Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: PYROPHOSPHATE 2-
PDB ligand accession: POP
DrugBank: n/a
PubChem: 4995;18628280;57345951;
ChEMBL: n/a
InChI Key: XPPKVPWEQAFLFU-UHFFFAOYSA-L
SMILES: OP(=O)([O-])OP(=O)(O)[O-]

ClassyFire chemical classification:

List of proteins that are targets for POP

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P0DTD1_POP P0DTD1 Replicase polyprotein 1ab n/a
2 P13513_POP P13513 Trichodiene synthase (EC n/a
3 P0A8V2_POP P0A8V2 DNA-directed RNA polymerase n/a
4 Q9K5E4_POP Q9K5E4 S-adenosylmethionine synthase (AdoMet n/a
5 P50384_POP P50384 Anthranilate phosphoribosyltransferase (EC n/a
6 P30803_POP P30803 Adenylate cyclase type n/a
7 P9WJJ2_POP P9WJJ2 Glutamine-dependent NAD(+) synthetase n/a
8 Q18664_POP Q18664 deleted n/a
9 P39594_POP P39594 Thiamine-phosphate synthase (TP n/a
10 Q4JAT2_POP Q4JAT2 Conserved Archaeal protein n/a
11 O30564_POP O30564 Glucosamine-6-phosphate deaminase (EC n/a
12 P76407_POP P76407 Lipid kinase YegS n/a
13 Q5NFU1_POP Q5NFU1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n/a
14 P56153_POP P56153 Inorganic pyrophosphatase (EC n/a
15 A0A059ZFC5_POP A0A059ZFC5 Phosphopantetheine adenylyltransferase (EC n/a
16 Q9UYB2_POP Q9UYB2 Threonylcarbamoyl-AMP synthase (TC-AMP n/a
17 Q4JH30_POP Q4JH30 inorganic diphosphatase (EC n/a
18 P15318_POP P15318 Bifunctional hemolysin/adenylate cyclase n/a
19 P47075_POP P47075 Vacuolar transporter chaperone n/a
20 P31153_POP P31153 S-adenosylmethionine synthase isoform n/a
21 P14324_POP P14324 Farnesyl pyrophosphate synthase n/a
22 Q9NYA1_POP Q9NYA1 Sphingosine kinase 1 n/a
23 O57883_POP O57883 235aa long hypothetical n/a
24 P22887_POP P22887 Nucleoside diphosphate kinase, n/a
25 Q8KNG2_POP Q8KNG2 CalE7 n/a
26 H6QM91_POP H6QM91 RNA-directed RNA polymerase n/a
27 Q93IG4_POP Q93IG4 Deoxyguanosine kinase (EC n/a
28 Q8PJZ4_POP Q8PJZ4 deleted n/a
29 D2W2Z5_POP D2W2Z5 Predicted protein n/a
30 O67911_POP O67911 CC-adding tRNA nucleotidyltransferase n/a
31 Q32ZE1_POP Q32ZE1 Genome polyprotein [Cleaved n/a
32 V5TDY7_POP V5TDY7 Hapalindole dimethylallyltransferase (EC n/a
33 P61823_POP P61823 Ribonuclease pancreatic (EC n/a
34 P22314_POP P22314 Ubiquitin-like modifier-activating enzyme n/a
35 Q77J78_POP Q77J78 dUTP diphosphatase (EC n/a
36 P18357_POP P18357 Regulatory protein BlaR1 n/a
37 P40136_POP P40136 Calmodulin-sensitive adenylate cyclase n/a
38 P00573_POP P00573 T7 RNA polymerase n/a
39 Q4K5A6_POP Q4K5A6 Geranyltranstransferase (EC 2.5.1.10) n/a
40 P0A6I6_POP P0A6I6 Phosphopantetheine adenylyltransferase (EC n/a
41 P08164_POP P08164 NH(3)-dependent NAD(+) synthetase n/a
42 Q8Y8D7_POP Q8Y8D7 NAD kinase 1 n/a
