Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: PROLINE
PDB ligand accession: PRO
DrugBank: DB00172
PubChem: 145742;6971047;
ChEMBL: CHEMBL54922
InChI Key: ONIBWKKTOPOVIA-BYPYZUCNSA-N
SMILES: C1CC(NC1)C(=O)O

ClassyFire chemical classification:

List of proteins that are targets for PRO

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 A0A0R1IQH8_PRO A0A0R1IQH8 deleted n/a
2 Q8I5R7_PRO Q8I5R7 Proline--tRNA ligase (PfPRS) n/a
3 Q08499_PRO Q08499 3',5'-cyclic-AMP phosphodiesterase 4D n/a
4 P0AEX9_PRO P0AEX9 Maltose/maltodextrin-binding periplasmic protein n/a
5 Q12125_PRO Q12125 Golgi to ER n/a
6 P11974_PRO P11974 Pyruvate kinase PKM n/a
7 F8W4B7_PRO F8W4B7 Histone deacetylase 6 n/a
8 P00734_PRO P00734 Prothrombin (EC 3.4.21.5) n/a
9 O95149_PRO O95149 Snurportin-1 (RNA U n/a
10 P62937_PRO P62937 Peptidyl-prolyl cis-trans isomerase binder
11 P14127_PRO P14127 Small ribosomal subunit n/a
12 P96084_PRO P96084 Proline iminopeptidase (PIP) n/a
13 P0DTC2_PRO P0DTC2 Spike glycoprotein (S n/a
14 P00698_PRO P00698 Lysozyme C (EC n/a
15 P30419_PRO P30419 Glycylpeptide N-tetradecanoyltransferase 1 n/a
16 Q8A861_PRO Q8A861 L-Ala-D/L-Glu epimerase (AE n/a
17 A0A7J6JUK2_PRO A0A7J6JUK2 proline--tRNA ligase (EC n/a
18 Q2A612_PRO Q2A612 deleted n/a
19 P0A7L0_PRO P0A7L0 Large ribosomal subunit n/a
20 P07814_PRO P07814 Bifunctional glutamate/proline--tRNA ligase n/a
21 G0S4M2_PRO G0S4M2 Ribosomal RNA-processing protein n/a
22 Q92ZP9_PRO Q92ZP9 Stachydrine N-demethylase (EC n/a
23 O14980_PRO O14980 Exportin-1 (Exp1) (Chromosome n/a
24 Q9AJ26_PRO Q9AJ26 EscU (EscU/YscU/HrcU family n/a
25 A0A2V0QX35_PRO A0A2V0QX35 deleted n/a
26 P07751_PRO P07751 Spectrin alpha chain, n/a
27 B2HF11_PRO B2HF11 Molecular chaperone (Small n/a
28 P14779_PRO P14779 Bifunctional cytochrome P450/NADPH--P450 n/a
29 Q5NF57_PRO Q5NF57 Pantothenate synthetase (PS) n/a
30 Q5SI02_PRO Q5SI02 L-glutamate gamma-semialdehyde dehydrogenase n/a
31 O93970_PRO O93970 Peptidyl-prolyl cis-trans isomerase n/a
32 Q95460_PRO Q95460 Major histocompatibility complex n/a
33 A0A4V8H034_PRO A0A4V8H034 proline--tRNA ligase (EC n/a
34 Q9NW38_PRO Q9NW38 E3 ubiquitin-protein ligase n/a
35 Q5SM28_PRO Q5SM28 Proline--tRNA ligase (EC n/a
36 P02407_PRO P02407 Small ribosomal subunit n/a
37 P11838_PRO P11838 Endothiapepsin (EC 3.4.23.22) n/a
38 Q9HTW6_PRO Q9HTW6 Xaa-Pro aminopeptidase (EC n/a
39 P09546_PRO P09546 Bifunctional protein PutA n/a
40 P14618_PRO P14618 Pyruvate kinase PKM n/a
41 P83849_PRO P83849 L-glutamate gamma-semialdehyde dehydrogenase n/a
42 Q9YCJ0_PRO Q9YCJ0 Oxidoreductase n/a
43 B3LI22_PRO B3LI22 Small ribosomal subunit n/a
44 B7T1P0_PRO B7T1P0 Erythrocyte membrane protein n/a
45 Q5W271_PRO Q5W271 L-prolyl-[peptidyl-carrier protein] dehydrogenase n/a
46 P12955_PRO P12955 Xaa-Pro dipeptidase (X-Pro n/a
