Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: MALONIC ACID
PDB ligand accession: MLA
DrugBank: DB02175
PubChem: 867;23511544;
ChEMBL: CHEMBL7942
InChI Key: OFOBLEOULBTSOW-UHFFFAOYSA-N
SMILES: C(C(=O)O)C(=O)O

ClassyFire chemical classification:

List of proteins that are targets for MLA

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q8CHT0_MLA Q8CHT0 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial n/a
2 S0AP56_MLA S0AP56 ORF1ab polyprotein n/a
3 Q99497_MLA Q99497 Parkinson disease protein n/a
4 P9WFY1_MLA P9WFY1 Tryptophan synthase alpha n/a
5 P31153_MLA P31153 S-adenosylmethionine synthase isoform n/a
6 P40161_MLA P40161 Histone chaperone RTT106 n/a
7 Q9EV84_MLA Q9EV84 2-hydroxymuconate tautomerase (EC n/a
8 A0A0B4KIF6_MLA A0A0B4KIF6 NicR n/a
9 O53611_MLA O53611 Isocitrate dehydrogenase [NADP] n/a
10 A4F255_MLA A4F255 Immunoblobulin G1 Fab n/a
11 Q9FH83_MLA Q9FH83 Disease resistance protein n/a
12 Q16552_MLA Q16552 Interleukin-17A (IL-17) (IL-17A) n/a
13 D5DKI8_MLA D5DKI8 Cytochrome P450 (EC n/a
14 A0A014M399_MLA A0A014M399 DAC domain-containing protein n/a
15 P0CL19_MLA P0CL19 Putative ribose 5-phosphate n/a
16 P62992_MLA P62992 Ubiquitin-ribosomal protein eS31 n/a
17 A1JMF7_MLA A1JMF7 Pectin degradation protein n/a
18 Q8YUQ7_MLA Q8YUQ7 Alr2278 protein n/a
19 Q9EV85_MLA Q9EV85 2-hydroxymuconate tautomerase (EC n/a
20 Q02251_MLA Q02251 Mycocerosic acid synthase n/a
21 P0DTC1_MLA P0DTC1 Replicase polyprotein 1a n/a
22 P48730_MLA P48730 Casein kinase I n/a
23 Q04636_MLA Q04636 FACT complex subunit n/a
24 D0X4R4_MLA D0X4R4 D-galactonate dehydratase family n/a
25 Q8D151_MLA Q8D151 Acyl-CoA thioesterase II n/a
26 Q9ULW0_MLA Q9ULW0 Targeting protein for n/a
27 P12821_MLA P12821 Angiotensin-converting enzyme (ACE) n/a
28 B2UQG6_MLA B2UQG6 Beta-hexosaminidase Amuc_0868 (EC n/a
29 Q57658_MLA Q57658 Aspartate-semialdehyde dehydrogenase (ASA n/a
30 Q6R2Q7_MLA Q6R2Q7 Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (EC n/a
31 Q54873_MLA Q54873 Hyaluronate lyase (EC n/a
32 Q9H7X0_MLA Q9H7X0 N-alpha-acetyltransferase 60 (hNaa60) n/a
33 Q8ZPC0_MLA Q8ZPC0 Acetyl transferase (EC n/a
34 P25774_MLA P25774 Cathepsin S (EC n/a
35 Q9FCA6_MLA Q9FCA6 Biflaviolin synthase CYP158A2 n/a
36 Q8RX71_MLA Q8RX71 BAG family molecular n/a
37 P04585_MLA P04585 Gag-Pol polyprotein (Pr160Gag-Pol) n/a
38 Q830Y8_MLA Q830Y8 Nicotinate phosphoribosyltransferase (EC n/a
39 Q94CL7_MLA Q94CL7 Protein PHOSPHATE STARVATION n/a
40 Q1HRL7_MLA Q1HRL7 Odorant-binding protein 22 n/a
41 Q9AIX7_MLA Q9AIX7 Benzoyl-CoA oxygenase component n/a
42 Q5W271_MLA Q5W271 L-prolyl-[peptidyl-carrier protein] dehydrogenase n/a
43 P42390_MLA P42390 Indole-3-glycerol phosphate lyase, n/a
44 P0AAI9_MLA P0AAI9 Malonyl CoA-acyl carrier n/a
