Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: SINEFUNGIN
PDB ligand accession: SFG
DrugBank: DB01910
PubChem: 65482
ChEMBL: CHEMBL1214186
InChI Key: LMXOHSDXUQEUSF-YECHIGJVSA-N
SMILES: c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O)N

ClassyFire chemical classification:

List of proteins that are targets for SFG

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 O57712_SFG O57712 tRNA (cytosine(72)-C(5))-methyltransferase (tRNA:m(5)C72 n/a
2 Q6DFW7_SFG Q6DFW7 Histone-lysine N-methyltransferase Smyd1 n/a
3 Q86TU7_SFG Q86TU7 Actin-histidine N-methyltransferase (EC n/a
4 Q79N53_SFG Q79N53 Erm(38) n/a
5 Q9H7B4_SFG Q9H7B4 Histone-lysine N-methyltransferase SMYD3 n/a
6 Q9H9B1_SFG Q9H9B1 Histone-lysine N-methyltransferase EHMT1 n/a
7 C1KBQ3_SFG C1KBQ3 Genome polyprotein n/a
8 B7MFQ9_SFG B7MFQ9 Ribosomal RNA large n/a
9 Q96KQ7_SFG Q96KQ7 Histone-lysine N-methyltransferase EHMT2 n/a
10 Q86X55_SFG Q86X55 Histone-arginine methyltransferase CARM1 n/a
11 P25397_SFG P25397 Tellurite methyltransferase (EC n/a
12 Q79FX8_SFG Q79FX8 Hydroxymycolate synthase MmaA4 n/a
13 B2MU09_SFG B2MU09 site-specific DNA-methyltransferase (adenine-specific) n/a
14 Q9BYW2_SFG Q9BYW2 Histone-lysine N-methyltransferase SETD2 n/a
15 P68431_SFG P68431 Histone H3.1 (Histone n/a
16 P22734_SFG P22734 Catechol O-methyltransferase (EC n/a
17 Q8R5A0_SFG Q8R5A0 N-lysine methyltransferase SMYD2 n/a
18 P21964_SFG P21964 Catechol O-methyltransferase (EC n/a
19 O58581_SFG O58581 450aa long hypothetical n/a
20 A0A1B0YUR2_SFG A0A1B0YUR2 Genome polyprotein n/a
21 P14385_SFG P14385 Type II methyltransferase n/a
22 P36566_SFG P36566 tRNA 5-carboxymethoxyuridine methyltransferase n/a
23 Q9Q6P4_SFG Q9Q6P4 Genome polyprotein [Cleaved n/a
24 Q9UBP6_SFG Q9UBP6 tRNA (guanine-N(7)-)-methyltransferase (EC n/a
25 Q9WVG6_SFG Q9WVG6 Histone-arginine methyltransferase CARM1 n/a
26 Q76KU6_SFG Q76KU6 DNA methyltransferase n/a
27 K0BWD0_SFG K0BWD0 ORF1ab polyprotein n/a
28 Q84BQ9_SFG Q84BQ9 Ribosomal protein L11 n/a
29 Q8WTS6_SFG Q8WTS6 Histone-lysine N-methyltransferase SETD7 n/a
30 Q8U248_SFG Q8U248 tRNA (guanine(6)-N2)-methyltransferase (EC n/a
31 Q6NZB1_SFG Q6NZB1 Protein arginine N-methyltransferase n/a
32 C8XPB0_SFG C8XPB0 Genome polyprotein n/a
33 Q8N4J0_SFG Q8N4J0 Carnosine N-methyltransferase (EC n/a
34 O96028_SFG O96028 Histone-lysine N-methyltransferase NSD2 n/a
35 P0C6X6_SFG P0C6X6 Replicase polyprotein 1ab n/a
36 O43148_SFG O43148 mRNA cap guanine-N(7) n/a
37 Q54527_SFG Q54527 Aclacinomycin 10-hydroxylase RdmB n/a
38 O14744_SFG O14744 Protein arginine N-methyltransferase n/a
