Gene name: PRMT5
Protein name: Protein arginine N-methyltransferase
List of molecules and drugs that interact with protein O14744
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | O14744_0XU | 0XU | n/a | 60210984 | n/a | (2S,5S,6E)-2,5-diamino-6-[(3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxydihydrofuran-2(3H)-ylidene]hexanoic acid | n/a | |
| 2 | O14744_3XV | 3XV | n/a | 90241673 | CHEMBL4060831 | N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide | n/a | |
| 3 | O14744_4Z2 | 4Z2 | n/a | 117072552 | CHEMBL4542380 | 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl]pyridine-4-carboxamide | n/a | |
| 4 | O14744_5QH | 5QH | n/a | 76903444 | CHEMBL3963350 | ~{N}-[(2~{S})-3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-propyl]-3-pyridin-2-yl-benzamide | n/a | |
| 5 | O14744_5QJ | 5QJ | n/a | 90335209 | CHEMBL3891092 | (2~{S})-1-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-3-[[4-(3-methylbenzimidazol-5-yl)pyridin-2-yl]amino]propan-2-ol | n/a | |
| 6 | O14744_5QK | 5QK | n/a | 90241758 | CHEMBL3958947 | ~{N}-[(2~{R})-3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-propyl]-2-quinolin-8-yloxy-ethanamide | n/a | |
| 7 | O14744_5QL | 5QL | n/a | 90241843 | CHEMBL3938760 | ~{N}-[(2~{S})-3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-propyl]-3-(oxan-4-ylamino)benzamide | n/a | |
| 8 | O14744_81X | 81X | n/a | 816623 | CHEMBL5082733 | 4-(aminomethyl)phthalazin-1(2H)-one | n/a | |
| 9 | O14744_84W | 84W | n/a | 162421359 | n/a | [7-(1-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrophthalazin-1-yl]methanaminium | n/a | |
| 10 | O14744_85E | 85E | n/a | 162421360 | n/a | {7-[(5M)-5-(1-cyano-3-fluoronaphthalen-2-yl)-1-methyl-1H-pyrazol-4-yl]-4-oxo-3,4-dihydrophthalazin-1-yl}methanaminium | n/a | |
| 11 | O14744_85K | 85K | n/a | 162421361 | n/a | (7-{(5M)-5-[3-chloro-6-cyano-5-(cyclopropyloxy)-2-fluorophenyl]-1-methyl-1H-pyrazol-4-yl}-4-oxo-3,4-dihydrophthalazin-1-yl)methanaminium | n/a | |
| 12 | O14744_97L | 97L | n/a | 156151509 | CHEMBL5090360 | (2M)-2-{4-[4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl]-1-methyl-1H-pyrazol-5-yl}-1-benzothiophene-3-carbonitrile | n/a | |
| 13 | O14744_97X | 97X | n/a | 156151675 | CHEMBL5094637 | (2P)-2-{4-[4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl]-1-methyl-1H-pyrazol-5-yl}naphthalene-1-carbonitrile | n/a | |
| 14 | O14744_ACE | ACE | n/a | 177 | CHEMBL170365 | ACETYL GROUP | n/a | |
| 15 | O14744_ADN | ADN | DB00640 | 60961 | CHEMBL477 | ADENOSINE | n/a | |
| 16 | O14744_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 17 | O14744_CUX | CUX | n/a | 138753159 | CHEMBL4539373 | 2-[[7-[(2~{R},3~{R},4~{S},5~{R})-5-[(~{R})-(4-chlorophenyl)-oxidanyl-methyl]-3,4-bis(oxidanyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidin-4-yl]amino]ethanal | n/a | |
| 18 | O14744_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 19 | O14744_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 20 | O14744_EPE | EPE | DB16872 | 23830;23831;3275884; | CHEMBL1232545 | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | n/a | |
| 21 | O14744_F5J | F5J | n/a | 122669401 | CHEMBL4168754 | 7-[(5R)-5-C-phenyl-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a | |
| 22 | O14744_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 23 | O14744_JYX | JYX | n/a | 63758165 | CHEMBL5194111 | 3-ethylimidazo[4,5-b]pyridin-2-amine | n/a | |
