Gene name: PIK3CD
Protein name: Phosphatidylinositol 4,5-bisphosphate 3-kinase
List of molecules and drugs that interact with protein O00329
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O00329_5H5 | 5H5 | n/a | 58204997 | CHEMBL3771364 | (2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide | n/a | |
| 2 | O00329_799 | 799 | DB12108 | 51001932 | CHEMBL2387080 | 2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1H-pyrazol-1-yl)propanamide | n/a | |
| 3 | O00329_7KA | 7KA | n/a | 70674592 | CHEMBL3901527 | 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile | n/a | |
| 4 | O00329_85S | 85S | n/a | 132209868 | CHEMBL4071580 | 1-[4-(3-{4-amino-5-[1-(oxan-4-yl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)piperazin-1-yl]ethan-1-one | n/a | |
| 5 | O00329_9EM | 9EM | n/a | 127053611 | CHEMBL4059848 | 4-acetyl-1-(3-{4-amino-5-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)-3,3-dimethylpiperazin-2-one | n/a | |
| 6 | O00329_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 7 | O00329_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 8 | O00329_EO5 | EO5 | n/a | 90102336 | CHEMBL4166977 | ~{N}-[3-[4-[[(1~{S})-1-(5-methyl-4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]-7~{H}-pyrrolo[ 2,3-d]pyrimidin-5-yl]-5-oxidanyl-phenyl]methanesulfonamide | n/a | |
| 9 | O00329_I3H | I3H | n/a | 168010740 | CHEMBL5412958 | 9-[2-(3,4-dichlorophenyl)ethyl]-2-(3-hydroxyphenyl)-8-oxidanylidene-7~{H}-purine-6-carboxamide | n/a | |
| 10 | O00329_M5D | M5D | n/a | 145704650 | CHEMBL4634634 | 5-{(3R)-3-methyl-4-[(1R,2R)-2-methylcyclopropane-1-carbonyl]piperazin-1-yl}-3-(1-methyl-1H-pyrazol-4-yl)pyrazine-2-carbonitrile | n/a | |
| 11 | O00329_M5V | M5V | n/a | 145704649 | CHEMBL4648691 | 4-[(1S,4S)-5-(3-chlorophenyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]-2-(pyridin-3-yl)pyrimidine-5-carbonitrile | n/a | |
| 12 | O00329_P5J | P5J | n/a | 145946114 | CHEMBL4452905 | (3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimidin-5-yl)pyrazolo[1,5-a]pyrimidin-3-yl]-1,3-dihydro-2H-indol-2-one | n/a | |
| 13 | O00329_P5V | P5V | n/a | 138857923 | CHEMBL4524356 | (3S)-1'-(cyclopropanecarbonyl)-5-(quinoxalin-6-yl)spiro[indole-3,2'-pyrrolidin]-2(1H)-one | n/a | |
| 14 | O00329_VBS | VBS | n/a | 131964682 | CHEMBL4744546 | (3S)-3-benzyl-5-[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]-3-methyl-1,3-dihydro-2H-indol-2-one | n/a | |
| 15 | O00329_Y5Y | Y5Y | n/a | 90168938 | CHEMBL4853960 | cyclopropyl[(3S)-3-{[9-ethyl-8-(2-methylpyrimidin-5-yl)-9H-purin-6-yl]amino}pyrrolidin-1-yl]methanone | n/a | |
| 16 | O00329_YA7 | YA7 | n/a | 162639275 | CHEMBL4863978 | N-(5-(6-(2-((2S,6R)-2,6-dimethylmorpholino)pyridin-4-yl)-1-oxoisoindolin-4-yl)-2-methoxypyridin-3-yl)methanesulfonamide | n/a | |
| 17 | O00329_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 18 | O00329_CFF | CFF | DB00201 | 2519 | CHEMBL113 | Caffeine | inhibitor | |
| 19 | O00329_B6J | B6J | DB05552 | 10427712 | CHEMBL230011 | TG100-115 | inhibitor | |
| 20 | O00329_039 | 039 | DB06831 | 6852165 | CHEMBL1213083 | 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE | n/a | |
| 21 | O00329_40L | 40L | DB09054 | 11625818 | CHEMBL2216870 | Idelalisib | inhibitor | IC50(nM) = 2.0 |
| 22 | O00329_DB11952 | n/a | DB11952 | n/a | n/a | Duvelisib | inhibitor | |
| 23 | O00329_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor | |
| 24 | O00329_6E2 | 6E2 | DB12483 | 24989044 | CHEMBL3218576 | Copanlisib | inhibitor | |
| 25 | O00329_DB14989 | n/a | DB14989 | n/a | n/a | Umbralisib | inhibitor |