Medvedev Lab DrugDomain Protein List Small Molecules Download GitHub
Ligand name: THYMIDINE-5'-TRIPHOSPHATE
PDB ligand accession: TTP
DrugBank: DB02452
PubChem: 64968
ChEMBL: CHEMBL363559
InChI Key: NHVNXKFIZYSCEB-XLPZGREQSA-N
SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O

ClassyFire chemical classification:

List of proteins that are targets for TTP

# DrugDomain Data UniProt Accession Protein name Drug Action Affinity data
1 Q9KFV3_TTP Q9KFV3 dCTP deaminase, dUMP-forming n/a
2 D9N168_TTP D9N168 DNA polymerase I n/a
3 P03366_TTP P03366 Gag-Pol polyprotein (Pr160Gag-Pol) inhibitor
4 P56689_TTP P56689 DNA polymerase (EC n/a
5 O00142_TTP O00142 Thymidine kinase 2, n/a
6 Q47155_TTP Q47155 DNA polymerase IV n/a
7 P04183_TTP P04183 Thymidine kinase, cytosolic inhibitor
8 P19821_TTP P19821 DNA polymerase I, n/a
9 O33839_TTP O33839 Vitamin B12-dependent ribonucleotide n/a
10 Q97W02_TTP Q97W02 DNA polymerase IV n/a
11 H6WFU3_TTP H6WFU3 Deoxycytidylate deaminase n/a
12 Q9HU22_TTP Q9HU22 Glucose-1-phosphate thymidylyltransferase (EC n/a
13 P9WH13_TTP P9WH13 Glucose-1-phosphate thymidylyltransferase (Glc-1-P n/a
14 Q9UNA4_TTP Q9UNA4 DNA polymerase iota n/a
15 Q08698_TTP Q08698 Ribonucleoside-diphosphate reductase 2 n/a
16 O57203_TTP O57203 Thymidine kinase (EC n/a
17 P28248_TTP P28248 dCTP deaminase (EC n/a
18 Q9AGY4_TTP Q9AGY4 Glucose-1-phosphate thymidylyltransferase (EC n/a
19 Q9UGP5_TTP Q9UGP5 DNA polymerase lambda n/a
20 Q38087_TTP Q38087 DNA-directed DNA polymerase n/a
21 E1C9K5_TTP E1C9K5 DNA polymerase I n/a
22 O07247_TTP O07247 dCTP deaminase, dUMP-forming n/a
23 P52026_TTP P52026 DNA polymerase I n/a
24 P12689_TTP P12689 DNA repair protein n/a
25 P21189_TTP P21189 DNA polymerase II n/a
26 Q9NP87_TTP Q9NP87 DNA-directed DNA/RNA polymerase n/a
27 P23921_TTP P23921 Ribonucleoside-diphosphate reductase large n/a
28 Q9XZT6_TTP Q9XZT6 Deoxynucleoside kinase (EC n/a
29 P06746_TTP P06746 DNA polymerase beta n/a
30 Q4QC75_TTP Q4QC75 Thymidine kinase (EC n/a
31 Q9Y3Z3_TTP Q9Y3Z3 Deoxynucleoside triphosphate triphosphohydrolase n/a
32 P9WPQ5_TTP P9WPQ5 Dethiobiotin synthetase BioD n/a
33 P00452_TTP P00452 Ribonucleoside-diphosphate reductase 1 n/a
34 Q9UBT6_TTP Q9UBT6 DNA polymerase kappa n/a
35 P21524_TTP P21524 Ribonucleoside-diphosphate reductase large n/a
36 Q9T0V5_TTP Q9T0V5 Anaerobic ribonucleoside-triphosphate reductase n/a
37 Q8DSE5_TTP Q8DSE5 Deoxycytidylate deaminase n/a
38 Q836G9_TTP Q836G9 HD domain protein n/a
39 Q975F9_TTP Q975F9 Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase n/a
40 V9H0F6_TTP V9H0F6 Polymerase n/a
41 A0A1Q9N9I8_TTP A0A1Q9N9I8 deleted n/a
42 P61887_TTP P61887 Glucose-1-phosphate thymidylyltransferase 2 n/a
43 Q9PPP5_TTP Q9PPP5 Thymidine kinase (EC n/a
44 O41078_TTP O41078 CMP/dCMP-type deaminase domain-containing n/a
45 A0A2L0AR76_TTP A0A2L0AR76 DNA polymerase (EC n/a
46 P21951_TTP P21951 DNA polymerase epsilon n/a
47 P13699_TTP P13699 Nucleoprotein (EC 3.1.13.-) n/a
48 A0A162Q3J9_TTP A0A162Q3J9 deleted n/a
49 P00581_TTP P00581 DNA-directed DNA polymerase n/a
50 Q9F7K6_TTP Q9F7K6 Glucose-1-phosphate thymidylyltransferase (EC n/a
51 P13569_TTP P13569 Cystic fibrosis transmembrane n/a
52 R6BY16_TTP R6BY16 deleted n/a
53 O05891_TTP O05891 Thymidylate kinase (EC n/a
54 Q9F7G8_TTP Q9F7G8 Glucose-1-phosphate thymidylyltransferase (EC n/a
55 Q0H9H6_TTP Q0H9H6 deleted n/a
56 P03680_TTP P03680 DNA polymerase (EC n/a
57 Q9Y253_TTP Q9Y253 DNA polymerase eta n/a
58 P03692_TTP P03692 DNA helicase/primase (EC n/a