45 C5ATQ9_MLA C5ATQ9 Maleylacetoacetate isomerase (Glutathione n/a
46 P50120_MLA P50120 Retinol-binding protein 2 n/a
47 P09883_MLA P09883 Colicin-E9 (EC 3.1.-.-) n/a
48 Q9XGM3_MLA Q9XGM3 Disease resistance protein n/a
49 Q0SPG7_MLA Q0SPG7 lysozyme (EC 3.2.1.17) n/a
50 A0A378KFD4_MLA A0A378KFD4 Lysophospholipase A (EC n/a
51 O60341_MLA O60341 Lysine-specific histone demethylase n/a
52 J7QD06_MLA J7QD06 Esterase (Alpha/beta hydrolase) n/a
53 P07203_MLA P07203 Glutathione peroxidase 1 n/a
54 P49040_MLA P49040 Sucrose synthase 1 n/a
55 Q53637_MLA Q53637 C5a peptidase (EC n/a
56 D8LJ35_MLA D8LJ35 Polyketide Synthase III n/a
57 O95257_MLA O95257 Growth arrest and n/a
58 P00766_MLA P00766 Chymotrypsinogen A (EC n/a
59 C7HEF6_MLA C7HEF6 deleted n/a
60 Q9EVR0_MLA Q9EVR0 L-lactate dehydrogenase (L-LDH) n/a
61 Q88JL2_MLA Q88JL2 Glucanase (EC 3.2.1.-) n/a
62 P29017_MLA P29017 T-cell surface glycoprotein n/a
63 Q12HD7_MLA Q12HD7 TRAP dicarboxylate transporter, n/a
64 P49841_MLA P49841 Glycogen synthase kinase-3 n/a
65 Q9BYJ9_MLA Q9BYJ9 YTH domain-containing family n/a
66 Q91786_MLA Q91786 Galectin n/a
67 P35961_MLA P35961 Envelope glycoprotein gp160 n/a
68 P13633_MLA P13633 C4-dicarboxylate transport sensor n/a
69 P0A790_MLA P0A790 Aspartate 1-decarboxylase (EC n/a
70 P9WFX9_MLA P9WFX9 Tryptophan synthase beta n/a
71 Q8A6S1_MLA Q8A6S1 Electron transfer flavoprotein n/a
72 A0A174J845_MLA A0A174J845 SGNH/GDSL hydrolase family n/a
73 P13988_MLA P13988 Transposon Tn7 transposition n/a
74 Q93009_MLA Q93009 Ubiquitin carboxyl-terminal hydrolase n/a
75 P37231_MLA P37231 Peroxisome proliferator-activated receptor n/a
76 P21642_MLA P21642 Phosphoenolpyruvate carboxykinase [GTP], n/a
77 P17412_MLA P17412 Fumarate reductase flavoprotein n/a
78 P01011_MLA P01011 Alpha-1-antichymotrypsin (ACT) (Cell n/a
79 Q8K409_MLA Q8K409 DNA polymerase beta n/a
80 Q45070_MLA Q45070 Glucuronoxylanase XynC (EC n/a
81 Q83JJ2_MLA Q83JJ2 Altronate hydrolase n/a
82 O75832_MLA O75832 26S proteasome non-ATPase n/a
83 Q2SWH9_MLA Q2SWH9 Threonine synthase (EC n/a
84 P58687_MLA P58687 3-dehydroquinate dehydratase (3-dehydroquinase) n/a
85 P13688_MLA P13688 Cell adhesion molecule n/a
86 P0CG47_MLA P0CG47 Polyubiquitin-B [Cleaved into: n/a
87 P09012_MLA P09012 U1 small nuclear n/a
88 Q92LZ4_MLA Q92LZ4 2-hydroxyacid dehydrogenase n/a
89 A0A3R9EDI8_MLA A0A3R9EDI8 Protease Lon-related BREX n/a
90 P44969_MLA P44969 Immunoglobulin A1 protease n/a
91 P46075_MLA P46075 Extracellular metalloproteinase mep n/a
92 Q2YQA0_MLA Q2YQA0 Isocitrate lyase (EC n/a
93 Q13237_MLA Q13237 cGMP-dependent protein kinase n/a
94 P47229_MLA P47229 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase (HOPDA n/a
95 Q9ZIV5_MLA Q9ZIV5 Malonamidase E2 n/a
