Ligand name: S-ADENOSYLMETHIONINE
PDB ligand accession: SAM
DrugBank: DB00118
PubChem: n/a
ChEMBL: CHEMBL1235831
InChI Key: MEFKEPWMEQBLKI-FCKMPRQPSA-N
SMILES: C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Nucleosides, nucleotides, and analogues
    • Class: 5'-deoxyribonucleosides
      • Subclass: 5'-deoxy-5'-thionucleosides

List of proteins that are targets for SAM

#	DrugDomain Data	UniProt Accession	Drug Action	Affinity data
1	O57965_SAM	O57965	n/a
2	P75864_SAM	P75864	n/a
3	Q9H867_SAM	Q9H867	n/a
4	P35520_SAM	P35520	activator
5	A0A080VNW8_SAM	A0A080VNW8	n/a
6	P42596_SAM	P42596	n/a
7	V0ZE41_SAM	V0ZE41	n/a
8	Q9X0Z6_SAM	Q9X0Z6	n/a
9	O32036_SAM	O32036	n/a
10	H9M652_SAM	H9M652	n/a
11	Q96L73_SAM	Q96L73	n/a
12	A9AC61_SAM	A9AC61	n/a
13	Q8N4J0_SAM	Q8N4J0	n/a
14	A0A391FC11_SAM	A0A391FC11	n/a
15	O59493_SAM	O59493	n/a
16	O66653_SAM	O66653	n/a
17	O31474_SAM	O31474	n/a
18	U5HK48_SAM	U5HK48	n/a
19	Q8TBK2_SAM	Q8TBK2	n/a
20	P36979_SAM	P36979	n/a
21	Q5T8I9_SAM	Q5T8I9	n/a
22	P46597_SAM	P46597	n/a
23	O96028_SAM	O96028	n/a
24	Q980S9_SAM	Q980S9	n/a
25	C1KBQ3_SAM	C1KBQ3	n/a
26	Q86TU7_SAM	Q86TU7	n/a
27	P93324_SAM	P93324	n/a
28	C3SBW0_SAM	C3SBW0	n/a
29	Q97C13_SAM	Q97C13	n/a
30	P0ADR6_SAM	P0ADR6	n/a
31	P13009_SAM	P13009	n/a
32	H0Q7C9_SAM	H0Q7C9	n/a
33	Q58293_SAM	Q58293	n/a
34	P26358_SAM	P26358	n/a
35	A5K867_SAM	A5K867	n/a
36	G9MQB8_SAM	G9MQB8	n/a
37	P38123_SAM	P38123	n/a
38	A0A0D6HIR7_SAM	A0A0D6HIR7	n/a
39	B9MNH4_SAM	B9MNH4	n/a
40	Q5SL84_SAM	Q5SL84	n/a
41	Q9X1Q6_SAM	Q9X1Q6	n/a
42	P22087_SAM	P22087	n/a
43	B5L6K6_SAM	B5L6K6	n/a
44	Q8U248_SAM	Q8U248	n/a
45	G0SDW4_SAM	G0SDW4	n/a
46	Q8G907_SAM	Q8G907	n/a
47	P05769_SAM	P05769	n/a
48	Q9H9B1_SAM	Q9H9B1	n/a
49	Q8KNF4_SAM	Q8KNF4	n/a
50	Q7M0R2_SAM	Q7M0R2	n/a
51	Q4FZB7_SAM	Q4FZB7	n/a
52	Q6CIT4_SAM	Q6CIT4	n/a
53	H9A910_SAM	H9A910	n/a
54	O29998_SAM	O29998	n/a
