Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: HISTIDINE
PDB ligand accession: HIS
DrugBank: DB00117
PubChem: 5288559;5460943;86580368;
ChEMBL: n/a
InChI Key: HNDVDQJCIGZPNO-YFKPBYRVSA-O
SMILES: c1c([nH+]c[nH]1)CC(C(=O)O)N

ClassyFire chemical classification:

List of proteins that are targets for HIS

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P02910_HIS P02910 Histidine-binding periplasmic protein n/a
2 P04804_HIS P04804 Histidine--tRNA ligase (EC n/a
3 D1B4R1_HIS D1B4R1 Periplasmic binding protein n/a
4 A0A2U0QMK8_HIS A0A2U0QMK8 4-hydroxy-tetrahydrodipicolinate synthase (HTPA n/a
5 A0A086HW61_HIS A0A086HW61 Histidine--tRNA ligase (EC n/a
6 A0A0H2UKY8_HIS A0A0H2UKY8 ABC transporter substrate-binding n/a
7 Q8Y4T3_HIS Q8Y4T3 Lmo2349 protein n/a
8 P52704_HIS P52704 (S)-hydroxynitrile lyase (HbHNL) n/a
9 Q51817_HIS Q51817 Lys-gingipain W83 (EC n/a
10 G7IKX3_HIS G7IKX3 Histidinol dehydrogenase, chloroplastic n/a
11 Q0P844_HIS Q0P844 Peptide ABC-transport system n/a
12 B5Z9J2_HIS B5Z9J2 Iron (III) ABC n/a
13 P23979_HIS P23979 5-hydroxytryptamine receptor 3A n/a
14 D0WGK0_HIS D0WGK0 Ketol-acid reductoisomerase (NADP(+)) n/a
15 Q2SWE3_HIS Q2SWE3 Histidine--tRNA ligase (EC n/a
16 O31785_HIS O31785 Polyketide biosynthesis cytochrome n/a
17 Q7CJS8_HIS Q7CJS8 Solute-binding protein n/a
18 P00915_HIS P00915 Carbonic anhydrase 1 n/a
19 Q8IUH5_HIS Q8IUH5 Palmitoyltransferase ZDHHC17 (EC n/a
20 A0A0F6B499_HIS A0A0F6B499 Lysine/arginine/ornithine transport protein n/a
21 A0R5M8_HIS A0R5M8 Histidine N-alpha-methyltransferase (EC n/a
22 A0A077ECF2_HIS A0A077ECF2 Histidinol dehydrogenase (HDH) n/a
23 P00782_HIS P00782 Subtilisin BPN' (EC n/a
24 P02911_HIS P02911 Lysine/arginine/ornithine-binding periplasmic protein n/a
25 Q7NUG2_HIS Q7NUG2 Probable chitinase n/a
26 Q4FTX3_HIS Q4FTX3 ATP phosphoribosyltransferase regulatory n/a
27 Q4DA54_HIS Q4DA54 histidine--tRNA ligase (EC n/a
28 Q5HJE1_HIS Q5HJE1 deleted n/a
29 P19113_HIS P19113 Histidine decarboxylase (HDC) n/a
30 D0VWX8_HIS D0VWX8 ArtJ n/a
31 A4IK89_HIS A4IK89 Hut operon positive n/a
32 Q8AA93_HIS Q8AA93 Acetohydroxyacid synthase small n/a
33 A9FDB7_HIS A9FDB7 C-19 steroid 1alpha-hydroxylase n/a
34 P62374_HIS P62374 Histidine--tRNA ligase (EC n/a
35 Q62696_HIS Q62696 Disks large homolog n/a
36 P12081_HIS P12081 Histidine--tRNA ligase, cytoplasmic n/a
37 E6UTM3_HIS E6UTM3 deleted n/a
38 C8WS74_HIS C8WS74 Aminoglycoside phosphotransferase n/a
39 Q8IDJ8_HIS Q8IDJ8 Lysine--tRNA ligase (EC n/a
40 P33590_HIS P33590 Nickel-binding periplasmic protein n/a
41 P06988_HIS P06988 Histidinol dehydrogenase (HDH) n/a
42 Q9PPB4_HIS Q9PPB4 4-hydroxy-tetrahydrodipicolinate synthase (HTPA n/a
43 P00918_HIS P00918 Carbonic anhydrase 2 n/a
44 A0A266CGC0_HIS A0A266CGC0 Dihydrolipoamide dehydrogenase (FAD-containing n/a
45 O27550_HIS O27550 ATP phosphoribosyltransferase (ATP-PRT) n/a
46 P74102_HIS P74102 Orange carotenoid-binding protein n/a
47 P9WMN1_HIS P9WMN1 ATP phosphoribosyltransferase (ATP-PRT) n/a
48 P25084_HIS P25084 Transcriptional activator protein n/a
49 G7JFL4_HIS G7JFL4 ATP phosphoribosyltransferase (EC n/a
50 Q9GSQ9_HIS Q9GSQ9 Merozoite surface protein n/a
51 O53306_HIS O53306 Long-chain-fatty-acid--CoA ligase FadD13 n/a
52 Q2G2P5_HIS Q2G2P5 Nickel-binding protein NikA n/a
53 P10943_HIS P10943 Hut operon positive n/a
54 P56194_HIS P56194 Histidine--tRNA ligase (EC n/a
55 P60759_HIS P60759 ATP phosphoribosyltransferase (ATP-PRT) n/a
56 Q8RCC3_HIS Q8RCC3 ABC-type amino acid n/a
57 P05092_HIS P05092 Peptidyl-prolyl cis-trans isomerase n/a
58 Q9X0D2_HIS Q9X0D2 ATP phosphoribosyltransferase (ATP-PRT) n/a
59 Q9X0D3_HIS Q9X0D3 ATP phosphoribosyltransferase regulatory n/a
60 P40926_HIS P40926 Malate dehydrogenase, mitochondrial n/a
61 Q45070_HIS Q45070 Glucuronoxylanase XynC (EC n/a
62 Q5HSJ4_HIS Q5HSJ4 ATP phosphoribosyltransferase (ATP-PRT) n/a
63 G9BWN9_HIS G9BWN9 Cytochrome P450 RhF n/a
64 P96896_HIS P96896 Leucine-responsive regulatory protein n/a
65 W6DY02_HIS W6DY02 deleted n/a
66 P0A2K1_HIS P0A2K1 Tryptophan synthase beta n/a