Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: SUCCINIC ACID
PDB ligand accession: SIN
DrugBank: DB00139
PubChem: 1110;21952380;
ChEMBL: CHEMBL576
InChI Key: KDYFGRWQOYBRFD-UHFFFAOYSA-N
SMILES: C(CC(=O)O)C(=O)O

ClassyFire chemical classification:

List of proteins that are targets for SIN

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P02751_SIN P02751 Fibronectin (FN) (Cold-insoluble n/a
2 O14976_SIN O14976 Cyclin-G-associated kinase (EC n/a
3 O50174_SIN O50174 N-succinylglutamate 5-semialdehyde dehydrogenase n/a
4 Q12737_SIN Q12737 Bilirubin oxidase (EC n/a
5 P53590_SIN P53590 Succinate--CoA ligase [GDP-forming] n/a
6 P0ABU0_SIN P0ABU0 1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA n/a
7 P00749_SIN P00749 Urokinase-type plasminogen activator n/a
8 Q9ZS17_SIN Q9ZS17 glutathione transferase (EC n/a
9 S5TUM1_SIN S5TUM1 Phytanoyl-CoA dioxygenase n/a
10 Q8CHT0_SIN Q8CHT0 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial n/a
11 G0S583_SIN G0S583 Uncharacterized protein n/a
12 Q9SI37_SIN Q9SI37 WRKY transcription factor n/a
13 T2D1F5_SIN T2D1F5 Glutamate dehydrogenase n/a
14 Q5YXQ1_SIN Q5YXQ1 Maleate isomerase (MI) n/a
15 P11974_SIN P11974 Pyruvate kinase PKM n/a
16 Q7CN02_SIN Q7CN02 deleted n/a
17 Q9I5L8_SIN Q9I5L8 Aldoketomutase (Glyoxalase I) n/a
18 Q9BXA5_SIN Q9BXA5 Succinate receptor 1 n/a
19 C7QJ42_SIN C7QJ42 L-lysine 3-hydroxylase (EC n/a
20 Q81GQ9_SIN Q81GQ9 Isocitrate lyase (EC n/a
21 P83223_SIN P83223 Fumarate reductase (cytochrome) n/a
22 O05435_SIN O05435 Probable peptidoglycan biosynthesis n/a
23 Q86Y07_SIN Q86Y07 Serine/threonine-protein kinase VRK2 n/a
24 Q5F6E9_SIN Q5F6E9 Transaldolase (EC 2.2.1.2) n/a
25 Q96323_SIN Q96323 Leucoanthocyanidin dioxygenase (LDOX) n/a
26 P21816_SIN P21816 Cysteine dioxygenase type n/a
27 P58486_SIN P58486 o-succinylbenzoate synthase (OSB n/a
28 Q7NDN8_SIN Q7NDN8 Proton-gated ion channel n/a
29 P52293_SIN P52293 Importin subunit alpha-1 n/a
30 P0AFL3_SIN P0AFL3 Peptidyl-prolyl cis-trans isomerase n/a
31 Q9SB64_SIN Q9SB64 Protein NBR1 homolog n/a
32 I6Y4H4_SIN I6Y4H4 deleted n/a
33 Q2MFS1_SIN Q2MFS1 Putative oxidase/hydroxylase n/a
34 P27616_SIN P27616 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC n/a
35 Q9RN67_SIN Q9RN67 SnoN n/a
36 A0A0U1X4V6_SIN A0A0U1X4V6 Putative beta-lactamase n/a
37 A3M8H2_SIN A3M8H2 Succinyl-diaminopimelate desuccinylase (SDAP n/a
38 C0QQ26_SIN C0QQ26 Metal dependent phosphohydrolase n/a
39 Q39VF8_SIN Q39VF8 Cyclic nucleotide-binding domain n/a
40 Q3K9A1_SIN Q3K9A1 Alkanesulfonate monooxygenase (EC n/a
41 Q9Y5Y4_SIN Q9Y5Y4 Prostaglandin D2 receptor n/a
42 Q89VB6_SIN Q89VB6 Blr1131 protein n/a
43 P05161_SIN P05161 Ubiquitin-like protein ISG15 n/a