55	A0A0H3U5V8_SAM	A0A0H3U5V8	n/a
56	Q5SLS0_SAM	Q5SLS0	n/a
57	Q5ZUS4_SAM	Q5ZUS4	n/a
58	Q8SR66_SAM	Q8SR66	n/a
59	P52391_SAM	P52391	n/a
60	Q8ZD36_SAM	Q8ZD36	n/a
61	P18644_SAM	P18644	n/a
62	Q8EGW3_SAM	Q8EGW3	n/a
63	Q89Z59_SAM	Q89Z59	n/a
64	P0A817_SAM	P0A817	n/a
65	Q3ABV3_SAM	Q3ABV3	n/a
66	Q9FAC4_SAM	Q9FAC4	n/a
67	C8XPB0_SAM	C8XPB0	n/a
68	Q08282_SAM	Q08282	n/a
69	Q86VU5_SAM	Q86VU5	n/a
70	P9WJZ7_SAM	P9WJZ7	n/a
71	Q9CCZ4_SAM	Q9CCZ4	n/a
72	A0EKU1_SAM	A0EKU1	n/a
73	D3T7F1_SAM	D3T7F1	n/a
74	C5Z4W3_SAM	C5Z4W3	n/a
75	Q6T755_SAM	Q6T755	n/a
76	O05979_SAM	O05979	n/a
77	Q8WTS6_SAM	Q8WTS6	n/a
78	O58523_SAM	O58523	n/a
79	Q7DBA6_SAM	Q7DBA6	n/a
80	P43912_SAM	P43912	n/a
81	P04043_SAM	P04043	n/a
82	P0A8U6_SAM	P0A8U6	n/a
83	Q9NRN9_SAM	Q9NRN9	n/a
84	Q5SI81_SAM	Q5SI81	n/a
85	Q6CLY5_SAM	Q6CLY5	n/a
86	Q9H7B4_SAM	Q9H7B4	n/a
87	Q91L20_SAM	Q91L20	n/a
88	Q9WYV8_SAM	Q9WYV8	n/a
89	P12996_SAM	P12996	n/a
90	C9E871_SAM	C9E871	n/a
91	Q57564_SAM	Q57564	n/a
92	A0A0A1DYG7_SAM	A0A0A1DYG7	n/a
93	Q9WZX6_SAM	Q9WZX6	n/a
94	Q46E78_SAM	Q46E78	n/a
95	P42898_SAM	P42898	n/a
96	Q5LES9_SAM	Q5LES9	n/a
97	Q5SJD8_SAM	Q5SJD8	n/a
98	Q57913_SAM	Q57913	n/a
99	A0A0J5Q3C4_SAM	A0A0J5Q3C4	n/a
100	P08957_SAM	P08957	n/a
101	A0A8J1LTD2_SAM	A0A8J1LTD2	n/a
102	Q9ZGH6_SAM	Q9ZGH6	n/a
103	Q9XBQ8_SAM	Q9XBQ8	n/a
104	P41212_SAM	P41212	n/a
105	Q8TEA1_SAM	Q8TEA1	n/a
106	O60016_SAM	O60016	n/a
107	Q06528_SAM	Q06528	n/a
108	A0A1B2TT09_SAM	A0A1B2TT09	n/a
109	Q7T918_SAM	Q7T918	n/a
110	O88491_SAM	O88491	n/a
111	Q9BVS5_SAM	Q9BVS5	n/a
112	O14744_SAM	O14744	n/a
113	Q9K5E4_SAM	Q9K5E4	n/a
114	Q8QL64_SAM	Q8QL64	n/a
115	C7Q5P8_SAM	C7Q5P8	n/a
116	Q9NRG4_SAM	Q9NRG4	n/a
117	Q8RJY2_SAM	Q8RJY2	n/a
118	Q5LVY3_SAM	Q5LVY3	n/a
119	C0JV69_SAM	C0JV69	n/a
120	G8T6H8_SAM	G8T6H8	n/a
121	A0A7I9D0Y8_SAM	A0A7I9D0Y8	n/a
122	Q04081_SAM	Q04081	n/a
123	A0A062UZ78_SAM	A0A062UZ78	n/a
