Ligand name: OROTIC ACID
PDB ligand accession: ORO
DrugBank: DB02262
PubChem: 967;5280334;
ChEMBL: CHEMBL1235017
InChI Key: PXQPEWDEAKTCGB-UHFFFAOYSA-N
SMILES: C1=C(NC(=O)NC1=O)C(=O)O

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Organoheterocyclic compounds
    • Class: Diazines
      • Subclass: Pyrimidines and pyrimidine derivatives

List of proteins that are targets for ORO

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	Q4D3W2_ORO	Q4D3W2	Dihydroorotate dehydrogenase (fumarate)	n/a
2	P54322_ORO	P54322	Dihydroorotate dehydrogenase B	n/a
3	P08870_ORO	P08870	Orotate phosphoribosyltransferase (OPRT)	n/a
4	Q08210_ORO	Q08210	Dihydroorotate dehydrogenase (quinone),	inhibitor
5	P9WFQ9_ORO	P9WFQ9	Uracil-DNA glycosylase (UDG)	n/a
6	Q4QEW7_ORO	Q4QEW7	Dihydroorotate dehydrogenase (fumarate)	n/a
7	P05020_ORO	P05020	Dihydroorotase (DHOase) (EC	inhibitor
8	Q54A96_ORO	Q54A96	Dihydroorotate dehydrogenase (quinone),	n/a
9	P27708_ORO	P27708	Multifunctional protein CAD	n/a
10	D0VWT2_ORO	D0VWT2	Dihydroorotate dehydrogenase (fumarate)	n/a
11	Q57U83_ORO	Q57U83	Dihydroorotate dehydrogenase (fumarate)	n/a
12	U6KL66_ORO	U6KL66	Dihydroorotate dehydrogenase (quinone),	n/a
13	C6BW16_ORO	C6BW16	TRAP dicarboxylate transporter,	n/a
14	P0A7E3_ORO	P0A7E3	Orotate phosphoribosyltransferase (OPRT)	n/a
15	Q63707_ORO	Q63707	Dihydroorotate dehydrogenase (quinone),	n/a
16	P54321_ORO	P54321	Dihydroorotate dehydrogenase A	n/a
17	Q02127_ORO	Q02127	Dihydroorotate dehydrogenase (quinone),	n/a
18	P0A7E1_ORO	P0A7E1	Dihydroorotate dehydrogenase (quinone)	n/a
19	A0A0V8EUT4_ORO	A0A0V8EUT4	deleted	n/a
20	P13298_ORO	P13298	Orotate phosphoribosyltransferase 1	n/a
21	B7GZW7_ORO	B7GZW7	Dihydroorotate dehydrogenase (quinone)	n/a