Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
PDB ligand accession: GNP
DrugBank: DB02082
PubChem: 36735;5288455;135403657;
ChEMBL: CHEMBL1233085
InChI Key: UQABYHGXWYXDTK-UUOKFMHZSA-N
SMILES: c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(NP(=O)(O)O)O)O)O)N=C(NC2=O)N

ClassyFire chemical classification:

List of proteins that are targets for GNP

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 O18334_GNP O18334 Ras-related protein Rab6 n/a
2 P0A0C1_GNP P0A0C1 Bifunctional AAC/APH [Includes: n/a
3 Q9QZ85_GNP Q9QZ85 Interferon-inducible GTPase 1 n/a
4 O00429_GNP O00429 Dynamin-1-like protein (EC n/a
5 P57772_GNP P57772 Selenocysteine-specific elongation factor n/a
6 P63012_GNP P63012 Ras-related protein Rab-3A n/a
7 G1TRL5_GNP G1TRL5 Eukaryotic translation initiation n/a
8 Q72I01_GNP Q72I01 Elongation factor G n/a
9 A6TF32_GNP A6TF32 Ferrous iron transport n/a
10 Q9QUI0_GNP Q9QUI0 Transforming protein RhoA n/a
11 P53290_GNP P53290 GTP-binding protein GTR2 n/a
12 A0A1C7D1G9_GNP A0A1C7D1G9 tRNA(His)-5'-guanylyltransferase (Thg1) like n/a
13 P14081_GNP P14081 Selenocysteine-specific elongation factor n/a
14 P0A6N1_GNP P0A6N1 Elongation factor Tu n/a
15 P01112_GNP P01112 GTPase HRas (EC n/a
16 O18333_GNP O18333 Ras-related protein Rab-2 n/a
17 Q5SM23_GNP Q5SM23 GTPase Era n/a
18 Q8PXB3_GNP Q8PXB3 Protein translation elongation n/a
19 O26359_GNP O26359 Probable translation initiation n/a
20 A8ISN6_GNP A8ISN6 ADP-ribosylation factor-like protein n/a
21 P08134_GNP P08134 Rho-related GTP-binding protein n/a
22 P32455_GNP P32455 Guanylate-binding protein 1 n/a
23 Q57986_GNP Q57986 Fe(2+) transporter FeoB n/a
24 Q5M586_GNP Q5M586 Ferrous iron transport n/a
25 Q62636_GNP Q62636 Ras-related protein Rap-1b n/a
26 A0A0H2XK72_GNP A0A0H2XK72 Ribosome biogenesis GTPase n/a
27 P28523_GNP P28523 Casein kinase II n/a
28 P61010_GNP P61010 Signal recognition particle n/a
29 Q5SHN6_GNP Q5SHN6 Elongation factor Tu-A n/a
30 Q61411_GNP Q61411 GTPase HRas (EC n/a
31 Q4CPV7_GNP Q4CPV7 protein-synthesizing GTPase (EC n/a
32 Q5ZWZ3_GNP Q5ZWZ3 LidA n/a
33 P61212_GNP P61212 ADP-ribosylation factor-like protein n/a
34 Q07960_GNP Q07960 Rho GTPase-activating protein n/a
35 P0AGD7_GNP P0AGD7 Signal recognition particle n/a
36 P55042_GNP P55042 GTP-binding protein RAD n/a
37 A8INQ0_GNP A8INQ0 ADP-ribosylation factor-like protein n/a
38 P84095_GNP P84095 Rho-related GTP-binding protein n/a
39 O31743_GNP O31743 Ribosome biogenesis GTPase n/a
40 O60841_GNP O60841 Eukaryotic translation initiation n/a
41 P35278_GNP P35278 Ras-related protein Rab-5C n/a
42 Q969S9_GNP Q969S9 Ribosome-releasing factor 2, n/a
43 P15303_GNP P15303 Protein transport protein n/a
44 Q9NQL2_GNP Q9NQL2 Ras-related GTP-binding protein n/a
45 Q9WXQ8_GNP Q9WXQ8 Ferrous iron transport n/a