124	A0A0Z8EWX1_SAM	A0A0Z8EWX1	n/a
125	C5YH12_SAM	C5YH12	n/a
126	O28192_SAM	O28192	n/a
127	Q47KX2_SAM	Q47KX2	n/a
128	O67010_SAM	O67010	n/a
129	Q12314_SAM	Q12314	n/a
130	B7MFQ9_SAM	B7MFQ9	n/a
131	P65388_SAM	P65388	n/a
132	Q9NQV7_SAM	Q9NQV7	n/a
133	Q9HGR1_SAM	Q9HGR1	n/a
134	Q9NW70_SAM	Q9NW70	n/a
135	Q58952_SAM	Q58952	n/a
136	Q8N1G2_SAM	Q8N1G2	n/a
137	Q5JID5_SAM	Q5JID5	n/a
138	A0A0G9F5E5_SAM	A0A0G9F5E5	n/a
139	C4TPE0_SAM	C4TPE0	n/a
140	A0A6L9JR93_SAM	A0A6L9JR93	n/a
141	Q6LY14_SAM	Q6LY14	n/a
142	Q8TZR3_SAM	Q8TZR3	n/a
143	Q5SKW0_SAM	Q5SKW0	n/a
144	O67789_SAM	O67789	n/a
145	Q9UI43_SAM	Q9UI43	n/a
146	Q96KQ7_SAM	Q96KQ7	n/a
147	P23192_SAM	P23192	n/a
148	Q8A3I2_SAM	Q8A3I2	n/a
149	Q12009_SAM	Q12009	n/a
150	Q643C8_SAM	Q643C8	n/a
151	O59416_SAM	O59416	n/a
152	P36999_SAM	P36999	n/a
153	P62805_SAM	P62805	n/a
154	Q5NF57_SAM	Q5NF57	n/a
155	Q84HC8_SAM	Q84HC8	n/a
156	O52805_SAM	O52805	n/a
157	O85726_SAM	O85726	n/a
158	A0A1D3F5D3_SAM	A0A1D3F5D3	n/a
159	O24770_SAM	O24770	n/a
160	Q6ICE6_SAM	Q6ICE6	n/a
161	S6G476_SAM	S6G476	n/a
162	O58832_SAM	O58832	n/a
163	Q6N6X2_SAM	Q6N6X2	n/a
164	O67440_SAM	O67440	n/a
165	Q8VZ17_SAM	Q8VZ17	n/a
166	A8C927_SAM	A8C927	n/a
167	Q8TZW1_SAM	Q8TZW1	n/a
168	Q92800_SAM	Q92800	n/a
169	P0C6X7_SAM	P0C6X7	n/a
170	O33253_SAM	O33253	n/a
171	P60390_SAM	P60390	n/a
172	P84233_SAM	P84233	n/a
173	O31423_SAM	O31423	n/a
174	Q43088_SAM	Q43088	n/a
175	P27915_SAM	P27915	n/a
176	A0A0J8AIC3_SAM	A0A0J8AIC3	n/a
177	P0A8I5_SAM	P0A8I5	n/a
178	F6KV61_SAM	F6KV61	n/a
179	P11086_SAM	P11086	n/a
180	P37634_SAM	P37634	n/a
181	C3MWA1_SAM	C3MWA1	n/a
182	Q5ZRE6_SAM	Q5ZRE6	n/a
183	Q97T38_SAM	Q97T38	n/a
184	Q9F5K6_SAM	Q9F5K6	n/a
185	Q5JD38_SAM	Q5JD38	n/a
186	C5W761_SAM	C5W761	n/a
187	A4X3Q0_SAM	A4X3Q0	n/a
188	Q8R9Q4_SAM	Q8R9Q4	n/a
189	Q914N6_SAM	Q914N6	n/a
190	Q06287_SAM	Q06287	n/a
191	B1MDI3_SAM	B1MDI3	n/a
