Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: PHENYLALANINE
PDB ligand accession: PHE
DrugBank: DB00120
PubChem: 6140;6925665;
ChEMBL: CHEMBL301523
InChI Key: COLNVLDHVKWLRT-QMMMGPOBSA-N
SMILES: c1ccc(cc1)CC(C(=O)O)N

ClassyFire chemical classification:

List of proteins that are targets for PHE

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 A7ZUJ2_PHE A7ZUJ2 Elongation factor Tu n/a
2 Q8VPD4_PHE Q8VPD4 L-amino acid oxidase n/a
3 P9WFU3_PHE P9WFU3 Phenylalanine--tRNA ligase alpha n/a
4 P04816_PHE P04816 Leucine-specific-binding protein (L-BP) n/a
5 P40969_PHE P40969 Centromere DNA-binding protein n/a
6 P05187_PHE P05187 Alkaline phosphatase, placental n/a
7 Q59771_PHE Q59771 Phenylalanine dehydrogenase (PheDH) n/a
8 O67854_PHE O67854 Na(+):neurotransmitter symporter (Snf n/a
9 Q84FL5_PHE Q84FL5 AdmH n/a
10 O95363_PHE O95363 Phenylalanine--tRNA ligase, mitochondrial n/a
11 P30793_PHE P30793 GTP cyclohydrolase 1 n/a
12 Q5M4H8_PHE Q5M4H8 Di-or tripeptide:H+ symporter n/a
13 P46781_PHE P46781 Small ribosomal subunit n/a
14 O75884_PHE O75884 Serine hydrolase RBBP9 n/a
15 Q9LCC8_PHE Q9LCC8 D-Amino acid amidase n/a
16 C9QTZ3_PHE C9QTZ3 deleted n/a
17 A7Y7W1_PHE A7Y7W1 Periplasmic dipeptide-binding protein n/a
18 Q9KT04_PHE Q9KT04 ABC transporter substrate-binding n/a
19 P14124_PHE P14124 Large ribosomal subunit n/a
20 P42738_PHE P42738 Chorismate mutase 1, n/a
21 P32449_PHE P32449 Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited n/a
22 Q8RY79_PHE Q8RY79 Phenylacetaldehyde synthase (AtPAAS) n/a
23 Q8KBW6_PHE Q8KBW6 Prephenate dehydratase (PDT) n/a
24 P14779_PHE P14779 Bifunctional cytochrome P450/NADPH--P450 n/a
25 P00439_PHE P00439 Phenylalanine-4-hydroxylase (PAH) (EC n/a
26 P62424_PHE P62424 Large ribosomal subunit n/a
27 A0A520KTT2_PHE A0A520KTT2 3-oxoacyl-ACP reductase FabG n/a
28 Q16773_PHE Q16773 Kynurenine--oxoglutarate transaminase 1 n/a
29 Q9K169_PHE Q9K169 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC n/a
30 Q9Y285_PHE Q9Y285 Phenylalanine--tRNA ligase alpha n/a
31 Q9WXM1_PHE Q9WXM1 L-Ala-D/L-Glu epimerase (AE n/a
32 A0A287AF82_PHE A0A287AF82 Large ribosomal subunit n/a
33 P00918_PHE P00918 Carbonic anhydrase 2 n/a
34 P70552_PHE P70552 GTP cyclohydrolase 1 n/a
35 A0A4Y7X244_PHE A0A4Y7X244 Na+-dependent transporter (Sodium-dependent n/a
36 P25084_PHE P25084 Transcriptional activator protein n/a
37 P30047_PHE P30047 GTP cyclohydrolase 1 n/a
38 P81382_PHE P81382 L-amino-acid oxidase (LAO) n/a
39 P0A8P1_PHE P0A8P1 Leucyl/phenylalanyl-tRNA--protein transferase (EC n/a
40 P14687_PHE P14687 Gramicidin S synthase n/a
41 C4YJ02_PHE C4YJ02 Aromatic amino acid n/a
42 P30967_PHE P30967 Phenylalanine-4-hydroxylase (PAH) (EC n/a
