Ligand name: 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
PDB ligand accession: HFZ
DrugBank: DB00774
PubChem: 3647
ChEMBL: CHEMBL1763
InChI Key: DMDGGSIALPNSEE-UHFFFAOYSA-N
SMILES: c1c(c(cc2c1NCNS2(=O)=O)S(=O)(=O)N)C(F)(F)F

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Thiadiazines
      • Subclass: Benzothiadiazines

List of proteins that are targets for HFZ

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	Q12791_HFZ	Q12791	Calcium-activated potassium channel	inducer
2	P19491_HFZ	P19491	Glutamate receptor 2	n/a
3	P00915_HFZ	P00915	Carbonic anhydrase 1	inhibitor	Ki(nM) = 2840.0
4	P00918_HFZ	P00918	Carbonic anhydrase 2	inhibitor	Ki(nM) = 435.0
5	Q16790_HFZ	Q16790	Carbonic anhydrase 9	inhibitor	Ki(nM) = 412.0
6	P22748_HFZ	P22748	Carbonic anhydrase 4	inhibitor	Ki(nM) = 4780.0
7	O43570_HFZ	O43570	Carbonic anhydrase 12	inhibitor	Ki(nM) = 305.0
8	P05023_HFZ	P05023	Sodium/potassium-transporting ATPase subunit	inducer
9	P43166_HFZ	P43166	Carbonic anhydrase 7	inhibitor	Ki(nM) = 433.0