Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: TRIS(HYDROXYETHYL)AMINOMETHANE
PDB ligand accession: TAM
DrugBank: DB04237
PubChem: 448009
ChEMBL: n/a
InChI Key: GKODZWOPPOTFGA-UHFFFAOYSA-N
SMILES: C(CO)C(CCO)(CCO)N

ClassyFire chemical classification:

List of proteins that are targets for TAM

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q7MXR4_TAM Q7MXR4 Phenylalanine--tRNA ligase beta n/a
2 O29329_TAM O29329 Putative branched-chain-amino-acid aminotransferase n/a
3 Q6PIF6_TAM Q6PIF6 Unconventional myosin-VIIb n/a
4 P0A881_TAM P0A881 Trp operon repressor n/a
5 J9PBR2_TAM J9PBR2 Small laccase, multi-copper n/a
6 Q3AG28_TAM Q3AG28 Carbon monoxide dehydrogenase n/a
7 I2DBY1_TAM I2DBY1 Dye-decolorizing peroxidase AauDyP1 n/a
8 P54651_TAM P54651 Heat shock cognate n/a
9 I0RTF3_TAM I0RTF3 deleted n/a
10 Q9I5L8_TAM Q9I5L8 Aldoketomutase (Glyoxalase I) n/a
11 Q9EQZ5_TAM Q9EQZ5 Prostaglandin reductase 1 n/a
12 P73600_TAM P73600 Sll1785 protein n/a
13 H0ZAB5_TAM H0ZAB5 Polypeptide N-acetylgalactosaminyltransferase 3 n/a
14 Q9EA62_TAM Q9EA62 Hemagglutinin [Cleaved into: n/a
15 A5U5E1_TAM A5U5E1 Nucleoside diphosphate kinase n/a
16 P0CG48_TAM P0CG48 Polyubiquitin-C [Cleaved into: n/a
17 Q9P2E7_TAM Q9P2E7 Protocadherin-10 n/a
18 C0IR58_TAM C0IR58 Alclohol dehydrogenase/short-chain dehydrogenase n/a
19 Q05636_TAM Q05636 Exosome complex component n/a
20 Q8U3V1_TAM Q8U3V1 PIG-L family deacetylase n/a
21 P00514_TAM P00514 cAMP-dependent protein kinase n/a
22 P70408_TAM P70408 Cadherin-10 (T2-cadherin) n/a
23 P04745_TAM P04745 Alpha-amylase 1A (EC n/a
24 A0A379CIH2_TAM A0A379CIH2 Formate--tetrahydrofolate ligase (EC n/a
25 Q99LC4_TAM Q99LC4 Igh protein n/a
26 O15350_TAM O15350 Tumor protein p73 n/a
27 A0A0H3PA01_TAM A0A0H3PA01 Iron transporter n/a
28 Q3AET8_TAM Q3AET8 Putative CoA-substrate-specific enzyme n/a
29 B7IEN1_TAM B7IEN1 Thioredoxin n/a
30 Q9KJ90_TAM Q9KJ90 Beta-lactamase inhibitory protein n/a
31 P12497_TAM P12497 Gag-Pol polyprotein (Pr160Gag-Pol) n/a
32 A0A0C5GWS2_TAM A0A0C5GWS2 Pulullanase (EC 3.2.1.41) n/a
33 P06280_TAM P06280 Alpha-galactosidase A (EC n/a
34 O14786_TAM O14786 Neuropilin-1 (Vascular endothelial n/a
35 Q9UZ55_TAM Q9UZ55 Na+/H+ antiporter, putative n/a
36 P27431_TAM P27431 Ribosomal protein uL16 n/a
37 A6THC4_TAM A6THC4 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase n/a
38 Q8TBZ3_TAM Q8TBZ3 WD repeat-containing protein n/a
39 Q9X0Z6_TAM Q9X0Z6 [FeFe] hydrogenase maturase n/a
40 Q858B1_TAM Q858B1 Tail spike protein n/a
41 P31133_TAM P31133 Putrescine-binding periplasmic protein n/a
42 A0FCI1_TAM A0FCI1 Hemagglutinin [Cleaved into: n/a