43 P05744_PHE P05744 Large ribosomal subunit n/a
44 Q4QDU3_PHE Q4QDU3 UTP--glucose-1-phosphate uridylyltransferase (EC n/a
45 B4SLK2_PHE B4SLK2 Dipeptidyl-peptidase (EC 3.4.14.-) n/a
46 P19573_PHE P19573 Nitrous-oxide reductase (EC n/a
47 P27001_PHE P27001 Phenylalanine--tRNA ligase alpha n/a
48 Q9X0L9_PHE Q9X0L9 Branched chain amino n/a
49 P22288_PHE P22288 GTP cyclohydrolase 1 n/a
50 P18077_PHE P18077 Large ribosomal subunit n/a
51 P96896_PHE P96896 Leucine-responsive regulatory protein n/a
52 P96084_PHE P96084 Proline iminopeptidase (PIP) n/a
53 P01180_PHE P01180 Vasopressin-neurophysin 2-copeptin (AVP-NPII) n/a
54 F8W4B7_PHE F8W4B7 Histone deacetylase 6 n/a
55 Q9QWW1_PHE Q9QWW1 Homer protein homolog n/a
56 P14618_PHE P14618 Pyruvate kinase PKM n/a
57 E9P5T5_PHE E9P5T5 Glutamate receptor 1 n/a
58 P00886_PHE P00886 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive n/a
59 A0A0M0ELU2_PHE A0A0M0ELU2 Bifunctional N-acyl-homoserine lactone n/a
60 P0CE48_PHE P0CE48 Elongation factor Tu n/a
61 A0A0J9X1X3_PHE A0A0J9X1X3 L-lysine oxidase (EC n/a
62 P50914_PHE P50914 Large ribosomal subunit n/a
63 Q2YPM5_PHE Q2YPM5 prephenate dehydratase (EC n/a
64 I6Y4H4_PHE I6Y4H4 deleted n/a
65 A1R118_PHE A1R118 Prephenate dehydratase (PDT) n/a
66 A0A3X8N4T9_PHE A0A3X8N4T9 deleted n/a
67 A0QSD5_PHE A0QSD5 Small ribosomal subunit n/a
68 A0A0G9F5E5_PHE A0A0G9F5E5 S-adenosylmethionine synthase (AdoMet n/a
69 A0R215_PHE A0R215 Large ribosomal subunit n/a
70 S1EA57_PHE S1EA57 deleted n/a
71 Q5W9R9_PHE Q5W9R9 Phenylalanine 2-monooxygenase precursor n/a
72 P0A7M9_PHE P0A7M9 Large ribosomal subunit n/a
73 P61247_PHE P61247 Small ribosomal subunit n/a
74 P0A988_PHE P0A988 Beta sliding clamp n/a
75 P01175_PHE P01175 Oxytocin-neurophysin 1 (OT-NPI) n/a
76 Q9S7N2_PHE Q9S7N2 L-tryptophan--pyruvate aminotransferase 1 n/a
77 Q9YBQ2_PHE Q9YBQ2 Acylamino-acid-releasing enzyme (AARE) n/a
78 C3SID2_PHE C3SID2 Transcription termination/antitermination protein n/a
79 A0A7L8TXW5_PHE A0A7L8TXW5 deleted n/a
80 Q9SX29_PHE Q9SX29 ATP-dependent Clp protease n/a
81 A0A1D8PMC5_PHE A0A1D8PMC5 Aromatic-amino-acid:2-oxoglutarate transaminase n/a
82 Q02878_PHE Q02878 Large ribosomal subunit n/a
83 P0AFG1_PHE P0AFG1 Transcription termination/antitermination protein n/a
84 O53512_PHE O53512 Phospho-2-dehydro-3-deoxyheptonate aldolase AroG n/a
85 P36105_PHE P36105 Large ribosomal subunit n/a
86 P80561_PHE P80561 Aminopeptidase S (EC n/a
87 Q02326_PHE Q02326 Large ribosomal subunit n/a
88 P62861_PHE P62861 Ubiquitin-like FUBI-ribosomal protein n/a
89 P03418_PHE P03418 Nucleoprotein (Protein N) n/a
90 P12737_PHE P12737 Large ribosomal subunit n/a
91 P04825_PHE P04825 Aminopeptidase N (EC n/a
92 E2QFJ4_PHE E2QFJ4 Elongation factor Tu n/a