43 Q569R2_POP Q569R2 U8 snoRNA-decapping enzyme n/a
44 Q8ZMF7_POP Q8ZMF7 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n/a
45 Q81TP1_POP Q81TP1 dTDP-4-dehydrorhamnose 3,5-epimerase (EC n/a
46 B1XKC6_POP B1XKC6 Polyketide synthase n/a
47 Q9R8E3_POP Q9R8E3 Carboxyethyl-arginine beta-lactam-synthase (EC n/a
48 Q7CH55_POP Q7CH55 Peptidoglycan-associated lipoprotein (PAL) n/a
49 A3LHH1_POP A3LHH1 deleted n/a
50 P12689_POP P12689 DNA repair protein n/a
51 B3VQP5_POP B3VQP5 Genome polyprotein [Cleaved n/a
52 O51934_POP O51934 Reverse gyrase (EC n/a
53 P62623_POP P62623 4-hydroxy-3-methylbut-2-enyl diphosphate reductase n/a
54 P00817_POP P00817 Inorganic pyrophosphatase (EC n/a
55 P03950_POP P03950 Angiogenin (EC 3.1.27.-) n/a
56 D3KVM3_POP D3KVM3 glycerol kinase (EC n/a
57 Q32ZD5_POP Q32ZD5 Genome polyprotein [Cleaved n/a
58 P0A8N6_POP P0A8N6 Lysine--tRNA ligase, heat n/a
59 Q6FV03_POP Q6FV03 Candida glabrata strain n/a
60 A9JQL9_POP A9JQL9 4,4'-diapophytoene synthase (DAP n/a
61 Q9XWJ1_POP Q9XWJ1 Nonsense-mediated mRNA decay n/a
62 O67648_POP O67648 UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc n/a
63 D9N168_POP D9N168 DNA polymerase I n/a
64 A6QFS4_POP A6QFS4 deleted n/a
65 P04079_POP P04079 GMP synthase [glutamine-hydrolyzing] n/a
66 Q9H008_POP Q9H008 Phospholysine phosphohistidine inorganic n/a
67 Q9A6I1_POP Q9A6I1 Polyprenyl synthetase family n/a
68 Q6X3H6_POP Q6X3H6 AadB n/a
69 A8PWE4_POP A8PWE4 deleted n/a
70 O67060_POP O67060 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) n/a
71 P26769_POP P26769 Adenylate cyclase type n/a
72 P29464_POP P29464 Uridylate kinase (UK) n/a
73 P33734_POP P33734 Imidazole glycerol phosphate n/a
74 P0A7A9_POP P0A7A9 Inorganic pyrophosphatase (EC n/a
75 Q16875_POP Q16875 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase n/a
76 H9A910_POP H9A910 Genome polyprotein [Cleaved n/a
77 P21695_POP P21695 Glycerol-3-phosphate dehydrogenase [NAD(+)], n/a
78 V0ZE41_POP V0ZE41 deleted n/a
79 Q96PN6_POP Q96PN6 Adenylate cyclase type n/a
80 Q81TP2_POP Q81TP2 Glucose-1-phosphate thymidylyltransferase (EC n/a
81 P02787_POP P02787 Serotransferrin (Transferrin) (Beta-1 n/a
82 Q00277_POP Q00277 Glutathione peroxidase (GPX) n/a
83 Q8RQE9_POP Q8RQE9 DNA-directed RNA polymerase n/a
84 O60701_POP O60701 UDP-glucose 6-dehydrogenase (UDP-Glc n/a
85 P0A8T7_POP P0A8T7 DNA-directed RNA polymerase n/a
86 C9QTS9_POP C9QTS9 deleted n/a
87 P0A5L6_POP P0A5L6 Glutamine-dependent NAD(+) synthetase n/a
88 O30297_POP O30297 NAD kinase (EC n/a
89 P15925_POP P15925 Folylpolyglutamate synthase (FPGS) n/a
90 P34736_POP P34736 Transketolase (TK) (EC n/a
91 E5RPG3_POP E5RPG3 Genome polyprotein [Cleaved n/a