43 A0A5S8WFA6_TAM A0A5S8WFA6 Exosialidase from uncultured n/a
44 P76045_TAM P76045 Outer membrane porin n/a
45 O16299_TAM O16299 Fidgetin-like protein 1 n/a
46 P13035_TAM P13035 Aerobic glycerol-3-phosphate dehydrogenase n/a
47 A0MK70_TAM A0MK70 Fiber-1 n/a
48 Q91MA7_TAM Q91MA7 Hemagglutinin [Cleaved into: n/a
49 O67987_TAM O67987 Chlorocatechol 1,2-dioxygenase (EC n/a
50 P00720_TAM P00720 Endolysin (EC 3.2.1.17) n/a
51 P33022_TAM P33022 Pyrimidine-specific ribonucleoside hydrolase n/a
52 P01892_TAM P01892 HLA class I n/a
53 Q7CY45_TAM Q7CY45 histidine kinase (EC n/a
54 Q9JI33_TAM Q9JI33 Netrin-4 (Beta-netrin) n/a
55 G2K2K4_TAM G2K2K4 deleted n/a
56 Q8I4S1_TAM Q8I4S1 Thymidylate kinase (PfTMK) n/a
57 P22483_TAM P22483 ATP synthase subunit n/a
58 B8N653_TAM B8N653 deleted n/a
59 A0A5B8RNS7_TAM A0A5B8RNS7 MHC class I n/a
60 Q9I741_TAM Q9I741 Type VI secretion n/a
61 A7LY27_TAM A7LY27 deleted n/a
62 P05132_TAM P05132 cAMP-dependent protein kinase n/a
63 I2D7A8_TAM I2D7A8 Hemagglutinin [Cleaved into: n/a
64 P23687_TAM P23687 Prolyl endopeptidase (PE) n/a
65 I6Y9J2_TAM I6Y9J2 L,D-transpeptidase 2 (LDT n/a
66 P62161_TAM P62161 Calmodulin-2 n/a
67 B3PD60_TAM B3PD60 Beta-xylosidase/alpha-L-arabinfuranosidase, putative, gly43N n/a
68 P49017_TAM P49017 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial n/a
69 Q04609_TAM Q04609 Glutamate carboxypeptidase 2 n/a
70 Q9SZU7_TAM Q9SZU7 Probable esterase KAI2 n/a
71 Q60362_TAM Q60362 Na(+)/H(+) antiporter 1 n/a
72 Q59166_TAM Q59166 ATP synthase subunit n/a
73 P80385_TAM P80385 5'-AMP-activated protein kinase n/a
74 P00178_TAM P00178 Cytochrome P450 2B4 n/a
75 E8X8J1_TAM E8X8J1 tRNA threonylcarbamoyladenosine biosynthesis n/a
76 P00719_TAM P00719 Lysozyme g (EC n/a
77 Q7CL15_TAM Q7CL15 Hemophore HasA n/a
78 Q3AET9_TAM Q3AET9 Dehydratase family protein n/a
79 P00441_TAM P00441 Superoxide dismutase [Cu-Zn] n/a
80 P37432_TAM P37432 Outer membrane porin n/a
81 Q70626_TAM Q70626 Envelope glycoprotein gp160 n/a
82 P55776_TAM P55776 Fatty acid-binding protein n/a
83 G0LWB2_TAM G0LWB2 Putative P450-like enzyme n/a
84 Q7L266_TAM Q7L266 Isoaspartyl peptidase/L-asparaginase (EC n/a
85 P09989_TAM P09989 Ribosome-inactivating protein alpha-trichosanthin n/a
86 P00778_TAM P00778 Alpha-lytic protease (EC n/a
87 Q14558_TAM Q14558 Phosphoribosyl pyrophosphate synthase-associated n/a
88 Q8RGD7_TAM Q8RGD7 ATP synthase subunit n/a
89 G8UQH9_TAM G8UQH9 ATPase n/a
90 A0A0T9EA39_TAM A0A0T9EA39 deleted n/a
91 Q09472_TAM Q09472 Histone acetyltransferase p300 n/a
92 P46948_TAM P46948 Exosome complex component n/a
93 G3XAP7_TAM G3XAP7 AA9 family lytic n/a