47 P0ACJ8_PRO P0ACJ8 DNA-binding transcriptional dual n/a
48 P46882_PRO P46882 Monoamine oxidase N n/a
49 P0CX53_PRO P0CX53 Large ribosomal subunit n/a
50 Q830N9_PRO Q830N9 Thioredoxin reductase/glutathione-related protein n/a
51 P14639_PRO P14639 Albumin n/a
52 Q7YZ69_PRO Q7YZ69 deleted n/a
53 P05092_PRO P05092 Peptidyl-prolyl cis-trans isomerase n/a
54 Q89E26_PRO Q89E26 Bifunctional protein PutA n/a
55 P32322_PRO P32322 Pyrroline-5-carboxylate reductase 1, n/a
56 A0A0E2ZLH6_PRO A0A0E2ZLH6 deleted n/a
57 Q7CX36_PRO Q7CX36 ABC transporter, substrate n/a
58 Q9A1S9_PRO Q9A1S9 Pyrroline-5-carboxylate reductase (P5C n/a
59 F7X6I3_PRO F7X6I3 Bifunctional protein PutA n/a
60 Q51714_PRO Q51714 prolyl oligopeptidase (EC n/a
61 Q3K7T6_PRO Q3K7T6 Putative methyl-accepting chemotaxis n/a
62 A3FQ68_PRO A3FQ68 Peptidyl-prolyl cis-trans isomerase n/a
63 K5ZWV5_PRO K5ZWV5 Beta-galactosidase n/a
64 B3VHM9_PRO B3VHM9 Albumin n/a
65 Q12315_PRO Q12315 mRNA export factor n/a
66 P11347_PRO P11347 Nitrogenase molybdenum-iron protein n/a
67 P11172_PRO P11172 Uridine 5'-monophosphate synthase n/a
68 P22515_PRO P22515 Ubiquitin-activating enzyme E1 n/a
69 Q6F3I7_PRO Q6F3I7 Dipeptidyl aminopeptidase 4 n/a
70 P52011_PRO P52011 Peptidyl-prolyl cis-trans isomerase n/a
71 A0A4P1LXE0_PRO A0A4P1LXE0 Maltodextrin-binding protein n/a
72 Q15233_PRO Q15233 Non-POU domain-containing octamer-binding n/a
73 Q989T9_PRO Q989T9 L-proline cis-4-hydroxylase (P4H) n/a
74 Q28943_PRO Q28943 Dihydropyrimidine dehydrogenase [NADP(+)] n/a
75 H3ZMH5_PRO H3ZMH5 Proline racemase n/a
76 Q08745_PRO Q08745 Small ribosomal subunit n/a
77 P24300_PRO P24300 Xylose isomerase (EC n/a
78 G7KRM5_PRO G7KRM5 Pyrroline-5-carboxylate reductase (EC n/a
79 Q8CHT0_PRO Q8CHT0 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial n/a
80 Q9SJQ9_PRO Q9SJQ9 Fructose-bisphosphate aldolase 6, n/a
81 A7YT55_PRO A7YT55 Hdac6 protein n/a
82 Q8A9T8_PRO Q8A9T8 Clostripain-related protein n/a
83 S5TUM1_PRO S5TUM1 Phytanoyl-CoA dioxygenase n/a
84 H3ZMH3_PRO H3ZMH3 Ornithine cyclodeaminase family n/a
85 P23687_PRO P23687 Prolyl endopeptidase (PE) n/a
86 Q3MFZ5_PRO Q3MFZ5 Amino acid/amide ABC n/a
87 A0A379CIH2_PRO A0A379CIH2 Formate--tetrahydrofolate ligase (EC n/a
88 P12821_PRO P12821 Angiotensin-converting enzyme (ACE) n/a Ki(nM) = 86000.0
89 P32905_PRO P32905 Small ribosomal subunit n/a
90 A0A0H6VSA0_PRO A0A0H6VSA0 deleted n/a
91 P29066_PRO P29066 Beta-arrestin-1 (Arrestin beta-1) n/a
92 Q13526_PRO Q13526 Peptidyl-prolyl cis-trans isomerase n/a
93 A0A3S5WQC2_PRO A0A3S5WQC2 diguanylate cyclase (EC n/a
94 O86049_PRO O86049 BFT-3 (Metalloprotease) n/a
95 P15034_PRO P15034 Xaa-Pro aminopeptidase (EC n/a
96 Q9UDR5_PRO Q9UDR5 Alpha-aminoadipic semialdehyde synthase, n/a
97 D9UBW0_PRO D9UBW0 Lysine cyclodeaminase (EC n/a