Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: THIAMINE DIPHOSPHATE
PDB ligand accession: TPP
DrugBank: n/a
PubChem: 1132
ChEMBL: CHEMBL1236376
InChI Key: AYEKOFBPNLCAJY-UHFFFAOYSA-O
SMILES: Cc1c(sc[n+]1Cc2cnc(nc2N)C)CCOP(=O)(O)OP(=O)(O)O

ClassyFire chemical classification:

List of proteins that are targets for TPP

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 A0A1A0DLW4_TPP A0A1A0DLW4 deleted n/a
2 V5MX36_TPP V5MX36 deleted n/a
3 Q9LCV9_TPP Q9LCV9 N(2)-(2-carboxyethyl)arginine synthase (CEA n/a
4 P27302_TPP P27302 Transketolase 1 (TK n/a
5 Q8DVV9_TPP Q8DVV9 Thiamine diphosphokinase (EC n/a
6 D6PAH1_TPP D6PAH1 Probable phosphoketolase (EC n/a
7 P27696_TPP P27696 Acetolactate synthase, catabolic n/a
8 Q02218_TPP Q02218 2-oxoglutarate dehydrogenase complex n/a
9 P0AFG8_TPP P0AFG8 Pyruvate dehydrogenase E1 n/a
10 A0A0S3F934_TPP A0A0S3F934 1-deoxy-D-xylulose-5-phosphate synthase (EC n/a
11 A8IAN1_TPP A8IAN1 transketolase (EC 2.2.1.1) n/a
12 P37063_TPP P37063 Pyruvate oxidase (EC n/a
13 P29401_TPP P29401 Transketolase (TK) (EC n/a
14 P9WNS3_TPP P9WNS3 1-deoxy-D-xylulose-5-phosphate synthase (EC n/a
15 Q0P7Y3_TPP Q0P7Y3 Transketolase (EC 2.2.1.1) n/a
16 A0A0B8QZ66_TPP A0A0B8QZ66 Alpha-keto-acid decarboxylase n/a
17 P40149_TPP P40149 Oxalyl-CoA decarboxylase (EC n/a
18 A0L8G4_TPP A0L8G4 Pyruvate flavodoxin/ferredoxin oxidoreductase n/a
19 Q9F4L3_TPP Q9F4L3 Benzaldehyde lyase n/a
20 A0A1D8PJF9_TPP A0A1D8PJF9 Acetolactate synthase (EC n/a
21 Q5SLR3_TPP Q5SLR3 2-oxoisovalerate dehydrogenase subunit n/a
22 Q6R2Q7_TPP Q6R2Q7 Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase (EC n/a
23 P0AFG9_TPP P0AFG9 Pyruvate dehydrogenase E1 n/a
24 Q5SM35_TPP Q5SM35 Transketolase (EC 2.2.1.1) n/a
25 Q2RI42_TPP Q2RI42 Oxalate oxidoreductase subunit n/a
26 P23970_TPP P23970 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC n/a
27 Q8MPM3_TPP Q8MPM3 Transketolase (EC 2.2.1.1) n/a
28 Q1WQU8_TPP Q1WQU8 Transketolase (EC 2.2.1.1) n/a
29 Q0SCE8_TPP Q0SCE8 acetolactate synthase (EC n/a
30 A0L8G5_TPP A0L8G5 Pyruvate ferredoxin/flavodoxin oxidoreductase, n/a
31 A0R2B1_TPP A0R2B1 Multifunctional 2-oxoglutarate metabolism n/a
32 Q4KB02_TPP Q4KB02 Benzoylformate decarboxylase (EC n/a
33 P0DUV9_TPP P0DUV9 2-hydroxyacyl-CoA lyase (AcHACL) n/a
34 Q2RI41_TPP Q2RI41 Oxalate oxidoreductase subunit n/a
35 Q8KTX6_TPP Q8KTX6 pyruvate decarboxylase (EC n/a
36 P17109_TPP P17109 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC n/a
37 P17597_TPP P17597 Acetolactate synthase, chloroplastic n/a
38 Q81Y15_TPP Q81Y15 Transketolase (EC 2.2.1.1) n/a
39 P94692_TPP P94692 Pyruvate:ferredoxin oxidoreductase (PFOR) n/a
40 Q9CFH4_TPP Q9CFH4 Probable phosphoketolase (EC n/a
41 P9WK11_TPP P9WK11 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC n/a
42 P0AFI0_TPP P0AFI0 Oxalyl-CoA decarboxylase (EC n/a
43 P12694_TPP P12694 2-oxoisovalerate dehydrogenase subunit n/a
44 P15363_TPP P15363 High affinity transport n/a
45 P21874_TPP P21874 Pyruvate dehydrogenase E1 n/a
46 A9H275_TPP A9H275 pyruvate decarboxylase (EC n/a