39 I6XFS7_SFG I6XFS7 RNA/DNA methyltransferase Rv2966c n/a
40 A0AAB0B2A3_SFG A0AAB0B2A3 site-specific DNA-methyltransferase (cytosine-N(4)-specific) n/a
41 A0AAB0B2A1_SFG A0AAB0B2A1 site-specific DNA-methyltransferase (cytosine-N(4)-specific) n/a
42 Q8TEA1_SFG Q8TEA1 tRNA (cytosine(72)-C(5))-methyltransferase NSUN6 n/a
43 O53532_SFG O53532 S-adenosylmethionine-dependent methyltransferase Rv2258c n/a
44 A0A2R2JFI5_SFG A0A2R2JFI5 Methyltransferase/ribosomally synthesized cyclic n/a
45 P26358_SFG P26358 DNA (cytosine-5)-methyltransferase 1 n/a
46 C4TPE0_SFG C4TPE0 Genome polyprotein n/a
47 H0Q7C9_SFG H0Q7C9 deleted n/a
48 P43912_SFG P43912 tRNA (guanine-N(1)-)-methyltransferase (EC n/a
49 A0A117KU88_SFG A0A117KU88 tRNA (Guanine(10)-N2)-dimethyltransferase n/a
50 Q02RL6_SFG Q02RL6 tRNA (guanine-N(1)-)-methyltransferase (EC n/a
51 O67010_SFG O67010 tRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase (EC n/a
52 Q8SR66_SFG Q8SR66 mRNA cap guanine-N(7) n/a
53 A0A072ZPM2_SFG A0A072ZPM2 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ n/a
54 P0DTD1_SFG P0DTD1 Replicase polyprotein 1ab n/a
55 Q86U44_SFG Q86U44 N(6)-adenosine-methyltransferase catalytic subunit n/a
56 P14751_SFG P14751 Type II methyltransferase n/a
57 P9WGW9_SFG P9WGW9 Ribosomal RNA small n/a
58 P13009_SFG P13009 Methionine synthase (EC n/a
59 Q183J3_SFG Q183J3 site-specific DNA-methyltransferase (adenine-specific) n/a
60 A1L1Q4_SFG A1L1Q4 Protein arginine methyltransferase n/a
61 P41212_SFG P41212 Transcription factor ETV6 n/a
62 A8C927_SFG A8C927 16S rRNA (adenine(1408)-N(1))-methyltransferase n/a
63 P0A4X6_SFG P0A4X6 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC n/a
64 P04392_SFG P04392 DNA adenine methylase n/a
65 D3KYU3_SFG D3KYU3 Geranyl diphosphate 2-C-methyltransferase n/a
66 Q5WPU5_SFG Q5WPU5 Genome polyprotein [Cleaved n/a
67 K0BRZ6_SFG K0BRZ6 Genome polyprotein n/a
68 P0C6X7_SFG P0C6X7 Replicase polyprotein 1ab n/a
69 Q58293_SFG Q58293 tRNA (guanine(37)-N(1))-methyltransferase Trm5b n/a
70 O25315_SFG O25315 Adenine specific DNA n/a
71 A0A1B2TT09_SFG A0A1B2TT09 OxaC n/a
72 Q6T755_SFG Q6T755 Phosphoethanolamine N-methyltransferase (PfPMT) n/a
73 Q57977_SFG Q57977 Ribosomal RNA small n/a
74 P13956_SFG P13956 rRNA adenine N-6-methyltransferase n/a
75 Q60343_SFG Q60343 tRNA (cytosine(48)-C(5))-methyltransferase (EC n/a
76 A0A0F6N8X1_SFG A0A0F6N8X1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase n/a
77 Q43088_SFG Q43088 Ribulose-1,5 bisphosphate carboxylase/oxygenase n/a
78 O52805_SFG O52805 PCZA361.24 n/a