Gene name: PDE2A
Protein name: cGMP-dependent 3',5'-cyclic phosphodiesterase
List of molecules and drugs that interact with protein O00408
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O00408_19F | 19F | n/a | 25273570;135564787; | CHEMBL370962 | 2-(3,4-dimethoxybenzyl)-7-[(2R,3R)-2-hydroxy-6-phenylhexan-3-yl]-5-methylimidazo[5,1-f][1,2,4]triazin-4(3H)-one | n/a | |
| 2 | O00408_1L6 | 1L6 | n/a | 71305062 | CHEMBL2387140 | 1-(2-hydroxyethyl)-3-(2-methylbutan-2-yl)-5-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8(1H)-one | n/a | |
| 3 | O00408_788 | 788 | n/a | 71153223 | CHEMBL4863742 | N-benzyl-4-methyl-1-phenyl[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide | n/a | |
| 4 | O00408_7OG | 7OG | n/a | 118471483 | CHEMBL4076035 | [(3S)-3-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl](naphthalen-2-yl)methanone | n/a | |
| 5 | O00408_7OJ | 7OJ | n/a | 118479645 | CHEMBL4074744 | (3-bromo-4-fluorophenyl)[(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone | n/a | |
| 6 | O00408_7OM | 7OM | n/a | 137348657 | n/a | (3~{R})-1-(5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)-~{N}-naphthalen-2-yl-piperidine-3-carboxamide | n/a | |
| 7 | O00408_7OP | 7OP | n/a | 137348658 | n/a | [(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl](4-fluorophenyl)methanone | n/a | |
| 8 | O00408_7OV | 7OV | n/a | 137348659 | n/a | [(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl](4-fluoro-3-iodophenyl)methanone | n/a | |
| 9 | O00408_7OY | 7OY | n/a | 137348661 | n/a | (3-chloro-4-fluorophenyl)[(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]methanone | n/a | |
| 10 | O00408_7P4 | 7P4 | n/a | 137348662 | n/a | [(5S)-3,3-difluoro-5-(5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl](3,4-difluorophenyl)methanone | n/a | |
| 11 | O00408_7XS | 7XS | n/a | 129010130 | CHEMBL4095252 | 4-[3-(4-methoxyphenoxy)azetidin-1-yl]-1-methyl-3-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidine | n/a | |
| 12 | O00408_7XV | 7XV | n/a | 137348670 | CHEMBL4074798 | 5-[2-(2-methoxyphenyl)ethoxy]-3-(2-methylpropyl)[1,2,4]triazolo[4,3-a]pyrazine | n/a | |
| 13 | O00408_7Y1 | 7Y1 | n/a | 137348671 | CHEMBL4085594 | 3-[5-(4-ethylphenyl)-1-methyl-1H-pyrazol-4-yl]-5-propoxy[1,2,4]triazolo[4,3-a]pyrazine | n/a | |
| 14 | O00408_7Y4 | 7Y4 | n/a | 90654177 | CHEMBL3676182 | (3R)-1-{3-[5-(4-ethylphenyl)-1-methyl-1H-pyrazol-4-yl]-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}-N,N-dimethylpyrrolidin-3-amine | n/a | |
| 15 | O00408_87R | 87R | n/a | 137348687 | CHEMBL4059831 | 6-methyl-N-[(1R)-1-[4-(trifluoromethyloxy)phenyl]propyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 16 | O00408_9GA | 9GA | n/a | 87056188 | CHEMBL5268162 | N-{(1S)-2-hydroxy-2-methyl-1-[4-(trifluoromethoxy)phenyl]propyl}-6-methyl-5-(3-methyl-1H-1,2,4-triazol-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | n/a | |
| 17 | O00408_9GJ | 9GJ | n/a | 72190879 | CHEMBL4060569 | N-{(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide | n/a | |
| 18 | O00408_C6Z | C6Z | n/a | 2764775 | n/a | 6-[(2,4-dichlorophenyl)methyl]pyridazine-3-thiol | n/a | |