192	A0A140E7U5_SAM	A0A140E7U5	n/a
193	O34522_SAM	O34522	n/a
194	Q2FXG9_SAM	Q2FXG9	n/a
195	Q9Y9U3_SAM	Q9Y9U3	n/a
196	P0DTD1_SAM	P0DTD1	n/a
197	P32131_SAM	P32131	n/a
198	I3PLQ5_SAM	I3PLQ5	n/a
199	O95568_SAM	O95568	n/a
200	Q5SII2_SAM	Q5SII2	n/a
201	Q59034_SAM	Q59034	n/a
202	P36929_SAM	P36929	n/a
203	E0TY72_SAM	E0TY72	n/a
204	A0A6V8RR65_SAM	A0A6V8RR65	n/a
205	Q04089_SAM	Q04089	n/a
206	B3L8G9_SAM	B3L8G9	n/a
207	Q9UNQ2_SAM	Q9UNQ2	n/a
208	Q6WB93_SAM	Q6WB93	n/a
209	P38238_SAM	P38238	n/a
210	Q86U44_SAM	Q86U44	n/a
211	A0A0E3UPZ3_SAM	A0A0E3UPZ3	n/a
212	A0A1U7N2Z8_SAM	A0A1U7N2Z8	n/a
213	Q7L0Y3_SAM	Q7L0Y3	n/a
214	Q9S7B5_SAM	Q9S7B5	n/a
215	A0A192GPS6_SAM	A0A192GPS6	n/a
216	A0A174NUT3_SAM	A0A174NUT3	n/a
217	Q9LYU8_SAM	Q9LYU8	n/a
218	A0A364MK46_SAM	A0A364MK46	n/a
219	Q8WVM0_SAM	Q8WVM0	n/a
220	O34614_SAM	O34614	n/a
221	A0A0K1YW34_SAM	A0A0K1YW34	n/a
222	Q4DA73_SAM	Q4DA73	n/a
223	P05102_SAM	P05102	n/a
224	P14751_SAM	P14751	n/a
225	P0C1V0_SAM	P0C1V0	n/a
226	Q79N53_SAM	Q79N53	n/a
227	A0A146CJG7_SAM	A0A146CJG7	n/a
228	O26771_SAM	O26771	n/a
229	B9U1J2_SAM	B9U1J2	n/a
230	B8NJH3_SAM	B8NJH3	n/a
231	Q6NIF5_SAM	Q6NIF5	n/a
232	P58032_SAM	P58032	n/a
233	A0A2R2JFI5_SAM	A0A2R2JFI5	n/a
234	Q8JZM0_SAM	Q8JZM0	n/a
235	P46959_SAM	P46959	n/a
236	D3KYU3_SAM	D3KYU3	n/a
237	P31153_SAM	P31153	cofactor
238	A0A5S8WF76_SAM	A0A5S8WF76	n/a
239	Q8SRR4_SAM	Q8SRR4	n/a
240	A9LIE0_SAM	A9LIE0	n/a
241	K0BWD0_SAM	K0BWD0	n/a
242	P17562_SAM	P17562	n/a
243	Q9BYW2_SAM	Q9BYW2	n/a
244	A0A446F868_SAM	A0A446F868	n/a
245	P95748_SAM	P95748	n/a
246	Q8UIF7_SAM	Q8UIF7	n/a
247	O57712_SAM	O57712	n/a
248	P49017_SAM	P49017	n/a
249	Q6NDF6_SAM	Q6NDF6	n/a
250	Q9LCY2_SAM	Q9LCY2	n/a
251	P37468_SAM	P37468	n/a
252	Q70GK9_SAM	Q70GK9	n/a
253	Q3IV08_SAM	Q3IV08	n/a
254	A0A0N0C224_SAM	A0A0N0C224	n/a
255	Q8TCB7_SAM	Q8TCB7	n/a
256	Q9UIC8_SAM	Q9UIC8	n/a
