Ligand name: 3,5,7,3',4'-PENTAHYDROXYFLAVONE
PDB ligand accession: QUE
DrugBank: DB04216
PubChem: 5280343
ChEMBL: CHEMBL50
InChI Key: REFJWTPEDVJJIY-UHFFFAOYSA-N
SMILES: c1cc(c(cc1C2=C(C(=O)c3c(cc(cc3O2)O)O)O)O)O

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Phenylpropanoids and polyketides
    • Class: Flavonoids
      • Subclass: Flavones

List of proteins that are targets for QUE

#	DrugDomain Data	UniProt Accession	Protein name	Drug Action	Affinity data
1	P16083_QUE	P16083	Ribosyldihydronicotinamide dehydrogenase [quinone]	inhibitor
2	Q8NFU5_QUE	Q8NFU5	Inositol polyphosphate multikinase	n/a	IC50(nM) = 2300.0
3	P02766_QUE	P02766	Transthyretin (ATTR) (Prealbumin)	n/a
4	O02697_QUE	O02697	Phosphatidylinositol 4,5-bisphosphate 3-kinase	n/a
5	P80457_QUE	P80457	Xanthine dehydrogenase/oxidase [Includes:	n/a	Ki(nM) = 1200.0 IC50(nM) = 31900.0
6	Q9LNE6_QUE	Q9LNE6	Flavonol 7-O-rhamnosyltransferase (EC	n/a
7	A2VA43_QUE	A2VA43	Quercetinase QueD	n/a
8	O68183_QUE	O68183	APH(2'')-Id	n/a
9	P68400_QUE	P68400	Casein kinase II	n/a	Ki(nM) = 1180.0
10	O00303_QUE	O00303	Eukaryotic translation initiation	n/a
11	Q6VT83_QUE	Q6VT83	Ara h 8	n/a
12	P07900_QUE	P07900	Heat shock protein	n/a
13	O94768_QUE	O94768	Serine/threonine-protein kinase 17B	n/a
14	P06576_QUE	P06576	ATP synthase F(1)	n/a
15	Q15393_QUE	Q15393	Splicing factor 3B	n/a
16	Q16678_QUE	Q16678	Cytochrome P450 1B1	n/a	Ki(nM) = 23.0 IC50(nM) = 77.0 EC50(nM) = 1100.0
17	E9NWK5_QUE	E9NWK5	Beta-lactamase NDM-1 (Metallo	n/a
18	P00829_QUE	P00829	ATP synthase F(1)	n/a
19	P60709_QUE	P60709	Actin, cytoplasmic 1	n/a
20	P08631_QUE	P08631	Tyrosine-protein kinase HCK	n/a
21	Q9Y230_QUE	Q9Y230	RuvB-like 2 (EC	n/a
22	P53355_QUE	P53355	Death-associated protein kinase	n/a	IC50(nM) = 8900.0
23	P0DTC1_QUE	P0DTC1	Replicase polyprotein 1a	n/a
24	Q9AIU0_QUE	Q9AIU0	HTH-type transcriptional regulator	n/a
25	O22304_QUE	O22304	Anthocyanidin 3-O-glucosyltransferase UFGT	n/a
26	P05631_QUE	P05631	ATP synthase F(1)	n/a
27	P11309_QUE	P11309	Serine/threonine-protein kinase pim-1	n/a	IC50(nM) = 43.0 Kd(nM) = 25.0
28	P67870_QUE	P67870	Casein kinase II	n/a
29	P36542_QUE	P36542	ATP synthase F(1)	n/a
30	O75469_QUE	O75469	Nuclear receptor subfamily	activator
31	Q96323_QUE	Q96323	Leucoanthocyanidin dioxygenase (LDOX)	n/a
32	P32361_QUE	P32361	Serine/threonine-protein kinase/endoribonuclease IRE1	n/a
33	P19483_QUE	P19483	ATP synthase F(1)	n/a
34	P00749_QUE	P00749	Urokinase-type plasminogen activator	n/a	IC50(nM) = 12100.0
35	P93799_QUE	P93799	Flavanone 4-reductase (EC	n/a
36	Q8N6T7_QUE	Q8N6T7	NAD-dependent protein deacylase	n/a	IC50(nM) = 1900.0 EC50(nM) = 990000.0
37	P22314_QUE	P22314	Ubiquitin-like modifier-activating enzyme	n/a
38	P03372_QUE	P03372	Estrogen receptor (ER)	n/a
39	P35869_QUE	P35869	Aryl hydrocarbon receptor	n/a
40	P40947_QUE	P40947	Single-stranded DNA-binding protein	n/a
41	P48736_QUE	P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase	n/a	IC50(nM) = 3800.0 Kd(nM) = 280.0
42	P46422_QUE	P46422	Glutathione S-transferase F2	n/a
43	P25705_QUE	P25705	ATP synthase F(1)	n/a
44	Q8IXJ6_QUE	Q8IXJ6	NAD-dependent protein deacetylase	n/a
45	P00489_QUE	P00489	Glycogen phosphorylase, muscle	n/a
46	Q6NVY1_QUE	Q6NVY1	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	n/a
47	Q92731_QUE	Q92731	Estrogen receptor beta	n/a
48	Q6NUS8_QUE	Q6NUS8	UDP-glucuronosyltransferase 3A1 (UDPGT	n/a
49	Q7SIC2_QUE	Q7SIC2	Quercetin 2,3-dioxygenase (EC	n/a
50	Q5G940_QUE	Q5G940	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ	n/a
51	P04278_QUE	P04278	Sex hormone-binding globulin	n/a
52	P54652_QUE	P54652	Heat shock-related 70	n/a
53	P16152_QUE	P16152	Carbonyl reductase [NADPH]	n/a