47 P20906_TPP P20906 Benzoylformate decarboxylase (BFD) n/a
48 Q31LF9_TPP Q31LF9 Probable phosphoketolase (EC n/a
49 Q4K6F7_TPP Q4K6F7 Acetolactate synthase II, n/a
50 Q9RUB5_TPP Q9RUB5 1-deoxy-D-xylulose-5-phosphate synthase (EC n/a
51 P11177_TPP P11177 Pyruvate dehydrogenase E1 n/a
52 Q96XT4_TPP Q96XT4 2-oxoacid:ferredoxin oxidoreductase 2, n/a
53 P07003_TPP P07003 Pyruvate dehydrogenase [ubiquinone] n/a
54 A0A3Q0L1E1_TPP A0A3Q0L1E1 oxoglutarate dehydrogenase (succinyl-transferring) n/a
55 Q96HY7_TPP Q96HY7 2-oxoadipate dehydrogenase complex n/a
56 P0AEP7_TPP P0AEP7 Glyoxylate carboligase (EC n/a
57 C6VNC6_TPP C6VNC6 deleted n/a
58 P21873_TPP P21873 Pyruvate dehydrogenase E1 n/a
59 P08142_TPP P08142 Acetolactate synthase isozyme n/a
60 P51852_TPP P51852 Indole-3-pyruvate decarboxylase (Indolepyruvate n/a
61 P0ABE7_TPP P0ABE7 Soluble cytochrome b562 n/a
62 P09060_TPP P09060 2-oxoisovalerate dehydrogenase subunit n/a
63 S6CP45_TPP S6CP45 Xylulose5phosphatefructose6phosphate phosphoketolase n/a
64 B7V7R4_TPP B7V7R4 1-deoxy-D-xylulose-5-phosphate synthase (EC n/a
65 A4SXU0_TPP A4SXU0 Thiamine pyrophosphate enzyme n/a
66 P23234_TPP P23234 Indole-3-pyruvate decarboxylase (Indolepyruvate n/a
67 D6D942_TPP D6D942 deleted n/a
68 Q8JZL3_TPP Q8JZL3 Thiamine-triphosphatase (ThTPase) (EC n/a
69 Q6QBS4_TPP Q6QBS4 Alpha-keto-acid decarboxylase n/a
70 P84129_TPP P84129 2-oxoisovalerate dehydrogenase subunit n/a
71 Q8NRC3_TPP Q8NRC3 2-oxoglutarate dehydrogenase E1/E2 n/a
72 P77488_TPP P77488 1-deoxy-D-xylulose-5-phosphate synthase (EC n/a
73 P06169_TPP P06169 Pyruvate decarboxylase isozyme n/a
74 Q2SZA7_TPP Q2SZA7 Transketolase (EC 2.2.1.1) n/a
75 P06672_TPP P06672 Pyruvate decarboxylase (PDC) n/a
76 Q9H3S4_TPP Q9H3S4 Thiamine pyrophosphokinase 1 n/a
77 C5AX46_TPP C5AX46 Oxalyl-CoA decarboxylase (Oxc, n/a
78 Q7SIC9_TPP Q7SIC9 Transketolase, chloroplastic (TK) n/a
79 Q8L388_TPP Q8L388 pyruvate decarboxylase (EC n/a
80 Q12629_TPP Q12629 Pyruvate decarboxylase (EC n/a
81 Q2RMD6_TPP Q2RMD6 Pyruvate:ferredoxin oxidoreductase (PFOR) n/a
82 P0CH62_TPP P0CH62 Cyclohexane-1,2-dione hydrolase (EC n/a
83 P23254_TPP P23254 Transketolase 1 (TK n/a
84 P06958_TPP P06958 Pyruvate dehydrogenase E1 n/a
85 P84130_TPP P84130 2-oxoisovalerate dehydrogenase subunit n/a
86 A0A8T9U4A0_TPP A0A8T9U4A0 deleted n/a
87 Q5SLR4_TPP Q5SLR4 2-oxoisovalerate dehydrogenase subunit n/a
88 P08559_TPP P08559 Pyruvate dehydrogenase E1 n/a
89 P07342_TPP P07342 Acetolactate synthase catalytic n/a
90 Q96XT2_TPP Q96XT2 2-oxoacid:ferredoxin oxidoreductase 2, n/a
91 A0A0D5YC82_TPP A0A0D5YC82 Thiamine-monophosphate kinase (TMP n/a
92 A0A0I9QGZ2_TPP A0A0I9QGZ2 Transketolase (TK) (EC n/a
93 O67883_TPP O67883 Thiamine-monophosphate kinase (TMP n/a
94 Q82ZE3_TPP Q82ZE3 Thiamine diphosphokinase (EC n/a
95 P34736_TPP P34736 Transketolase (TK) (EC n/a
96 S5L6I0_TPP S5L6I0 deleted n/a
97 O06811_TPP O06811 Transketolase (TK) (EC n/a
98 A0A390C306_TPP A0A390C306 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC n/a