284 Peptidyl-prolyl cis-trans isomerase n/a
98 Q96W94_DTT Q96W94 Beta-alanine synthase (EC n/a
99 Q3J677_DTT Q3J677 AppA, antirepressor of n/a
100 C6FX40_DTT C6FX40 NosA n/a
101 A0A023GUL3_DTT A0A023GUL3 Monooxygenase n/a
102 P11798_DTT P11798 Calcium/calmodulin-dependent protein kinase n/a
103 Q2G029_DTT Q2G029 2,3-bisphosphoglycerate-independent phosphoglycerate mutase n/a
104 P60174_DTT P60174 Triosephosphate isomerase (TIM) n/a
105 Q9RC92_DTT Q9RC92 Unsaturated glucuronyl hydrolase n/a
106 Q14790_DTT Q14790 Caspase-8 (CASP-8) (EC n/a
107 P52013_DTT P52013 Peptidyl-prolyl cis-trans isomerase n/a
108 Q13526_DTT Q13526 Peptidyl-prolyl cis-trans isomerase n/a
109 Q9Y697_DTT Q9Y697 Cysteine desulfurase (EC n/a
110 P07607_DTT P07607 Thymidylate synthase (TS) n/a
111 Q5MK11_DTT Q5MK11 Cyanovirin-N homolog (CV-N n/a
112 P43490_DTT P43490 Nicotinamide phosphoribosyltransferase (NAmPRTase) n/a
113 G4V8J4_DTT G4V8J4 deleted n/a
114 P04789_DTT P04789 Triosephosphate isomerase, glycosomal n/a
115 P04629_DTT P04629 High affinity nerve n/a
116 Q73PT7_DTT Q73PT7 Peptide methionine sulfoxide n/a
117 A0QU89_DTT A0QU89 N-acetylglucosamine-6-phosphate deacetylase (EC n/a
118 O87949_DTT O87949 Chaperone protein TorD n/a
119 P04035_DTT P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase n/a
120 Q9GT24_DTT Q9GT24 Probable serine/threonine-protein kinase n/a
121 Q8PYK9_DTT Q8PYK9 Deoxyribodipyrimidine photo-lyase (EC n/a
122 Q08499_DTT Q08499 3',5'-cyclic-AMP phosphodiesterase 4D n/a
123 P07342_DTT P07342 Acetolactate synthase catalytic n/a
124 P07663_DTT P07663 Period circadian protein n/a
125 P22262_DTT P22262 Listeriolysin regulatory protein n/a
126 P75966_DTT P75966 Ribosomal large subunit n/a
127 P10802_DTT P10802 Dihydrolipoyllysine-residue acetyltransferase component n/a
128 P58753_DTT P58753 Toll/interleukin-1 receptor domain-containing n/a
129 Q16658_DTT Q16658 Fascin (55 kDa n/a
130 R4GRU1_DTT R4GRU1 Agglutinin (BOA) n/a
131 Q9UMX1_DTT Q9UMX1 Suppressor of fused n/a
132 P00352_DTT P00352 Aldehyde dehydrogenase 1A1 n/a
133 Q970Q8_DTT Q970Q8 Probable thymidylate kinase n/a
134 Q7M537_DTT Q7M537 ADP-dependent glucose/glucosamine kinase n/a
135 P49327_DTT P49327 Fatty acid synthase n/a
136 Q96QT4_DTT Q96QT4 Transient receptor potential n/a
137 O87605_DTT O87605 Cytochrome P450 monooxygenase n/a
138 A0R5B5_DTT A0R5B5 glucarate dehydratase (EC n/a
139 A6VQF1_DTT A6VQF1 Glucarate dehydratase (EC n/a
140 P0A884_DTT P0A884 Thymidylate synthase (TS) n/a
141 O15169_DTT O15169 Axin-1 (Axis inhibition n/a
142 Q9UJ68_DTT Q9UJ68 Mitochondrial peptide methionine n/a
143 Q9X0C6_DTT Q9X0C6 Imidazole glycerol phosphate n/a
144 A0A191KW96_DTT A0A191KW96 RNA-directed RNA polymerase n/a
145 P22392_DTT P22392 Nucleoside diphosphate kinase n/a
146 P21340_DTT P21340 Spermidine/spermine N(1)-acetyltransferase (SSAT) n/a