44 D4L313_SIN D4L313 RNA-directed DNA polymerase n/a
45 O19069_SIN O19069 Succinate--CoA ligase [ADP/GDP-forming] n/a
46 Q8ECK4_SIN Q8ECK4 TRAP-type C4-dicarboxylate:H+ symport n/a
47 P00509_SIN P00509 Aspartate aminotransferase (AspAT) n/a
48 K4L7X3_SIN K4L7X3 3-sulfinopropanoyl-CoA desulfinase (EC n/a
49 C4NCJ7_SIN C4NCJ7 Beta-hydroxylase n/a
50 P59997_SIN P59997 Lysine-specific demethylase 2A n/a
51 Q11KV9_SIN Q11KV9 Argininosuccinate lyase (EC n/a
52 A0A1H0BKU7_SIN A0A1H0BKU7 ArpA protein n/a
53 D7RIG0_SIN D7RIG0 HLA class II n/a
54 A0A2D8IND4_SIN A0A2D8IND4 deleted n/a
55 Q9XJ43_SIN Q9XJ43 Hyoscyamine 6-beta-hydroxylase (EC n/a
56 P00698_SIN P00698 Lysozyme C (EC n/a
57 Q5AR53_SIN Q5AR53 Iron/alpha-ketoglutarate-dependent dioxygenase asqJ n/a
58 A0A7M4DUG9_SIN A0A7M4DUG9 Alginate lyase AlyC3 n/a
59 P75002_SIN P75002 Glucose--fructose oxidoreductase (GFOR) n/a
60 P0DTD1_SIN P0DTD1 Replicase polyprotein 1ab n/a
61 Q6DRA1_SIN Q6DRA1 Beta-lactamase (EC 3.5.2.6) n/a
62 P44514_SIN P44514 Succinyl-diaminopimelate desuccinylase (SDAP n/a
63 P05050_SIN P05050 Alpha-ketoglutarate-dependent dioxygenase AlkB n/a
64 B9L0X7_SIN B9L0X7 Lipase n/a
65 A0A0H5BL38_SIN A0A0H5BL38 Glycoside hydrolase family n/a
66 P00760_SIN P00760 Serine protease 1 n/a
67 Q8XYC3_SIN Q8XYC3 Cyclase n/a
68 D1AZL7_SIN D1AZL7 TRAP dicarboxylate transporter, n/a
69 I0CBY7_SIN I0CBY7 Clavaminate synthase 3 n/a
70 P25774_SIN P25774 Cathepsin S (EC n/a
71 Q5ZUE7_SIN Q5ZUE7 Dot/Icm T4SS effector n/a
72 P0A5H3_SIN P0A5H3 Isocitrate lyase (ICL) n/a
73 P10902_SIN P10902 L-aspartate oxidase (LASPO) n/a
74 G0S156_SIN G0S156 Nucleoporin NUP53 (Nuclear n/a
75 Q9WWU5_SIN Q9WWU5 Alpha-ketoglutarate-dependent sulfate ester n/a
76 P81461_SIN P81461 Concanavalin-A (Con A) n/a
77 Q8N371_SIN Q8N371 Bifunctional peptidase and n/a
78 Q9UIQ6_SIN Q9UIQ6 Leucyl-cystinyl aminopeptidase (Cystinyl n/a
79 Q8TF76_SIN Q8TF76 Serine/threonine-protein kinase haspin n/a
80 A0A0E3URV8_SIN A0A0E3URV8 Leucine hydroxylase n/a
81 P38247_SIN P38247 Protein SLM4 (EGO n/a
82 O95470_SIN O95470 Sphingosine-1-phosphate lyase 1 n/a
83 B0VCI2_SIN B0VCI2 deleted n/a
84 P21375_SIN P21375 Fumarate reductase 2 n/a
85 O53611_SIN O53611 Isocitrate dehydrogenase [NADP] n/a
86 A9SS48_SIN A9SS48 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase n/a
87 C7C419_SIN C7C419 Serpin H1 (Collagen-binding n/a
88 A0A3R9EDI8_SIN A0A3R9EDI8 Protease Lon-related BREX n/a
89 A0A0N9HQ36_SIN A0A0N9HQ36 Deoxypodophyllotoxin synthase (EC n/a
90 H9A910_SIN H9A910 Genome polyprotein [Cleaved n/a
91 P18548_SIN P18548 Deacetoxycephalosporin C synthase n/a
92 Q96I99_SIN Q96I99 Succinate--CoA ligase [GDP-forming] n/a
