Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
PDB ligand accession: FK5
DrugBank: DB00864
PubChem: 445643
ChEMBL: CHEMBL269732
InChI Key: QJJXYPPXXYFBGM-LFZNUXCKSA-N
SMILES: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC

ClassyFire chemical classification:

List of proteins that are targets for FK5

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 U3N5X4_FK5 U3N5X4 peptidylprolyl isomerase (EC n/a
2 A5K8X6_FK5 A5K8X6 peptidylprolyl isomerase (EC n/a
3 Q13451_FK5 Q13451 Peptidyl-prolyl cis-trans isomerase n/a Ki(nM) = 79.0
Kd(nM) = 104.0
4 J3K9C5_FK5 J3K9C5 Sas10/Utp3 family protein n/a
5 P26885_FK5 P26885 Peptidyl-prolyl cis-trans isomerase n/a
6 A0A0D8JSK0_FK5 A0A0D8JSK0 Calcineurin subunit B n/a
7 J3K5Z5_FK5 J3K5Z5 peptidylprolyl isomerase (EC n/a
8 P62942_FK5 P62942 Peptidyl-prolyl cis-trans isomerase inhibitor Ki(nM) = 0.4
IC50(nM) = 2.3
Kd(nM) = 0.2
9 Q93ZG9_FK5 Q93ZG9 Peptidyl-prolyl cis-trans isomerase n/a
10 P48452_FK5 P48452 Protein phosphatase 3 n/a
11 P45523_FK5 P45523 FKBP-type peptidyl-prolyl cis-trans n/a
12 O94746_FK5 O94746 FK506-binding protein 1 n/a
13 Q4WUR1_FK5 Q4WUR1 Serine/threonine-protein phosphatase 2B n/a
14 O42773_FK5 O42773 Serine/threonine-protein phosphatase 2B n/a
15 P20081_FK5 P20081 FK506-binding protein 1 n/a
16 A0A2H4A315_FK5 A0A2H4A315 peptidylprolyl isomerase (EC n/a
17 Q4WDF2_FK5 Q4WDF2 Calcineurin subunit B n/a
18 Q6FMA3_FK5 Q6FMA3 FK506-binding protein 1 n/a
19 Q5SLE7_FK5 Q5SLE7 Peptidyl-prolyl cis-trans isomerase n/a
20 Q02790_FK5 Q02790 Peptidyl-prolyl cis-trans isomerase n/a Kd(nM) = 23.0
21 A0A229WIB4_FK5 A0A229WIB4 peptidylprolyl isomerase (EC n/a
22 P28870_FK5 P28870 FK506-binding protein 1 n/a
23 J9VL81_FK5 J9VL81 Calcineurin subunit B n/a
24 Q4WLV6_FK5 Q4WLV6 FK506-binding protein 1A n/a
25 Q12306_FK5 Q12306 Ubiquitin-like protein SMT3 n/a
26 Q8I4V8_FK5 Q8I4V8 Peptidyl-prolyl cis-trans isomerase n/a
27 Q00688_FK5 Q00688 Peptidyl-prolyl cis-trans isomerase n/a
28 P63099_FK5 P63099 Calcineurin subunit B n/a
29 C4YS24_FK5 C4YS24 Calcineurin subunit B n/a
30 C4YFI3_FK5 C4YFI3 Serine/threonine-protein phosphatase (EC n/a
31 Q3JK38_FK5 Q3JK38 Peptidyl-prolyl cis-trans isomerase n/a