Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: GLUTAMIC ACID
PDB ligand accession: GLU
DrugBank: DB00142
PubChem: 33032;44272391;88747398;
ChEMBL: CHEMBL575060
InChI Key: WHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES: C(CC(=O)O)C(C(=O)O)N

ClassyFire chemical classification:

List of proteins that are targets for GLU

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q836J0_GLU Q836J0 Glutamate racemase (EC n/a
2 Q8W5Y8_GLU Q8W5Y8 Ply protein n/a
3 P50286_GLU P50286 L-asparaginase (L-ASNase) (EC n/a
4 Q9Y3Q0_GLU Q9Y3Q0 N-acetylated-alpha-linked acidic dipeptidase n/a
5 A7XY94_GLU A7XY94 Glutamate receptor ionotropic, n/a
6 Q2SX36_GLU Q2SX36 Glutamate--tRNA ligase (EC n/a
7 O60885_GLU O60885 Bromodomain-containing protein 4 n/a
8 E6B7H4_GLU E6B7H4 deleted n/a
9 A9W3R9_GLU A9W3R9 deleted n/a
10 O94925_GLU O94925 Glutaminase kidney isoform, n/a
11 M0QTV3_GLU M0QTV3 Fiber n/a
12 Q5FAK7_GLU Q5FAK7 Amino-acid acetyltransferase (EC n/a
13 P80077_GLU P80077 Glutamate mutase epsilon n/a
14 A9W3R7_GLU A9W3R7 deleted n/a
15 P00805_GLU P00805 L-asparaginase 2 (EC n/a
16 C3SWD2_GLU C3SWD2 Racemase (EC 5.1.1.10) n/a
17 A0A6A5PZB5_GLU A0A6A5PZB5 deleted n/a
18 F8WQK8_GLU F8WQK8 Asp/Glu-specific dipeptidyl-peptidase (EC n/a
19 Q65480_GLU Q65480 Genome polyprotein n/a
20 Q9U1M8_GLU Q9U1M8 Myosin-I heavy chain n/a
21 G3V9C5_GLU G3V9C5 Glutamate receptor n/a
22 P00962_GLU P00962 Glutamine--tRNA ligase (EC n/a
23 P41594_GLU P41594 Metabotropic glutamate receptor n/a Ki(nM) = 390.0
EC50(nM) = 4100.0
24 P32322_GLU P32322 Pyrroline-5-carboxylate reductase 1, n/a
25 P42260_GLU P42260 Glutamate receptor ionotropic, n/a Ki(nM) = 330.0
EC50(nM) = 66000.0
26 O59096_GLU O59096 Aminotransferase (EC 2.6.1.-) n/a
27 P0A5L6_GLU P0A5L6 Glutamine-dependent NAD(+) synthetase n/a
28 Q9VDH5_GLU Q9VDH5 Kainate-type ionotropic glutamate n/a
29 Q9HZ66_GLU Q9HZ66 Phosphoserine aminotransferase (EC n/a
30 Q8VHX0_GLU Q8VHX0 Voltage-dependent calcium channel n/a
31 Q55434_GLU Q55434 Phytochrome-like protein cph2 n/a
32 B0TZW0_GLU B0TZW0 L-amino acid-D/L-Glu epimerase n/a
33 Q7A6D8_GLU Q7A6D8 deleted n/a
34 Q15370_GLU Q15370 Elongin-B (EloB) (Elongin n/a
35 Q9VMP3_GLU Q9VMP3 Glutamate receptor IIB n/a
36 Q51693_GLU Q51693 Capsule biosynthesis protein n/a
37 O33289_GLU O33289 Amino-acid acetyltransferase (EC n/a
38 P06201_GLU P06201 Glutamine synthetase (GS) n/a
39 Q9BXR0_GLU Q9BXR0 Queuine tRNA-ribosyltransferase catalytic n/a
40 O51345_GLU O51345 Glutamate--tRNA ligase (EC n/a
41 O25743_GLU O25743 Glutathione hydrolase proenzyme n/a
42 O57946_GLU O57946 Aminotransferase class I/classII n/a
43 V5YM14_GLU V5YM14 Dipeptidyl aminopeptidase BII n/a
44 P0C0U4_GLU P0C0U4 Ribosomal protein bS6--L-glutamate n/a
45 P18956_GLU P18956 Glutathione hydrolase proenzyme n/a