92 Q24973_POP Q24973 Guanine phosphoribosyltransferase n/a
93 Q57872_POP Q57872 dCTP deaminase, dUMP-forming n/a
94 P66992_POP P66992 Anthranilate phosphoribosyltransferase (EC n/a
95 Q3UZ80_POP Q3UZ80 DNA nucleotidylexotransferase (EC n/a
96 Q5NGF2_POP Q5NGF2 Phosphoribosylformylglycinamidine cyclo-ligase (EC n/a
97 P08536_POP P08536 Sulfate adenylyltransferase (EC n/a
98 Q6WP50_POP Q6WP50 Presilphiperfolan-8-beta-ol synthase (PSPS) n/a
99 Q97W02_POP Q97W02 DNA polymerase IV n/a
100 A5U4M0_POP A5U4M0 Anthranilate phosphoribosyltransferase (EC n/a
101 A0AA82WP13_POP A0AA82WP13 Terpene synthase (EC n/a
102 Q47506_POP Q47506 MccB protein n/a
103 P00349_POP P00349 6-phosphogluconate dehydrogenase, decarboxylating n/a
104 P96382_POP P96382 Bifunctional protein GlmU n/a
105 P62979_POP P62979 Ubiquitin-ribosomal protein eS31 n/a
106 P58758_POP P58758 Adenylate dimethylallyltransferase (EC n/a
107 P29468_POP P29468 Poly(A) polymerase (PAP) n/a
108 A0A364LX79_POP A0A364LX79 Squalene synthase (SQS) n/a
109 Q81VW8_POP Q81VW8 Dihydropteroate synthase (DHPS) n/a
110 X5IYJ5_POP X5IYJ5 Cyclolavandulyl diphosphate synthase n/a
111 P00492_POP P00492 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) n/a
112 Q6IA69_POP Q6IA69 Glutamine-dependent NAD(+) synthetase n/a
113 Q9ZIV5_POP Q9ZIV5 Malonamidase E2 n/a
114 P44815_POP P44815 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase n/a
115 O59245_POP O59245 tRNA-splicing ligase RtcB n/a
116 Q6FNA9_POP Q6FNA9 FAD synthase (EC n/a
117 P43490_POP P43490 Nicotinamide phosphoribosyltransferase (NAmPRTase) n/a
118 Q81RP3_POP Q81RP3 NH(3)-dependent NAD(+) synthetase n/a
119 A0QUZ2_POP A0QUZ2 8-oxo-(d)GTP phosphatase (8-oxo-(d)GTPase) n/a
120 P68693_POP P68693 Thymidylate kinase (EC n/a
121 Q05599_POP Q05599 Bifunctional adenosylcobalamin biosynthesis n/a
122 Q8TPS4_POP Q8TPS4 Di-trans-poly-cis-decaprenylcistransferase n/a
123 A0A182DWE5_POP A0A182DWE5 Prenyltransferase (PriB) n/a
124 O29630_POP O29630 D-aminoacyl-tRNA deacylase (EC n/a
125 Q859P9_POP Q859P9 Virion DNA-directed RNA n/a
126 Q97VZ8_POP Q97VZ8 KaiC domain-containing protein n/a
127 Q5ZTD3_POP Q5ZTD3 Saframycin Mx1 synthetase n/a
128 A0A6M9XZI2_POP A0A6M9XZI2 deleted n/a
129 A0A1Y0PY16_POP A0A1Y0PY16 4-hydroxythreonine-4-phosphate dehydrogenase PdxA n/a
130 Q6A562_POP Q6A562 RNA-dependent RNA polymerase n/a
131 P21359_POP P21359 Neurofibromin (Neurofibromatosis-related protein n/a
132 Q5ZTK6_POP Q5ZTK6 Calmodulin-dependent glutamylase SidJ n/a
133 Q07820_POP Q07820 Induced myeloid leukemia n/a
134 P20035_POP P20035 Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGPRT) n/a
135 Q5FAC0_POP Q5FAC0 S-adenosylmethionine synthase (AdoMet n/a