257	Q54527_SAM	Q54527	n/a
258	P25627_SAM	P25627	n/a
259	Q9BZ95_SAM	Q9BZ95	n/a
260	Q9NQR1_SAM	Q9NQR1	n/a
261	Q194Q4_SAM	Q194Q4	n/a
262	O66552_SAM	O66552	n/a
263	A0A0H3JXA8_SAM	A0A0H3JXA8	n/a
264	Q8GBB2_SAM	Q8GBB2	n/a
265	Q8IEL9_SAM	Q8IEL9	n/a
266	B1C2R2_SAM	B1C2R2	n/a
267	P14583_SAM	P14583	n/a
268	Q96CB9_SAM	Q96CB9	n/a
269	P14385_SAM	P14385	n/a
270	A0A125SA05_SAM	A0A125SA05	n/a
271	Q8TEK3_SAM	Q8TEK3	n/a
272	P13956_SAM	P13956	n/a
273	Q5VVY1_SAM	Q5VVY1	n/a
274	Q9H5I1_SAM	Q9H5I1	n/a
275	I6XG39_SAM	I6XG39	n/a
276	C9QPQ6_SAM	C9QPQ6	n/a
277	P21964_SAM	P21964	cofactor
278	O67624_SAM	O67624	n/a
279	Q02RL6_SAM	Q02RL6	n/a
280	O29206_SAM	O29206	n/a
281	P69848_SAM	P69848	n/a
282	Q0TTH1_SAM	Q0TTH1	n/a
283	A7RNF3_SAM	A7RNF3	n/a
284	P28692_SAM	P28692	n/a
285	O58214_SAM	O58214	n/a
286	A3DDA2_SAM	A3DDA2	n/a
287	P67087_SAM	P67087	n/a
288	P13864_SAM	P13864	n/a
289	Q8XDG3_SAM	Q8XDG3	n/a
290	D7PC21_SAM	D7PC21	n/a
291	E4THH1_SAM	E4THH1	n/a
292	Q5FAC0_SAM	Q5FAC0	n/a
293	Q8U4M1_SAM	Q8U4M1	n/a
294	O24891_SAM	O24891	n/a
295	A0A1B1AYF2_SAM	A0A1B1AYF2	n/a
296	Q5CKX0_SAM	Q5CKX0	n/a
297	Q79FX8_SAM	Q79FX8	n/a
298	Q47592_SAM	Q47592	n/a
299	Q58435_SAM	Q58435	n/a
300	Q8U4M2_SAM	Q8U4M2	n/a
301	Q86Y97_SAM	Q86Y97	n/a
302	Q9UBP6_SAM	Q9UBP6	n/a
303	Q3U8K7_SAM	Q3U8K7	n/a
304	Q8Y6U9_SAM	Q8Y6U9	n/a
305	P22734_SAM	P22734	n/a
306	Q97PJ9_SAM	Q97PJ9	n/a
307	A0A979HMS8_SAM	A0A979HMS8	n/a
308	A6L5C0_SAM	A6L5C0	n/a
309	P07617_SAM	P07617	n/a
310	Q9NR48_SAM	Q9NR48	n/a
311	Q6F5A0_SAM	Q6F5A0	n/a
312	Q84BQ9_SAM	Q84BQ9	n/a
313	Q9Y5N5_SAM	Q9Y5N5	n/a
314	Q00266_SAM	Q00266	cofactor
315	P0A9N4_SAM	P0A9N4	n/a
316	O42898_SAM	O42898	n/a
317	Q5SKI6_SAM	Q5SKI6	n/a
318	B2NE58_SAM	B2NE58	n/a
319	Q8KGE0_SAM	Q8KGE0	n/a
320	A3DDW1_SAM	A3DDW1	n/a
321	P13255_SAM	P13255	n/a
322	Q55467_SAM	Q55467	n/a
323	Q9V1J7_SAM	Q9V1J7	n/a
324	Q92SJ4_SAM	Q92SJ4	n/a