46 A0A0E8TWE4_GLU A0A0E8TWE4 Aminotransferase (Aspartate transaminase) n/a
47 P12425_GLU P12425 Glutamine synthetase (GS) n/a
48 Q5M4H8_GLU Q5M4H8 Di-or tripeptide:H+ symporter n/a
49 P19493_GLU P19493 Glutamate receptor 4 n/a Ki(nM) = 354.0
EC50(nM) = 17000.0
50 Q72IC1_GLU Q72IC1 Glutamate dehydrogenase n/a
51 N1P8Q8_GLU N1P8Q8 Nta1p n/a
52 A9CIT6_GLU A9CIT6 Dipeptide epimerase (EC n/a
53 C3W5S0_GLU C3W5S0 Polymerase acidic protein n/a
54 A0QWT1_GLU A0QWT1 DNA-directed RNA polymerase n/a
55 A0A4Y5PW23_GLU A0A4Y5PW23 Allophycocyanin beta n/a
56 Q9R174_GLU Q9R174 Glutamate receptor 2 n/a
57 Q9SIE1_GLU Q9SIE1 Bifunctional aspartate aminotransferase n/a
58 Q7WWK9_GLU Q7WWK9 L-asparaginase (EC 3.5.1.1) n/a
59 P06608_GLU P06608 L-asparaginase (L-ASNase) (EC n/a
60 Q53940_GLU Q53940 Glutamate N-acetyltransferase Oat2 n/a
61 P19440_GLU P19440 Glutathione hydrolase 1 n/a
62 P24295_GLU P24295 NAD-specific glutamate dehydrogenase n/a
63 Q1LBR9_GLU Q1LBR9 Phthalate 4,5-dioxygenase, subunit n/a
64 Q04609_GLU Q04609 Glutamate carboxypeptidase 2 n/a IC50(nM) = 428000.0
65 I6Y9J2_GLU I6Y9J2 L,D-transpeptidase 2 (LDT n/a
66 A0QSL8_GLU A0QSL8 DNA-directed RNA polymerase n/a
67 D0VWX9_GLU D0VWX9 Ionotropic glutamate receptor n/a
68 P19491_GLU P19491 Glutamate receptor 2 n/a Ki(nM) = 280.0
EC50(nM) = 14700.0
69 Q976J8_GLU Q976J8 Alpha-aminoadipate/glutamate carrier protein n/a
70 C0KD15_GLU C0KD15 Glutamate receptor ionotropic, n/a
71 E9P5T5_GLU E9P5T5 Glutamate receptor 1 n/a
72 P48052_GLU P48052 Carboxypeptidase A2 (EC n/a
73 A0A173M0G2_GLU A0A173M0G2 Taste receptor, type n/a
74 P0A6W9_GLU P0A6W9 Glutamate--cysteine ligase (EC n/a
75 P00897_GLU P00897 Anthranilate synthase component n/a
76 O86237_GLU O86237 Uncharacterized protein HI_1388.1 n/a
77 A0A173M094_GLU A0A173M094 Taste receptor type n/a
78 P04825_GLU P04825 Aminopeptidase N (EC n/a
79 P19490_GLU P19490 Glutamate receptor 1 n/a Ki(nM) = 169.0
IC50(nM) = 613.0
EC50(nM) = 3400.0
80 P77754_GLU P77754 Periplasmic chaperone Spy n/a
81 Q83S74_GLU Q83S74 deleted n/a
82 P54422_GLU P54422 Glutathione hydrolase proenzyme n/a
83 P39086_GLU P39086 Glutamate receptor ionotropic, n/a Ki(nM) = 701.0
EC50(nM) = 75000.0
84 C0KD18_GLU C0KD18 Glutamate receptor ionotropic, n/a
85 Q07075_GLU Q07075 Glutamyl aminopeptidase (EAP) n/a
86 Q51162_GLU Q51162 Fe-regulated protein B n/a
87 Q8XLA4_GLU Q8XLA4 N-acetylmuramoyl-L-alanine amidase n/a
88 D8A942_GLU D8A942 deleted n/a
89 P43005_GLU P43005 Excitatory amino acid n/a Ki(nM) = 51.0
IC50(nM) = 32000.0
90 P83817_GLU P83817 Glutamate receptor n/a
91 A0A0J9X1V2_GLU A0A0J9X1V2 deleted n/a
92 O00222_GLU O00222 Metabotropic glutamate receptor n/a Ki(nM) = 20.0
IC50(nM) = 5.7
93 P22756_GLU P22756 Glutamate receptor ionotropic, n/a Ki(nM) = 140.0
EC50(nM) = 35200.0
94 Q8VHW5_GLU Q8VHW5 Voltage-dependent calcium channel n/a