136 P08799_POP P08799 Myosin-2 heavy chain n/a
137 Q9BY32_POP Q9BY32 Inosine triphosphate pyrophosphatase n/a
138 P06999_POP P06999 ATP-dependent 6-phosphofructokinase isozyme n/a
139 Q8NBZ7_POP Q8NBZ7 UDP-glucuronic acid decarboxylase n/a
140 P0A817_POP P0A817 S-adenosylmethionine synthase (AdoMet n/a
141 Q2A4B6_POP Q2A4B6 deleted n/a
142 A6Y463_POP A6Y463 deleted n/a
143 O31801_POP O31801 Deoxyuridine 5'-triphosphate nucleotidohydrolase n/a
144 Q53W52_POP Q53W52 Isopentenyl-diphosphate delta-isomerase (IPP n/a
145 E5RPG2_POP E5RPG2 Genome polyprotein [Cleaved n/a
146 O94609_POP O94609 Ubiquitin-activating enzyme E1 n/a
147 Q9UR08_POP Q9UR08 Aristolochene synthase (AS) n/a
148 D9IEF7_POP D9IEF7 Endolysin (EC 3.2.1.17) n/a
149 P0AC11_POP P0AC11 Dihydropteroate synthase type-2 n/a
150 Q8PWY1_POP Q8PWY1 Pyrrolysine--tRNA ligase (EC n/a
151 H0USY5_POP H0USY5 Inorganic pyrophosphatase (EC n/a
152 H2L2L6_POP H2L2L6 Inorganic pyrophosphatase (EC n/a
153 Q9K499_POP Q9K499 Epi-isozizaene synthase (EIZS) n/a
154 Q26997_POP Q26997 Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGPRT) n/a
155 Q9YGA6_POP Q9YGA6 Trehalose/maltose import ATP-binding n/a
156 Q7CKJ1_POP Q7CKJ1 Dihydropteroate synthase (DHPS) n/a
157 Q3JUV5_POP Q3JUV5 Inorganic pyrophosphatase (EC n/a
158 M1JS91_POP M1JS91 Farnesyl pyrophosphate synthase n/a
159 P03313_POP P03313 Genome polyprotein [Cleaved n/a
160 P69848_POP P69848 GTP 3',8-cyclase (EC n/a
161 Q55928_POP Q55928 Bifunctional NMN adenylyltransferase/Nudix n/a
162 Q980Q4_POP Q980Q4 Uracil phosphoribosyltransferase (EC n/a
163 P04789_POP P04789 Triosephosphate isomerase, glycosomal n/a
164 Q5V8Y6_POP Q5V8Y6 RNA-directed RNA polymerase n/a
165 I1RDR8_POP I1RDR8 Terpene synthase (EC n/a
166 P9WHQ9_POP P9WHQ9 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) n/a
167 A5K709_POP A5K709 guanylate kinase (EC n/a
168 O81192_POP O81192 (+)-bornyl diphosphate synthase, n/a
169 M4T4U9_POP M4T4U9 Undecaprenyl diphosphate synthase n/a
170 A0A5S9I252_POP A0A5S9I252 Terpene cyclase 6 n/a
171 Q8RQE8_POP Q8RQE8 DNA-directed RNA polymerase n/a
172 A0A071L2P8_POP A0A071L2P8 GDP-6-deoxy-D-mannose reductase (EC n/a
173 Q9BXS1_POP Q9BXS1 Isopentenyl-diphosphate delta-isomerase 2 n/a
174 P11124_POP P11124 RNA-directed RNA polymerase n/a
175 Q53W80_POP Q53W80 Sugar ABC transporter, n/a
176 A0A011_POP A0A011 MoeO5 n/a
177 P9WI55_POP P9WI55 Inorganic pyrophosphatase (EC n/a
178 Q4QCD2_POP Q4QCD2 methionine--tRNA ligase (EC n/a
179 O57933_POP O57933 375aa long hypothetical n/a
180 I6YCM5_POP I6YCM5 deleted n/a
181 O28126_POP O28126 CCA-adding enzyme (EC n/a
182 A4IQU1_POP A4IQU1 Spore photoproduct lyase n/a