46 Q9C0L9_GNP Q9C0L9 Protein SEY1 (EC n/a
47 Q15382_GNP Q15382 GTP-binding protein Rheb n/a
48 P60766_GNP P60766 Cell division control n/a
49 F2UBE5_GNP F2UBE5 Ras protein n/a
50 P15790_GNP P15790 Casein kinase II n/a
51 A0A3P7EHT1_GNP A0A3P7EHT1 Apyrase n/a
52 Q41009_GNP Q41009 Translocase of chloroplast n/a
53 Q980A5_GNP Q980A5 Translation initiation factor n/a
54 Q9NP72_GNP Q9NP72 Ras-related protein Rab-18 n/a
55 P61224_GNP P61224 Ras-related protein Rap-1b n/a
56 Q9UZK7_GNP Q9UZK7 Probable translation initiation n/a
57 P62834_GNP P62834 Ras-related protein Rap-1A n/a
58 Q8J307_GNP Q8J307 Selenocysteine-specific elongation factor n/a
59 P09527_GNP P09527 Ras-related protein Rab-7a n/a
60 Q9HB90_GNP Q9HB90 Ras-related GTP-binding protein n/a
61 P51148_GNP P51148 Ras-related protein Rab-5C n/a
62 P36017_GNP P36017 Vacuolar protein sorting-associated n/a
63 Q9SSX0_GNP Q9SSX0 Rac-like GTP-binding protein n/a
64 P01123_GNP P01123 GTP-binding protein YPT1 n/a
65 Q7L523_GNP Q7L523 Ras-related GTP-binding protein n/a
66 P10121_GNP P10121 Signal recognition particle n/a
67 P49792_GNP P49792 E3 SUMO-protein ligase n/a
68 P10398_GNP P10398 Serine/threonine-protein kinase A-Raf n/a
69 P20337_GNP P20337 Ras-related protein Rab-3B n/a
70 P57735_GNP P57735 Ras-related protein Rab-25 n/a
71 Q9WZM6_GNP Q9WZM6 Ribosome biogenesis GTPase n/a
72 Q15907_GNP Q15907 Ras-related protein Rab-11B n/a
73 P61586_GNP P61586 Transforming protein RhoA n/a
74 Q8TAI7_GNP Q8TAI7 GTPase RhebL1 (EC n/a
75 P50743_GNP P50743 GTPase Der (GTP-binding n/a
76 P25228_GNP P25228 Ras-related protein Rab-3 n/a
77 Q9D0J4_GNP Q9D0J4 ADP-ribosylation factor-like protein n/a
78 A0A164SGC3_GNP A0A164SGC3 deleted n/a
79 G1TCX6_GNP G1TCX6 SRP receptor subunit n/a
80 A0A1M2U897_GNP A0A1M2U897 deleted n/a
81 O58429_GNP O58429 Nucleoside diphosphate kinase n/a
82 Q9WUL7_GNP Q9WUL7 ADP-ribosylation factor-like protein n/a
83 Q13636_GNP Q13636 Ras-related protein Rab-31 n/a
84 A0A037UPJ1_GNP A0A037UPJ1 deleted n/a
85 P51398_GNP P51398 Small ribosomal subunit n/a
86 P25519_GNP P25519 GTPase HflX (GTP-binding n/a
87 A0A5F9CI80_GNP A0A5F9CI80 SRP receptor subunit n/a
88 O67618_GNP O67618 Elongation factor 4 n/a
89 P0A705_GNP P0A705 Translation initiation factor n/a
90 Q92730_GNP Q92730 Rho-related GTP-binding protein n/a
91 P51157_GNP P51157 Ras-related protein Rab-28 n/a
92 O19069_GNP O19069 Succinate--CoA ligase [ADP/GDP-forming] n/a
93 O74718_GNP O74718 Eukaryotic peptide chain n/a
94 Q01960_GNP Q01960 Flagellar biosynthesis protein n/a
95 O67141_GNP O67141 Selenocysteine-specific elongation factor n/a
96 P51996_GNP P51996 GTP-binding protein YPT32/YPT11 n/a
97 O07347_GNP O07347 Signal recognition particle n/a
98 P23175_GNP P23175 GTPase HRas (EC n/a
99 P28185_GNP P28185 Ras-related protein RABA1a n/a