95 Q3SYY0_GLU Q3SYY0 Glutamate dehydrogenase 1, n/a
96 Q15369_GLU Q15369 Elongin-C (EloC) (Elongin n/a
97 Q9HXN1_GLU Q9HXN1 Membrane-bound lytic murein n/a
98 Q9C8E7_GLU Q9C8E7 Glutamate receptor 3.3 n/a
99 P00900_GLU P00900 Anthranilate synthase component n/a
100 P0A790_GLU P0A790 Aspartate 1-decarboxylase (EC n/a
101 P17169_GLU P17169 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] n/a
102 P25060_GLU P25060 Type II secretion n/a
103 Q9UPY5_GLU Q9UPY5 Cystine/glutamate transporter (Amino n/a
104 A0QW02_GLU A0QW02 RNA polymerase sigma n/a
105 O15399_GLU O15399 Glutamate receptor ionotropic, n/a
106 Q9I6J4_GLU Q9I6J4 Probable glutamine amidotransferase n/a
107 A0A1T3HI54_GLU A0A1T3HI54 Glutamate--tRNA ligase (EC n/a
108 P19492_GLU P19492 Glutamate receptor 3 n/a Ki(nM) = 62.0
EC50(nM) = 1300.0
109 Q9VNW6_GLU Q9VNW6 Delta-1-pyrroline-5-carboxylate synthase [Includes: n/a
110 A4ZKM1_GLU A4ZKM1 Fiber n/a
111 A9W3S0_GLU A9W3S0 deleted n/a
112 P81511_GLU P81511 Metallocarboxypeptidase inhibitor (Leech n/a
113 O26771_GLU O26771 Methyltransferase n/a
114 Q8GXJ4_GLU Q8GXJ4 Glutamate receptor 3.4 n/a
115 A0A140T871_GLU A0A140T871 Glutamate dehydrogenase 1, n/a
116 Q970U6_GLU Q970U6 Glutamate--LysW ligase ArgX n/a
117 Q9QJ78_GLU Q9QJ78 Pol protein n/a
118 A9W3R8_GLU A9W3R8 deleted n/a
119 P04958_GLU P04958 Tetanus toxin (EC n/a
120 A9YTT0_GLU A9YTT0 Glutathione hydrolase proenzyme n/a
121 P96847_GLU P96847 Valine--pyruvate aminotransferase (EC n/a
122 C9QXA7_GLU C9QXA7 deleted n/a
123 Q05586_GLU Q05586 Glutamate receptor ionotropic, n/a
124 P12821_GLU P12821 Angiotensin-converting enzyme (ACE) n/a
125 P42264_GLU P42264 Glutamate receptor ionotropic, n/a Ki(nM) = 490.0
126 P00800_GLU P00800 Thermolysin (EC 3.4.24.27) n/a
127 Q9HT65_GLU Q9HT65 Probable glutamine synthetase n/a
128 Q03445_GLU Q03445 Glutamate receptor 1 n/a
129 Q00961_GLU Q00961 Glutamate receptor ionotropic, n/a
130 B7ZSK1_GLU B7ZSK1 Glutamate receptor ionotropic, n/a
131 Q8CHT0_GLU Q8CHT0 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial n/a
132 O30298_GLU O30298 Fructose-1,6-bisphosphatase/inositol-1-monophosphatase (FBPase/IMPase) (EC n/a
133 P96257_GLU P96257 Probable glutamine-binding lipoprotein n/a
134 O23736_GLU O23736 Glutamate--cysteine ligase, chloroplastic n/a
135 Q9UXR8_GLU Q9UXR8 Glutamyl-tRNA reductase (GluTR) n/a
136 Q5ZVE3_GLU Q5ZVE3 Aminopeptidase N (EC n/a
137 Q14833_GLU Q14833 Metabotropic glutamate receptor n/a Ki(nM) = 1400.0
EC50(nM) = 15000.0
138 Q14832_GLU Q14832 Metabotropic glutamate receptor n/a Ki(nM) = 4000.0
EC50(nM) = 1002.0
139 Q06210_GLU Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] n/a
140 Q0ASS9_GLU Q0ASS9 Acetylglutamate kinase (EC n/a
141 P63096_GLU P63096 Guanine nucleotide-binding protein n/a
142 P22634_GLU P22634 Glutamate racemase (EC n/a