93 P53597_SIN P53597 Succinate--CoA ligase [ADP/GDP-forming] n/a
94 P14639_SIN P14639 Albumin n/a
95 Q9Y3Z3_SIN Q9Y3Z3 Deoxynucleoside triphosphate triphosphohydrolase n/a
96 Q4D3W2_SIN Q4D3W2 Dihydroorotate dehydrogenase (fumarate) n/a
97 P76621_SIN P76621 Glutarate 2-hydroxylase (G-2-H) n/a
98 Q6FLB1_SIN Q6FLB1 Transcription elongation factor n/a
99 P18079_SIN P18079 5-aminolevulinate synthase (EC n/a
100 Q9Z4Z5_SIN Q9Z4Z5 L-asparagine oxygenase (EC n/a
101 P32656_SIN P32656 Glutathione-specific gamma-glutamylcyclotransferase (Gamma-GCG) n/a
102 A0A125SA14_SIN A0A125SA14 Secreted hydrolase n/a
103 A0A0K0Q8K4_SIN A0A0K0Q8K4 deleted n/a
104 F7BAY6_SIN F7BAY6 Albumin n/a
105 A6P7M9_SIN A6P7M9 Sphingomyelinase C (EC n/a
106 Q4W8A1_SIN Q4W8A1 Voltage-sensor containing phosphatase n/a
107 Q2IUT5_SIN Q2IUT5 TRAP dicarboxylate transporter n/a
108 Q79N53_SIN Q79N53 Erm(38) n/a
109 P02754_SIN P02754 Beta-lactoglobulin (Beta-LG) (allergen n/a
110 Q8ZJZ9_SIN Q8ZJZ9 Aspartate racemase n/a
111 P13633_SIN P13633 C4-dicarboxylate transport sensor n/a
112 P51649_SIN P51649 Succinate-semialdehyde dehydrogenase, mitochondrial inhibitor
113 Q9KQS3_SIN Q9KQS3 histidine kinase (EC n/a
114 P23687_SIN P23687 Prolyl endopeptidase (PE) n/a
115 Q9HVZ9_SIN Q9HVZ9 UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC n/a
116 P27431_SIN P27431 Ribosomal protein uL16 n/a
117 A3QCW5_SIN A3QCW5 C4-dicarboxylate-binding periplasmic protein n/a
118 P37610_SIN P37610 Alpha-ketoglutarate-dependent taurine dioxygenase n/a
119 D0ZHW1_SIN D0ZHW1 deleted n/a
120 P00805_SIN P00805 L-asparaginase 2 (EC n/a
121 Q9KNE0_SIN Q9KNE0 Transporter, NadC family n/a
122 Q9VU77_SIN Q9VU77 Bifunctional peptidase and n/a
123 A0QLU8_SIN A0QLU8 Acetate kinase (EC n/a
124 Q8ZQM7_SIN Q8ZQM7 Cytoplasmic protein n/a
125 Q8Y7N7_SIN Q8Y7N7 Glutamate racemase (EC n/a
126 Q7D785_SIN Q7D785 Salicylate synthase (Chorismate n/a
127 Q02SG6_SIN Q02SG6 deleted n/a
128 Q9I2Q1_SIN Q9I2Q1 Peptidoglycan amidase Tse1 n/a
129 C7C422_SIN C7C422 Metallo-beta-lactamase type 2 n/a
130 J3BZS6_SIN J3BZS6 L-lysine 4-hydroxylase (EC n/a
131 B3DUR4_SIN B3DUR4 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) n/a
132 Q9Z9H2_SIN Q9Z9H2 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC n/a
133 O84093_SIN O84093 Yop proteins translocation n/a
134 A0A2D2D5X0_SIN A0A2D2D5X0 Methane monooxygenase component n/a
135 G9MBV2_SIN G9MBV2 Hydroxylase (EC 1.14.11.41) n/a
136 Q3JLL8_SIN Q3JLL8 Betaine aldehyde dehydrogenase n/a
137 P77541_SIN P77541 2-methylisocitrate lyase (2-MIC) n/a
138 P83310_SIN P83310 (R)-phenoxypropionate/alpha-ketoglutarate-dioxygenase (RdpA) (EC n/a
139 O14607_SIN O14607 Histone demethylase UTY n/a