100 Q96DA2_GNP Q96DA2 Ras-related protein Rab-39B n/a
101 P32939_GNP P32939 Ypt/Rab-type GTPase YPT7 n/a
102 C5AP93_GNP C5AP93 Methylmalonyl-CoA mutase accessory n/a
103 Q5RJP4_GNP Q5RJP4 Ectonucleoside triphosphate diphosphohydrolase n/a
104 Q8NHV1_GNP Q8NHV1 GTPase IMAP family n/a
105 P08240_GNP P08240 Signal recognition particle n/a
106 P51159_GNP P51159 Ras-related protein Rab-27A n/a
107 Q9ULW5_GNP Q9ULW5 Ras-related protein Rab-26 n/a
108 P20338_GNP P20338 Ras-related protein Rab-4A n/a
109 Q8IYM1_GNP Q8IYM1 Septin-12 n/a
110 P61011_GNP P61011 Signal recognition particle n/a
111 P0A7D4_GNP P0A7D4 Adenylosuccinate synthetase (AMPSase) n/a
112 P20339_GNP P20339 Ras-related protein Rab-5A n/a
113 P01116_GNP P01116 GTPase KRas (EC n/a
114 A0A1U7REJ8_GNP A0A1U7REJ8 Ras-related protein Rab-8A n/a
115 B5ZA44_GNP B5ZA44 Guanosine pentaphosphate phosphohydrolase n/a
116 P11233_GNP P11233 Ras-related protein Ral-A n/a
117 Q5SJ82_GNP Q5SJ82 Probable gliding protein n/a
118 A0A6P5IP77_GNP A0A6P5IP77 GTPase KRas isoform n/a
119 P11904_GNP P11904 Plasmid segregation protein n/a
120 O67800_GNP O67800 GTPase Era n/a
121 P51149_GNP P51149 Ras-related protein Rab-7a n/a
122 R4YE37_GNP R4YE37 deleted n/a
123 P60338_GNP P60338 Elongation factor Tu-A n/a
124 P62826_GNP P62826 GTP-binding nuclear protein n/a
125 Q00582_GNP Q00582 GTP-binding protein GTR1 n/a
126 Q9UL25_GNP Q9UL25 Ras-related protein Rab-21 n/a
127 P27414_GNP P27414 Signal recognition particle n/a
128 P60953_GNP P60953 Cell division control n/a
129 O00522_GNP O00522 Krev interaction trapped n/a
130 P60339_GNP P60339 Elongation factor Tu-B n/a
131 Q01698_GNP Q01698 Elongation factor Tu n/a
132 P40616_GNP P40616 ADP-ribosylation factor-like protein n/a
133 G1SG72_GNP G1SG72 ATP binding cassette n/a
134 P42641_GNP P42641 GTPase ObgE/CgtA (EC n/a
135 P01116-2_GNP P01116-2 n/a
136 Q8VEL9_GNP Q8VEL9 GTP-binding protein REM n/a
137 O14807_GNP O14807 Ras-related protein M-Ras n/a
138 Q15771_GNP Q15771 Ras-related protein Rab-30 n/a
139 O23680_GNP O23680 Translocase of chloroplast n/a
140 P35285_GNP P35285 Ras-related protein Rab-22A n/a
141 A0A7I9GU03_GNP A0A7I9GU03 deleted n/a
142 P06780_GNP P06780 GTP-binding protein RHO1 n/a
143 Q9NRY4_GNP Q9NRY4 Rho GTPase-activating protein n/a
144 P61026_GNP P61026 Ras-related protein Rab-10 n/a
145 A0A0U2WWJ1_GNP A0A0U2WWJ1 GTPase n/a
146 P78356_GNP P78356 Phosphatidylinositol 5-phosphate 4-kinase n/a
147 P05453_GNP P05453 Eukaryotic peptide chain n/a
148 Q9NP90_GNP Q9NP90 Ras-related protein Rab-9B n/a
149 P20606_GNP P20606 Small COPII coat n/a
150 P10949_GNP P10949 Ras-related protein Rab-3C n/a
151 P20171_GNP P20171 GTPase HRas (EC n/a
152 E7QAP0_GNP E7QAP0 deleted n/a
153 P42208_GNP P42208 Septin-2 (Neural precursor n/a
