Ligand name: NICOTINIC ACID
PDB ligand accession: NIO
DrugBank: DB00627
PubChem: 938;117629482;
ChEMBL: CHEMBL573
InChI Key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
SMILES: c1cc(cnc1)C(=O)O

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Pyridines and derivatives
      • Subclass: Pyridinecarboxylic acids and derivatives

List of proteins that are targets for NIO

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P49019_NIO	P49019	Hydroxycarboxylic acid receptor	agonist	EC50(nM) = 10000.0
2	Q8TDS4_NIO	Q8TDS4	Hydroxycarboxylic acid receptor	agonist	Ki(nM) = 50.0 IC50(nM) = 130.0 EC50(nM) = 8.7
3	P00918_NIO	P00918	Carbonic anhydrase 2	n/a
4	Q05603_NIO	Q05603	Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI	n/a
5	P38489_NIO	P38489	Oxygen-insensitive NAD(P)H nitroreductase	n/a
6	Q0QLF2_NIO	Q0QLF2	Nicotinate dehydrogenase large	n/a
7	A4HRG8_NIO	A4HRG8	nicotinamidase (EC 3.5.1.19)	n/a
8	P40261_NIO	P40261	Nicotinamide N-methyltransferase (EC	binder
9	P02240_NIO	P02240	Leghemoglobin-2 (LlLb2) (Leghemoglobin	n/a
10	P43490_NIO	P43490	Nicotinamide phosphoribosyltransferase (NAmPRTase)	n/a
11	Q9CED0_NIO	Q9CED0	Nitroreductase domain-containing protein	n/a
12	P02238_NIO	P02238	Leghemoglobin 3 (GmLb3)	n/a
13	O25423_NIO	O25423	Zinc ABC transporter	n/a
14	A1TY68_NIO	A1TY68	Anti-ECFsigma factor, ChrR	n/a
15	P68400_NIO	P68400	Casein kinase II	n/a
16	Q57431_NIO	Q57431	Putative NAD(P)H nitroreductase	n/a
17	Q2RWX8_NIO	Q2RWX8	Twin-arginine translocation pathway	n/a
18	Q15274_NIO	Q15274	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	binder
19	Q0QLF1_NIO	Q0QLF1	Nicotinate dehydrogenase medium	n/a
20	A0A3Q7HTY9_NIO	A0A3Q7HTY9	Abscisic acid receptor	n/a
21	Q9KDJ7_NIO	Q9KDJ7	Transcriptional regulator	n/a
22	P24627_NIO	P24627	Lactotransferrin (Lactoferrin) (EC	n/a
23	Q58993_NIO	Q58993	UPF0284 protein MJ1598	n/a
24	Q830Y8_NIO	Q830Y8	Nicotinate phosphoribosyltransferase (EC	n/a
25	B0VA03_NIO	B0VA03	deleted	n/a
26	P19784_NIO	P19784	Casein kinase II	n/a
27	A0AA82WNY3_NIO	A0AA82WNY3	nicotinate-nucleotide diphosphorylase (carboxylating)	n/a
28	A0A0U1RIB4_NIO	A0A0U1RIB4	NAD(P)H-flavin oxidoreductase	n/a