96 P02879_MLA P02879 Ricin [Cleaved into: n/a
97 P01730_MLA P01730 T-cell surface glycoprotein n/a
98 Q6RFZ0_MLA Q6RFZ0 Beta-lactamase (EC 3.5.2.6) n/a
99 G0S1Z8_MLA G0S1Z8 ferroxidase (EC 1.16.3.1) n/a
100 P68106_MLA P68106 Peptidyl-prolyl cis-trans isomerase n/a
101 O06420_MLA O06420 Putative non-heme bromoperoxidase n/a
102 Q16875_MLA Q16875 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase n/a
103 O75874_MLA O75874 Isocitrate dehydrogenase [NADP] n/a
104 Q58531_MLA Q58531 GMP synthase [glutamine-hydrolyzing] n/a
105 W7JP72_MLA W7JP72 Lysine--tRNA ligase (EC n/a
106 O07015_MLA O07015 Sigma factor SigB n/a
107 P12931_MLA P12931 Proto-oncogene tyrosine-protein kinase n/a IC50(nM) = 4.0E7
108 A8PUY5_MLA A8PUY5 Secreted mono- and n/a
109 Q4KCY5_MLA Q4KCY5 L-proline--[L-prolyl-carrier protein] ligase n/a
110 P00918_MLA P00918 Carbonic anhydrase 2 n/a
111 A3DCJ4_MLA A3DCJ4 Dockerin type 1 n/a
112 P00338_MLA P00338 L-lactate dehydrogenase A n/a
113 P31946_MLA P31946 14-3-3 protein beta/alpha n/a
114 Q7VTJ9_MLA Q7VTJ9 Argininosuccinate synthase (EC n/a
115 P54195_MLA P54195 General odorant-binding protein n/a
116 Q8AAV8_MLA Q8AAV8 NUDIX family hydrolase n/a
117 A2NAI0_MLA A2NAI0 Variable region-beta 8.5 n/a
118 Q8ISF8_MLA Q8ISF8 Red fluorescent protein n/a
119 P28482_MLA P28482 Mitogen-activated protein kinase n/a
120 Q7WXQ4_MLA Q7WXQ4 hydrogenase (acceptor) (EC n/a
121 U5Q2N8_MLA U5Q2N8 XimE n/a
122 P52839_MLA P52839 Cytosolic sulfotransferase 12 n/a
123 P03322_MLA P03322 Gag polyprotein [Cleaved n/a
124 Q14451_MLA Q14451 Growth factor receptor-bound n/a
125 P23291_MLA P23291 Casein kinase I n/a
126 E9AE57_MLA E9AE57 Fumarate hydratase 2 n/a
127 Q3JRA0_MLA Q3JRA0 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n/a
128 A0A159BDB5_MLA A0A159BDB5 Tail fiber n/a
129 P13134_MLA P13134 Kexin (EC 3.4.21.61) n/a
130 P61769_MLA P61769 Beta-2-microglobulin [Cleaved into: n/a
131 P49137_MLA P49137 MAP kinase-activated protein n/a
132 P0AEE5_MLA P0AEE5 D-galactose/methyl-galactoside binding periplasmic n/a
133 Q8PYS1_MLA Q8PYS1 Geranylfarnesyl diphosphate synthase n/a
134 B6ETQ5_MLA B6ETQ5 C5a peptidase (EC n/a
135 Q9NPH0_MLA Q9NPH0 Lysophosphatidic acid phosphatase n/a
136 Q9H269_MLA Q9H269 Vacuolar protein sorting-associated n/a
137 B7MLA1_MLA B7MLA1 CTP synthase (EC n/a
138 D0VWQ0_MLA D0VWQ0 3-hydroxybutyrate dehydrogenase (EC n/a
139 Q7NDN8_MLA Q7NDN8 Proton-gated ion channel n/a
140 V9M2S5_MLA V9M2S5 Disease resistance protein n/a
141 A3LT82_MLA A3LT82 NADPH dehydrogenase n/a
142 Q2YNY7_MLA Q2YNY7 Ribokinase:Carbohydrate kinase, PfkB n/a
143 P13760_MLA P13760 HLA class II n/a
144 P04825_MLA P04825 Aminopeptidase N (EC n/a
145 Q9Y3E1_MLA Q9Y3E1 Hepatoma-derived growth factor-related n/a