Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: TRYPTOPHAN
PDB ligand accession: TRP
DrugBank: DB00150
PubChem: 6305;6923516;
ChEMBL: CHEMBL54976
InChI Key: QIVBCDIJIAJPQS-VIFPVBQESA-N
SMILES: c1ccc2c(c1)c(c[nH]2)CC(C(=O)O)N

ClassyFire chemical classification:

List of proteins that are targets for TRP

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 P28820_TRP P28820 Aminodeoxychorismate synthase component n/a
2 P00953_TRP P00953 Tryptophan--tRNA ligase (EC inhibitor
3 Q97QX5_TRP Q97QX5 deleted n/a
4 P23381_TRP P23381 Tryptophan--tRNA ligase, cytoplasmic inhibitor
5 Q9X6J6_TRP Q9X6J6 Transcription attenuation protein n/a
6 P17770_TRP P17770 Aromatic-L-amino-acid decarboxylase (AADC) n/a
7 P00929_TRP P00929 Tryptophan synthase alpha n/a
8 Q9I4L4_TRP Q9I4L4 Negative regulator YfiR n/a
9 P48775_TRP P48775 Tryptophan 2,3-dioxygenase (TDO) n/a Ki(nM) = 1.15E7
10 Q96I25_TRP Q96I25 Splicing factor 45 n/a
11 P00918_TRP P00918 Carbonic anhydrase 2 n/a
12 A0A399DY85_TRP A0A399DY85 Endoglucanase H (EC n/a
13 A0A0D6FWC1_TRP A0A0D6FWC1 Tryptophan synthase alpha n/a
14 Q9I000_TRP Q9I000 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC n/a
15 P04825_TRP P04825 Aminopeptidase N (EC n/a
16 Q2MFY2_TRP Q2MFY2 DMATS type aromatic n/a
17 Q5CYP8_TRP Q5CYP8 tryptophan--tRNA ligase (EC n/a
18 P0A2K1_TRP P0A2K1 Tryptophan synthase beta n/a
19 C9ZDC6_TRP C9ZDC6 Putative P450-like protein n/a
20 P0A881_TRP P0A881 Trp operon repressor n/a
21 Q9PIB4_TRP Q9PIB4 Tryptophan--tRNA ligase (EC n/a
22 Q5F7X0_TRP Q5F7X0 Tryptophan--tRNA ligase (EC n/a
23 P14618_TRP P14618 Pyruvate kinase PKM n/a
24 P00897_TRP P00897 Anthranilate synthase component n/a
25 P05041_TRP P05041 Aminodeoxychorismate synthase component n/a
26 P19466_TRP P19466 Transcription attenuation protein n/a
27 P14902_TRP P14902 Indoleamine 2,3-dioxygenase 1 binder IC50(nM) = 498700.0
28 A1E280_TRP A1E280 Tryptophan 6-halogenase ThaL n/a
29 A0A182DWE5_TRP A0A182DWE5 Prenyltransferase (PriB) n/a
30 P14779_TRP P14779 Bifunctional cytochrome P450/NADPH--P450 n/a
31 A8M6W6_TRP A8M6W6 Aromatic prenyltransferase, DMATS n/a
32 Q8U093_TRP Q8U093 Tryptophan synthase beta n/a
33 P24171_TRP P24171 Dipeptidyl carboxypeptidase (EC n/a
34 P00898_TRP P00898 Anthranilate synthase component n/a
35 A0A4R8NF71_TRP A0A4R8NF71 deleted n/a
36 Q9K169_TRP Q9K169 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC n/a
37 A0A861B387_TRP A0A861B387 AetD n/a
38 A4D0H5_TRP A4D0H5 Tryptophan 5-halogenase PyrH n/a
39 Q6L8Q5_TRP Q6L8Q5 aminodeoxychorismate synthase (EC n/a
40 A0A0H0Z019_TRP A0A0H0Z019 Methyl-accepting chemotaxis protein n/a
41 O96771_TRP O96771 Tryptophan--tRNA ligase (EC n/a
42 P19573_TRP P19573 Nitrous-oxide reductase (EC n/a
43 P67589_TRP P67589 Tryptophan--tRNA ligase (EC n/a
44 A0A8I3AZV5_TRP A0A8I3AZV5 calcium-sensing receptor n/a
45 P43835_TRP P43835 Tryptophan--tRNA ligase (EC n/a
46 P00766_TRP P00766 Chymotrypsinogen A (EC n/a