143 Q65KZ6_GLU Q65KZ6 Glutathione hydrolase proenzyme n/a
144 Q12879_GLU Q12879 Glutamate receptor ionotropic, n/a IC50(nM) = 70.0
145 A7Y7W1_GLU A7Y7W1 Periplasmic dipeptide-binding protein n/a
146 Q14416_GLU Q14416 Metabotropic glutamate receptor n/a Ki(nM) = 1100.0
EC50(nM) = 1767.0
147 A0MK70_GLU A0MK70 Fiber-1 n/a
148 P42262_GLU P42262 Glutamate receptor 2 n/a Ki(nM) = 940.0
EC50(nM) = 2190.0
149 O34508_GLU O34508 L-Ala-D/L-Glu epimerase (AE n/a
150 Q8KNF1_GLU Q8KNF1 CalS11 n/a
151 P73797_GLU P73797 Slr1257 protein n/a
152 P27000_GLU P27000 Glutamate--tRNA ligase (EC n/a
153 P0DTC2_GLU P0DTC2 Spike glycoprotein (S n/a
154 O75112_GLU O75112 LIM domain-binding protein n/a
155 A0A6A5PZI8_GLU A0A6A5PZI8 deleted n/a
156 P23385_GLU P23385 Metabotropic glutamate receptor n/a Ki(nM) = 10000.0
EC50(nM) = 1585.0
157 Q69ZX9_GLU Q69ZX9 Glutaminase kidney isoform, n/a
158 O17793_GLU O17793 deleted n/a
159 P43004_GLU P43004 Excitatory amino acid n/a Ki(nM) = 62000.0
IC50(nM) = 52000.0
160 Q8ZA87_GLU Q8ZA87 Acetylglutamate kinase (EC n/a
161 P9WFW3_GLU P9WFW3 Aspartate--tRNA(Asp/Asn) ligase (EC n/a
162 P40337_GLU P40337 von Hippel-Lindau disease n/a
163 P35439_GLU P35439 Glutamate receptor ionotropic, n/a Ki(nM) = 100.0
EC50(nM) = 450.0
164 Q3XZW5_GLU Q3XZW5 Glutamate ABC superfamily n/a
165 Q00960_GLU Q00960 Glutamate receptor ionotropic, n/a
166 Q06210-2_GLU Q06210-2 n/a
167 A0A0A7I435_GLU A0A0A7I435 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase n/a
168 Q0WDC2_GLU Q0WDC2 Dihydrofolate synthase/folylpolyglutamate synthase n/a
169 Q4DJ07_GLU Q4DJ07 9,11-endoperoxide prostaglandin H2 n/a
170 Q02574_GLU Q02574 DNA damage checkpoint n/a
171 Q62645_GLU Q62645 Glutamate receptor ionotropic, n/a
172 P38629_GLU P38629 Replication factor C n/a
173 P0A7B5_GLU P0A7B5 Glutamate 5-kinase (EC n/a
174 P60281_GLU P60281 DNA-directed RNA polymerase n/a
175 O31562_GLU O31562 Putative metal-dependent hydrolase n/a
176 C7MWN7_GLU C7MWN7 ABC-type Fe3+-hydroxamate transport n/a
177 Q4U1A6_GLU Q4U1A6 Glutaminase (EC 3.5.1.2) n/a
178 A0QS66_GLU A0QS66 DNA-directed RNA polymerase n/a
179 Q9RNB4_GLU Q9RNB4 McyF n/a
180 P04805_GLU P04805 Glutamate--tRNA ligase (EC n/a
181 Q716G6_GLU Q716G6 Gene 9 protein n/a
182 P32477_GLU P32477 Glutamate--cysteine ligase (EC n/a
183 Q7W0A0_GLU Q7W0A0 Exported protein n/a
184 Q9RTX5_GLU Q9RTX5 Branched-chain-amino-acid aminotransferase (EC n/a
185 W9BH30_GLU W9BH30 Bestrophin family ion n/a
186 G0S061_GLU G0S061 Pentafunctional AROM polypeptide n/a
187 P31422_GLU P31422 Metabotropic glutamate receptor n/a EC50(nM) = 58.0
188 Q8DLI5_GLU Q8DLI5 Glutamate--tRNA ligase (EC n/a
189 Q5SI02_GLU Q5SI02 L-glutamate gamma-semialdehyde dehydrogenase n/a
190 Q88K39_GLU Q88K39 Glutaminase-asparaginase (EC 3.5.1.38) n/a
191 Q00959_GLU Q00959 Glutamate receptor ionotropic, n/a EC50(nM) = 1800.0