154 P21359_GNP P21359 Neurofibromin (Neurofibromatosis-related protein n/a
155 P60763_GNP P60763 Ras-related C3 botulinum n/a
156 P53590_GNP P53590 Succinate--CoA ligase [GDP-forming] n/a
157 Q8WXF7_GNP Q8WXF7 Atlastin-1 (EC 3.6.5.-) n/a
158 Q92930_GNP Q92930 Ras-related protein Rab-8B n/a
159 Q9V1G0_GNP Q9V1G0 Translation initiation factor n/a
160 W7PD87_GNP W7PD87 deleted n/a
161 P0A7I4_GNP P0A7I4 Peptide chain release n/a
162 P17081_GNP P17081 Rho-related GTP-binding protein n/a
163 P63000_GNP P63000 Ras-related C3 botulinum n/a
164 P01111_GNP P01111 GTPase NRas (EC n/a
165 P62491_GNP P62491 Ras-related protein Rab-11A n/a
166 P60785_GNP P60785 Elongation factor 4 n/a
167 P23112_GNP P23112 Elongation factor 2 n/a
168 Q9UH03_GNP Q9UH03 Neuronal-specific septin-3 n/a
169 Q9ERI2_GNP Q9ERI2 Ras-related protein Rab-27A n/a
170 P32324_GNP P32324 Elongation factor 2 n/a
171 Q97W59_GNP Q97W59 Translation initiation factor n/a
172 P61006_GNP P61006 Ras-related protein Rab-8A n/a
173 O35963_GNP O35963 Ras-related protein Rab-33B n/a
174 P83749_GNP P83749 Signal recognition particle n/a
175 P11076_GNP P11076 ADP-ribosylation factor 1 n/a
176 Q9RVK2_GNP Q9RVK2 Nudix hydrolase DR_1025 n/a
177 C9QRL8_GNP C9QRL8 deleted n/a
178 Q96QF0_GNP Q96QF0 Rab-3A-interacting protein (Rab3A-interacting n/a
179 P32769_GNP P32769 Elongation factor 1 n/a
180 Q9H0U4_GNP Q9H0U4 Ras-related protein Rab-1B n/a
181 Q04230_GNP Q04230 TrwB n/a
182 Q97ZE7_GNP Q97ZE7 Signal recognition particle n/a
183 P0DTD1_GNP P0DTD1 Replicase polyprotein 1ab n/a
184 P10824_GNP P10824 Guanine nucleotide-binding protein n/a
185 P0CE47_GNP P0CE47 Elongation factor Tu n/a
186 Q6Z1J6_GNP Q6Z1J6 Obg-like ATPase 1 n/a
187 P61589_GNP P61589 Transforming protein RhoA n/a
188 P11234_GNP P11234 Ras-related protein Ral-B n/a
189 Q96RP9_GNP Q96RP9 Elongation factor G, n/a
190 A5TYT6_GNP A5TYT6 Phosphoenolpyruvate carboxykinase [GTP] n/a
191 C8ZIG2_GNP C8ZIG2 Small COPII coat n/a
192 P63092_GNP P63092 Guanine nucleotide-binding protein n/a
193 O75695_GNP O75695 Protein XRP2 n/a
194 C9ZVV9_GNP C9ZVV9 ADP-ribosylation factor, putative n/a
195 Q9R0M6_GNP Q9R0M6 Ras-related protein Rab-9A n/a
196 O08989_GNP O08989 Ras-related protein M-Ras n/a
197 P39286_GNP P39286 Small ribosomal subunit n/a
198 P13551_GNP P13551 Elongation factor G n/a
199 P63320_GNP P63320 Ras-related protein Ral-A n/a
200 P0CE48_GNP P0CE48 Elongation factor Tu n/a
201 P20340_GNP P20340 Ras-related protein Rab-6A n/a
202 P41391_GNP P41391 Ran GTPase-activating protein n/a
203 Q5ZUA2_GNP Q5ZUA2 Ectonucleoside triphosphate diphosphohydrolase n/a
204 P07560_GNP P07560 Ras-related protein SEC4 n/a
205 B1X6I9_GNP B1X6I9 deleted n/a
206 P46199_GNP P46199 Translation initiation factor n/a
207 O00212_GNP O00212 Rho-related GTP-binding protein n/a