47 P32178_TRP P32178 Chorismate mutase (CM) n/a
48 C6FX51_TRP C6FX51 3-methyl-2-indolic acid synthase n/a
49 Q8PDA8_TRP Q8PDA8 Tryptophan 2,3-dioxygenase (TDO) n/a
50 P00800_TRP P00800 Thermolysin (EC 3.4.24.27) n/a
51 O84589_TRP O84589 Tryptophan--tRNA ligase (EC n/a
52 X2D812_TRP X2D812 Cupin superfamily protein n/a
53 P95481_TRP P95481 Monodechloroaminopyrrolnitrin synthase PrnB n/a
54 A9S498_TRP A9S498 chorismate mutase (EC n/a
55 Q8IDW3_TRP Q8IDW3 tryptophan--tRNA ligase (EC n/a
56 Q12109_TRP Q12109 Tryptophan--tRNA ligase, cytoplasmic n/a
57 P41180_TRP P41180 Extracellular calcium-sensing receptor n/a
58 P04958_TRP P04958 Tetanus toxin (EC n/a
59 Q9KNV7_TRP Q9KNV7 Tryptophan--tRNA ligase (EC n/a
60 P70080_TRP P70080 Tryptophan 5-hydroxylase 1 n/a
61 Q56232_TRP Q56232 Aspartate/prephenate aminotransferase (AspAT n/a
62 Q50EL0_TRP Q50EL0 Tryptophan dimethylallyltransferase (EC n/a
63 O93523_TRP O93523 Zinc metalloproteinase-disintegrin-like bothropasin n/a
64 Q3K0B5_TRP Q3K0B5 Probable manganese-dependent inorganic n/a
65 P80561_TRP P80561 Aminopeptidase S (EC n/a
66 Q9S3V1_TRP Q9S3V1 Flavin-dependent L-tryptophan oxidase n/a
67 O07746_TRP O07746 Secreted chorismate mutase n/a
68 A0A5F2KFW0_TRP A0A5F2KFW0 deleted n/a
69 Q65I22_TRP Q65I22 deleted n/a
70 Q9UHI5_TRP Q9UHI5 Large neutral amino n/a
71 Q97SP8_TRP Q97SP8 deleted n/a
72 Q59TS4_TRP Q59TS4 Chorismate mutase (EC n/a
73 A5YKK6_TRP A5YKK6 CCR4-NOT transcription complex n/a
74 M9QSI0_TRP M9QSI0 Tryptophan 6-halogenase n/a
75 Q9RVD6_TRP Q9RVD6 Tryptophan--tRNA ligase 2 n/a
76 P23979_TRP P23979 5-hydroxytryptamine receptor 3A n/a
77 Q8KHZ8_TRP Q8KHZ8 Tryptophan 7-halogenase RebH n/a
78 Q92600_TRP Q92600 CCR4-NOT transcription complex n/a
79 P95480_TRP P95480 Tryptophan 7-halogenase PrnA n/a
80 P96896_TRP P96896 Leucine-responsive regulatory protein n/a
81 P02768_TRP P02768 Albumin n/a
82 G3QPX8_TRP G3QPX8 CD207 molecule n/a
83 O67854_TRP O67854 Na(+):neurotransmitter symporter (Snf n/a
84 Q9WYW2_TRP Q9WYW2 Tryptophan--tRNA ligase (EC n/a
85 A0R5M8_TRP A0R5M8 Histidine N-alpha-methyltransferase (EC n/a
86 A0A6L9JR93_TRP A0A6L9JR93 Methyltransferase n/a
87 R4QPW9_TRP R4QPW9 Cucumopine synthase n/a
88 Q9RVZ5_TRP Q9RVZ5 Aminopeptidase N (EC n/a
89 Q9Y924_TRP Q9Y924 Tryptophan--tRNA ligase (EC n/a
90 O53512_TRP O53512 Phospho-2-dehydro-3-deoxyheptonate aldolase AroG n/a
91 Q8NNL5_TRP Q8NNL5 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC n/a
92 Q9KCC6_TRP Q9KCC6 Transcription attenuation protein n/a
93 Q9UJ71_TRP Q9UJ71 C-type lectin domain n/a
94 S0EH60_TRP S0EH60 Dimethylallyltryptophan synthase 1 n/a
95 Q9KDT3_TRP Q9KDT3 Sodium-dependent transporter n/a
96 A0A0E8NFD1_TRP A0A0E8NFD1 deleted n/a
97 D6RT90_TRP D6RT90 6-dimethylallyltryptophan synthase (Tryptophan n/a
98 Q9UKV8_TRP Q9UKV8 Protein argonaute-2 (Argonaute2) n/a
99 P00954_TRP P00954 Tryptophan--tRNA ligase (EC n/a