Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: SPERMIDINE
PDB ligand accession: SPD
DrugBank: DB03566
PubChem: 1102
ChEMBL: CHEMBL19612
InChI Key: ATHGHQPFGPMSJY-UHFFFAOYSA-N
SMILES: C(CCNCCCN)CN

ClassyFire chemical classification:

List of proteins that are targets for SPD

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P0CX51_SPD P0CX51 Small ribosomal subunit n/a
2 Q9RTP8_SPD Q9RTP8 Divalent metal cation n/a
3 Q5QD04_SPD Q5QD04 Trace amine-associated receptor n/a
4 G7K2D1_SPD G7K2D1 thermospermine synthase (EC n/a
5 P0CX27_SPD P0CX27 Large ribosomal subunit n/a
6 A0A6M9XK53_SPD A0A6M9XK53 deleted n/a
7 O80467_SPD O80467 Spermidine sinapoyl-CoA acyltransferase n/a
8 A0A8H6BVY8_SPD A0A8H6BVY8 60S ribosomal protein n/a
9 O64411_SPD O64411 Polyamine oxidase 1 n/a
10 P08588_SPD P08588 Beta-1 adrenergic receptor n/a
11 P19491_SPD P19491 Glutamate receptor 2 n/a
12 S5FV19_SPD S5FV19 Pilus tip adhesin n/a
13 Q8II73_SPD Q8II73 Spermidine synthase (EC n/a
14 J3F2B0_SPD J3F2B0 CRISPR-associated endonuclease Cas9 n/a
15 G1TJW1_SPD G1TJW1 Small ribosomal subunit n/a
16 P02406_SPD P02406 Large ribosomal subunit n/a
17 G1T0C1_SPD G1T0C1 Large ribosomal subunit n/a
18 T2FY33_SPD T2FY33 deleted n/a
19 Q5JIZ3_SPD Q5JIZ3 N(4)-bis(aminopropyl)spermidine synthase (EC n/a
20 P36578_SPD P36578 Large ribosomal subunit n/a
21 D0VX11_SPD D0VX11 Basic phospholipase A2 n/a
22 A0A0N8ETI8_SPD A0A0N8ETI8 Large ribosomal subunit n/a
23 A0A0V0H357_SPD A0A0V0H357 Putative 60S ribosomal n/a
24 A0A1D8PEV4_SPD A0A1D8PEV4 Large ribosomal subunit n/a
25 A0A8D1P8R7_SPD A0A8D1P8R7 Small ribosomal subunit n/a
26 P51697_SPD P51697 Gamma-hexachlorocyclohexane dehydrochlorinase (Gamma-HCH n/a
27 Q9RXJ1_SPD Q9RXJ1 Large ribosomal subunit n/a
28 P23861_SPD P23861 Spermidine/putrescine-binding periplasmic protein n/a
29 P19623_SPD P19623 Spermidine synthase (SPDSY) n/a
30 Q2PYN0_SPD Q2PYN0 Putative glyoxalase II n/a
31 O64470_SPD O64470 Spermidine hydroxycinnamoyl transferase n/a
32 U9Y9G2_SPD U9Y9G2 deleted n/a
33 Q2FJE0_SPD Q2FJE0 Large ribosomal subunit n/a
34 Q8SS76_SPD Q8SS76 60S RIBOSOMAL PROTEIN n/a
35 Q9I6J0_SPD Q9I6J0 Spermidine-binding periplasmic protein n/a
36 P39040_SPD P39040 Trypanothione reductase (TR) n/a
37 P0A0F8_SPD P0A0F8 Large ribosomal subunit n/a
38 P62277_SPD P62277 Small ribosomal subunit n/a
39 A0A3B8MYE1_SPD A0A3B8MYE1 Glycine/betaine ABC transporter n/a
40 P61175_SPD P61175 Large ribosomal subunit n/a
41 Q9KL03_SPD Q9KL03 Spermidine N(1)-acetyltransferase (SAT) n/a
42 P68135_SPD P68135 Actin, alpha skeletal n/a
43 P49366_SPD P49366 Deoxyhypusine synthase (DHS) n/a
44 Q9Y5W5_SPD Q9Y5W5 Wnt inhibitory factor n/a
45 P05756_SPD P05756 Small ribosomal subunit n/a
46 D9J2T9_SPD D9J2T9 rRNA N-glycosylase (EC n/a
47 Q2FW07_SPD Q2FW07 Large ribosomal subunit n/a
48 C3SQU2_SPD C3SQU2 Large ribosomal subunit n/a
49 Q9RM86_SPD Q9RM86 4-Hydroxybutyrate CoA-transferase (Acetyl-CoA n/a
50 P61927_SPD P61927 Large ribosomal subunit n/a
51 A0A3Q7GZ10_SPD A0A3Q7GZ10 Large ribosomal subunit n/a
52 A3MU81_SPD A3MU81 Polyamine aminopropyltransferase (Putrescine n/a
53 P61313_SPD P61313 Large ribosomal subunit n/a
54 Q53396_SPD Q53396 Aminoglycoside-(3)-N-acetyltransferase n/a
55 I2X6U5_SPD I2X6U5 deleted n/a
56 O60783_SPD O60783 Small ribosomal subunit n/a
57 A0A1D8PSC5_SPD A0A1D8PSC5 Large ribosomal subunit n/a
58 P10408_SPD P10408 Protein translocase subunit n/a
59 P21796_SPD P21796 Non-selective voltage-gated ion n/a
60 Q8RFS1_SPD Q8RFS1 BD-FAE-like domain-containing protein n/a
61 P08978_SPD P08978 Large ribosomal subunit n/a
62 A0A1S4BFD5_SPD A0A1S4BFD5 60S ribosomal protein n/a
63 A0A287B3R8_SPD A0A287B3R8 Small ribosomal subunit n/a
64 P05748_SPD P05748 Large ribosomal subunit n/a
65 Q02753_SPD Q02753 Large ribosomal subunit n/a
66 A0A1D8PF08_SPD A0A1D8PF08 Large ribosomal subunit n/a
67 P66207_SPD P66207 Large ribosomal subunit n/a
68 A0A069QID4_SPD A0A069QID4 Extracellular solute-binding protein n/a
69 G1SNY0_SPD G1SNY0 Large ribosomal subunit n/a
70 P0AG30_SPD P0AG30 Transcription termination factor n/a
71 P09001_SPD P09001 Large ribosomal subunit n/a
72 O62581_SPD O62581 Large ribosomal subunit n/a
73 Q31QK9_SPD Q31QK9 Polyamine aminopropyltransferase (Putrescine n/a
74 M1E1F8_SPD M1E1F8 LOV protein n/a
75 P31133_SPD P31133 Putrescine-binding periplasmic protein n/a
76 P02413_SPD P02413 Large ribosomal subunit n/a
77 A0A1S4AU23_SPD A0A1S4AU23 40S ribosomal protein n/a
78 Q2FW13_SPD Q2FW13 Large ribosomal subunit n/a
79 Q2FW38_SPD Q2FW38 Large ribosomal subunit n/a
80 A0A6S5NLK9_SPD A0A6S5NLK9 deleted n/a
81 P07550_SPD P07550 Beta-2 adrenergic receptor n/a
82 Q9KS37_SPD Q9KS37 Putrescine-binding periplasmic protein n/a
83 P50264_SPD P50264 Polyamine oxidase FMS1 n/a
84 Q9RXJ4_SPD Q9RXJ4 Large ribosomal subunit n/a
85 P52788_SPD P52788 Spermine synthase (SPMSY) n/a