| 19 | O00408_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 20 | O00408_CZV | CZV | n/a | 131801460 | CHEMBL4216198 | 6-chloro-N-{1-[4-(trifluoromethyl)phenyl]cyclopropyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 21 | O00408_CZY | CZY | n/a | 131801461 | CHEMBL4212115 | 6-chloro-1-methyl-N-{(1R)-1-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 22 | O00408_D07 | D07 | n/a | 220780 | CHEMBL4217231 | 6-chloro-N,1-dimethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 23 | O00408_DY1 | DY1 | n/a | 134823954 | CHEMBL4229054 | [(1S)-6-fluoro-8-(methylsulfonyl)-9-{(1R)-1-[4-(trifluoromethyl)phenyl]ethyl}-2,3,4,9-tetrahydro-1H-carbazol-1-yl]acetic acid | n/a | |
| 24 | O00408_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 25 | O00408_EH9 | EH9 | DB07711 | 149790 | CHEMBL296435 | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol | n/a | IC50(nM) = 635.0 |
| 26 | O00408_EOG | EOG | n/a | 71153303 | CHEMBL4169339 | 1-(2-chlorophenyl)-N,4-dimethyl[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide | n/a | |
| 27 | O00408_EOJ | EOJ | n/a | n/a | n/a | 1-(2-chlorophenyl)-4-methyl-N-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl][1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide | n/a | |
| 28 | O00408_EOS | EOS | n/a | 137349270 | CHEMBL4168797 | 1-[2-chloro-5-(2-methylpropoxy)phenyl]-N,4-dimethyl[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide | n/a | |
| 29 | O00408_EOY | EOY | n/a | n/a | n/a | 1-[2-chloro-5-(2-methylpropoxy)phenyl]-4-methyl-N-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl][1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide | n/a | |
| 30 | O00408_EP7 | EP7 | n/a | 137349274 | CHEMBL4161432 | 1-(2-chloro-5-methoxyphenyl)-4-methyl-N-(2-methylpropyl)[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide | n/a | |
| 31 | O00408_EPV | EPV | n/a | 137349275 | CHEMBL4159391 | 1-(5-tert-butoxy-2-chlorophenyl)-4-methyl-N-(2-methylpropyl)[1,2,4]triazolo[4,3-a]quinoxaline-8-carboxamide | n/a | |
| 32 | O00408_FKG | FKG | n/a | 135567412 | CHEMBL4211122 | 3-(hydroxymethyl)-6-methyl-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | n/a | |
| 33 | O00408_FKJ | FKJ | n/a | 135567411 | CHEMBL4205666 | 3-(hydroxymethyl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | n/a | |
| 34 | O00408_FKV | FKV | n/a | 135567410 | CHEMBL4217892 | 3-(2,2,2-trifluoroethyl)-1-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-1H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione | n/a | |
| 35 | O00408_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 36 | O00408_IBM | IBM | DB07954 | 3758 | CHEMBL275084 | 3-ISOBUTYL-1-METHYLXANTHINE | inhibitor | IC50(nM) = 4000.0 |
| 37 | O00408_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 38 | O00408_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 39 | O00408_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 40 | O00408_Q2T | Q2T | n/a | 71153408 | CHEMBL3331521 | 1-(5-butoxypyridin-3-yl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline | n/a | |
| 41 | O00408_QMZ | QMZ | n/a | 92412618 | n/a | [(3~{S})-3-([1,2,4]triazolo[1,5-a]pyrimidin-7-yl)piperidin-1-yl]-(3,4,5-trimethoxyphenyl)methanone | n/a | |
| 42 | O00408_QOQ | QOQ | n/a | 155804505 | CHEMBL4797527 | 5-[bis(fluoranyl)methyl]-7-[(3~{S})-1-[(2-chloranyl-6-methyl-pyridin-4-yl)methyl]piperidin-3-yl]-[1,2,4]triazolo[1,5-a]pyrimidine | n/a | |
| 43 | O00408_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 44 | O00408_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 45 | O00408_35G | 35G | DB02315 | 24316;5280386;135398570; | CHEMBL395336 | Cyclic GMP | inhibitor | |
| 46 | O00408_SLO | SLO | DB06246 | 5472495 | CHEMBL488025 | Exisulind | n/a | |
| 47 | O00408_JPU | JPU | DB08811 | 5502 | CHEMBL404216 | Tofisopam | inhibitor |