Ligand name: PYROPHOSPHATE
PDB ligand accession: PPV
DrugBank: DB04160
PubChem: 1023;21961011;
ChEMBL: CHEMBL1160571
InChI Key: XPPKVPWEQAFLFU-UHFFFAOYSA-N
SMILES: OP(=O)(O)OP(=O)(O)O

ClassyFire chemical classification:

• Kingdom: Inorganic compounds
  • Superclass: Homogeneous non-metal compounds
    • Class: Non-metal oxoanionic compounds
      • Subclass: Non-metal pyrophosphates

List of proteins that are targets for PPV

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P43490_PPV	P43490	Nicotinamide phosphoribosyltransferase (NAmPRTase)	n/a
2	P04050_PPV	P04050	DNA-directed RNA polymerase	n/a
3	Q04631_PPV	Q04631	Protein farnesyltransferase/geranylgeranyltransferase type-1	n/a
4	O22287_PPV	O22287	Mannose-1-phosphate guanylyltransferase 1	n/a
5	P07741_PPV	P07741	Adenine phosphoribosyltransferase (APRT)	n/a
6	A0A372DCN7_PPV	A0A372DCN7	LynF/TruF/PatF family peptide	n/a
7	Q59263_PPV	Q59263	Bifunctional riboflavin kinase/FMN	n/a
8	Q9LUE2_PPV	Q9LUE2	Terpenoid synthase 18	n/a
9	A0A0S7ASE9_PPV	A0A0S7ASE9	deleted	n/a
10	A3LNL5_PPV	A3LNL5	Decapping nuclease RAI1	n/a
11	P02281_PPV	P02281	Histone H2B 1.1	n/a
12	Q5UFR5_PPV	Q5UFR5	Cya1120 (EC 4.6.1.1)	n/a
13	Q4JA33_PPV	Q4JA33	Digeranylgeranylglycerophospholipid reductase (DGGGPL	n/a
14	A9GK58_PPV	A9GK58	10-epi-cubebol synthase (EC	n/a
15	A0A1Z0YU86_PPV	A0A1Z0YU86	Deoxyuridine 5'-triphosphate nucleotidohydrolase	n/a
16	Q12051_PPV	Q12051	Geranylgeranyl pyrophosphate synthase	n/a
17	P08518_PPV	P08518	DNA-directed RNA polymerase	n/a
18	A3MTM6_PPV	A3MTM6	Glycerol-1-phosphate dehydrogenase [NAD(P)+]	n/a
19	Q2FZ20_PPV	Q2FZ20	Polyribonucleotide nucleotidyltransferase (EC	n/a
20	A0A158RFK9_PPV	A0A158RFK9	Labdane-related diterpene synthase	n/a
21	A0A1U9AK63_PPV	A0A1U9AK63	Packaging NTPase	n/a
22	I1S104_PPV	I1S104	Longiborneol synthase CLM1	n/a
23	Q9WVY4_PPV	Q9WVY4	Lincosamide nucleotidyltransferase	n/a
24	Q5HSE9_PPV	Q5HSE9	deleted	n/a
25	Q5JHF1_PPV	Q5JHF1	Pantoate kinase (PoK)	n/a
26	P53559_PPV	P53559	6-carboxyhexanoate--CoA ligase (EC	n/a
27	A0A7J6JUK2_PPV	A0A7J6JUK2	proline--tRNA ligase (EC	n/a
28	Q57V32_PPV	Q57V32	adenine phosphoribosyltransferase (EC	n/a
29	Q4WAR0_PPV	Q4WAR0	UDP-N-acetylglucosamine diphosphorylase (EC	n/a
30	P06746_PPV	P06746	DNA polymerase beta	n/a
31	Q0QEE1_PPV	Q0QEE1	Genome polyprotein	n/a
32	X2KZJ9_PPV	X2KZJ9	UTP--glucose-1-phosphate uridylyltransferase (EC	n/a
33	Q9RY20_PPV	Q9RY20	Polyphosphate kinase-2-related domain-containing	n/a
34	A0AAJ6N6A9_PPV	A0AAJ6N6A9	Terpene synthase (EC	n/a
35	Q9UGP5_PPV	Q9UGP5	DNA polymerase lambda	n/a
36	O08315_PPV	O08315	GTP cyclohydrolase-2 (EC	n/a
37	Q9SBR3_PPV	Q9SBR3	Geranyl diphosphate synthase	n/a
38	P05058_PPV	P05058	Kanamycin nucleotidyltransferase (EC	n/a
39	B5HDJ6_PPV	B5HDJ6	Selina-4(15),7(11)-diene synthase ((2E,6E)-farnesyl	n/a
40	P07884_PPV	P07884	tRNA dimethylallyltransferase (DMATase)	n/a
41	C9K1X5_PPV	C9K1X5	Cyclooctat-9-en-7-ol synthase (EC	n/a
42	Q6M1Q8_PPV	Q6M1Q8	deleted	n/a
43	Q02293_PPV	Q02293	Protein farnesyltransferase subunit	n/a
44	G4ENZ9_PPV	G4ENZ9	deleted	n/a
45	Q57514_PPV	Q57514	Kanamycin nucleotidyltransferase	n/a
46	Q980A5_PPV	Q980A5	Translation initiation factor	n/a
47	P0A776_PPV	P0A776	RNA pyrophosphohydrolase (EC	n/a
48	Q9NP87_PPV	Q9NP87	DNA-directed DNA/RNA polymerase	n/a
49	L7W5I6_PPV	L7W5I6	Polyprenyl synthetase	n/a
50	Q56366_PPV	Q56366	DNA polymerase (EC	n/a
51	Q9WYV0_PPV	Q9WYV0	UvrABC system protein	n/a
52	P31153_PPV	P31153	S-adenosylmethionine synthase isoform	n/a
53	Q9FT89_PPV	Q9FT89	Solanesyl diphosphate synthase	n/a
54	P0AFC0_PPV	P0AFC0	Dihydroneopterin triphosphate diphosphatase	n/a
55	A0R5T1_PPV	A0R5T1	DNA polymerase LigD,	n/a