140 Q5ZVR1_SIN Q5ZVR1 Urocanate hydratase (Urocanase) n/a
141 A0A2U2H063_SIN A0A2U2H063 Uncharacterized protein n/a
142 Q6R2Q7_SIN Q6R2Q7 Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (EC n/a
143 P16009_SIN P16009 Pre-baseplate central spike n/a
144 P59846_SIN P59846 Argininosuccinate synthase (EC n/a
145 P28482_SIN P28482 Mitogen-activated protein kinase n/a
146 Q9BS26_SIN Q9BS26 Endoplasmic reticulum resident n/a
147 A0A0E3TT64_SIN A0A0E3TT64 deleted n/a
148 Q10BI6_SIN Q10BI6 Oxidoreductase, 2OG-Fe oxygenase n/a
149 P69332_SIN P69332 G-protein coupled receptor n/a
150 Q8EHB5_SIN Q8EHB5 Anhydro-N-acetylmuramic acid kinase n/a
151 Q5NIQ1_SIN Q5NIQ1 Adenylosuccinate lyase (EC n/a
152 P9WKK7_SIN P9WKK7 Isocitrate lyase (ICL) n/a
153 D4N500_SIN D4N500 Thebaine 6-O-demethylase (EC n/a
154 P02511_SIN P02511 Alpha-crystallin B chain n/a
155 P25114_SIN P25114 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase n/a
156 Q5H7I4_SIN Q5H7I4 Non-structural protein 1 n/a
157 Q6UQ65_SIN Q6UQ65 BsaWI endonuclease n/a
158 P0CB42_SIN P0CB42 Nucleic acid dioxygenase n/a
159 A0A1V4VDZ9_SIN A0A1V4VDZ9 ATP citrate synthase n/a
160 Q3BCT8_SIN Q3BCT8 Thaumatin-like protein n/a
161 Q9NWT6_SIN Q9NWT6 Hypoxia-inducible factor 1-alpha n/a
162 Q0D9D0_SIN Q0D9D0 1,4-alpha-glucan branching enzyme n/a
163 P78556_SIN P78556 C-C motif chemokine n/a
164 A0A0E1SLC7_SIN A0A0E1SLC7 deleted n/a
165 A0A067YX61_SIN A0A067YX61 WelO5 n/a
166 Q24451_SIN Q24451 Alpha-mannosidase 2 (EC n/a
167 P06608_SIN P06608 L-asparaginase (L-ASNase) (EC n/a
168 O08395_SIN O08395 Citrate synthase n/a
169 O75164_SIN O75164 Lysine-specific demethylase 4A n/a
170 J9VYP5_SIN J9VYP5 Bifunctional purine biosynthetic n/a
171 P00746_SIN P00746 Complement factor D n/a
172 P15888_SIN P15888 Oxygen-insensitive NAD(P)H nitroreductase n/a
173 Q6WZB0_SIN Q6WZB0 Alpha-ketoglutarate-dependent L-arginine hydroxylase n/a
174 P58687_SIN P58687 3-dehydroquinate dehydratase (3-dehydroquinase) n/a
175 X4QP62_SIN X4QP62 deleted n/a
176 P35747_SIN P35747 Albumin (allergen Equ n/a
177 A0A0N7KZ58_SIN A0A0N7KZ58 D-succinylase n/a
178 O60885_SIN O60885 Bromodomain-containing protein 4 n/a
179 E9AE57_SIN E9AE57 Fumarate hydratase 2 n/a
180 Q739M5_SIN Q739M5 Spore coat protein n/a
181 D9PZ08_SIN D9PZ08 Beta-galactosidase (EC 3.2.1.23) n/a
182 Q08BA6_SIN Q08BA6 RNA demethylase ALKBH5 n/a
183 Q88E10_SIN Q88E10 Methyl-accepting chemotaxis protein n/a
184 B3LNW5_SIN B3LNW5 Protein AF-9 homolog n/a
185 C6XID6_SIN C6XID6 beta-lactamase (EC 3.5.2.6) n/a
186 Q59523_SIN Q59523 Mycinamicin IV hydroxylase/epoxidase n/a
187 Q81MV2_SIN Q81MV2 Phenazine biosynthesis protein, n/a
188 P0C6W3_SIN P0C6W3 Replicase polyprotein 1ab n/a