Ligand name: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE
PDB ligand accession: TTC
DrugBank: DB01030
PubChem: 60700
ChEMBL: CHEMBL84
InChI Key: UCFGDBYHRUNTLO-QHCPKHFHSA-N
SMILES: CCC1(C2=C(COC1=O)C(=O)N3Cc4cc5c(ccc(c5CN(C)C)O)nc4C3=C2)O
Drug action: inhibitor

ClassyFire chemical classification:

• Kingdom: Organic compounds
  • Superclass: Alkaloids and derivatives
    • Class: Camptothecins
      • Subclass: None

List of drug binding-associated PTMs

List of PDB structures and/or AlphaFold models with target protein P11387

PDB/AF Accession	PyMOL script	Experimental / Predicted	Interacting ECOD domains	ECOD X-group name	LigPlot
1RR8	Download	Experimental	e1rr8C5 e1rr8C6 e1rr8C8	HTH HTH Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	LigPlot
1K4T	Download	Experimental	e1k4tA2 e1k4tA3 e1k4tA1	HTH HTH Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment	LigPlot
1RRJ	Download	Experimental	e1rrjA1 e1rrjA2 e1rrjA3	Beta-strand domain in eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment HTH HTH	LigPlot