147 Q99873_DTT Q99873 Protein arginine N-methyltransferase n/a
148 O67503_DTT O67503 OsmC family peroxiredoxin n/a
149 P07320_DTT P07320 Gamma-crystallin D (Gamma-D-crystallin) n/a
150 P28720_DTT P28720 Queuine tRNA-ribosyltransferase (EC n/a
151 Q9NDD3_DTT Q9NDD3 Thymidylate synthase (EC n/a
152 P0DTC1_DTT P0DTC1 Replicase polyprotein 1a n/a
153 B1PWB9_DTT B1PWB9 Thioredoxin n/a
154 P77398_DTT P77398 Bifunctional polymyxin resistance n/a
155 O92810_DTT O92810 Gag-Pro polyprotein (Pr95) n/a
156 P52293_DTT P52293 Importin subunit alpha-1 n/a
157 Q8IWA4_DTT Q8IWA4 Mitofusin-1 (EC 3.6.5.-) n/a
158 Q9Y6W6_DTT Q9Y6W6 Dual specificity protein n/a
159 P19120_DTT P19120 Heat shock cognate n/a
160 Q9Y052_DTT Q9Y052 Thymidylate synthase (EC n/a
161 Q6NB62_DTT Q6NB62 Hydrogenase expression/formation protein n/a
162 P52292_DTT P52292 Importin subunit alpha-1 n/a
163 A0A0S0VKY7_DTT A0A0S0VKY7 Outer capsid protein n/a
164 A0A0H3FJT8_DTT A0A0H3FJT8 N-acetylneuraminate lyase (NAL) n/a
165 Q9KM65_DTT Q9KM65 CAI-1 autoinducer synthase n/a
166 Q31PL2_DTT Q31PL2 Phosphoribulokinase (EC 2.7.1.19) n/a
167 Q24008_DTT Q24008 Inactivation-no-after-potential D protein n/a
168 P00183_DTT P00183 Camphor 5-monooxygenase (EC n/a
169 Q04207_DTT Q04207 Transcription factor p65 n/a
170 P84123_DTT P84123 Large ribosomal subunit n/a
171 Q02201_DTT Q02201 Oxysterol-binding protein homolog n/a
172 P0AEP7_DTT P0AEP7 Glyoxylate carboligase (EC n/a
173 P24481_DTT P24481 Phenylalanine ammonia-lyase 1 n/a
174 Q9P371_DTT Q9P371 AMSH-like protease sst2 n/a
175 P38272_DTT P38272 SWI5-dependent HO expression n/a
176 P13188_DTT P13188 Glutamine--tRNA ligase (EC n/a
177 Q1QUN7_DTT Q1QUN7 NAD-dependent epimerase/dehydratase n/a
178 P04637_DTT P04637 Cellular tumor antigen n/a
179 O36030_DTT O36030 Uncharacterized WD repeat-containing n/a
180 O60885_DTT O60885 Bromodomain-containing protein 4 n/a
181 P42765_DTT P42765 3-ketoacyl-CoA thiolase, mitochondrial n/a
182 P0C6U2_DTT P0C6U2 Replicase polyprotein 1a n/a
183 O60341_DTT O60341 Lysine-specific histone demethylase n/a
184 A0A1U9IS38_DTT A0A1U9IS38 deleted n/a
185 P42574_DTT P42574 Caspase-3 (CASP-3) (EC n/a
186 O76290_DTT O76290 Pteridine reductase n/a
187 P0ACS2_DTT P0ACS2 Redox-sensitive transcriptional activator n/a
188 Q28399_DTT Q28399 Aldehyde dehydrogenase, cytosolic n/a
189 P35968_DTT P35968 Vascular endothelial growth n/a
190 P15924_DTT P15924 Desmoplakin (DP) (250/210 n/a
191 P25440_DTT P25440 Bromodomain-containing protein 2 n/a
192 P10537_DTT P10537 Beta-amylase (EC 3.2.1.2) n/a
193 M4VRJ6_DTT M4VRJ6 Alcohol dehydrogenase GroES-like n/a
194 Q94M05_DTT Q94M05 NTPase P4 n/a
195 Q7JYX0_DTT Q7JYX0 Glutathione S-transferase E14 n/a
196 Q923J1_DTT Q923J1 Transient receptor potential n/a
197 Q14145_DTT Q14145 Kelch-like ECH-associated protein n/a
198 Q9HZZ3_DTT Q9HZZ3 Organic hydroperoxide resistance n/a