| 24 | O14744_K8H | K8H | n/a | 130418846 | CHEMBL4595238 | (2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-5-(1,8-diazaspiro[4.5]decan-1-ylmethyl)oxolane-3,4-diol | n/a | |
| 25 | O14744_K8N | K8N | n/a | 126637809 | CHEMBL4249337 | (1~{S},2~{R},3~{S},5~{R})-3-[2-(2-azanyl-3-bromanyl-quinolin-7-yl)ethyl]-5-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)cyclop entane-1,2-diol | n/a | |
| 26 | O14744_LB3 | LB3 | n/a | 163321818 | CHEMBL5178474 | (9R,10R,11S,12R,13R,14R)-4-amino-9-(3,4-difluorophenyl)-6,7,8,9,10,11,12,13-octahydro-10,13-epoxy[1,3]diazecino[1,2-e]purine-11,12-diol | n/a | |
| 27 | O14744_MTA | MTA | DB02282 | 439176 | CHEMBL277041 | 5'-DEOXY-5'-METHYLTHIOADENOSINE | n/a | |
| 28 | O14744_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 29 | O14744_NXF | NXF | n/a | 164664430 | CHEMBL5171494 | (2M)-2-[(4M)-4-{4-(aminomethyl)-1-oxo-8-[(2R)-oxolan-2-yl]-1,2-dihydrophthalazin-6-yl}-1-methyl-1H-pyrazol-5-yl]-1-benzothiophene-3-carbonitrile | n/a | |
| 30 | O14744_P2R | P2R | n/a | 155177429 | n/a | N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide | n/a | |
| 31 | O14744_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 32 | O14744_PJ0 | PJ0 | n/a | 30484461 | CHEMBL5186479 | 3-methyl-1,5-naphthyridin-2-amine | n/a | |
| 33 | O14744_PUI | PUI | n/a | 91623614 | CHEMBL5169665 | 4-methyl-1,5-naphthyridin-2-amine | n/a | |
| 34 | O14744_PWL | PWL | n/a | 92130857 | CHEMBL4932251 | 6-bromo-1H-pyrrolo[3,2-b]pyridin-5-amine | n/a | |
| 35 | O14744_PWX | PWX | n/a | 43661428 | CHEMBL5197731 | 7-chloro-1-methyl-1H-benzimidazol-2-amine | n/a | |
| 36 | O14744_QKY | QKY | n/a | 154573805 | n/a | (5R)-2-amino-5-(2-cyclohexylethyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one | n/a | |
| 37 | O14744_QL1 | QL1 | n/a | n/a | n/a | (5R)-2-amino-5-(4-methoxyphenyl)-3-methyl-5-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-yl]-3,5-dihydro-4H-imidazol-4-one | n/a | |
| 38 | O14744_QN4 | QN4 | n/a | 155804497 | n/a | 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-sulfamoylphenyl)acetamide | n/a | |
| 39 | O14744_SAH | SAH | DB01752 | 439155;25246222; | CHEMBL418052 | S-ADENOSYL-L-HOMOCYSTEINE | n/a | |
| 40 | O14744_SAM | SAM | DB00118 | n/a | CHEMBL1235831 | S-ADENOSYLMETHIONINE | n/a | |
| 41 | O14744_SFG | SFG | DB01910 | 65482 | CHEMBL1214186 | SINEFUNGIN | n/a | |
| 42 | O14744_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 43 | O14744_U6K | U6K | n/a | n/a | n/a | (2~{R},3~{R},4~{S},5~{R})-2-[(4~{a}~{S},7~{a}~{S})-4-azanyl-1,4,4~{a},7~{a}-tetrahydropyrrolo[2,3-d]pyrimidin-7-yl]-5-(quinolin-7-yloxymethyl)oxolane-3,4-diol | n/a | |
| 44 | O14744_UNL | UNL | n/a | |||||
| 45 | O14744_WFM | WFM | n/a | 146346406 | CHEMBL4867267 | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol | n/a | |
| 46 | O14744_WFS | WFS | n/a | 146346407 | CHEMBL4868831 | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol | n/a | |
| 47 | O14744_WFV | WFV | n/a | 155899161 | CHEMBL4861625 | (1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol | n/a | |
| 48 | O14744_YJG | YJG | n/a | 155818904 | CHEMBL4850835 | 2-(5-chloro-6-oxopyridazin-1(6H)-yl)-N-(4-methyl-3-{[2-(pyridin-2-yl)ethyl]sulfamoyl}phenyl)acetamide | n/a | |
| 49 | O14744_ZR1 | ZR1 | n/a | 132200405 | CHEMBL4563402 | (1S,2S,3S,5R)-3-{[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol | n/a | |
| 50 | O14744_ZR4 | ZR4 | n/a | 122497021 | CHEMBL4441584 | 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine | n/a |